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962 results on '"Sterkers, Olivier"'

7. Predicting Matrix Test Effectiveness for Evaluating Auditory Performance in Noise Using Pure-Tone Audiometry and Speech Recognition in Quiet in Cochlear Implant Recipients.

Author

Flament, Jonathan, De Seta, Daniele, Russo, Francesca Yoshie, Bestel, Julie, Sterkers, Olivier, Ferrary, Evelyne, Nguyen, Yann, Mosnier, Isabelle, and Torres, Renato

Subjects
SPEECH perception, AUDITORY perception, ACOUSTIC field, COCHLEAR implants, SPEECH audiometry
Abstract

Introduction: Auditory performance in noise of cochlear implant recipients can be assessed with the adaptive Matrix test (MT); however, when the speech-to-noise ratio (SNR) exceeds 15 dB, the background noise has any negative impact on the speech recognition. Here, we aim to evaluate the predictive power of aided pure-tone audiometry and speech recognition in quiet and establish cut-off values for both tests that indicate whether auditory performance in noise can be assessed using the Matrix sentence test in a diffuse noise environment. Methods: Here, we assessed the power of pure-tone audiometry and speech recognition in quiet to predict the response to the MT. Ninety-eight cochlear implant recipients were assessed using different sound processors from Advanced Bionics (n = 56) and CochlearTM (n = 42). Auditory tests were performed at least 1 year after cochlear implantation or upgrading the sound processor to ensure the best benefit of the implant. Auditory assessment of the implanted ear in free-field conditions included: pure-tone average (PTA), speech discrimination score (SDS) in quiet at 65 dB, and speech recognition threshold (SRT) in noise that is the SNR at which the patient can correctly recognize 50% of the words using the MT in a diffuse sound field. Results: The SRT in noise was determined in 60 patients (61%) and undetermined in 38 (39%) using the MT. When cut-off values for PTA <36 dB and SDS >41% were used separately, they were able to predict a positive response to the MT in 83% of recipients; using both cut-off values together, the predictive value reached 92%. Discussion: As the pure-tone audiometry is standardized universally and the speech recognition in quiet could vary depending on the language used; we propose that the MT should be performed in recipients with PTA <36 dB, and in recipients with PTA >36 dB, a list of Matrix sentences at a fixed SNR should be presented to determine the percentage of words understood. This approach should enable clinicians to obtain information about auditory performance in noise whenever possible. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Phase II study of mTORC1 inhibition by everolimus in neurofibromatosis type 2 patients with growing vestibular schwannomas

Author

Goutagny, Stéphane, Raymond, Eric, Esposito-Farese, Marina, Trunet, Stéphanie, Mawrin, Christian, Bernardeschi, Daniele, Larroque, Béatrice, Sterkers, Olivier, Giovannini, Marco, and Kalamarides, Michel

Subjects
Rare Diseases, Neurosciences, Neurofibromatosis, Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Antineoplastic Agents, Biomarkers, Tumor, Cranial Nerve Neoplasms, Disease Progression, Disease-Free Survival, Everolimus, Female, Follow-Up Studies, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Neurilemmoma, Neurofibromatosis 2, Prospective Studies, TOR Serine-Threonine Kinases, Treatment Outcome, Tumor Burden, Vestibulocochlear Nerve Diseases, Young Adult, Tumor stabilization, Time to tumor progression, Vestibular schwannoma, Meningioma, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Neurofibromatosis type 2 (NF2) is a genetic disorder with bilateral vestibular schwannomas (VS) as the most frequent manifestation. Merlin, the NF2 tumor suppressor, was identified as a negative regulator of mammalian target of rapamycin complex 1. Pre-clinical data in mice showed that mTORC1 inhibition delayed growth of NF2-schwannomas. We conducted a prospective single-institution open-label phase II study to evaluate the effects of everolimus in ten NF2 patients with progressive VS. Drug activity was monitored every 3 months. Everolimus was administered orally for 12 months and, if the decrease in tumor volume was >20 % from baseline, treatment was continued for 12 additional months. Other patients stopped when completed 12 months of everolimus but were allowed to resume treatment when VS volume was >20 % during 1 year follow-up. Nine patients were evaluable. Safety was evaluated using CTCAE 3.0 criteria. After 12 months of everolimus, no reduction in volume ≥20 % was observed. Four patients had progressive disease, and five patients had stable disease with a median annual growth rate decreasing from 67 %/year before treatment to 0.5 %/year during treatment. In these patients, tumor growth resumed within 3-6 months after treatment discontinuation. Everolimus was then reintroduced and VS decreased by a median 6.8 % at 24 months. Time to tumor progression increased threefold from 4.2 months before treatment to > 12 months. Hearing was stable under treatment. The safety of everolimus was manageable. Although the primary endpoint was not reached, further studies are required to confirm the potential for stabilization of everolimus.

Published
2015

29. Haptic Rendering on Deformable Anatomical Tissues with Strong Heterogeneities

Author

Kazmitcheff, Guillaume, Courtecuisse, Hadrien, Nguyen, Yann, Miroir, Mathieu, Grayeli, Alexis Bozorg, Cotin, Stéphane, Sterkers, Olivier, Duriez, Christian, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Auvray, Malika, editor, and Duriez, Christian, editor

Published
2014
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30. Les auteurs

Author

Truy, Éric, primary, Lescanne, Emmanuel, additional, Loundon, Natalie, additional, Roman, Stéphane, additional, Alhamwi, Abir, additional, Avan, Paul, additional, Bakhos, David, additional, Barone, Pascal, additional, Beliaeff, Michel, additional, Belmin, Joël, additional, Bernardeschi, Daniele, additional, Blanchet, Catherine, additional, Borel, Stéphanie, additional, Charpiot, Anne, additional, Coez, Arnaud, additional, Couloigner, Vincent, additional, Darrouzet, Vincent, additional, Deggouj, Naïma, additional, Deguine, Olivier, additional, Denoyelle, Françoise, additional, Deveze, Arnaud, additional, El-Amraoui, Aziz, additional, Estève-Fraysse, Marie-José, additional, Farinetti, Anne, additional, Farné, Alessandro, additional, Franco, Valérie, additional, Gallego, Stéphane, additional, Gaveau, Valérie, additional, Giraudet, Fabrice, additional, Gnansia, Dan, additional, Godey, Benoît, additional, Guevara, Nicolas, additional, Jourdes, Vincent, additional, Kalamarides, Michel, additional, Laurent, Stéphane, additional, Lazard, Diane S., additional, Lebour, Josselin, additional, Lemesre, Pierre-Emmanuel, additional, Le Normand, Marie-Thérèse, additional, Leruez-Ville, Marianne, additional, Lina-Granade, Geneviève, additional, Londero, Alain, additional, Lorenzi, Christian, additional, Macherey, Olivier, additional, Marlin, Sandrine, additional, Martinez, Quentin, additional, Marx, Mathieu, additional, Micheyl, Christophe, additional, Mom, Thierry, additional, Mondain, Michel, additional, Mosnier, Isabelle, additional, Moulin, Annie, additional, Neagu, Alexandra, additional, Nguyen, Yann, additional, Norena, Arnaud, additional, Ohresser, Martine, additional, Parietti-Winkler, Cécile, additional, Parodi, Marine, additional, Pavani, Francesco, additional, Pawelczyk, Thierry, additional, Perrot, Xavier, additional, Puechmaille, Mathilde, additional, Puel, Jean-Luc, additional, Quatre, Raphaële, additional, Risoud, Michaël, additional, Robier, Mathieu, additional, Schmerber, Sébastien, additional, Siepmann, Juergen, additional, Sterkers, Olivier, additional, Teissier, Natacha, additional, Thai-Van, Hung, additional, Tringali, Stéphane, additional, Van Den Abbeele, Thierry, additional, Venail, Frédéric, additional, Veuillet, Évelyne, additional, Villeneuve, Alexandre, additional, Vincent, Christophe, additional, and Virole, Benoît, additional

Published
2018
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35. Registration of a Validated Mechanical Atlas of Middle Ear for Surgical Simulation

Author

Kazmitcheff, Guillaume, Duriez, Christian, Miroir, Mathieu, Nguyen, Yann, Sterkers, Olivier, Grayeli, Alexis Bozorg, Cotin, Stéphane, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Sudan, Madhu, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Vardi, Moshe Y., Series editor, Weikum, Gerhard, Series editor, Mori, Kensaku, editor, Sakuma, Ichiro, editor, Sato, Yoshinobu, editor, Barillot, Christian, editor, and Navab, Nassir, editor

Published
2013
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37. Simultaneous Bilateral Cochlear Implantation in Very Young Children Improves Adaptability and Social Skills: A Prospective Cohort Study

Author

Chen, Ying, primary, Li, Yun, additional, Jia, Huan, additional, Gu, Wenxi, additional, Wang, Zhaoyan, additional, Zhang, Zhihua, additional, Xue, Minbo, additional, Li, Jingjie, additional, Shi, Wentao, additional, Jiang, Linlin, additional, Yang, Lu, additional, Sterkers, Olivier, additional, and Wu, Hao, additional

Published
2022
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43. Functional Staging of Acoustic Neuromas

Author

Grayeli, Alexis Bozorg, Kalamarides, Michel, Bouccara, Didier, Rey, Alain, Sterkers, Olivier, Kanzaki, Jin, editor, Tos, Mirko, editor, Sanna, Mario, editor, Moffat, David A., editor, Kunihiro, Takanobu, editor, and Inoue, Yasuhiro, editor

Published
2003
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