Search

Your search keyword '"Sterner O"' showing total 523 results
Start Over Author "Sterner O"
523 results on '"Sterner O"'

6. Characteristics, clinical effect profile and tolerability of a nasal spray preparation of Artemisia abrotanum L. for allergic rhinitis

Author

Remberg, P., Bjork, L., Hedner, T., and Sterner, O.

Subjects
Hay-fever -- Diagnosis, Respiratory tract diseases -- Diagnosis, Medicinal plants -- Usage -- Product development, Intranasal medication -- Product development -- Usage, Biological sciences, Health, Science and technology, Diagnosis, Usage, Product development
Abstract

Summary A nasal spray formulation containing an extract of Artemisia abrotanum L. was developed for therapeutic use in patients with allergic rhinitis and other upper airway disorders. The nasal spray [...]

Published
2004

14. TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Delta(9)-tetrahydrocannabiorcol

Author

Andersson, D. (D) A. (A), Gentry, C. (C), Alenmyr, L. (L), Killander, D. (D), Lewis, S. (S) E. (E), Andersson, A. (A), Bucher, B. (Bernard), Galzi, J. (Jean-Luc) L. (L), Sterner, O. (O), Bevan, S. (S), Hogestatt, E. (E) D. (D), and Zygmunt, P. (P) M. (M)

Subjects
digestive, oral, and skin physiology, Aucun, food and beverages, psychological phenomena and processes
Abstract

TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics. Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice. The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. These metabolites also activate native TRPA1 and, as a consequence, sensory neurons. The N-acetyl-p-benzoquinoneimine metabolite L-cysteinyl-S-acetaminophen was detected in the mouse spinal cord after systemic acetaminophen administration. In the hot-plate test, intrathecal administration of N-acetyl-p-benzoquinoneimine, p-benzoquinone and the electrophilic TRPA1 activator cinnamaldehyde Trpa1(-/-) mice. Intrathecal injection of a non-electrophilic cannabinoid, Delta(9)-tetrahydrocannabiorcol, also produced TRPA1-dependent antinociception in this test. Our study provides a molecular mechanism for the antinociceptive effect of acetaminophen and discloses spinal TRPA1 activation as a potential pharmacological strategy to alleviate pain.

Published
2011

18. 4,5-Epoxide-1,6-dimethyl-1-vinylhexyl p-coumarate: A novel monoterpene derivative from Cleistopholis patens

Author

Ngnokam, D., Apollinaire Tsopmo, Ayafor, J. F., Nuzillard, J. M., and Sterner, O.

Subjects
Cleistopholis patens, Annonaceae, Oligosaccharide, Partially acetylated tri- and tetrarhamnoside dodecanyl ether derivatives, Cleistrioside, Cleistetroside, Monoterpene derivative
Abstract

A novel monoterpene derivative (1) and four known partially and total acetylated tri- and tetrarhamonoside dodecanyl ether derivatives: cleistrioside-2 (2) and cleistrioside-3 (3), cleistetroside-6 (4) and cleistetroside peracetate (5) have been isolated from the fruits of Cleistopholis patens. KEY WORDS: Cleistopholis patens, Annonaceae, Oligosaccharide, Partially acetylated tri- and tetrarhamnoside dodecanyl ether derivatives, Cleistrioside, Cleistetroside, Monoterpene derivative Bull. Chem. Soc. Ethiop. 2003, 17(2), 177-180.

Published
2004

19. A new P-glycoprotein inhibitor from the caper spurge (Euphorbia lathyris)

Author

Appendino, G., Dellaporta, C., Conseil, G., Sterner, O., Mercalli, E., Dumontet, C., Dipietro, A., and Deleage, Gilbert

Subjects
[SDV.BBM] Life Sciences [q-bio]/Biochemistry, Molecular Biology
Abstract

The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.The macrocyclic lathyrane polyester Euphorbia factor L10 (1a) has been obtained from the seeds of the caper spurge (E. lathyris). The interaction of L10 (1a) and its acetyl derivative (1b) with P-glycoprotein, a multidrug transporter overexpressed in cancer cells and responsible for resistance to chemotherapy, was investigated. The results established lathyrane diterpenoids as a novel chemotype for P-glycoprotein inhibitors.

Published
2003

20. Heterocycles of biological importance: Part 7. Synthesis of biologicallyactive pyrimido[2,1-b]benzothiazoles from acetylenic acids and2-aminobenzothiazoles

Author

Wahe H., Mbafor J., Nkengfack A., Fomum Z., Cherkasov R., Sterner O., and Doepp D.

Subjects
Cyclocondensation, Michael addition, Fused nitrogen heterocycles, Amidines
Abstract

Conjugate addition of the imino nitrogen of 2-aminobenzothiazoles 1 to the alkyne β-carbon atom of acetylenic acids 2 followed by ring closure gives rise to novel 2H-pyrimido[2,1-b]-benzothiazol-2-ones in good yield.

Published
2003

Catalog

Books, media, physical & digital resources
See catalog results