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4 results on '"Stephane Gellee"'

1. Extended Pseudo-Subarachnoid Hemorrhage Post-Percutaneous Coronary Intervention

Author

Antoine Sauguet, Louis David Rivière, Stephane Gellee, Bruno Farah, and Benjamin Honton

Subjects
0301 basic medicine, medicine.medical_specialty, Subarachnoid hemorrhage, no-reflow phenomenon, medicine.medical_treatment, 030105 genetics & heredity, 03 medical and health sciences, 0302 clinical medicine, PCI - Percutaneous coronary intervention, Internal medicine, ischemic stroke, medicine, Diseases of the circulatory (Cardiovascular) system, pseudo-subarachnoid hemorrhage, cardiovascular diseases, Imaging Vignette: Clinical Vignette, PCI, percutaneous coronary intervention, business.industry, percutaneous coronary intervention, Percutaneous coronary intervention, Mini-Focus Issue: Heart Failure, PSAH, pseudo-subarachnoid hemorrhage, medicine.disease, CT, computed tomography, MRI - Magnetic resonance imaging, RC666-701, No reflow phenomenon, Ischemic stroke, Cardiology, Cardiology and Cardiovascular Medicine, business, MRI, magnetic resonance imaging, 030217 neurology & neurosurgery
Abstract

We report the case of an extended pseudo-subarachnoid hemorrhage (PSAH) related to contrast intracerebral diffusion from blood-brain barrier breakdown on periprocedural percutaneous coronary intervention right corticofrontal ischemic stroke. PSAH is a rare and complex phenomenon, and it is important to differentiate PSAH from subarachnoid hemorrhage to avoid inappropriate treatment with potentially severe consequences. (Level of Difficulty: Beginner.), Graphical abstract, We report the case of an extended pseudo-subarachnoid hemorrhage (PSAH) related to contrast intracerebral diffusion from blood-brain barrier…

Published
2020
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2. Extended Pseudo-Subarachnoid Hemorrhage Post-Percutaneous Coronary Intervention

Author

Benjamin Honton, MD, Antoine Sauguet, MD, Bruno Farah, MD, Stéphane Gellee, MD, and Louis David Rivière, MD

Subjects
ischemic stroke, no-reflow phenomenon, percutaneous coronary intervention, pseudo-subarachnoid hemorrhage, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

We report the case of an extended pseudo-subarachnoid hemorrhage (PSAH) related to contrast intracerebral diffusion from blood-brain barrier breakdown on periprocedural percutaneous coronary intervention right corticofrontal ischemic stroke. PSAH is a rare and complex phenomenon, and it is important to differentiate PSAH from subarachnoid hemorrhage to avoid inappropriate treatment with potentially severe consequences. (Level of Difficulty: Beginner.)

Published
2020
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3. Intervertebral disc swelling demonstrated by 3D and water content magnetic resonance analyses after a 3-day dry immersion simulating microgravity

Author

Loïc Treffel, Karen Mkhitaryan, Stéphane Gellee, Guillemette Gauquelin-Koch, Claude Gharib, Stephane Blanc, and Catherine Millet

Subjects
Back Pain, microgravity, Disc herniation, dry immersion, Disc swelling, vertebral deconditioning, Physiology, QP1-981
Abstract

Background Vertebral deconditioning is commonly experienced after space flight andsimulation studies. Disc herniation (DH) is quadrupled after space flight.Purpose The main hypothesis formulated by the authors is that microgravity results inintervertebral disc swelling.Study Design The aim of the study was to identify the morphological changes of the spine andtheir clinical consequences after simulated microgravity by 3-day dry immersion (DI).The experimental protocol was performed on 12 male volunteers using magnetic resonanceimaging and spectroscopy before and after DI.Methods All the experiment was financially supported by CNES (Centre national d’étudesspatiales i.e. French Space Agency).Results We observed an increase in rachis height of 1.5 ± 0.4 cm and a decrease in curvature,particularly for the lumbar region with a decrease of -4 ± 2.5°. We found a significantincrease in intervertebral disc (IVD) volume of +8 ± 9% at T12-L1 and +11 ± 9% at L5-S1.This phenomenon is likely associated with the increase in disc intervertebral water content(IWC), 17 ± 27%. During the 3 days in DI, 92% of the subjects developed back pain in thelumbar region below the diaphragmatic muscle. This clinical observation may be linked to themorphological changes of the spine.Conclusions The morphological changes observed and, specifically, the disc swelling causedby increased IWC may contribute to understanding disc herniation after microgravityexposure. Our results confirmed the efficiency of the 3-day DI model to reproduce quickly theeffects of microgravity on spine morphology. Our findings raise the question of the subjectselection in spatial studies, especially studies about spine morphology and reconditioningprograms after space flight. These results may contribute to a better understanding of themechanisms underlying disc herniation and may serve as the basis to developcountermeasures for astronauts and to prevent IVD herniation and back pain on Earth.

Published
2016
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4. 0174 : RadiothErapy for BrEast Cancer and early detection of CArdiotoxicity (REBECCA): a prospective cohort study

Author

Fabien Milliat, Stephane Gellee, Radia Tamarat, Sophie Jacob, S. Derreumaux, Matthieu Berry, Hervé Rousseau, Olivier Lairez, Marie-Odile Bernier, David Broggio, Jean Ferrières, Marc Benderitter, Luc Simon, and Carole Massabeau

Subjects
Oncology, medicine.medical_specialty, Cardiotoxicity, business.industry, medicine.medical_treatment, Cancer, medicine.disease, Surgery, Coronary arteries, Radiation therapy, medicine.anatomical_structure, Breast cancer, Internal medicine, Cohort, medicine, business, Prospective cohort study, Cardiology and Cardiovascular Medicine, Cardiac imaging
Abstract

Breast radiotherapy (RT) techniques used until the 1990s were responsible for increased mortality due to long term cardiac complications. Since the 2000s, improved techniques of RT have appeared leading to different dose distributions to organ at risks such as heart. But up to now, little is known on their cardiac toxicity. The aim of the REBECCA study is to evaluate whether helical tomotherapy (HT) induces cardiac toxicity that could be detected in the first two years after treatment based on analysis of subclinical functional and anatomical cardiac lesions at myocardial and coronary levels and evolution of circulating biomarkers. REBECCA study is a prospective cohort study that will include 120 women treated with adjuvant HT for breast cancer at the Institut Universitaire du Cancer Toulouse-Oncopole (IUCT), and followed up for 2 years after RT. Women aged 40 to 70 years, surgically treated at IUCT for breast cancer and for whom adjuvant RT with HT is indicated, without chemotherapy will be eligible for the study. Follow-up will include measures of a panel circulating biomarkers, coronary plaque index based on Coronary computed tomography angiography and myocardial strain based on 2D-speckle tracking echocardiography. Absorbed doses will be evaluated for the whole heart and for each different parts of heart, in particular coronary arteries. Analysis will focus on dose-response relationship between subclinical cardiac lesions, biomarkers, and different organ absorbed doses. Furthermore, this study aims to create a bio-bank of plasma and blood of this cohort for future investigations. This clinical research study is a novel approach to early detect cardiotoxicity of current breast RT, combining anatomical and functional heart consequences based on cardiac imaging, a panel of circulating biomarkers and a detailed heart dosimetry. With this approach, REBECCA aims to improve understanding of the mechanisms and circumstances that underlie the development of potential heart side effects and sequelaes.

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