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12 results on '"Stets, Colin W."'

8. Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma

Author

Bill, Kate Lynn J., primary, Seligson, Nathan D., additional, Hays, John L., additional, Awasthi, Achal, additional, Demoret, Bryce, additional, Stets, Colin W., additional, Duggan, Megan C., additional, Bupathi, Manojkumar, additional, Brock, Guy N., additional, Millis, Sherri Z., additional, Shakya, Reena, additional, Timmers, Cynthia D., additional, Wakely, Paul E., additional, Pollock, Raphael E., additional, and Chen, James L., additional

Published
2019
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12. Metabolic Effects of Social Isolation in Adult C57BL/6 Mice.

Author

Meng Sun, Choi, Eugene Y., Magee, Daniel J., Stets, Colin W., During, Matthew J., and Lin, En-Ju D.

Subjects
OBESITY, METABOLIC disorders, TYPE 2 diabetes risk factors, LABORATORY mice, SOCIAL support, BODY weight
Abstract

Obesity and metabolic dysfunction are risk factors for a number of chronic diseases, such as type 2 diabetes, hypertension, heart disease, stroke, and certain forms of cancers. Both animal studies and human population-based and clinical studies have suggested that chronic stress is a risk factor for metabolic disorders. A good social support system is known to exert positive effects on the mental and physical well-being of an individual. On the other hand, long-term deprivation of social contacts may represent a stressful condition that has negative effects on health. In the present study, we investigated the effects of chronic social isolation on metabolic parameters in adult C57BL/6 mice. We found that individually housed mice had increased adipose mass compared to group-housed mice, despite comparable body weight. The mechanism for the expansion of white adipose tissue mass was depot-specific. Notably, food intake was reduced in the social isolated animals, which occurred around the light-dark phase transition periods. Similarly, reductions in heat generated and the respiratory exchange ratio were observed during the light-dark transitions. These phase-specific changes due to long-term social isolation have not been reported previously. Our study shows social isolation contributes to increased adiposity and altered metabolic functions. [ABSTRACT FROM AUTHOR]

Published
2014
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