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The use of identification points (IPs) is a new approach to set up quality criteria for the identification of organic residues and contaminants: a laboratory is allowed to use any molecular spectrometric technique or combination of techniques in order to earn a minimum number of points. The system of IPs balances the identification power of the different analytical techniques and has the advantage that new techniques can be introduced very easily. © 2001 Elsevier Science B.V. All rights reserved.

Analytical results serve a purpose and this can always be defined in terms of a decision to be taken. Examples are classifying a material according to value, or safety decisions such as ''no action required, all is well", The nature of the decision determines the requirements put to the analysis such as the quantitative ones, e.g. limits of detection, or the qualitative ones, e.g. amount of certainty, that the identification of a compound is unambiguous. The classical approach to unambiguity is a detailed description of procedures. However, this approach has some drawbacks. A standard method by virtue of its immobility is apt to become old-fashioned. Modern highly sophisticated apparatus ask for dedicated analytical procedures, which are not generally applicable. Changes in custom-made reagents or equipment force adaptation of the procedure. For quantitative analysis the flexibility can be attained by a system of quality parameters. These are inadequate for qualitative analysis. In order to create a system in which well-defined limits of ambiguity can be set we have introduced the concept of "quality criteria" to be applied to the identification method(s) used. The quality criteria for each detection method have to be stated and adopted by a board of experts for that detection method. But, once an analysis fulfils the adopted criteria of a detection method, the presence of the investigated analyte in the sample can be taken as proved within the limits of ambiguity chosen for the decision process. In particular for spectrometric identification methods such quality criteria are of essential interest. Quality criteria are presented for low resolution MS, high resolution MS, IR, on line spectrometric detection with TLC and HPLC, furthermore for off line separation techniques (GC, TLC, HPLC), as well as general considerations for the whole analytical procedure. The criteria are incorporated in the EEC ''Commission Decision of 14 July 1987 laying down the methods to be used for detecting residues of substances having a hormonal action and substances having a thyrostatic action". Throughout this report, some differences with respect to the EEC text occur.

Er zijn ongeveer 300 runderurines afkomstig uit het VHI-bewakingsonderzoek onafhankelijk van elkaar door BCO (in opdracht van RIVI-1) en RIKILT onderzocht met Celite RIA.

The sources discussed in this literature study give the level of androgens, estrogens, and progestogens found in the blood, urine and feces of veal calves. Since there were not eneough data available in these three matrices for veal valves, the literature data for male and female breeding calves in the age group of 7-11 months has also been added.

Een literatuurstudie is verricht betreffende de gehalten aan androgenen, oestrogenen en progestagenen in bloed, urine en faeces bij vleeskalveren. Omdat er niet voldoende gegevens beschikbaar waren voor genoemde hormonen in de 3 genoemde matrices bij vleeskalveren zijn ook literatuurgegevens van mannelijke en vrouwelijke fokkalveren in de leeftijdscategorie van ca. 7 tot ca. 11 maanden verwerkt. De meeste analyses zijn uitgevoerd met een radioimmunochemische methode (RIA).

Het testen door het RIKILT van de aldaar toegepaste celite-RIA methode en bevestigingsmethoden voor het aantonen van DES in urine met praktijkmonsters runderurine .