Search

Your search keyword '"Stepien, Rebecca L."' showing total 184 results
Start Over Author "Stepien, Rebecca L."
184 results on '"Stepien, Rebecca L."'

1. Accuracy of Doppler echocardiographic estimates of pulmonary artery pressures in a canine model of pulmonary hypertension

Author

Soydan, Lydia C, Kellihan, Heidi B, Bates, Melissa L, Stepien, Rebecca L, Consigny, Daniel W, Bellofiore, Alessandro, Francois, Christopher J, and Chesler, Naomi C

Subjects
Veterinary Sciences, Agricultural, Veterinary and Food Sciences, Heart Disease, Cardiovascular, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Animals, Blood Pressure Determination, Cardiac Catheterization, Dog Diseases, Dogs, Echocardiography, Doppler, Female, Hypertension, Pulmonary, Pulmonary Artery, Radiography, Tricuspid regurgitation, Right heart catheterization, Right atrial pressure, Pulmonic regurgitation, Dog, Veterinary sciences
Abstract

ObjectivesTo compare noninvasive estimates of pulmonary artery pressure (PAP) obtained via echocardiography (ECHO) to invasive measurements of PAP obtained during right heart catheterization (RHC) across a range of PAP. To examine the accuracy of estimating right atrial pressure via ECHO (RAPECHO) compared to RAP measured by RHC (RAPRHC), and determine if adding RAPECHO improves the accuracy of noninvasive PAP estimations.Animals14 healthy female beagle dogs.MethodsComparison of ECHO and RHC measures of PAP, both at normal PAP and increased PAP generated by microbead embolization.ResultsNoninvasive estimates of PAP were moderately but significantly correlated (r of 0.68-0.78; p

Published
2015

2. Severity of Mitral Valve Degeneration Is Associated with Chromosome 15 Loci in Whippet Dogs.

Author

Stern, Joshua A, Hsue, Weihow, Song, Kun-Ho, Ontiveros, Eric S, Luis Fuentes, Virginia, and Stepien, Rebecca L

Subjects
Mitral Valve, Chromosomes, Mammalian, Animals, Dogs, Mitral Valve Insufficiency, Dog Diseases, Genetic Predisposition to Disease, Female, Male, Genome-Wide Association Study, Chromosomes, Mammalian, General Science & Technology
Abstract

Mitral valve degeneration (MVD) is the most common form of heart disease in dogs, frequently leading to left-sided congestive heart failure and cardiac mortality. Although breed-specific disease characteristics and overrepresentation point towards a genetic origin for MVD, a causative mutation and complete molecular pathogenesis are unknown. Whippet dogs are overrepresented in incidence of MVD, suggesting an inherited component in this breed. Expressivity of this condition is variable with some dogs showing evidence of more severe disease at earlier ages than other dogs. This phenomenon makes a traditional case versus control genetic study prone to phenotyping error. This study sought to avoid these common pitfalls by identifying genetic loci associated with severity of MVD in Whippets through a genome-wide association study (GWAS). 138 Whippet dogs were characterized for MVD by echocardiographic examination and a novel disease severity score was developed and adjusted for age in each subject. Single nucleotide polymorphism (SNP) genotype data (170k Illumina CanineHD SnpChip) was obtained for DNA isolated from blood of each study subject. Continuous variable genome wide association was performed after correction for population stratification by efficient mixed model association expedited (EMMAX) in 130 dogs. A genome wide significant association was identified on chromosome 15 (peak locus 57,770,326; Padj = 0.049) and secondary loci of suggestive association were identified on chromosome 2 (peak locus 37,628,875; Padj = 0.079). Positional candidate genes were identified within the primary and secondary loci including follistatin-related protein 5 precursor (FSTL5) and Rho GTPase-activating protein 26 (ARHGAP26). These results support the hypothesis that severity of MVD in whippets has a genetic basis and warrants further study by either candidate gene sequencing or next-generation techniques.

Published
2015

14. Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats

Author

Fox, Philip R., Oyama, Mark A., Reynolds, Caryn, Rush, John E., DeFrancesco, Terri C., Keene, Bruce W., Atkins, Clark E., MacDonald, Kristin A., Schober, Karsten E., Bonagura, John D., Stepien, Rebecca L., Kellihan, Heidi B., Nguyenba, Thaibinh P., Lehmkuhl, Linda B., Lefbom, Bonnie K., Moise, N. Sydney, and Hogan, Daniel F.

Published
2009
Full Text
View/download PDF

16. Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

Author

Boswood, Adrian, Gordon, Sonya G., Haggstrom, Jens, Vanselow, Martin, Wess, Gerhard, Stepien, Rebecca L., Oyama, Mark A., Keene, Bruce W., Bonagura, John, MacDonald, Kristin A., Patteson, Mark, Smith, Sarah, Fox, Philip R., Sanderson, Karen, Woolley, Richard, Szatmari, Viktor, Menaut, Pierre, Church, Whitney M., O'Sullivan, M. Lynne, Jaudon, Jean-Philippe, Kresken, Jan-Gerd, Rush, John, Barrett, Kirstie A., Rosenthal, Steven L., Saunders, Ashley B., Ljungvall, Ingrid, Deinert, Michael, Bomassi, Eric, Estrada, Amara H., Fernandez Del Palacio, Maria J., Moise, N. Sydney, Abbott, Jonathan A., Fujii, Yoko, Spier, Alan, Luethy, Michael W., Santilli, Roberto A., Uechi, Masami, Tidholm, Anna, Schummer, Christoph, and Watson, Philip

Subjects
clinical trials, cardiovascular, canine, heart failure, cardiovascular diseases, clinical epidemiology, physical examination, radiology and diagnostic imaging
Abstract

Background The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF). Objectives To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF. Animals One hundred and thirty-five, and 73 dogs that did or did not develop CHF, respectively. Materials and methods The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home-measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points. Results The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF. Conclusions and Clinical Importance Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF. Boehringer Ingelheim Animal Health GmbHBoehringer Ingelheim Boehringer Ingelheim Animal Health GmbH

Published
2020

18. Letter to the editor regarding “Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial”

Author

Atkins, Clarke, primary, Keene, Bruce, additional, DeFrancesco, Teresa C., additional, Tou, Sandra, additional, Chetboul, Valérie, additional, Côté, Étienne, additional, Ettinger, Stephen, additional, Fox, Philip R., additional, Hamlin, Robert L., additional, Mochel, Jonathan P., additional, Pouchelon, Jean‐Louis, additional, and Stepien, Rebecca L., additional

Published
2021
Full Text
View/download PDF

22. Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

Author

Boswood, Adrian, primary, Gordon, Sonya G., additional, Häggström, Jens, additional, Vanselow, Martin, additional, Wess, Gerhard, additional, Stepien, Rebecca L., additional, Oyama, Mark A., additional, Keene, Bruce W., additional, Bonagura, John, additional, MacDonald, Kristin A., additional, Patteson, Mark, additional, Smith, Sarah, additional, Fox, Philip R., additional, Sanderson, Karen, additional, Woolley, Richard, additional, Szatmári, Viktor, additional, Menaut, Pierre, additional, Church, Whitney M., additional, O'Sullivan, M. Lynne, additional, Jaudon, Jean‐Philippe, additional, Kresken, Jan‐Gerd, additional, Rush, John, additional, Barrett, Kirstie A., additional, Rosenthal, Steven L., additional, Saunders, Ashley B., additional, Ljungvall, Ingrid, additional, Deinert, Michael, additional, Bomassi, Eric, additional, Estrada, Amara H., additional, Fernandez Del Palacio, Maria J., additional, Moise, N. Sydney, additional, Abbott, Jonathan A., additional, Fujii, Yoko, additional, Spier, Alan, additional, Luethy, Michael W., additional, Santilli, Roberto A., additional, Uechi, Masami, additional, Tidholm, Anna, additional, Schummer, Christoph, additional, and Watson, Philip, additional

Published
2020
Full Text
View/download PDF

24. Contributors

Author

Anderson, Nancy L., primary, Alvarez, Francisco J., additional, Armbrust, Laura J., additional, Aron, Dennis N., additional, Bateman, Shane W., additional, Beale, Karin Muth, additional, Bednarski, Richard M., additional, Bellah, Jamie R., additional, Berkwitt, Larry, additional, Bettenay, Sonya V., additional, Biller, David S., additional, Birchard, Stephen J., additional, Bjorling, Dale E., additional, Bohling, Mark W., additional, Bonagura, John D., additional, Bonczynski, Jennifer, additional, Boothe, Harry W., additional, Boudrieau, Randy J., additional, Bowles, Heather L., additional, Bright, Ronald M., additional, Brooks, Marjory B., additional, Budsberg, Steven C., additional, Buffington, C. Anthony, additional, Calvert, Clay A., additional, Carothers, Marcia A., additional, Chen, Sue, additional, Chew, Dennis J., additional, Cole, Lynette K., additional, Colitz, Carmen M.H., additional, Osborn, Sarah Colombini, additional, Cuddon, Paul A., additional, Costa-Gómez, Támara M., additional, Davis, Kechia M., additional, DeCamp, Charles E., additional, Dueland, R. Tass, additional, Dziezyc, Joan, additional, Egger, Erick L., additional, Ellis, Christine, additional, Fenner, William R., additional, Fingland, Roger B., additional, Ford, Richard B., additional, Forrester, S. Dru, additional, Frank, Linda A., additional, Gamblin, Rance M., additional, Gieg, Jennifer, additional, Gilson, Stephen D., additional, Glaze, Mary B., additional, Graham, Joanne C., additional, Grant, David, additional, Graves, Thomas K., additional, Greco, Deborah S., additional, Green, Henry W., additional, Greenberg, Tia B., additional, Griffin, Craig E., additional, Grooters, Amy M., additional, Hamlin, Robert L., additional, Harris, Don J., additional, Hay, Callum W., additional, Hedlund, Cheryl S., additional, Helton-Rhodes, Karen, additional, Hillier, Andrew, additional, Holloway, Cheryl, additional, Hitchinson, Robert V., additional, Hubbell, John A.E., additional, Jerram, Richard M., additional, Johnson, Lynelle R., additional, Johnson, Susan E., additional, Johnston, Matthew S., additional, Jones, Denise, additional, Kay, Nancy D., additional, Keene, Bruce W., additional, Kern, Thomas J., additional, Kintzer, Peter P., additional, Kirschner, Susan E., additional, Kisseberth, William C., additional, Knapp, David W., additional, Koplitz, Shianne L., additional, Kowaleski, Michael P., additional, Kunkle, Gail A., additional, Kwochka, Kenneth W., additional, Labato, Mary Anna, additional, Lehmkuhl, Linda B., additional, Luttgen, Patricia J., additional, Manley, Paul A., additional, March, Philip A., additional, Marretta, Sandra Manfra, additional, Matthews, Hilary K., additional, McEntee, Margaret C., additional, McLoughlin, Mary A., additional, Miller, Michael S., additional, Millichamp, Nicholas J., additional, Millis, Darryl L., additional, Milovancev, Milan, additional, Moore, Cecil P., additional, Morris, Daniel O., additional, Mueller, Ralf S., additional, Muir, William W., additional, Mundell, Alan C., additional, Nichols, Rhett, additional, Noxon, James O., additional, Oglesbee, Barbara L., additional, Olmstead, Marvin L., additional, Page, Rodney L., additional, Palmisano, Matthew, additional, Panciera, David L., additional, Parker, Robert B., additional, Peterson, Janet L., additional, Peterson, Mark E., additional, Pilny, Anthony, additional, Pinchbeck, Lauren R., additional, Podell, Michael, additional, Prueter, James C., additional, Quesenberry, Katherine E., additional, Randolph, John F., additional, Raskin, Rose E., additional, Reine, Nyssa J., additional, Ridge, Laura G., additional, Rochat, Mark C., additional, Rosenkrantz, Wayne S., additional, Rosser, Edmund J., additional, Roush, James K., additional, Rush, John E., additional, Samii, Valerie F., additional, Scagliotti, Randall H., additional, Scheidt, Vicki J., additional, Schenck, Patricia A., additional, Schertel, Eric R., additional, Schober, Karsten E., additional, Shell, Linda G., additional, Shelton, G. Diane, additional, Sherding, Robert G., additional, Shires, Peter, additional, Sicard, Gretchen K., additional, Smeak, Daniel D., additional, Smith, Francis W.K., additional, Smith, Mark M., additional, Stepien, Rebecca L., additional, Stone, Elizabeth A., additional, Stone, Michael, additional, Swaim, Steven F., additional, Taylor, Robert A., additional, Tilley, Larry P., additional, Tomlinson, James, additional, Vail, David M., additional, Wack, Raymund F., additional, White, Stephen D., additional, and Wilkie, David A., additional

Published
2006
Full Text
View/download PDF

25. Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

Author

Interne geneeskunde GD, dCSCA AVR, CS_Welfare & emerging diseases, Boswood, Adrian, Gordon, Sonya G., Häggström, Jens, Vanselow, Martin, Wess, Gerhard, Stepien, Rebecca L., Oyama, Mark A., Keene, Bruce W., Bonagura, John, MacDonald, Kristin A., Patteson, Mark, Smith, Sarah, Fox, Philip R., Sanderson, Karen, Woolley, Richard, Szatmári, Viktor, Menaut, Pierre, Church, Whitney M., O'Sullivan, M. Lynne, Jaudon, Jean Philippe, Kresken, Jan Gerd, Rush, John, Barrett, Kirstie A., Rosenthal, Steven L., Saunders, Ashley B., Ljungvall, Ingrid, Deinert, Michael, Bomassi, Eric, Estrada, Amara H., Fernandez Del Palacio, Maria J., Moise, N. Sydney, Abbott, Jonathan A., Fujii, Yoko, Spier, Alan, Luethy, Michael W., Santilli, Roberto A., Uechi, Masami, Tidholm, Anna, Schummer, Christoph, Watson, Philip, Interne geneeskunde GD, dCSCA AVR, CS_Welfare & emerging diseases, Boswood, Adrian, Gordon, Sonya G., Häggström, Jens, Vanselow, Martin, Wess, Gerhard, Stepien, Rebecca L., Oyama, Mark A., Keene, Bruce W., Bonagura, John, MacDonald, Kristin A., Patteson, Mark, Smith, Sarah, Fox, Philip R., Sanderson, Karen, Woolley, Richard, Szatmári, Viktor, Menaut, Pierre, Church, Whitney M., O'Sullivan, M. Lynne, Jaudon, Jean Philippe, Kresken, Jan Gerd, Rush, John, Barrett, Kirstie A., Rosenthal, Steven L., Saunders, Ashley B., Ljungvall, Ingrid, Deinert, Michael, Bomassi, Eric, Estrada, Amara H., Fernandez Del Palacio, Maria J., Moise, N. Sydney, Abbott, Jonathan A., Fujii, Yoko, Spier, Alan, Luethy, Michael W., Santilli, Roberto A., Uechi, Masami, Tidholm, Anna, Schummer, Christoph, and Watson, Philip

Published
2020

27. CONTRIBUTORS

Author

Abbott, Jonathan A., primary, Armstrong, Julie, additional, Atkins, Clarke E., additional, Baty, Catherine J., additional, Beardow, Andrew W., additional, Blischok, Darlene R., additional, Bonagura, John D., additional, Bond, Betsy R., additional, Borde, Davin J., additional, Bossbaly, Maribeth J., additional, Bright, Janice McIntosh, additional, Brown, William A., additional, Buoscio, Dana A., additional, Calvert, Clay A., additional, Caulkett, Nigel A., additional, DeFrancesco, Teresa C., additional, Dunn, Marilyn, additional, Farrow, Charles S., additional, Fuentes, Virginia Luis, additional, Gomph, Rebecca E., additional, Goodwin, John-Karl, additional, Hamlin, Robert L., additional, Knight, David H., additional, Laste, Nancy J., additional, Lesser, Michael B., additional, Loyer, Carroll, additional, Marks, Steven L., additional, Mellema, Matthew S., additional, Porzio, Paolo, additional, Sammarco, Carl D., additional, Schrope, Donald P., additional, Sleeper, Margaret M., additional, Smith, Francis W.K., additional, Snyder, Patti S., additional, Stamoulis, Mark E., additional, Stepien, Rebecca L., additional, Ware, Wendy A., additional, and Wright, Kathy N., additional

Published
2000
Full Text
View/download PDF

29. Long‐term incidence and risk of noncardiovascular and all‐cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

Author

Fox, Philip R., primary, Keene, Bruce W., additional, Lamb, Kenneth, additional, Schober, Karsten E., additional, Chetboul, Valérie, additional, Luis Fuentes, Virginia, additional, Payne, Jessie Rose, additional, Wess, Gerhard, additional, Hogan, Daniel F., additional, Abbott, Jonathan A., additional, Häggström, Jens, additional, Culshaw, Geoffrey, additional, Fine‐Ferreira, Deborah, additional, Cote, Etienne, additional, Trehiou‐Sechi, Emilie, additional, Motsinger‐Reif, Alison A., additional, Nakamura, Reid K., additional, Singh, Manreet, additional, Ware, Wendy A., additional, Riesen, Sabine C., additional, Borgarelli, Michele, additional, Rush, John E., additional, Vollmar, Andrea, additional, Lesser, Michael B., additional, Van Israel, Nicole, additional, Lee, Pamela Ming‐Show, additional, Bulmer, Barret, additional, Santilli, Roberto, additional, Bossbaly, Maribeth J., additional, Quick, Nadine, additional, Bussadori, Claudio, additional, Bright, Janice, additional, Estrada, Amara H., additional, Ohad, Dan G., additional, del Palacio, Maria Josefa Fernández, additional, Brayley, Jennifer Lunney, additional, Schwartz, Denise S., additional, Gordon, Sonya G., additional, Jung, SeungWoo, additional, Bove, Christina M., additional, Brambilla, Paola G., additional, Moïse, N. Sydney, additional, Stauthammer, Christopher, additional, Quintavalla, Cecilia, additional, Manczur, Ferenc, additional, Stepien, Rebecca L., additional, Mooney, Carmel, additional, Hung, Yong‐Wei, additional, Lobetti, Remo, additional, Tamborini, Alice, additional, Oyama, Mark A., additional, Komolov, Andrey, additional, Fujii, Yoko, additional, Pariaut, Romain, additional, Uechi, Masami, additional, and Yukie Tachika Ohara, Victoria, additional

Published
2019
Full Text
View/download PDF

31. International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

Author

Fox, Philip R., primary, Keene, Bruce W., additional, Lamb, Kenneth, additional, Schober, Karsten A., additional, Chetboul, Valerie, additional, Luis Fuentes, Virginia, additional, Wess, Gerhard, additional, Payne, Jessie Rose, additional, Hogan, Daniel F., additional, Motsinger-Reif, Alison, additional, Häggström, Jens, additional, Trehiou-Sechi, Emilie, additional, Fine-Ferreira, Deborah M., additional, Nakamura, Reid K., additional, Lee, Pamela M., additional, Singh, Manreet K., additional, Ware, Wendy A., additional, Abbott, Jonathan A., additional, Culshaw, Geoffrey, additional, Riesen, Sabine, additional, Borgarelli, Michele, additional, Lesser, Michael B., additional, Van Israël, Nicole, additional, Côté, Etienne, additional, Rush, John E., additional, Bulmer, Barret, additional, Santilli, Roberto A., additional, Vollmar, Andrea C., additional, Bossbaly, Maribeth J., additional, Quick, Nadine, additional, Bussadori, Claudio, additional, Bright, Janice M., additional, Estrada, Amara H., additional, Ohad, Dan G., additional, Fernández-Del Palacio, Maria Josefa, additional, Lunney Brayley, Jenifer, additional, Schwartz, Denise S., additional, Bové, Christina M., additional, Gordon, Sonya G., additional, Jung, Seung Woo, additional, Brambilla, Paola, additional, Moïse, N. Sydney, additional, Stauthammer, Christopher D., additional, Stepien, Rebecca L., additional, Quintavalla, Cecilia, additional, Amberger, Christophe, additional, Manczur, Ferenc, additional, Hung, Yong-Wei, additional, Lobetti, Remo, additional, De Swarte, Marie, additional, Tamborini, Alice, additional, Mooney, Carmel T., additional, Oyama, Mark A., additional, Komolov, Andrey, additional, Fujii, Yoko, additional, Pariaut, Romain, additional, Uechi, Masami, additional, and Tachika Ohara, Victoria Yukie, additional

Published
2018
Full Text
View/download PDF

32. QUANTITATIVE PLANAR AND VOLUMETRIC CARDIAC MEASUREMENTS USING 64 MDCT AND 3T MRI VS. STANDARD 2D AND M-MODE ECHOCARDIOGRAPHY: DOES ANESTHETIC PROTOCOL MATTER?

Author

Drees, Randi, Johnson, Rebecca A, Stepien, Rebecca L, Rio, Alejandro Munoz Del, Saunders, Jimmy H, and François, Christopher J

Subjects
Isoflurane, Anesthetics, General, Cardiac Volume, Midazolam, Angiography, Blood Pressure, Heart, Magnetic Resonance Imaging, Article, Ventricular Function, Left, Fentanyl, Dogs, Echocardiography, Heart Rate, Anesthetics, Inhalation, Multidetector Computed Tomography, Image Processing, Computer-Assisted, Animals, Hypnotics and Sedatives, Prospective Studies, Propofol, Anesthetics, Intravenous, Dexmedetomidine, Preanesthetic Medication, Retrospective Studies
Abstract

Cross-sectional imaging of the heart utilizing computed tomography (CT) and magnetic resonance imaging (MRI) has been shown to be superior for the evaluation of cardiac morphology and systolic function in humans compared to echocardiography. The purpose of this prospective study was to test the effects of two different anesthetic protocols on cardiac measurements in 10 healthy beagle dogs using 64-multidetector row computed tomographic angiography (64-MDCTA), 3T magnetic resonance (MRI) and standard awake echocardiography. Both anesthetic protocols used propofol for induction and isoflourane for anesthetic maintenance. In addition, protocol A used midazolam/fentanyl and protocol B used dexmedetomedine as premedication and constant rate infusion during the procedure. Significant elevations in systolic and mean blood pressure were present when using protocol B. There was overall good agreement between the variables of cardiac size and systolic function generated from the MDCTA and MRI exams and no significant difference was found when comparing the variables acquired using either anesthetic protocol within each modality. Systolic function variables generated using 64-MDCTA and 3T MRI were only able to predict the left ventricular end diastolic volume as measured during awake echocardiogram when using protocol B and 64-MDCTA. For all other systolic function variables, prediction of awake echocardiographic results was not possible (P = 1). Planar variables acquired using MDCTA or MRI did not allow prediction of the corresponding measurements generated using echocardiography in the awake patients (P=1). Future studies are needed to validate this approach in a more varied population and clinically affected dogs.

Published
2014

35. Echocardiographic effects of dexmedetomidine–ketamine in chinchillas (Chinchilla lanigera).

Author

Doss, Grayson A., Mans, Christoph, and Stepien, Rebecca L.

Subjects
HEART function tests, DEXMEDETOMIDINE, ANALGESICS, KETAMINE, STRESS echocardiography
Abstract

Alpha2-agonist anesthetic combinations are often used in rodent anesthesia but no information about their effects on cardiac function in chinchillas exists. The purpose of this study was to utilize echocardiography to evaluate the cardiovascular effects of dexmedetomidine–ketamine anesthesia in chinchillas. Echocardiographic examinations were performed in eight adult chinchillas under manual restraint and following dexmedetomidine (0.015 mg/kg) and ketamine (4 mg/kg) administration. Dexmedetomidine–ketamine anesthesia resulted in a significantly decreased heart rate, fractional shortening, cardiac output, and flow velocity across the aortic and pulmonic valves, and significantly increased left ventricular internal diameter in systole. The observed changes in echocardiographic parameters are similar to those previously reported in chinchillas anesthetized with isoflurane. [ABSTRACT FROM AUTHOR]

Published
2017
Full Text
View/download PDF

37. Clinical usefulness of an assay for measurement of circulating N-terminal pro-B-type natriuretic peptide concentration in dogs and cats with heart disease

Author

Oyama, Mark A., primary, Boswood, Adrian, additional, Connolly, David J., additional, Ettinger, Stephen J., additional, Fox, Philip R., additional, Gordon, Sonya G., additional, Rush, John E., additional, Sisson, D. David, additional, Stepien, Rebecca L., additional, Wess, Gerhard, additional, and Zannad, Faiez, additional

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results