Author: "Stephan Seggewies" - Searchworks@Jio Institute Digital Library Search Results

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Author: Stephan Seggewies, Eberhard Breitmaier, and Kerstin Gunst
Subjects: chemistry.chemical_compound, Stereochemistry, Chemistry, Organic Chemistry, Chirality (chemistry), Tetrapyrrole, Catalysis
Published: 2001

Author: Thomas Schönemeier, Eberhard Breitmaier, Axel Drews, and Stephan Seggewies
Subjects: chemistry.chemical_compound, Chemistry, Stereochemistry, o-Phenylenediamine, Diaminomaleonitrile, Organic Chemistry, Annulene, Medicinal chemistry, Catalysis
Published: 1998

Author: Eberhard Breitmaier, Stephan Seggewies, and Thomas Schönemeier
Subjects: Chemistry, Organic Chemistry, Organic chemistry, Medicinal chemistry, Catalysis
Published: 1999

Author: Eberhard Breitmaier, Berta M Heinzmann, Klemens Heiden, Gerhard Rücker, D. Manns, Stephan Seggewies, Walter A. Maier, and Anne Marek
Subjects: Organic peroxide, Curcumin, Magnetic Resonance Spectroscopy, Bicyclic molecule, biology, Diene, Photochemistry, Pharmaceutical Science, Plasmodium falciparum, Mice, Inbred Strains, Sesquiterpene, biology.organism_classification, Chemical synthesis, In vitro, chemistry.chemical_compound, Antimalarials, Mice, chemistry, In vivo, Drug Discovery, Organic chemistry, Animals, Female, Sesquiterpenes
Abstract: 1,4-Epidioxy-bisabola-2,12-diene (3) and aromatic hydroperoxides (4, 5) were prepared by photoxidation of gamma-curcumene (1). Reduction and esterification of 6 and 7 afforded compounds 9 to 10. All compounds were tested in vitro for antimalarial activity. The activity could not be increased significantly, compared with 3. The most active compounds, 3 and 9, did not show in vivo antimalarial activity in mice.
Published: 1997

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