48 results on '"Stephen M. Rupp"'
Search Results
2. Chronic Central Venous Access: From Research Consensus Panel to National Multistakeholder Initiative
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Kevin M. Baskin, Kareem Abu-Elmagd, Leonard A. Mermel, Kamran Ahrar, Janna M. Journeycake, Seth M. Toomay, Stephen M. Rupp, John C. Camillus, Richard B. Towbin, Gordon McLennan, Darcy Doellman, Samuel A. Kocoshis, Barbara B. Drews, Haimanot Wasse, Jeremy C. Durack, and Sarah B. White
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Quality management ,business.industry ,MEDLINE ,medicine.disease ,Intensive care unit ,law.invention ,Venous access ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,law ,Cost control ,Vanguard ,Medicine ,030211 gastroenterology & hepatology ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Medical emergency ,Cardiology and Cardiovascular Medicine ,business - Published
- 2018
3. The Seattle Spine Team Approach to Adult Deformity Surgery: A Systems-Based Approach to Perioperative Care and Subsequent Reduction in Perioperative Complication Rates
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Jean-Christophe Leveque, Stephen M. Rupp, Rajiv K. Sethi, Thomas C. Dean, Ryan P. Pong, and Stephen J. Olivar
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medicine.medical_specialty ,business.industry ,Perioperative ,medicine.disease ,Group B ,Surgery ,Patient safety ,Multidisciplinary approach ,Orthopedic surgery ,Deformity ,Coagulopathy ,Medicine ,Orthopedics and Sports Medicine ,medicine.symptom ,Complication ,business - Abstract
Retrospective consecutive case review pre- and postintervention.Characterize the effects of the intervention.Complication rates in adult spinal deformity surgery are unacceptable. System approaches are necessary to increase patient safety. This group reported on the dual-attending surgeon approach, a live multidisciplinary preoperative screening conference, and the intraoperative protocol for the management of coagulopathy. The outcomes were demonstrated by complication rates before and after the institution of this protocol.Forty consecutive patients in Group A were managed without the 3-pronged approach. A total of 124 consecutive patients in Group B had a dual-attending surgeon approach, were presented and cleared by a live multidisciplinary preoperative conference, and were managed according to the intraoperative protocol.Group A had an average age of 62 years (range, 39-84 years). Group B had an average age of 64 years (range, 18-84 years). Most patients in both groups had fusions from 9 to 15 levels. Complication rates in Group B were significantly lower (16% vs. 52%) (p .001). Group B showed significantly lower return rates to the operating room during the perioperative 90-day period (0.8% vs. 12.5%) (p.001). Group B also had lower rates of wound infection requiring debridement (1.6% vs. 7.5%), lower rates of deep vein thrombosis/pulmonary embolism (3.2% vs. 10%), and lower rates of postoperative neurological complications (0.5% vs. 2.5%) (not significant). Group B had significantly lower rates of urinary tract infection requiring antibiotics (9.7% vs. 32.5%) (p.001).These data suggests that a team approach consisting of a dual-attending surgeon approach in the operating room, a live preoperative screening conference, and an intraoperative protocol for managing coagulopathy will significantly reduce perioperative complication rates and enhance patient safety in patients undergoing complex spinal reconstructions for adult spinal deformity.
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- 2014
4. Effectiveness of standardised preoperative assessment and patient instructions on admission blood glucose for patients with diabetes undergoing orthopaedic surgery at a tertiary referral hospital
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Barbara Williams, Stephen M. Rupp, Thérèse Franco, and C. Craig Blackmore
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Blood Glucose ,Male ,medicine.medical_specialty ,Leadership and Management ,Patient Instructions ,Tertiary referral hospital ,Tertiary Care Centers ,surgery ,Care setting ,03 medical and health sciences ,Patient Admission ,0302 clinical medicine ,Patient Education as Topic ,030202 anesthesiology ,Diabetes mellitus ,Preoperative Care ,Humans ,Medicine ,Orthopedic Procedures ,030212 general & internal medicine ,Limited evidence ,Elective surgery ,lean management ,Aged ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Perioperative ,Middle Aged ,Reference Standards ,medicine.disease ,prehospital care ,BMJ Quality improvement report ,diabetes mellitus ,Emergency medicine ,Orthopedic surgery ,Female ,business - Abstract
Diabetes and hyperglycaemia affect a significant number of people and are associated with a variety of untoward effects, especially under physiological stress such as surgery. Due, in large part to limited evidence, clinical practice in monitoring blood glucose and treating hyperglycaemic conditions in the perioperative period is variable. We used Lean methodologies to implement a standardised approach to preoperative management of patients undergoing elective surgery in an effort to improve glycaemic control. Overall, we saw an appropriate increase in monitoring and a decrease in the rate of hyperglycaemia on presentation to the operating room. This approach may be useful in other care settings or patient populations, potentially contributing to improved glycaemic control and subsequent decrease in associated complications.
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- 2019
5. Practice Guidelines for Central Venous Access
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Paradise Valley, Karen B. Domino, Casey D. Blitt, Lee A. Fleisher, Robert A. Caplan, Avery Tung, Jeffrey L. Apfelbaum, Stephen M. Rupp, Stuart A. Grant, Richard T. Connis, David G. Nickinovich, and Jonathan B. Mark
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medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Task force ,business.industry ,medicine ,MEDLINE ,Medical emergency ,medicine.disease ,Intensive care medicine ,business ,Venous access ,American society of anesthesiologists - Published
- 2012
6. Effectiveness of a multi-component quality improvement intervention on rates of hyperglycaemia
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Grace Lee, Stephen M. Rupp, C. Craig Blackmore, Laurel Brown, Thérèse Franco, and Barry Aaronson
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medicine.medical_specialty ,Quality management ,Leadership and Management ,Context (language use) ,quality improvement ,03 medical and health sciences ,0302 clinical medicine ,Acute care ,Medicine ,030212 general & internal medicine ,lean management ,030504 nursing ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Quality control ,Percentage point ,BMJ Quality Improvement Report ,medicine.disease ,Statistical process control ,Hospital medicine ,hospital medicine ,Emergency medicine ,Medical emergency ,0305 other medical science ,business ,Root cause analysis - Abstract
Purpose To evaluate the effectiveness of a multifaceted, hospital-wide glycaemic control quality improvement programme. Methods The quality improvement intervention comprised three components, derived through root cause analysis: standardising and simplifying care (including evidence-based order sets), increasing visibility (through provider access to clinical data and direct feedback) and educational outreach (directed at the entire institution). Effectiveness was determined at a single urban acute care hospital through time-series analysis with statistical process control charts. Primary outcomes included rate of hyperglycaemia and rate of hypoglycaemia. Results The study included 70 992 hospital admissions for 50 404 patients, with 3 35 645 patient days. The hyperglycaemia ratio decreased 25.2% from 14.1% to 10.5% (95% CI 3.3 to 3.9 percentage points, p299 mg/dL) decreased 31.8% from 4.8% to 3.3% (95% CI 1.4 to 1.7 percentage points, p
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- 2017
7. Unintentional Wrong-Sided Peripheral Nerve Block
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Stephen M. Rupp
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medicine.medical_specialty ,Harm reduction ,Nerve root ,business.industry ,MEDLINE ,General Medicine ,Peripheral nerve block ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Peripheral nervous system ,Health care ,medicine ,business ,Intensive care medicine - Published
- 2008
8. Manufacturing principles and human processes: Can we create a safer system?
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Stephen M. Rupp
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Anesthesiology and Pain Medicine ,Risk analysis (engineering) ,business.industry ,SAFER ,MEDLINE ,Medicine ,General Medicine ,business - Published
- 2005
9. Effects of Perioperative Analgesic Technique on Rate of Recovery after Colon Surgery
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Jack T. Fulmer, Stephen M. Rupp, Philip P. Metzger, Neil G. Feinglass, Timothy S. J. Shine, Richard C. Thirlby, Randall L. Carpenter, Spencer S. Liu, Stephen L. Smith, and David C. Mackey
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Male ,medicine.medical_specialty ,medicine.drug_class ,medicine.medical_treatment ,Preoperative care ,Colon surgery ,medicine ,Humans ,Colectomy ,Bupivacaine ,Morphine ,Patient-controlled analgesia ,business.industry ,Local anesthetic ,Analgesia, Patient-Controlled ,Perioperative ,Length of Stay ,Middle Aged ,Surgery ,Analgesia, Epidural ,Anesthesiology and Pain Medicine ,Anesthesia ,Female ,Gastrointestinal function ,business ,Digestive System ,medicine.drug - Abstract
Background Choice of perioperative analgesia may affect the rate of recovery of gastrointestinal function and thus duration and cost of hospitalization after colonic surgery. Methods Fifty-four patients undergoing partial colectomy surgery were randomized into four groups. All groups received a standardized general anesthetic. Group MB received a preoperative bolus of epidural bupivacaine and morphine followed by an infusion of morphine and bupivacaine. Group M received a preoperative bolus of epidural morphine followed by an infusion of morphine. Group B received a preoperative bolus of bupivacaine followed by an infusion of bupivacaine. Group P received a preoperative bolus of intravenous morphine followed by intravenous patient-controlled morphine postoperatively. All patients participated in a standardized recovery program to minimize the influence of nonanalgesic factors on recovery of gastrointestinal function. All epidural groups were double-blinded. All patients were deemed ready for discharge according to prospectively defined criteria. Results Groups B and MB reported superior analgesia with activity (P < 0.01). Group M had a greater incidence of pruritus (P < 0.05). Group B had a greater incidence of orthostatic hypotension (P = 0.04). Groups B and MB recovered gastrointestinal function and fulfilled discharge criteria approximately 1.5 days earlier than groups M and P (P < 0.005). Conclusions Epidural analgesia with bupivacaine and morphine provided the best balance of analgesia and side effects while accelerating postoperative recovery of gastrointestinal function and time to fulfillment of discharge criteria after colon surgery in relatively healthy patients within the context of a multimodal recovery program.
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- 1995
10. Intravenous Versus Epidural Administration of Hydromorphone
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Robert M. Weissman, Hugh W. Allen, Spencer S. Liu, Randall L. Carpenter, Theodore J. McGill, Stephen M. Rupp, and Michael F. Mulroy
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Chemotherapy ,medicine.medical_specialty ,business.industry ,Prostatectomy ,medicine.medical_treatment ,Hydromorphone ,law.invention ,Surgery ,Clinical trial ,Anesthesiology and Pain Medicine ,Randomized controlled trial ,Opioid ,law ,Anesthesia ,Medicine ,Epidural administration ,business ,Radical retropubic prostatectomy ,medicine.drug - Abstract
Background It remains unclear whether epidural administration of hydromorphone results in spinal analgesia or clinical benefit when compared with intravenous administration. Therefore, we undertook this study to determine whether epidural administration of hydromorphone resulted in decreased opioid requirement, improved analgesia, reduced side effects, more rapid return of gastrointestinal function, or shorter duration of hospital stay than intravenous administration. Methods Sixteen patients undergoing radical retropubic prostatectomy were randomized in a double-blind manner to receive either intravenous or epidural hydromorphone via patient-controlled analgesia (PCA) for postoperative analgesia. All patients underwent a standardized combined epidural and general anesthetic and all received ketorolac for 72 h postoperatively. To decrease variability, patients were cared for according to a standardized protocol and were deemed ready for discharge according to prospectively defined criteria. Results Patients in the intravenous PCA group required approximately twice as much opioid than the epidural PCA group (P < 0.008), but there were no differences between groups in pain scores or patient satisfaction. Epidural administration resulted in a greater incidence of pruritus (P = 0.02). Gastrointestinal function recovered quickly in all patients with little variation, and there were no differences between groups. All patients were deemed ready for discharge by the third postoperative day, and removal of surgical drains was the last discharge criterion reached in all patients. Conclusions Our results indicate that epidural administration of hydromorphone results in spinally mediated analgesia. However, epidural administration did not provide significant benefits in terms of postoperative analgesia, recovery of gastrointestinal function, or duration of hospitalization. Furthermore, we suggest that radical retropubic prostatectomy no longer be used as a model to assess the effects of analgesic technique on postoperative recovery, because control of discharge criteria revealed that hospital discharge was primarily dependent on removal of surgical drains.
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- 1995
11. Pituitary Resection, Transsphenoidal Approach
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Stephen M. Rupp
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medicine.medical_specialty ,medicine ,Resection ,Transsphenoidal approach ,Surgery - Published
- 2011
12. Contributors
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Sanjib Adhikary, Jorge Aguilar, Charles Ahere, Moustafa Ahmed, Jane C. Ahn, Shamsuddin Akhtar, David B. Albert, Nasrin N. Aldawoodi, John T. Algren, Gracie Almeida-Chen, David Amar, Zirka H. Anastasian, Stephen Aniskevich, Solomon Aronson, Harendra Arora, Amit Asopa, Joshua H. Atkins, John G. Augoustides, Mohammad Fareed Azam, Catherine R. Bachman, Douglas R. Bacon, Andrew D. Badley, Emily Baird, Alethia Baldwin, Ryan Ball, Amir Baluch, David Bandola, Shawn Banks, Paul G. Barash, Kathleen E. Barrett, Shawn T. Beaman, Jonathan C. Beathe, Christopher D. Beatie, W. Scott Beattie, Perry S. Bechtle, G. Richard Benzinger, Lauren Berkow, Jeffrey M. Berman, Wendy K. Bernstein, Arnold J. Berry, Frederic Berry, Ulrike Berth, Walter Bethune, Sumita Bhambhani, Shobana Bharadwaj, Neil Bhatt, Frederic T. Billings, Wendy B. Binstock, David J. Birnbach, Michael Bishop, Stephanie Black, Mary A. Blanchette, James M. Blum, Krishna Boddu, Lara Bonasera, Richard L. Boortz-Marx, Cecil O. Borel, Gregory H. Botz, Charles D. Boucek, William Bradford, Jason C. Brainard, Michelle Braunfeld, Ferne R. Braveman, Caridad Bravo-Fernandez, Peter H. Breen, Marjorie Brennan, Tricia Brentjens, Megan A. Brockel, Jay B. Brodsky, Todd A. Bromberg, Adam J. Broussard, Chris Broussard, Carmen Labrie-Brown, Robert H. Brown, Charles S. Brudney, Sorin J. Brull, Claude Brunson, Trent Bryson, Jacob M. Buchowski, Stefan Budac, Zachary D. Bush, John Butterworth, Lisbeysi Calo, Christopher Canlas, Ayana Cannon, Shawn M. Cantie, Lisa Caplan, Marco Caruso, Davide Cattano, Charles B. Cauldwell, Laura Cavallone, Maurizio Cereda, Thomas M. Chalifoux, Susan Chan, Theodore G. Cheek, Alexander Chen, Samuel A. Cherry, Albert T. Cheung, Grace L. Chien, Peter T. Choi, Christopher Ciarallo, Franklyn Cladis, Anthony J. Clapcich, Richard B. Clark, Mindy Cohen, Neal H. Cohen, Robert I. Cohen, Stephan J. Cohn, Aisling Conran, Richard I. Cook, Randall F. Coombs, David M. Corda, Daniel Cormican, Darren Cousin, Vincent S. Cowell, Lyndsey Cox, Paula A. Craigo, Richard C. Cross, Roy F. Cucchiara, William H. Daily, Gaurang Dalal, Priti Dalal, Michael Danekas, Ahmed M. Darwish, Ribal Darwish, Suanne M. Daves, Kathleen Davis, Peter J. Davis, Bracken J. De Witt, Ellise Delphin, Seema Deshpande, Dawn P. Desiderio, Tricia Desvarieux, Laura K. Diaz, Christian Diez, Sanjay Dixit, Meenakshi Dogra, Karen B. Domino, Kathryn Dorhauer, Todd Dorman, Don D. Doussan, James Duke, Ann C. Duncan, Frank W. Dupont, Andrew Dziewit, L. Jane Easdown, R. Blaine Easley, Thomas J. Ebert, David M. Eckmann, Talmage D. Egan, Seth Eisdorfer, Nabil M. Elkassabany, Ryan P. Ellender, Logan S. Emory, Monique Espinosa, Lucinda L. Everett, Nauder Faraday, James J. Fehr, James M. Feld, Lynn A. Fenton, Laura H. Ferguson, Matthew Fiegel, Aaron M. Fields, Gordon N. Finlayson, Alan Finley, Gregory W. Fischer, Gary Fiskum, Molly Fitzpatrick, Russell Flatto, Lee A. Fleisher, Ronda Flower, Annette G. Folgueras, Patrick J. Forte, Joseph F. Foss, Charles J. Fox, William R. Furman, Robert Gaiser, David R. Gambling, Scott Gardiner, Matthew L. Garvey, Abraham C. Gaupp, Steven Gayer, Jeremy M. Geiduschek, Frank Gencorelli, Eric Gewirtz, Ghaleb A. Ghani, Charles P. Gibbs, Jeremy L. Gibson, Lori Gilbert, Kevin J. Gingrich, Gregory Ginsburg, Christopher Giordano, Christine E. Goepfert, Hernando Gomez, Santiago Gomez, Alanna E. Goodman, Stephanie R. Goodman, Alexandru Gottlieb, Ori Gottlieb, Allan Gottschalk, Basavana Gouda Goudra, Harry J. Gould, Nikolaus Gravenstein, Megan Graybill, William J. Greeley, Patrick Guffey, Ala Sami Haddadin, John G. Hagen, Karim Abdel Hakim, Michael Hall, N. James Halliday, Raafat S. Hannallah, Jeremy Hansen, C. William Hanson, Charles B. Hantler, Andrew P. Harris, Jonathan Hastie, Henry A. Hawney, Stephen O. Heard, James E. Heavner, James G. Hecker, Elizabeth A. Hein, Eugenie Heitmiller, Mark Helfaer, Lori B. Heller, Andrew Hemphill, Adrian Hendrickse, Frederick A. Hensley, Ian A. Herrick, Douglas Hester, Eric J. Heyer, Michael S. Higgins, Roberta Hines, Charles W. Hogue, Kenneth J. Holroyd, Natalie F. Holt, Simon J. Howell, Faisal Huda, Keith E. Hude, Hayden R. Hughes, James M. Hunter, Brad J. Hymel, James W. Ibinson, Karen E. Iles, Robert M. Insoft, Shiroh Isono, Yulia Ivashkov, Bozena R. Jachna, Anna Jankowska, Norah Janosy, Arun L. Jayaraman, Nathalia Jimenez, Judy G. Johnson, Lyndia Jones, Edmund H. Jooste, Zeev N. Kain, Maudy Kalangie, Philip L. Kalarickal, Ihab Kamel, Mia Kang, Ivan Kangrga, Ravish Kapoor, Helen W. Karl, Christopher Karsanac, Swaminathan Karthik, Jeffrey A. Katz, Alan Kaye, Adam M. Kaye, A. Murat Kaynar, Nancy B. Kenepp, Miklos D. Kertai, Mary A. Keyes, Sarah Khan, Swapnil Khoche, David Y. Kim, Jerry H. Kim, Kimberly M. King, Jeffrey Kirsch, Matthew A. Klopman, Paul R. Knight, Donald D. Koblin, W. Andrew Kofke, Vincent J. Kopp, Joseph R. Koveleskie, Courtney Kowalczyk, Valeriy V. Kozmenko, Kaylyn Krummen, Sapna R. Kudchadkar, Nathan Kudrick, Adrienne Kung, C. Dean Kurth, Robert Kyle, J. Lance LaFleur, Jason G. Lai, Kirk Lalwani, William L. Lanier, Dawn M. Larson, Richard M. Layman, Chris C. Lee, Mark J. Lema, W. Casey Lenox, Jacqueline M. Leung, Roy C. Levitt, Jerrold H. Levy, J. Lance Lichtor, Charles Lin, Sharon L. Lin, Karen S. Lindeman, Lesley Lirette, Ronald S. Litman, Qianjin Liu, Renyu Liu, Wen-Shin Liu, Justin Lockman, Stanley L. Loftness, Martin J. London, Philip D. Lumb, M. Concetta Lupa, Anne Marie Lynn, Devi Mahendran, Jeffrey Mako, Anuj Malhotra, Vinod Malhotra, Andrew M. Malinow, Mark G. Mandabach, Dennis T. Mangano, Sobia Mansoor, Inna Maranets, Jonathan B. Mark, Sinisa Markovic, H. Michael Marsh, Choendal Martin, Nicole D. Martin, Douglas Martz, Veronica A. Matei, Letha Mathews, Lynne G. Maxwell, Philip McArdle, John P. McCarren, Brenda C. McClain, Brian McClure, William A. McDade, Kathryn E. McGoldrick, Brian J. McGrath, Gregory L. McHugh, David McIlroy, Jason McKeown, Thomas M. McLoughlin, R. Yan McRae, William L. Meadow, Sameer Menda, William T. Merritt, David G. Metro, Berend Mets, Hosni Mikhaeil, David W. Miller, Jessica Miller, Mohammed Minhaj, Marek A. Mirski, Nanhi Mitter, Alexander J.C. Mittnacht, Raj K. Modak, Pierre Moine, Constance L. Monitto, Richard C. Month, Richard E. Moon, Laurel E. Moore, Roger A. Moore, Thomas A. Moore, Debra E. Morrison, Jonathan Moss, John R. Moyers, Jesse J. Muir, Adam J. Munson-Young, Stanley Muravchick, John M. Murkin, Peter Nagele, Peter A. Nagi, Daniel A. Nahrwold, Michael L. Nahrwold, Madhavi Naik, Manchula Navaratnam, Stephan P. Nebbia, Priscilla Nelson, Thai T. Nguyen, Viet Nguyen, Stavroula Nikolaidis, Zoulfira Nisnevitch, Dolores B. Njoku, Mary J. Njoku, Edward J. Norris, Omonele O. Nwokolo, Daniel Nyhan, William T. O'Byrne, Edward A. Ochroch, Andrew Oken, Nathan Orgain, Nancy E. Oriol, Pedro Orozco, Andreas M. Ostermeier, Andranik Ovassapian, Mehmet S. Ozcan, Ira Padnos, Sheela S. Pai, Nirvik Pal, Dhamodaran Palaniappan, Susan K. Palmer, Howard D. Palte, Wei Pan, Oliver Panzer, Sibi Pappachan, Anthony Passannante, Dennis A. Patel, Dilipkumar K. Patel, Kirit M. Patel, Samir Patel, Shalin Patel, Sanup Pathak, Minda L. Patt, Ronald W. Pauldine, Olga Pawelek, Tim Pawelek, Kiarash Paydar, Ronald G. Pearl, Christine Peeters-Asdourian, Padmavathi R. Perela, Charise T. Petrovitch, Patricia H. Petrozza, Dennis Phillips, Mark C. Phillips, Christine Piefer, Edgar J. Pierre, S. William Pinson, Evan G. Pivalizza, Raymond M. Planinsic, Don Poldermans, Joel M. Pomerantz, Jason E. Pope, Wanda M. Popescu, Vivian H. Porche, Jahan Porhomayon, Dmitry Portnoy, Corinne K. Postle, Paul J. Primeaux, Donald S. Prough, Ferenc Puskas, Carlos A. Puyo, Forrest Quiggle, Mary Rabb, Bronwyn R. Rae, Muhammad B. Rafique, Jesse M. Raiten, Arvind Rajagopal, Srinivasan Rajagopal, Gaurav Rajpal, Chandra Ramamoorthy, Ira J. Rampil, James G. Ramsay, James A. Ramsey, Vidya N. Rao, Joana Ratsiu, Selina Read, Ronjeet Reddy, Leila L. Reduque, David L. Reich, Karene Ricketts, Cameron Ricks, Bernhard Riedel, Jyotsna Rimal, Joseph Rinehart, James M. Riopelle, Stacey A. Rizza, Amy C. Robertson, Stephen Robinson, Peter Rock, Yillam F. Rodriguez-Blanco, Michael F. Roizen, Daniel M. Roke, Ryan Romeo, Joseph Rosa, David A. Rosen, Kathleen Rosen, Stanley H. Rosenbaum, Andrew D. Rosenberg, Andrew L. Rosenberg, Henry Rosenberg, Meg A. Rosenblatt, Steven Roth, Brian Rothman, Justin L. Rountree, Matthew J. Rowan, Marc Rozner, Ryan Rubin, Stephen M. Rupp, W. John Russell, Thomas A. Russo, Alecia L. Sabartinelli, Tetsuro Sakai, Orlando J. Salinas, Paul L. Samm, Jibin Samuel, Tor Sandven, Ted J. Sanford, Joshua W. Sappenfield, Ponnusamy Saravanan, Subramanian Sathishkumar, R. Alexander Schlichter, Eric Schnell, David L. Schreibman, Armin Schubert, Peter Schulman, Todd A. Schultz, Alan Jay Schwartz, Jamie McElrath Schwartz, Jeffrey J. Schwartz, Benjamin K. Scott, Joseph L. Seltzer, Tamas Seres, Daniel I. Sessler, Navil F. Sethna, Amar Setty, Paul W. Shabaz, Pranav Shah, Saroj Mukesh Shah, Milad Sharifpour, Joanne Shay, Jay Shepherd, Jeffrey S. Shiffrin, Marina Shindell, Daniel Siker, Richard Silverman, Brett A. Simon, Nina Singh, Ashish C. Sinha, Robert N. Sladen, Kieran A. Slevin, Tod B. Sloan, Kathleen Smith, Timothy E. Smith, Victoria Smoot, Denis Snegovskikh, Betsy Ellen Soifer, Molly Solorzano, James M. Sonner, Aris Sophocles, James A. Sparrow, Joan Spiegel, Bruce D. Spiess, Ramprasad Sripada, Stanley W. Stead, Joshua D. Stearns, Kelly Stees, Clinton Steffey, Christopher Stemland, John Stene, Christopher T. Stephens, Tracey L. Stierer, O. Jameson Stokes, Bryant W. Stolp, David F. Stowe, Ted Strickland, Suzanne Strom, Erin A. Sullivan, Michele Sumler, Dajin Sun, Lena Sun, Esther Sung, Veronica C. Swanson, Judit Szolnoki, Joe Talarico, Gee Mei Tan, Darryl T. Tang, Paul Tarasi, René Tempelhoff, John E. Tetzlaff, Alisa C. Thorne, Arlyne Thung, Vasanti Tilak, Kate Tobin, Joseph R. Tobin, Michael J. Tobin, R. David Todd, Matthew Tomlinson, Thomas J. Toung, Lien B. Tran, Minh Chau Joe Tran, Kevin K. Tremper, Sanyo Tsai, George S. Tseng, Kenneth J. Tuman, Avery Tung, Cynthia Tung, Rebecca Twersky, Mark Twite, John A. Ulatowski, Michael Urban, Manuel C. Vallejo, Andrea Vannucci, Albert J. Varon, Anasuya Vasudevan, Susheela Viswanathan, Alexander A. Vitin, Wolfgang Voelckel, Ann Walia, Russell T. Wall, Terrence Wallace, Shu-Ming Wang, David C. Warltier, Lucy Waskell, Scott Watkins, Denise Wedel, Stuart J. Weiss, Charles Weissman, Nathaen Weitzel, Gregory Weller, Gina Whitney, Robert A. Whittington, Danny Wilkerson, Nancy C. Wilkes, Michael Williams, Jimmy Windsor, Bernard Wittels, Gregory A. Wolff, Andrew K. Wong, Stacie N. Woods, A.J. Wright, Zheng Xie, Christopher C. Young, Ian Yuan, Francine S. Yudkowitz, James R. Zaidan, Paul Zanaboni, Warren M. Zapol, Angela Zimmerman, and Maurice S. Zwass
- Published
- 2011
13. MONITORING NEUROMUSCULAR BLOCKADE
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Stephen M. Rupp
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Neuromuscular Blockade ,Anesthesiology and Pain Medicine ,Contraction (grammar) ,business.industry ,Anesthesia ,Medicine ,business - Published
- 1993
14. In Reply
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Jeffrey L, Apfelbaum, Stephen M, Rupp, Richard T, Connis, and David G, Nickinovich
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Research Report ,Catheterization, Central Venous ,Anesthesiology and Pain Medicine ,Anesthesiology ,Advisory Committees ,Practice Guidelines as Topic ,Humans ,Perioperative Care ,Societies, Medical - Published
- 2013
15. In Reply
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Stephen M. Rupp, Jeffrey L. Apfelbaum, Richard T. Connis, and David G. Nickinovich
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Anesthesiology and Pain Medicine - Published
- 2012
16. Color-Coding of Syringes May Not Enhance Safety
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Stephen M. Rupp
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Anesthesiology and Pain Medicine ,Information retrieval ,Text mining ,business.industry ,Color-coding ,Medicine ,General Medicine ,business - Published
- 2005
17. Regional Anesthesia and Analgesia
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Stephen M. Rupp
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Anesthesiology and Pain Medicine ,business.industry ,Regional anesthesia ,Anesthesia ,Medicine ,Pain management ,business - Published
- 1997
18. Intravenous Versus Epidural Administration of Hydromorphone
- Author
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Stephen M. Rupp, Robert M. Weissman, Theodore J. McGill, Spencer S. Liu, Randall L. Carpenter, Michael F. Mulroy, and Hugh W. Allen
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business.industry ,medicine.medical_treatment ,Anesthesia ,medicine ,Epidural administration ,Hydromorphone ,business ,Radical retropubic prostatectomy ,medicine.drug - Published
- 1996
19. Nitrous Oxide and Epinephrine-Induced Arrhythmias
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Patricia Whitendale, Ira J. Rampil, George H. Lampe, Stephen M. Rupp, Charles Wilson, Judith H. Donegan, Lawrence Litt, Kenneth E. Fouts, Linda Z. Wauk, Edmond I. Eger, and Barry M. Rose
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medicine.diagnostic_test ,Lidocaine ,business.industry ,Incidence (epidemiology) ,equipment and supplies ,Fentanyl ,Anesthesiology and Pain Medicine ,Epinephrine ,Isoflurane ,Anesthesia ,Hemostasis ,Anesthetic ,Medicine ,business ,Electrocardiography ,medicine.drug - Abstract
We asked whether the sympathomimetic effect of nitrous oxide (N2O) predisposed patients receiving N2O to arrhythmias in response to epinephrine administration. We also asked whether aging contributed to the development of arrhythmias, with or without N2O. One hundred patients having transsphenoidal hypophysectomy were randomly assigned to receive anesthesia including (n = 49) or excluding (n = 51) N2O. All patients were given an injection of epinephrine 1:200,000, with 0.5% lidocaine to produce hemostasis. Using intermittent 12-lead and continuous lead II electrocardiography, we determined the incidence of premature ventricular contraction, isorhythmic atrioventricular (AV) dissociation, and changes in T-wave morphology. Patients given N2O had a significantly higher incidence of isorhythmic AV dissociation (61.2% vs 41.2%). A trend toward a higher incidence of multiple premature ventricular contractions (16.3% vs 7.8%) was not statistically significant. Both anesthetic groups had a high incidence of postoperative changes in T-wave morphology (46.9% in the N2O group vs 50.9% in the group not given N2O). Aging alone did not affect the incidence of ventricular ectopic beats, isorhythmic AV dissociation, or changes in electrocardiographic morphology, but correlated with the development of ventricular ectopy during N2O anesthesia. We conclude that the use of N2O correlated with a higher incidence of isorhythmic AV dissociation in response to injection of epinephrine with lidocaine.
- Published
- 1990
20. Clinical Pharmacology of Vecuronium and Atracurium
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Stephen M. Rupp, Roy Cronnelly, Y. J. Sohn, Ronald D. Miller, Mark R. Fahey, and Dennis M. Fisher
- Subjects
Adult ,Drug ,Time Factors ,Adolescent ,Chemical Phenomena ,media_common.quotation_subject ,Succinylcholine ,Cardiovascular System ,law.invention ,Pregnancy ,law ,Anesthesia, Obstetrical ,Humans ,Medicine ,Anesthesia ,Pancuronium ,Child ,Aged ,media_common ,Acid-Base Equilibrium ,Cardiopulmonary Bypass ,Vecuronium Bromide ,Clinical pharmacology ,Dose-Response Relationship, Drug ,Cesarean Section ,business.industry ,Liver Diseases ,Age Factors ,Infant, Newborn ,Infant ,Middle Aged ,Isoquinolines ,Neostigmine ,Chemistry ,Kinetics ,Anesthesiology and Pain Medicine ,Child, Preschool ,Atracurium ,Female ,Neuromuscular Blocking Agents ,Vecuronium bromide ,business ,medicine.drug - Abstract
Vecuronium and atracurium provide addition flexibility to the clinician using neuromuscular blocking drugs. The shorter duration of action, lack of significant cardiovascular effects, and the lack of dependence on the kidney for elimination provide clinical advantages over, or alternatives to, currently available nondepolarizing neuromuscular blocking drugs.
- Published
- 1984
21. Vecuronium-induced Neuromuscular Blockade during Enflurane, Isoflurane, and Halothane Anesthesia in Humans
- Author
-
Peter J. Gencarelli, Stephen M. Rupp, and Ronald D. Miller
- Subjects
Methyl Ethers ,Neuromuscular Junction ,Enflurane ,chemistry.chemical_compound ,medicine ,Humans ,Pancuronium ,Neuromuscular Blockade ,Vecuronium Bromide ,Dose-Response Relationship, Drug ,Isoflurane ,business.industry ,Nitrous oxide ,Dose–response relationship ,Anesthesiology and Pain Medicine ,chemistry ,Neuromuscular Depolarizing Agents ,Anesthesia ,Anesthetic ,Neuromuscular Blocking Agents ,Vecuronium bromide ,Halothane ,business ,medicine.drug - Abstract
To determine the effect of the commonly used volatile anesthetics on a vecuronium-induced neuromuscular blockade, the authors studied 54 patients anesthetized with 1.2 MAC or 2.2 MAC enflurane, isoflurane, or halothane (MAC value includes contribution from 60% nitrous oxide). During 1.2 MAC enflurane, isoflurane, and halothane, the ED50S (the doses depressing twitch tension 50%) for vecuronium were 12.8, 14.7, and 16.9 micrograms/kg, respectively. During 2.2 MAC enflurane, isoflurane, and halothane, the ED50S for vecuronium were 6.3, 9.8, and 13.8 micrograms/kg, respectively (P less than 0.05). Time from injection to peak effect was the same for each anesthetic group (6.5 +/- 0.5 min, mean +/- SD), except for the group given 2.2 MAC enflurane (9.7 +/- 0.6 min) (P less than 0.05). The duration of a 50% block from injection to 90% recovery was the same for each group (mean 20 +/- 4 min), except for the group given 2.2 MAC enflurane (46.5 min) (P less than 0.05). The authors conclude that enflurane is the most potent volatile anesthetic, followed by isoflurane and then halothane, in augmenting a vecuronium-induced neuromuscular blockade. Increasing the concentration of volatile anesthetic has less effect on a neuromuscular blockade produced by vecuronium than on one produced by other nondepolarizing relaxants (e.g., pancuronium and d-tubucurarine).
- Published
- 1984
22. Effect of Epinephrine on Central Nervous System and Cardiovascular System Toxicity of Bupivacaine in Pigs
- Author
-
David L. Brown, Stephen M. Rupp, Gale E. Thompson, Randall L. Carpenter, Mark E. Kenter, and Christopher M. Bernards
- Subjects
Central Nervous System ,Epinephrine ,Swine ,medicine.drug_class ,Resuscitation ,Central nervous system ,Hemodynamics ,Cardiovascular System ,Seizures ,Suidae ,medicine ,Animals ,Bupivacaine ,Dose-Response Relationship, Drug ,biology ,business.industry ,Local anesthetic ,Arrhythmias, Cardiac ,biology.organism_classification ,Heart Arrest ,Drug Combinations ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,Anesthesia ,Ventricular Fibrillation ,Toxicity ,Catecholamine ,business ,medicine.drug - Abstract
To determine what effect the addition of epinephrine has on bupivacaine toxicity, toxic doses of bupivacaine were administered to awake spontaneously breathing pigs. Twenty animals were randomized to one of two groups. One group received an infusion of bupivacaine with epinephrine (5 micrograms/ml) at a rate of 2 mg.kg-1.min-1; the other received an infusion of plain bupivacaine at the same rate. Bupivacaine infusion was continued until cardiovascular collapse. Following cardiovascular collapse we attempted to resuscitate the animals via open chest cardiac massage and a standardized resuscitation protocol. The addition of epinephrine to bupivacaine significantly increased blood pressure and systemic vascular resistance but not heart rate or cardiac output early in the bupivacaine infusion. Epinephrine had no effect on the dose of bupivacaine that caused cardiovascular collapse (P = 0.1), on the plasma concentration of bupivacaine at collapse (P = 0.9), or on the ability to resuscitate animals following cardiovascular collapse. The addition of epinephrine decreased the dose of bupivacaine required to initiate cardiac dysrhythmias (P = 0.003). The first dysrhythmia experienced by the epinephrine group was second degree heart block, which contrasts with the premature ventricular and atrial dysrhythmias experienced by the plain group. The dose of bupivacaine that produced seizures was also reduced by the addition of epinephrine (P = 0.006). The addition of epinephrine to bupivacaine did not alter the dose of bupivacaine that caused cardiovascular collapse in awake spontaneously breathing pigs but did decrease the dose of bupivacaine that caused seizures and dysrhythmias.
- Published
- 1989
23. Neuromuscular Effects of Atracurlum during Halothane—Nitrous Oxide and Enflurane—Nitrous Oxide Anesthesia in Humans
- Author
-
Stephen M. Rupp, Ronald D. Miller, and Jimmy W. McChristian
- Subjects
Adult ,inorganic chemicals ,Neuromuscular Junction ,Nitrous Oxide ,Oxide ,Enflurane ,chemistry.chemical_compound ,medicine ,Humans ,Potency ,Drug Interactions ,Anesthetics ,Neuromuscular Blockade ,Dose-Response Relationship, Drug ,business.industry ,organic chemicals ,Nitrous oxide ,Isoquinolines ,Blockade ,Anesthesiology and Pain Medicine ,chemistry ,Anesthesia ,Anesthetic ,Atracurium ,Halothane ,business ,Neuromuscular Nondepolarizing Agents ,medicine.drug - Abstract
To compare the effect of halothane and enflurane on an atracurium-induced neuromuscular blockade, the authors studied 40 patients during elective surgery. During 1.25 MAC enflurane-nitrous oxide (n = 20) or halothane-nitrous oxide (n = 20) (MAC value includes contribution from 60% nitrous oxide), the doses depressing twitch tension 50% (ED50S) for atracurium were 70 and 77 micrograms/kg, respectively. The difference was not significant. Time from injection to peak effect did not differ between groups. However, the duration of action of atracurium (expressed as duration 50 or the duration of a 50% blockade) was longer during enflurane-nitrous oxide anesthesia (34.2 min) than during halothane-nitrous oxide anesthesia (25.5 min) (P less than 0.05). The authors conclude that the potency of atracurium does not differ during halothane-nitrous oxide and enflurane-nitrous oxide anesthesia. Combining the results of this study with a previous study (atracurium ED50 = 68 micrograms/kg and 83 micrograms/kg during isoflurane-nitrous oxide and fentanyl-nitrous oxide anesthesia respectively), the potency of atracurium does not differ by more than 20% among the four anesthetic techniques studied. The background anesthetic appears to have less effect on an atracurium-induced neuromuscular blockade than on one produced by other longer-acting nondepolarizing muscle relaxants (e.g., pancuronium and d-tubocurarine).
- Published
- 1985
24. Elimination of Atracurium in Humans
- Author
-
Stephen M. Rupp, Ronald D. Miller, Judith I. Rosen, P. Claver Canfell, Mark R. Fahey, Dennis M. Fisher, and Lewls B. Sheiner
- Subjects
Chromatography ,business.industry ,Hydrolysis ,Anesthesiology and Pain Medicine ,Renal Elimination ,Reaction rate constant ,Biochemistry ,Pharmacokinetics ,Cisatracurium besilate ,medicine ,Hofmann elimination ,Atracurium besilate ,business ,medicine.drug ,Whole blood - Abstract
Atracurium, a nondepolarizing muscle relaxant, is eliminated through several pathways, including Hofmann elimination (spontaneous degradation in plasma and tissue at normal body pH and temperature) and ester hydrolysis (catalysis by nonspecific esterases). Because elimination of atracurium occurs in both tissue and plasma, traditional pharmacokinetic models assuming elimination from a single central compartment are inaccurate for atracurium. The authors developed a two-compartment pharmacokinetic model in which hepatic and/or renal elimination occurs from the central compartment (Cl organ), and Hofmann elimination and ester hydrolysis occur from both central and peripheral compartments (Cl nonorgan). To determine the in vitro rate constant for Hofmann elimination and ester hydrolysis, atracurium was added to whole blood kept at each patient's pH and temperature. The values for this rate constant ranged from 0.0193 to 0.0238 per min. When these values were applied to the pharmacokinetic model, Cl total, Cl organ, and Cl nonorgan were 4.8 +/- 1.1, 3.0 +/- 0.9, and 1.9 +/- 0.6 ml . kg-1 . min-1, respectively. The authors conclude that more than one-half of the clearance of atracurium occurs via pathways other than Hofmann elimination and ester hydrolysis.
- Published
- 1986
25. Cell kinetic studies of in situ human brain tumors with bromodeoxyuridine
- Author
-
Victor A. Levin, Stephen M. Rupp, Ellen M. Levin, Takao Hoshino, Judith A. Murovic, and Tadashi Nagashima
- Subjects
Metabolic Clearance Rate ,medicine.drug_class ,Immunocytochemistry ,Biophysics ,Astrocytoma ,Monoclonal antibody ,Pathology and Forensic Medicine ,Flow cytometry ,Immunoenzyme Techniques ,chemistry.chemical_compound ,Endocrinology ,Glioma ,medicine ,Humans ,Interphase ,biology ,medicine.diagnostic_test ,Brain Neoplasms ,Cell Cycle ,Antibodies, Monoclonal ,DNA, Neoplasm ,Cell Biology ,Hematology ,Flow Cytometry ,medicine.disease ,Molecular biology ,Bromodeoxyuridine ,chemistry ,Immunology ,biology.protein ,Chromomycin A3 ,Glioblastoma ,Meningioma ,Thymidine ,Peroxidase - Abstract
At the time of surgery, 18 patients with various brain tumors were given a 1-h i.v. infusion of bromodeoxyuridine (BrdUrd), 150-200 mg/m2. At an infusion rate of 200 mg/m2/h, serum BrdUrd levels of 8 microM were achieved. After the infusion, tumor tissue was obtained and divided into two portions. One portion was fixed in 70% ethanol, embedded in paraffin, and sectioned; the sections were deparaffinized, denatured with 2 N HCl, and reacted with monoclonal antibodies against BrdUrd (anti-BrdUrd MAb). BrdUrd-labeled nuclei were demonstrated satisfactorily by an indirect peroxidase method. The other portion was dissociated into single cells with a DNase enzyme cocktail and reacted with FITC-conjugated anti-BrdUrd MAb to determine the percentage of BrdUrd-labeled cells or with chromomycin A3 for DNA analysis. The single-cell suspensions were analyzed by flow cytometry. The fraction of S-phase cells in the tissue sections was similar to both the percentage of BrdUrd-labeled nuclei and the S-phase fraction determined by flow cytometric analysis. The results obtained with BrdUrd-labeled nuclei were similar to those obtained from previous autoradiographic studies of various brain tumors exposed to a pulse of 3H-thymidine. Since BrdUrd is not radioactive and is nontoxic at the dosage used, these techniques, together with the histopathological diagnosis, may help to predict the biological malignancy of individual tumors.
- Published
- 1985
26. The pharmacokinetics and pharmacodynamics of atracurium in patients with and without renal failure
- Author
-
Manohar Sharma, Stephen M. Rupp, Pim J. Hennis, Dennis M. Fisher, Ronald D. Miller, Claver Canfell, Mark R. Fahey, and Kay Castagnoli
- Subjects
Renal function ,Anesthesia, General ,Models, Biological ,Laudanosine ,chemistry.chemical_compound ,Bolus (medicine) ,Pharmacokinetics ,Medicine ,Humans ,Neuromuscular Blockade ,Atracurium Besylate ,business.industry ,Chromatography, Ion Exchange ,Isoquinolines ,Kinetics ,Anesthesiology and Pain Medicine ,chemistry ,Pharmacodynamics ,Anesthesia ,Atracurium ,Kidney Failure, Chronic ,Halothane ,business ,medicine.drug ,Muscle Contraction ,Neuromuscular Nondepolarizing Agents - Abstract
To determine the influence of renal function on the pharmacology of atracurium, 10 patients with normal renal function and 10 with renal failure (scheduled for cadaver kidney transplant) were anesthetized with nitrous oxide and halothane. Atracurium besylate, 0.5 mg . kg-1, was given as an iv bolus and plasma samples were collected over a 4-h period. These samples were assayed for atracurium (all patients) and laudanosine, one of the principal metabolites (eight of the normal group), using an ion-exchange liquid chromatographic assay. The plasma concentrations of atracurium for each patient were fitted to a two-compartment pharmacokinetic model. The onset time, duration of action, and recovery time of atracurium neuromuscular blockade were measured. There were no differences found in the pharmacokinetics or pharmaco-dynamics of atracurium between patients with normal renal function and those with renal failure. There were measurable levels of laudanosine following atracurium administration with peak levels of 199 +/- 31 ng . ml-1 at 2 min. The authors conclude that the pharmacokinetics and pharmacodynamics of atracurium are not altered by renal failure.
- Published
- 1984
27. The effect of halothane, isoflurane, or sufentanil on the hypertensive response to cerebellar retraction during posterior fossa surgery
- Author
-
Charles B. Wilson, Stephen M. Rupp, Ira J. Rampil, James K. Wickersham, and Judith H. Donegan
- Subjects
medicine.medical_specialty ,Sufentanil ,Diastole ,Hemodynamics ,Blood Pressure ,Anesthesia, General ,Fentanyl ,Cerebellum ,medicine ,Humans ,Trigeminal Nerve ,Intraoperative Complications ,Aged ,Isoflurane ,business.industry ,Middle Aged ,Surgery ,Anesthesiology and Pain Medicine ,Blood pressure ,Cranial Fossa, Posterior ,Anesthesia ,Anesthetic ,Hypertension ,Halothane ,business ,medicine.drug - Abstract
The blood pressure (BP) response to cerebellar retraction during microvascular decompression of the fifth cranial nerve was investigated in 26 ASA physical status 2 or 3 patients with trigeminal neuralgia. One surgeon performed all operations. To determine the effect of three anesthetic techniques on the BP response, patients were randomly assigned to receive halothane, isoflurane, or sufentanil in sufficient doses with 60% nitrous oxide to achieve a precerebellar retraction systolic BP that was 10-20% below the average ward systolic BP (as per standard clinical practice). The resultant doses were halothane 1.65 +/- 0.27 (mean +/- SD) MAC, isoflurane 1.56 +/- 0.17 MAC (P greater than 0.05), and sufentanil 2.7 micrograms/kg (MAC values include 0.6 MAC contribution from 60% nitrous oxide). In all patients BP increased during the cerebellar retractor placement period compared with the preretractor placement period (P less than 0.05). The peak increase in systolic BP in response to cerebellar retraction was 17 +/- 6 mmHg for halothane, 38 +/- 20 mmHg for isoflurane, and 26 +/- 19 mmHg for sufentanil. The difference between halothane and isoflurane was significant (P less than 0.05). Mean and diastolic BP showed similar significant differences. The authors conclude that halothane attenuates the hypertensive response to cerebellar retraction more than isoflurane when administered in approximately 1.6 MAC concentrations (MAC value includes contribution from nitrous oxide).
- Published
- 1989
28. Effect of midazolam and diazepam premedication on central nervous system and cardiovascular toxicity of bupivacaine in pigs
- Author
-
Randall L. Carpenter, Brent V. Morse, David L. Brown, Stephen M. Rupp, Christopher M. Bernards, Robert C. Morell, and Gale E. Thompson
- Subjects
Central Nervous System ,Resuscitation ,Epinephrine ,medicine.drug_class ,Swine ,Midazolam ,Cardiovascular System ,Norepinephrine ,Heart rate ,medicine ,Animals ,Bupivacaine ,Benzodiazepine ,Diazepam ,Local anesthetic ,business.industry ,Hemodynamics ,Anesthesiology and Pain Medicine ,Anesthesia ,Premedication ,business ,Preanesthetic Medication ,medicine.drug - Abstract
To determine the effect of benzodiazepine premedication on central nervous system and cardiovascular effects of bupivacaine, the authors administered toxic doses of bupivacaine to awake spontaneously breathing pigs after intravenous premedication with midazolam (0.06 mg/kg), diazepam (0.15 mg/kg), or saline. Five minutes after administration of one of these solutions, they began an infusion of bupivacaine at 2 mg.kg-1.min-1. The bupivacaine infusion was continued until cardiovascular collapse. They then attempted to resuscitate the animals via open chest cardiac massage and a standard resuscitation protocol. Premedication with midazolam or diazepam significantly delayed the onset of ventricular dysrhythmias (P less than 0.05), decreased the incidence of seizures (P less than 0.05), and prevented the increase in blood pressure and heart rate following bupivacaine infusion (P less than 0.05). Benzodiazepine premedication did not affect the dose of bupivacaine or the blood concentration required to produce cardiovascular collapse. The ability to resuscitate animals premedicated with midazolam did not differ from control; however, significantly fewer animals premedicated with diazepam were resuscitated (P less than 0.05). A clinically relevant observation was that almost all animals premedicated with a benzodiazepine progressed directly to cardiovascular collapse without first manifesting seizures.
- Published
- 1989
29. Treatment of spontaneous cerebrospinal fluid leak with epidural blood patch. Case report
- Author
-
Charles Wilson and Stephen M. Rupp
- Subjects
Adult ,Epidural Space ,Leak ,medicine.medical_specialty ,Spontaneous cerebrospinal fluid leak ,Injections, Epidural ,Permeability ,Spinal Cord Diseases ,Cerebrospinal fluid ,Medicine ,Humans ,Cerebrospinal Fluid ,Epidural blood patch ,medicine.diagnostic_test ,business.industry ,Lumbosacral Region ,Sacrum ,Spinal cord ,medicine.disease ,Embolization, Therapeutic ,Surgery ,medicine.anatomical_structure ,Blood ,Anesthesia ,Female ,business ,Spinal Nerve Roots ,Myelography ,Lumbosacral joint - Abstract
✓ A case of spontaneous cerebrospinal fluid (CSF) leak from a sacral nerve root sleeve is reported. The leak resulted in CSF hypotension, which failed to resolve with prolonged bed rest. An epidural blood patch using autologous blood placed percutaneously via the caudal canal was successful in treating the problem.
- Published
- 1989
30. Refining the priming principle for vecuronium during rapid-sequence induction of anesthesia
- Author
-
Ronald D. Miller, Jose A. Taboada, and Stephen M. Rupp
- Subjects
Adult ,Diazepam ,Time Factors ,Vecuronium Bromide ,medicine.drug_class ,business.industry ,medicine.medical_treatment ,Priming (immunology) ,Muscle relaxant ,Twitch tension ,Rapid sequence induction ,Drug Administration Schedule ,Fentanyl ,Anesthesiology and Pain Medicine ,Anesthesia ,medicine ,Breathing ,Humans ,Pancuronium ,Neuromuscular Blocking Agents ,business ,medicine.drug - Abstract
Administration of a subparalyzing dose of a nondepolarizing muscle relaxant (priming dose) prior to its intubating dose hastens the onset time (time from muscle relaxant administration to 100% depression of twitch tension) of neuromuscular blockade. This study was undertaken to determine the optimal priming and intubating doses and time interval between these doses (priming interval) of vecuronium during rapid-sequence induction of anesthesia. The authors measured single-twitch tension in 79 healthy, awake, premedicated (fentanyl, 50-150 mu iv, and/or diazepam, 5-10 mg iv) patients. In Part A of the study, the priming dose was varied (0.0, 0.005, 0.01, 0.0015, or 0.02 mg/kg iv). Decrement of twitch tension and symptoms were recorded 3 min later. Four minutes after the priming dose, thiopental, 4-6 mg/kg iv, and vecuronium, 0.1 mg/kg iv, were given. Onset times for the 0.01, 0.015, and 0.02 mg/kg groups were significantly shorter than for 0.005 and 0.0 mg/kg groups. No breathing difficulties were encountered in any of the groups. Decrement of twitch tension greater than 25% of control only occurred in the 0.02 mg/kg group (4 of 11 patients). In Part B, the priming interval was varied (2, 4, or 6 min) after giving the optimal priming dose (0.01 mg/kg). Anesthesia was induced as in Part A. Onset times for the 4-min group were significantly faster than the 2- or 6-min groups. In Part C, the intubating dose was varied (0.07, 0.1, or 0.15 mg/kg iv) after the optimal priming dose and optimal priming interval (4 min). Onset times for the 0.1 mg/kg and 0.15 mg/kg groups were significantly faster than the 0.07 mg/kg group.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1986
31. Pancuronium and vecuronium pharmacokinetics and pharmacodynamics in younger and elderly adults
- Author
-
Dennis M. Fisher, Ronald D. Miller, Kay Castagnoli, and Stephen M. Rupp
- Subjects
Volume of distribution ,Adult ,Aged, 80 and over ,Aging ,Vecuronium Bromide ,business.industry ,Muscles ,Osmolar Concentration ,Neuromuscular Junction ,Healthy elderly ,Middle Aged ,Mass spectrometric ,Anesthesiology and Pain Medicine ,Pharmacokinetics ,Anesthesia ,Pharmacodynamics ,Medicine ,Distribution (pharmacology) ,Humans ,Pancuronium ,Elderly adults ,Young adult ,business ,Aged ,Half-Life - Abstract
To evaluate the effect of aging on the distribution, metabolism, and neuromuscular junction sensitivity to pancuronium and vecuronium, the authors determined the pharmacokinetics and pharmacodynamics of these drugs in 12 healthy elderly subjects (70-84 yr) and 12 young adults (30-57 yr) during halothane-nitrous oxide anesthesia. Plasma concentrations of the muscle relaxants were determined using a selective ion-monitoring mass spectrometric technique specific for the parent compound. For vecuronium, plasma clearance (3.7 +/- 1.0 and 5.2 +/- 0.8 ml X kg-1 X min-1, respectively), and volume of distribution at steady-state (179 +/- 31 and 244 +/- 38 ml X kg-1, respectively) were lower in the elderly than in young adults; values for distribution half-lives, elimination half-life, and sensitivity of the neuromuscular junction were similar for the two groups. For pancuronium, there were no statistically significant differences between groups for these pharmacokinetic or pharmacodynamic parameters. However, there was a trend toward reduced clearance (20%) and prolonged elimination half-life (16%) in the elderly as compared to the younger patients. The authors conclude that healthy elective surgical patients between the ages of 70 and 84 yr of age do not differ markedly from younger adults in their pharmacokinetic/pharmacodynamic response to vecuronium and pancuronium.
- Published
- 1987
32. Neostigmine and edrophonium antagonism of varying intensity neuromuscular blockade induced by atracurium, pancuronium, or vecuronium
- Author
-
Roy Cronnelly, Stephen M. Rupp, Ronald D. Miller, Jimmy W. McChristian, and Jose A. Taboada
- Subjects
Time Factors ,Neuromuscular Junction ,Nitrous Oxide ,Edrophonium ,Enflurane ,Atracurium besilate ,Medicine ,Humans ,Anesthesia ,Pancuronium ,Neuromuscular Blockade ,Vecuronium Bromide ,business.industry ,Isoquinolines ,Neostigmine ,Kinetics ,Anesthesiology and Pain Medicine ,Atracurium ,Halothane ,Vecuronium bromide ,business ,Antagonism ,medicine.drug - Abstract
To compare the time course of neostigmine and edrophonium antagonism of varying intensity neuromuscular blockade induced by atracurium, pancuronium, or vecuronium, the authors studied 98 patients anesthetized with nitrous oxide (60%) and halothane or enflurane. Neuromuscular blockade, as monitored by single stimulus-induced twitch tension (TT), was antagonized at varying degrees of spontaneous recovery (2-80% of control TT). Time to antagonism (time from injection of neostigmine or edrophonium to 90% recovery of control TT) was not different between edrophonium, 0.5 mg/kg, and neostigmine, 0.04 mg/kg, when spontaneous recovery had been allowed to occur to at least 11% of control TT prior to antagonist administration (P greater than 0.05). For profound neuromuscular blockade (TT less than or equal to 10% of control) induced by pancuronium or vecuronium, time (mean +/- SD) to antagonism with neostigmine, 0.04 mg/kg, was 7.0 +/- 2.2 min and 5.6 +/- 1.7 min, respectively, while the same for edrophonium, 0.5 mg/kg, was 20.0 +/- 8.0 min and 15.0 +/- 12.5 min, respectively (P less than 0.05). Time to antagonism of profound atracurium-induced neuromuscular blockade was 8.5 +/- 3.3 min for neostigmine, 0.04 mg/kg, and 9.8 +/- 7.0 min for edrophonium, 0.5 mg/kg, (P less than 0.05). For profound vecuronium-and pancuronium-induced neuromuscular blockade, time to antagonism by edrophonium, 1.0 mg/kg, was 4.6 +/- 3.0 min and 3.9 +/- 1.6 min respectively. The authors conclude that neostigmine, 0.04 mg/kg, antagonizes neuromuscular blockade within 12 min when TT is greater than 2% of control at time of reversal. When TT is greater than 10% of control, edrophonium, 0.5 mg/kg, produces similar time to antagonism.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1986
33. Head injury and airway management
- Author
-
Joseph M. Neal and Stephen M. Rupp
- Subjects
business.industry ,Respiration ,medicine.medical_treatment ,Head injury ,medicine.disease ,Craniocerebral trauma ,Text mining ,Anesthesia ,Emergency Medicine ,medicine ,Craniocerebral Trauma ,Humans ,Hypnotics and Sedatives ,Airway management ,Emergencies ,business - Published
- 1988
34. Cardiac Arrest during Spinal Anesthesia. III
- Author
-
Michael F. Mulroy, Gale E. Thompson, Donald H. Ramsey, L. Donald Bridenbaugh, Daniel C. Moore, Raneall L. Carpenter, David L. Brown, and Stephen M. Rupp
- Subjects
Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,Spinal anesthesia ,Medicine ,business ,Clinical death - Published
- 1988
35. Central Venous Pressure Monitoring during Cesarean Section
- Author
-
Stephen M. Rupp
- Subjects
Pregnancy ,Central Venous Pressure ,Cesarean Section ,business.industry ,Central venous pressure ,medicine.disease ,Anesthesiology and Pain Medicine ,Section (archaeology) ,Anesthesia ,medicine ,Humans ,Female ,business ,Monitoring, Physiologic - Published
- 1987
36. EFFECT OF ANESTHETICS ON HYPERTENSIVE RESPONSE TO CEREBELLAR RETRACTION DURING POSTERIQR FQSSA SURGERY
- Author
-
Charles Wilson, Ira J. Rampil, J. Wickersham, Judith H. Donegan, and Stephen M. Rupp
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,medicine ,business ,Surgery - Published
- 1988
37. ELIMINATION OF ATRACURIUM IN HUMANS
- Author
-
Claver Canfell, Dennis M. Fisher, Stephen M. Rupp, Ronald D. Miller, Judith I. Rosen, Mark R. Fahey, and Lewis B. Sheiner
- Subjects
Anesthesiology and Pain Medicine ,Biochemistry ,business.industry ,Hofmann elimination ,Medicine ,Ester hydrolysis ,business ,Medicinal chemistry - Published
- 1985
38. ATRACURIUM NEUROMUSCULAR BLOCKADE DURING HALOTHANE/N2O AND ENFLURANE/N2O ANESTHESIA IN HUMANS
- Author
-
Ronald D. Miller, Jimmy W. McChristian, and Stephen M. Rupp
- Subjects
Neuromuscular Blockade ,Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,Enflurane ,medicine ,Halothane ,business ,medicine.drug - Published
- 1984
39. EFFECT OF EPINEPHRINE ON BUPIVACAINE TOXICITY
- Author
-
David L. Brown, Cm. Bernards, Gale E. Thompson, Randall L. Carpenter, M E Kenter, and Stephen M. Rupp
- Subjects
Bupivacaine ,Anesthesiology and Pain Medicine ,Epinephrine ,business.industry ,Anesthesia ,Toxicity ,medicine ,business ,medicine.drug - Published
- 1989
40. NEUROMUSCULAR BLOCKING EFFECTS OF ATRACURIUM DURING N2o-FENTANYL OR ISOFLURANE ANESTHESIA
- Author
-
Mark R. Fahey, Ronald D. Miller, and Stephen M. Rupp
- Subjects
Anesthesiology and Pain Medicine ,Isoflurane ,Blocking (radio) ,business.industry ,Anesthesia ,medicine ,business ,Fentanyl ,medicine.drug - Published
- 1982
41. ELECTROCARDIOGRAPHS CHANGES FOLLOWING NEUROSURGERY
- Author
-
R. Morales, J. Bird, Stephen M. Rupp, E. Huycke, Judith H. Donegan, W. A. Shapiro, J. Wickersham, and Ira J. Rampil
- Subjects
medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Electrocardiographs ,business.industry ,General surgery ,Medicine ,Neurosurgery ,business - Published
- 1987
42. NEOSTIGMINE ANTAGONIZES A PROFOUND NEUROMUSCULAR BLOCKADE MORE RAPIDLY THAN EDROPHONIUM
- Author
-
Stephen M. Rupp, Ronald D. Miller, and Jimmy W. McChristian
- Subjects
Neuromuscular Blockade ,Anesthesiology and Pain Medicine ,business.industry ,Anesthesia ,medicine ,Edrophonium ,business ,Neostigmine ,medicine.drug - Published
- 1984
43. Neostigmine and Edrophonium Antagonism of Varying Intensity
- Author
-
Stephen M. Rupp, J. A. Taboada, Ronald D. Miller, R. Cronelly, and J. W. McCHRISTAN
- Subjects
Neuromuscular Blockade ,business.industry ,Anesthesia ,medicine ,Edrophonium ,Antagonism ,business ,Neostigmine ,medicine.drug ,Intensity (physics) - Published
- 1987
44. On the Efficacy of the Priming Principle with Vecuronium
- Author
-
Stephen M. Rupp, Jose A. Taboada, and Ronald D. Miller
- Subjects
Anesthesiology and Pain Medicine ,business.industry ,Medicine ,Pharmacology ,business ,Priming (psychology) - Published
- 1986
45. Pharmacokinetics and Pharmacodynamics of 4-Aminopyridine in Anesthetized Dogs
- Author
-
Jack Chalon, Dennis M. Fisher, Neal Castagnoli, Ronald D. Miller, Stephen M. Rupp, and Y. Shinohara
- Subjects
Pharmacokinetics ,business.industry ,4-Aminopyridine ,Medicine ,Pharmacology ,business ,medicine.drug - Published
- 1984
46. THE EFFECT OF BENZODIAZEPINE PREMEDICATION ON THE TOXICITY OF BUPIVACAINE
- Author
-
Gale E. Thompson, R. C. Morell, Randall L. Carpenter, David L. Brown, Stephen M. Rupp, Cm. Bernards, and B. V. Morse
- Subjects
Bupivacaine ,Benzodiazepine ,Anesthesiology and Pain Medicine ,medicine.drug_class ,business.industry ,Anesthesia ,Toxicity ,medicine ,Premedication ,business ,medicine.drug - Published
- 1988
47. Should Multiorifaced Central Venous Catheters be Heparin Bonded?
- Author
-
Judith H. Donegan and Stephen M. Rupp
- Subjects
Catheterization, Central Venous ,medicine.medical_specialty ,Anesthesiology and Pain Medicine ,Text mining ,Heparin ,business.industry ,Humans ,Medicine ,business ,Blood Coagulation ,Surgery ,medicine.drug - Published
- 1988
48. THE EFFECTS OF ENFLURANE, HALOTHANE AND ISOFLURANE ON VECURONIUM NEUROMUSCULAR BLOCKADE IN HUMANS
- Author
-
Ronald D. Miller, Stephen M. Rupp, and Peter J. Gencarelli
- Subjects
Neuromuscular Blockade ,Anesthesiology and Pain Medicine ,Isoflurane ,business.industry ,Anesthesia ,Enflurane ,medicine ,Halothane ,business ,medicine.drug - Published
- 1982
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