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Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.

Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comprehensive and comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to define parameters critical to disease progression and the extent to which they correlate with human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.One Sentence SummaryNonhuman primates develop COVID-19 following airborne virus exposure.

At their core, firms competing through international technology-based strategies rely on an organization system that uses a strong culture to bond human assets, senior leadership, and resources together in ways that cultivate and promote core competencies and capabilities. This paper presents empirical tests of the relationship between these factors and organization success. The study is based on the analysis of fifty-six case studies.

Surrogate-based Workload Application Performance Projection (SWAPP) is a framework for performance projections of High Performance Computing (HPC) applications using benchmark data. Performance projections of HPC applications onto various hardware platforms are important for hardware vendors and HPC users. The projections aid hardware vendors in the design of future systems and help HPC users with system procurement. SWAPP assumes that one has access to a base system and only benchmark data for a target system, the target system is not available for running the HPC application. Projections are developed using the performance profiles of the benchmarks and application on the base system and the benchmark data for the target system. SWAPP projects the performances of compute and communication components separately then combine the two projections to get the full application projection. In this paper SWAPP was used to project the performance of three NAS Multi-Zone benchmarks onto three systems (an IBM POWER6 575 cluster and an IBM Intel West mere x5670 both using an Infiniband interconnect and an IBM Blue Gene/P with a 3D Torus and Collective Tree interconnects), the base system is an IBM POWER5+ 575 cluster. The projected performance of the three benchmarks was within 11.44% average error magnitude and standard deviation of 2.64% for the three systems.