17 results on '"Stephen McMurray"'
Search Results
2. Effect of prenatal cocaine on early postnatal thermoregulation and ultrasonic vocalization production
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Matthew Stephen McMurray, Philip Sanford Zeskind, Stephanie M Meiners, Kristin A Garber, Hsiao eTien, and Josephine M Johns
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Thermogenesis ,stress ,Cardiac ,brown adipose tissue ,Prenatal cocaine ,ultrasonic vocalization ,Psychology ,BF1-990 - Abstract
Prenatal cocaine exposure can alter the postnatal care received by rat pups. Such effects could be caused in part by alterations in pup-produced stimuli that elicit early postnatal maternal care. Pup ultrasonic vocalizations are thought to be a particularly salient stimulus, and when paired with other cues, may elicit maternal attention. Cocaine is known to acutely alter thermoregulatory and cardiac function, thus prenatal cocaine may affect vocalizations through altering these functions. The data presented here determine the impact of full term prenatal cocaine exposure , saline exposure, or no exposure on thermogenic capacity, cardiac function, and the resulting ultrasonic vocalizations across the early postnatal period (days 1-5). Results indicated that while sharing many similar characteristics with saline-exposed and untreated animals, prenatal cocaine exposure was associated with specific alterations in vocalization characteristics on postnatal day 1 (PND 1), including call amplitude. Furthermore, numerous spectral parameters of their vocalizations were found altered on PND 3, including rate, call duration, and frequency, while no alterations were found on PND 5. Additionally, cocaine-exposed pups also showed a reduced thermoregulatory capacity compared to saline animals and reduced cardiac mass compared to untreated animals on PND 5. Together, these findings indicate that prenatal cocaine may be altering the elicitation of maternal care through its impact on vocalizations and thermoregulation, and suggests a potential mechanism for these effects through cocaine’s impact on developing stress systems.
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- 2013
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3. Combined Norepinephrine / Serotonergic Reuptake Inhibition: Effects on Maternal Behavior, Aggression and Oxytocin in the Rat
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Elizabeth Thomas Cox, Thomas Merryfield Jarrett, Matthew Stephen McMurray, Kevin eGreenhill, Vivian E Hofler, Sarah Kaye Williams, Paul Wayland Joyner, Christopher L Middleton, Cheryl H Walker, and Josephine M Johns
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Amitriptyline ,Desipramine ,Maternal Behavior ,Norepinephrine ,Oxytocin ,Serotonin ,Psychiatry ,RC435-571 - Abstract
BACKGROUND: Few systematic studies exist on the effects of chronic reuptake of monoamine neurotransmitter systems during pregnancy on the regulation of maternal behavior, although many drugs act primarily through one or more of these systems. Previous studies examining fluoxetine and amfonelic acid treatment during gestation on subsequent maternal behavior in rodents indicated significant alterations in postpartum maternal care, aggression and oxytocin levels. In this study, we extended our studies to include chronic gestational treatment with desipramine or amitriptyline to examine differential effects of reuptake inhibition of norepinephrine and combined noradrenergic and serotonergic systems on maternal behavior, aggression, and oxytocin system changes. METHODS: Pregnant Sprague-Dawley rats were treated throughout gestation with saline or one of three doses of either desipramine, which has a high affinity for the norepinephrine monoamine transporter, or amitriptyline, an agent with high affinity for both the norepinephrine and serotonin monoamine transporters. Maternal behavior and postpartum aggression were assessed on postpartum days one and six respectively. Oxytocin levels were measured in relevant brain regions on postpartum day seven. Predictions were that amitriptyline would decrease maternal behavior and increase aggression relative to desipramine, particularly at higher doses. Amygdaloidal oxytocin was expected to decrease with increased aggression. RESULTS: Amitriptyline and desiprimine differentially reduced maternal behavior, and at higher doses reduced aggressive behavior. Hippocampal oxytocin levels were lower after treatment with either drug but were not correlated with specific behavioral effects. These results, in combination with previous findings following gestational treatment with other selective neurotransmitter reuptake inhibitors, highlight the diverse effects of multiple monoamine systems thought to be involved in maternal care.
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- 2011
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4. The impact of funding cuts to further education colleges in Scotland
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Stephen McMurray
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Further education ,Medical education ,media_common.quotation_subject ,05 social sciences ,Retraining ,050301 education ,Employability ,Public administration ,Education ,Adult education ,Austerity ,Political science ,Vocational education ,0502 economics and business ,Unemployment ,Retrenchment ,0503 education ,050203 business & management ,media_common - Abstract
This article explores the impact of funding cuts to the Further Education colleges in Scotland. The reduction in the number of students in the colleges has been hugely politically controversial. The research utilised the Infact database on the Scottish Funding Council’s website and also a literature review. The research found there had been a significant reduction in the number of students aged under 16 and 25 and over. This is related to a decision to focus on full-time courses for school leavers and to stop funding courses which lead to no recognised qualifications or last less than ten hours. The implications of this are that an increased focus on employability and qualification attainment of school leavers is important to increase employability and reduce the likelihood of NEET and/or enter a long-term cycle of low skilled work and unemployment. However, the reduction of other courses may affect part-time and older students. Many people will be prevented from retraining or upskilling as they a...
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- 2017
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5. Association of Chronic Condition Special Needs Plan With Hospitalization and Mortality Among Patients With End-Stage Kidney Disease
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Dena E. Cohen, Steven M. Brunelli, Bryan Gregory, Jiacong Luo, Carey Colson, Kathryn S. Gray, Stephen McMurray, Nathan Lohmeyer, and Bryan N. Becker
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Male ,medicine.medical_specialty ,Chronic condition ,medicine.medical_treatment ,Cohort Studies ,Quality of life ,Renal Dialysis ,Internal medicine ,Outcome Assessment, Health Care ,medicine ,Humans ,Dialysis ,Original Investigation ,Aged ,business.industry ,Research ,Hazard ratio ,Case-control study ,General Medicine ,Middle Aged ,medicine.disease ,United States ,Hospitalization ,Online Only ,Nephrology ,Case-Control Studies ,Kidney Failure, Chronic ,Medicare Part C ,Female ,Hemodialysis ,business ,Kidney disease ,Cohort study - Abstract
Key Points Question Is enrollment in a chronic condition special needs plan (C-SNP) associated with improved outcomes in patients with end-stage kidney disease (ESKD)? Findings In this cohort study of 2545 C-SNP enrollees matched at the facility level to patients not enrolled in C-SNP and 1986 C-SNP enrollees matched at the county level to patients not enrolled in C-SNP, C-SNP enrollees had significantly lower hospitalization rates and mortality risk than matched patients who were not enrolled in a C-SNP. Meaning The findings of this study suggest that enrollment in a C-SNP may improve outcomes compared with standard care for patients with ESKD., This cohort study examines whether enrollment in a chronic condition special needs plan is associated with improved clinical outcomes and quality of life among patients with end-stage kidney disease (ESKD)., Importance While several studies have demonstrated the benefit of enrollment in chronic condition special needs plans (C-SNPs) for other chronic diseases (eg, diabetes), there is no evaluation of the association of C-SNPs with outcomes among patients with end-stage kidney disease (ESKD). Objective To examine whether and to what degree C-SNP enrollment was associated with improved clinical outcomes and quality of life in patients with ESKD. Design, Setting, and Participants This multicenter cohort study included 2718 patients who were newly enrolled in an ESKD C-SNP between January 1, 2013, and September 30, 2017, and receiving dialysis from DaVita Kidney Care. Patients were followed up until death, loss to follow-up, or end of study (ie, December 31, 2018). Enrollees in C-SNP were matched via multiple clinical and demographic characteristics with 2 different control populations, as follows: (1) those in the same facilities (n = 2545) or (2) those in similar counties (n = 1986). Patients enrolled in CareMore C-SNPs (n = 206) were excluded from the study. Data analysis was conducted June to December 2019. Exposures Standard ESKD care with dialysis plus access to an integrated care team who worked with the patient and the dialysis team, comprehensive health assessments done by the integrated care team, and access to select benefits (such as vision and dental care) as a C-SNP enrollee. Main Outcomes and Measures Hospitalizations, mortality, laboratory values indicative of metabolic control, and Kidney Disease Quality of Life 36-item (KDQOL-36) survey scores. Results The 2545 C-SNP enrollees in the facility-matched analysis had a mean (SD) age of 57.2 (12.9) years, and included 968 (38.0%) women, 1328 (52.2%) Hispanic individuals, and 553 (21.7%) African American individuals. The 1986 C-SNP enrollees in the county-matched analysis had a mean (SD) age of 57.8 (12.2) years, with 705 (35.5%) women, 1085 (54.6%) Hispanic individuals, and 472 (23.8%) African American individuals. Compared with patients not enrolled in C-SNP, enrollees had lower hospitalization rates, with incidence rate ratios of 0.90 (95% CI, 0.84-0.97; P = .006) in the facility-matched analysis and 0.76 (95% CI, 0.70-0.83; P
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- 2020
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6. A payer-provider partnership for integrated care of patients receiving dialysis
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Justin, Kindy, David, Roer, Robert, Wanovich, and Stephen, McMurray
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Male ,Insurance, Health ,Health Personnel ,Insurance Carriers ,Continuity of Patient Care ,United States ,Socioeconomic Factors ,Renal Dialysis ,Electronic Health Records ,Humans ,Kidney Failure, Chronic ,Female ,Health Expenditures ,Retrospective Studies - Abstract
Patients with end-stage renal disease (ESRD) are clinically complex, requiring intensive and costly care. Coordinated care may improve outcomes and reduce costs. The objective of this study was to determine the impact of a payer-provider care partnership on key clinical and economic outcomes in enrolled patients with ESRD.Retrospective observational study.Data on patient demographics and clinical outcomes were abstracted from the electronic health records of the dialysis provider. Data on healthcare costs were collected from payer claims. Data were collected for a baseline period prior to initiation of the partnership (July 2011-June 2012) and for two 12-month periods following initiation (April 2013-March 2014 and April 2014-March 2015).Among both Medicare Advantage and commercial insurance program members, the rate of central venous catheter use for vascular access was lower following initiation of the partnership compared with the baseline period. Likewise, hospital admission rates, emergency department visit rates, and readmission rates were lower following partnership initiation. Rates of influenza and pneumococcal vaccination were higher than 95% throughout all 3 time periods. Total medical costs were lower for both cohorts of members in the second 12-month period following partnership initiation compared with the baseline period.Promising trends were observed among members participating in this payer-provider care partnership with respect to both clinical and economic outcomes. This suggests that collaborations with shared incentives may be a valuable approach for patients with ESRD.
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- 2018
7. 16th International Conference on Dialysis. Advances in Chronic Kidney Disease 2014. January 22-25, 2014, Caesars Palace, Las Vegas, Nev.: Abstracts
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Jeroen P. Kooman, Giovanni Tripepi, Albert Power, Ralf Schindler, Margaret Nevin, Aileen Grassmann, Michael Etter, Adam Tashman, Ewa Żukowska-Szczechowska, Chi-Hung Cheng, Yuedong Wang, Mathias Schaller, Marianna Bellantoni, Giovannella Baggio, Claudia Barth, Annalisa Salari, Yosef S. Haviv, Flavio Basso, Neill Duncan, Marina Loucaidou, Judy Weintraub, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Magdalena Mokrejsova, Adrian Guinsburg, Shang-Feng Tsai, Cristina Marelli, Ya-Wen Chuang, Stephan Thijssen, Olaf Boenisch, Alessandra Brendolan, Lina Minazzato, Simon Beagle, Claire Edwards, Michiel G. H. Betjes, Umberto Cillo, Piero Amodio, Druck Reinhardt Druck Basel, Franklin W. Maddux, Frank M. van der Sande, Peter Kotanko, Kuo-Hsiung Shu, Giacomo Zanus, Ted Toffelmire, Nicolle H.R. Litjens, Ruud W. J. Meijers, Mary Carter, Seema K Singh, Dinna N. Cruz, Anna Clementi, Sonya Day, Werner Beck, Tung-Min Yu, Eva Pazourkova, Reinhold Deppisch, Sami Schiff, Runolfur Palsson, Inga Bayh, Vladimir Tesar, Ying-Chih Lo, Daniele Neri, Richard Corbett, Anna Giuliani, Sampson Antwi, Olafur Skuli Indridason, Allen R. Nissenson, Claudia Torino, Carmine Zoccali, Alessandra Brocca, Shih-Ting Huang, Vincenzo Cantaluppi, Massimo de Cal, Ales Horinek, Daniele Marcelli, Sachin S Soni, Peter Choi, Satz Mengensatzproduktion, Laura Scatizzi, Pasquale Piccinni, Francesca Mallamaci, Antonio Granata, Marie Korabecna, Ming-Ju Wu, F. Klefisch, Olof Viktorsdottir, Damien Ashby, Daniel Zickler, Cheng-Hsu Chen, Giovanna Berdin, Giorgio Vescovo, Grzegorz Wystrychowski, Gero von Gersdorff, Claudio Ronco, Giacomo Mason, C. Kneis, Caroline Williams, Marzena Wjewodzka, Stephen McMurray, Tonino Bianco, Terry Ketchersid, Rocco Tripepi, Nathan W. Levin, John Callegari, and Charles D. Pusey
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Gerontology ,medicine.medical_specialty ,Las vegas ,business.industry ,General surgery ,medicine.medical_treatment ,Hematology ,General Medicine ,medicine.disease ,Nephrology ,medicine ,business ,Dialysis ,Kidney disease - Published
- 2013
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8. Contents Vol. 36, 2013
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Jeroen P. Kooman, Daniel Zickler, Sachin S Soni, Olaf Boenisch, Yosef S. Haviv, Simon Beagle, Werner Beck, Michael Etter, Runolfur Palsson, Kuo-Hsiung Shu, Annalisa Salari, Dinna N. Cruz, Claudia Barth, Vincenzo Cantaluppi, Giovanni Tripepi, Laura Scatizzi, Marie Korabecna, Tonino Bianco, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Charles D. Pusey, Satz Mengensatzproduktion, Ying-Chih Lo, Shang-Feng Tsai, Shih-Ting Huang, Neill Duncan, Caroline Williams, Stephan Thijssen, Damien Ashby, Cheng-Hsu Chen, Grzegorz Wystrychowski, Cristina Marelli, Chi-Hung Cheng, Giorgio Vescovo, Olafur S. Indridason, Flavio Basso, Giacomo Zanus, Yuedong Wang, Judy Weintraub, Eva Pazourkova, Ales Horinek, Marzena Wjewodzka, Nathan W. Levin, Adrian Guinsburg, Ewa Żukowska-Szczechowska, Magdalena Mokrejsova, Claudia Torino, Frank M. van der Sande, Marianna Bellantoni, Massimo de Cal, Nicolle H.R. Litjens, Vladimir Tesar, Peter Choi, Francesca Mallamaci, Claire Edwards, Mathias Schaller, Daniele Marcelli, Terry Ketchersid, Antonio Granata, Pasquale Piccinni, Marina Loucaidou, Claudio Ronco, Ming-Ju Wu, Lina Minazzato, F. Klefisch, Ya-Wen Chuang, Mary Carter, Giacomo Mason, Druck Reinhardt Druck Basel, Alessandra Brocca, Ralf Schindler, Margaret Nevin, Piero Amodio, Rocco Tripepi, Franklin W. Maddux, Inga Bayh, Ted Toffelmire, Sampson Antwi, Sonya Day, Giovanna Berdin, Ruud W. J. Meijers, Stephen McMurray, John Callegari, Sami Schiff, Gero von Gersdorff, Michiel G. H. Betjes, Allen R. Nissenson, Reinhold Deppisch, Olof Viktorsdottir, Alessandra Brendolan, Anna Clementi, C. Kneis, Umberto Cillo, Daniele Neri, Seema K Singh, Tung-Min Yu, Anna Giuliani, Carmine Zoccali, Peter Kotanko, Aileen Grassmann, Richard Corbett, Albert Power, Adam Tashman, and Giovannella Baggio
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Nephrology ,Hematology ,General Medicine - Published
- 2013
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9. Agile waveforms for joint SAR-GMTI processing
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Jeffrey Corbeil, Stephen McMurray, Mark R. Bell, Steven Jaroszewski, Allan Corbeil, Michael J. Minardi, and Uttam Majumder
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Synthetic aperture radar ,020301 aerospace & aeronautics ,Computer science ,ComputerApplications_COMPUTERSINOTHERSYSTEMS ,02 engineering and technology ,Moving target indication ,law.invention ,Spread spectrum ,Continuous-wave radar ,symbols.namesake ,0203 mechanical engineering ,law ,Radar imaging ,symbols ,Electronic engineering ,Chirp ,Waveform ,Radar ,Doppler effect ,Remote sensing - Abstract
Wideband radar waveforms that employ spread-spectrum techniques were investigated and experimentally tested. The waveforms combine bi-phase coding with a traditional LFM chirp and are applicable to joint SAR-GMTI processing. After de-spreading, the received signals can be processed to support simultaneous GMTI and high resolution SAR imaging missions by airborne radars. The spread spectrum coding techniques can provide nearly orthogonal waveforms and offer enhanced operations in some environments by distributing the transmitted energy over a large instantaneous bandwidth. The LFM component offers the desired Doppler tolerance. In this paper, the waveforms are formulated and a shift-register approach for de-spreading the received signals is described. Hardware loop-back testing has shown the feasibility of using these waveforms in experimental radar test bed.
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- 2016
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10. Employer Demands from Business Graduates
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Matthew Dutton, Stephen McMurray, Alec Richard, and Ronald W McQuaid
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658 General management ,employers ,LB2300 Higher Education ,HD28 Management. Industrial Management ,Personnel selection ,Employability ,Graduates ,Education ,Likert scale ,Skills management ,HEI Key Information Sets ,0502 economics and business ,Pedagogy ,Transferable skills analysis ,ComputingMilieux_COMPUTERSANDEDUCATION ,graduate ,Employment Research Institute ,Life-span and Life-course Studies ,business ,Medical education ,skills ,students ,Management development ,ComputingMilieux_THECOMPUTINGPROFESSION ,05 social sciences ,050301 education ,Work experience ,AI and Technologies ,employment ,Workforce ,Business, Management and Accounting (miscellaneous) ,Psychology ,0503 education ,050203 business & management ,management - Abstract
Purpose – The purpose of this paper is to report on research carried out with employers to determine demand for business and management skills in the Scottish workforce. Design/methodology/approach – The research used a questionnaire in which employers were interviewed (either telephone or face to face), completed themselves and returned by e-mail, or completed an online survey. In total, 71 employers took part in the study. Findings – The research found that the factors which are most important to employers when recruiting graduates were; personal attitude, employability skills, relevant work experience and degree result. The most important transferable skills to employers when recruiting graduates were; trustworthiness, reliability, motivation, communication skills and a willingness to learn. Social implications – The paper shows the importance of graduates developing excellent job searching skills, high-quality work experience and developing business courses to enhance students’ employability and better meet employers’ wants. Originality/value – The paper is timely given the introduction of Key Information Sets. The provision of such information will drive HEI to further develop students’ employability to obtain graduate-level jobs.
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- 2016
11. ESRD special needs plans: a proof of concept for integrated care
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Mahesh, Krishnan, Eric, Franco, Stephen, McMurray, Eugene, Petra, and Allen R, Nissenson
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Accountable Care Organizations ,Delivery of Health Care, Integrated ,Medicaid ,Patient Protection and Affordable Care Act ,Humans ,Kidney Failure, Chronic ,Health Care Costs ,Medicare ,Centers for Medicare and Medicaid Services, U.S ,United States ,Quality of Health Care - Abstract
Since the completion of the Centers for Medicare and Medicaid Services' end-stage renal disease (ESRD) demonstration projects, passage of the Affordable Care Act, and announcement of ESRD Seamless Care Organizations (ESCOs) by CMS' Innovation Center, it seems that ESRD-centered accountable care organizations will be the future model for kidney care of Medicare beneficiaries. Regardless of what you call it--managed care organization, special needs plan, ESCO--balancing quality of health care with costs of health care will continue to be the primary directive for physicians and institutions using integrated care management (ICM) strategies to manage their ESRD patients' health. The renal community has had previous success with ICM, and these experiences could help to guide our way.
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- 2015
12. Toward population management in an integrated care model
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Stephen McMurray, Franklin W. Maddux, and Allen R. Nissenson
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Quality management ,Quality Assurance, Health Care ,Epidemiology ,Population ,Medicare ,Critical Care and Intensive Care Medicine ,Nursing ,Cost Savings ,Renal Dialysis ,Patient Protection and Affordable Care Act ,Health care ,Medicine ,Humans ,Operations management ,Incentive program ,Disease management (health) ,education ,Reimbursement, Incentive ,Quality of Health Care ,Transplantation ,education.field_of_study ,Accountable Care Organizations ,Prospective Payment System ,business.industry ,Delivery of Health Care, Integrated ,Environmental resource management ,Disease Management ,Hematology ,General Medicine ,Health Care Costs ,United States ,Integrated care ,Nephrology ,Kidney Failure, Chronic ,Prospective payment system ,business ,Medicaid - Abstract
Under the Patient Protection and Affordable Care Act of 2010, accountable care organizations (ACOs) will be the primary mechanism for achieving the dual goals of high-quality patient care at managed per capita costs. To achieve these goals in the newly emerging health care environment, the nephrology community must plan for and direct integrated delivery and coordination of renal care, focusing on population management. Even though the ESRD patient population is a complex group with comorbid conditions that may confound integration of care, the nephrology community has unique experience providing integrated care through ACO-like programs. Specifically, the recent ESRD Management Demonstration Project sponsored by the Centers for Medicare & Medicaid Services and the current ESRD Prospective Payment System with it Quality Incentive Program have demonstrated that integrated delivery of renal care can be accomplished in a manner that provides improved clinical outcomes with some financial margin of savings. Moving forward, integrated renal care will probably be linked to provider performance and quality outcomes measures, and clinical integration initiatives will share several common elements, namely performance-based payment models, coordination of communication via health care information technology, and development of best practices for care coordination and resource utilization. Integration initiatives must be designed to be measured and evaluated, and, consistent with principles of continuous quality improvement, each initiative will provide for iterative improvements of the initiative.
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- 2014
13. The importance of being busy
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Stephen, McMurray
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Volunteers ,Economic Recession ,Sex Factors ,Unemployment ,Mental Disorders ,Socialization ,Humans ,Rehabilitation, Vocational ,United Kingdom - Published
- 2012
14. The ESRD Demonstration Project: what it accomplished. DaVita Inc
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Allen R, Nissenson, Tami, Deeb, Eric, Franco, Mahesh, Krishnan, Stephen, McMurray, and Tracy J, Mayne
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Adult ,Male ,Young Adult ,Adolescent ,Delivery of Health Care, Integrated ,Outcome Assessment, Health Care ,Humans ,Kidney Failure, Chronic ,Female ,Health Care Costs ,Middle Aged ,United States ,Aged - Published
- 2011
15. Preference for monthly darbepoetin alfa dosing in patients with chronic kidney disease not receiving dialysis
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Paul Audhya, Stephen McMurray, Radha Prathikanti, Jeffrey Hoggard, Debra Scarlata, Thomas Crouch, and Michael Levine
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Male ,medicine.medical_specialty ,Darbepoetin alfa ,Anemia ,medicine.medical_treatment ,Drug Administration Schedule ,stomatognathic system ,Internal medicine ,medicine ,Humans ,Dosing ,Renal Insufficiency, Chronic ,Erythropoietin ,Dialysis ,Aged ,Clinical Trials as Topic ,business.industry ,virus diseases ,Epoetin alfa ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,Recombinant Proteins ,Surgery ,Epoetin Alfa ,Regimen ,Patient Satisfaction ,Hematinics ,Female ,business ,Kidney disease ,medicine.drug - Abstract
To determine patient preference for once-weekly Epoetin alfa versus once-monthly (QM) darbepoetin alfa in patients with chronic kidney disease (CKD) not receiving dialysis.AMPS (Aranesp Monthly Preference Study) consisted of two studies of similar design, each with a 2-week screening/baseline period, a 20-week QM darbepoetin alfa dosing period, and an 8-week follow-up period. Patients agedor = 18 years had a nephrologist-reported diagnosis of CKD but were not receiving dialysis, and were required to have at least two hemoglobin levels within 10-12 g/dL and to have been receiving a stable dose (25% change) of once-weekly or once-every-other-weekly Epoetin alfa for at least 8 weeks. At week 21, patients could continue on QM darbepoetin alfa or revert back to their previous Epoetin alfa regimen. The primary analysis assessed patient preference at week 21 for QM darbepoetin alfa versus previous once-weekly Epoetin alfa.AMPS enrolled 442 patients: 54% were female, 67% were Caucasian, and mean (SD) age was 68.3 (13.5) years. At week 21, 346 patients remained on study. Of the patients converted from once-weekly Epoetin alfa, 86% (138/161) preferred darbepoetin alfa QM, and of all patients who expressed a preference, regardless of previous Epoetin alfa dosing frequency, 96% (305/319) preferred QM darbepoetin alfa. Mean (SD) hemoglobin at week 29 of the study was similar to mean hemoglobin at baseline (for those who completed the study and were receiving QM darbepoetin alfa at week 29: 11.2 [1.1] g/dL at week 29 versus 11.4 [0.7] g/dL at baseline). QM darbepoetin alfa was well tolerated.These data show that the majority of study patients preferred QM darbepoetin alfa to more frequent Epoetin alfa, and that QM darbepoetin alfa maintained hemoglobin levels at week 29 and was well tolerated over the study period. The single-item questionnaire could be a potential limitation of this study and further investigation with a multi-question instrument may be helpful in confirming these results.
- Published
- 2006
16. A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD
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Michael Roppolo, Richard M. Mazey, David B. Van Wyck, Stephen Mcmurray, and Carlos O. Martinez
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Male ,medicine.medical_specialty ,Anemia ,Iron ,Administration, Oral ,Iron sucrose ,Gastroenterology ,Ferric Compounds ,Ferrous ,Glucaric Acid ,Hemoglobins ,iron deficiency ,Oral administration ,Multicenter trial ,Internal medicine ,medicine ,CKD ,Humans ,Erythropoiesis ,Renal Insufficiency, Chronic ,Aged ,Ferric Oxide, Saccharated ,biology ,business.industry ,iron sucrose ,Iron deficiency ,Middle Aged ,medicine.disease ,Surgery ,Ferritin ,Treatment Outcome ,Iron-deficiency anemia ,Nephrology ,Injections, Intravenous ,biology.protein ,Quality of Life ,Patient Compliance ,Female ,business ,medicine.drug - Abstract
A randomized, controlled trial comparing IV iron sucrose to oral iron in anemic patients with nondialysis-dependent CKD. Background Although iron deficiency frequently complicates anemia in patients with nondialysis-dependent CKD (ND-CKD), the comparative treatment value of IV iron infusion and oral iron supplementation has not been established. Methods In a randomized, controlled multicenter trial, we compared the efficacy of iron sucrose, given as 1g in divided IV doses over 14 days, with that of ferrous sulfate, given 325mg orally thrice daily for 56 days in patients with ND-CKD stages 3 to 5, Hb ≤11 g/dL, TSAT ≤25%, and ferritin ≤300 ng/mL. Epoetin/darbepoetin therapy, if any, was not changed for eight weeks prior to or during the study. Results The proportion of patients achieving the primary outcome (Hb increase ≥1 g/dL) was greater in the IV iron treatment group than in the oral iron treatment group (44.3% vs. 28.0%, P = 0.0344), as was the mean increase in Hb by day 42 (0.7 vs. 0.4 g/dL, P = 0.0298). Compared to those in the IV iron group, patients in the oral iron treatment group showed a greater decline in GFR during the study (-4.40 vs. -1.45 mL/min/1.73m 2 , P = 0.0100). No serious adverse drug events (ADE) were seen in patients administered IV iron sucrose as 200mg IV over two to five minutes, but drug-related hypotension, including one event considered serious, occurred in two females weighing less than 65kg after 500mg doses were given over four hours. Conclusion IV iron administration using 1000mg iron sucrose in divided doses is superior to oral iron therapy in the management of ND-CKD patients with anemia and low iron indices.
- Published
- 2005
17. Acknowledgement to the Reviewers
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Inga Bayh, Sampson Antwi, Reinhold Deppisch, Alessandra Brocca, Daniele Neri, Judy Weintraub, Damien Ashby, Giovanna Berdin, Yosef S. Haviv, Runolfur Palsson, Cheng-Hsu Chen, Neill Duncan, Gero von Gersdorff, Aileen Grassmann, Cristina Marelli, Terry Ketchersid, Caroline Williams, Vladimir Tesar, Daniele Marcelli, Lina Minazzato, Nathan W. Levin, Claudia Barth, Ewa Żukowska-Szczechowska, Piero Amodio, Anna Giuliani, Satz Mengensatzproduktion, C. Kneis, Flavio Basso, Adrian Guinsburg, Marzena Wjewodzka, Frank M. van der Sande, Ying-Chih Lo, Shang-Feng Tsai, Anna Clementi, Nicolle H.R. Litjens, Shih-Ting Huang, Seema K Singh, John Callegari, Grzegorz Wystrychowski, Claire Edwards, Alessandra Brendolan, Stephan Thijssen, Ruud W. J. Meijers, Rocco Tripepi, Tung-Min Yu, Michael Etter, Umberto Cillo, Ales Horinek, Carmine Zoccali, Stephen McMurray, Simon Beagle, Tonino Bianco, Daniel Zickler, Richard Corbett, Claudia Torino, Massimo de Cal, Charles D. Pusey, Chi-Hung Cheng, Yuedong Wang, Olafur S. Indridason, Mathias Schaller, Werner Beck, Druck Reinhardt Druck Basel, Kuo-Hsiung Shu, Albert Power, Pasquale Piccinni, Mary Carter, Michiel G. H. Betjes, Olof Viktorsdottir, Peter Choi, Claudio Ronco, Giacomo Mason, Vincenzo Cantaluppi, Giovanni Tripepi, Francesca Mallamaci, Ya-Wen Chuang, Ming-Ju Wu, Laura Scatizzi, Eva Pazourkova, Peter Kotanko, F. Klefisch, Sonya Day, Magdalena Mokrejsova, Sami Schiff, Allen R. Nissenson, Marianna Bellantoni, Antonio Granata, Olaf Boenisch, Marina Loucaidou, Sachin S Soni, Dinna N. Cruz, Giorgio Vescovo, Giacomo Zanus, Annalisa Salari, Giancarlo Bombonato, Grazia Maria Virzì, Len A. Usvyat, Jeroen P. Kooman, Marie Korabecna, Ralf Schindler, Margaret Nevin, Franklin W. Maddux, Ted Toffelmire, Adam Tashman, and Giovannella Baggio
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Medical education ,medicine.medical_specialty ,Nephrology ,business.industry ,Acknowledgement ,Immunology ,Alternative medicine ,medicine ,Hematology ,General Medicine ,business - Published
- 2013
- Full Text
- View/download PDF
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