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Context Return-to-activity (RTA) assessments are commonly administered after anterior cruciate ligament reconstruction (ACLR) to manage the patient's postoperative progressions back to activity. To date, few data are available on the clinical utility of these assessments to predict patient outcomes such as secondary anterior cruciate ligament (ACL) injury once the athlete has returned to activity. Objective To identify the measures of patient function at 6 months post-ACLR that best predict RTA and second ACL injury at a minimum of 2 years after ACLR. Design Prospective cohort study. Setting Laboratory. Patients or Other Participants A total of 234 patients with primary, unilateral ACLR completed functional assessments at approximately 6 months post-ACLR. Of these, 192 (82.1%) completed follow-up at ≥2 years post-ACLR. Main Outcome Measure(s) The 6-month functional assessments consisted of patient-reported outcomes, isokinetic knee-flexor and -extensor strength, and single-legged hopping. We collected RTA and secondary ACL injury data at ≥2 years after ACLR. Results Of the patients who were able to RTA (n = 155), 44 (28.4%) had a subsequent ACL injury, 24 (15.5%) to the ipsilateral graft ACL and 20 (12.9%) to the contralateral ACL. A greater proportion of females had a secondary injury to the contralateral ACL (15/24, 62.5%), whereas a greater proportion of males reinjured the ipsilateral ACL graft (15/20, 75.0%; P = .017). Greater knee-extension symmetry at 6 months increased the probability of reinjury (B = 0.016, P = .048). Among patients with RTA at 8 months, every month that RTA was delayed reduced the risk of reinjury by 28.4% (B = –0.284, P = .042). Descriptive statistics of patient function stratified between the early and delayed RTA groups can be found in the Supplemental Table (available online at http://dx.doi.org/10.4085/1062-6050-0407.20.S1). Conclusions Patients with more symmetric quadriceps strength at 6 months post-ACLR were more likely to experience another ACL rupture, especially those who returned to sport at

To assess the changes in patient strength and function from 4- to 6-month assessments following ACLR, determine relationships between changes in strength to changes in subjective function, and identify factors that predict patients that fail to increase in strength.Prospective, Cohort Study.Controlled Laboratory.Forty-seven patients(27 female, 24.3 ± 11.1 years) completed a battery of performance assessments at approximately 4- and 6-months following primary ACLR (4.03 ±0 .49 and 6.46 ±0 .68 months).Subjective scores and isokinetic knee flexor and extensor strength were compared across visits. Patients were categorized per their ability to increase in strength beyond a previously defined threshold(0.22 Nm/kg). Binary logistic regression models were used to determine predictors of patients that failed to meet strength changes.Patients demonstrated improvements in patient-reported outcomes and strength measures between visits(P's 0.05). Higher age (B = -0.073, P = .039), lower pre-injury activity levels (B = 0.61, P = .022), and higher limb symmetry indexes (B = -0.044, P = .05) at 4-months were predictors of patients that did not achieve improvements in quadriceps strength between assessments.From 4- to 6-months post-ACLR, increases in subjective function, strength and symmetry were observed. High quadriceps symmetry at interim assessments without consideration of the magnitude of strength values could overestimate recovery of quadriceps function.

BACKGROUND Sports injuries have increased dramatically in the pediatric and adolescent population. Return-to-sport testing and criteria are increasingly utilized, however, the guidelines for return to play in adolescents are unclear. The purpose of this study was to compare strength and function at the time of the return-to-sport progression to those with and without a failed anterior cruciate ligament reconstruction (ACLR). METHODS A total of 105 adolescent patients with primary ACLR were assessed at the time of return to sport. We identified graft failures/contralateral injury through medical records, clinic visits, or phone interviews at minimum 2 years of postsurgical follow-up. All patients completed bilateral isokinetic strength tests of the knee extensor/flexor groups and hop tests. Strength was expressed as torque-normalized-to-mass (Nm/kg), and limb-symmetry-index was expressed as a percentage of the uninvolved limb's strength. All patients completed outcome surveys. The χ2 analysis was used to compare failures between sexes and graft types. Independent sample t tests were used to compare knee extensor/flexor strength, symmetry, and hop test results between patients with and without secondary anterior cruciate ligament (ACL) injury. One-way analysis of variance was used to compare knee extensor/flexor strength and symmetry, hop test, and survey results between those (1) without secondary injury, (2) ACLR graft failure, and (3) contralateral ACL injury. RESULTS A total of 100 of 105 patients (95.2%) were included with 4±1.2 years of follow-up, with 28 (28%) sustaining subsequent injury (12% graft, 16% contralateral). Patients with graft failure demonstrated (1) stronger quadriceps strength (2.00±0.46 Nm/kg) compared with those with contralateral ACL injury (1.58±0.35 Nm/kg, P=0.039) and patients that did not have a secondary injury (1.58±0.44 Nm/kg, P=0.007), (2) greater quadriceps strength symmetry (85.7±0.11.2%) compared with patients without secondary injury ACL (72.9±17.9%, P=0.046), (3) a greater proportion of hamstring grafts compared with those without reinjury (P=0.028). CONCLUSIONS Adolescent patients who sustained ACLR graft failure had greater and more symmetric quadriceps strength at the time of return to sport compared with patients with no secondary injury. Objective measures of quadriceps strength at the time of the return-to-sport progression may not solely identify individuals that have a secondary ACL injury. STUDY DESIGN Level IV-retrospective cohort study.

Background: Meniscal injuries are commonly associated with anterior cruciate ligament (ACL) tears. Treatment of meniscal injuries can impart delayed weightbearing and range of motion restrictions, which can affect the rehabilitation protocol. The effect of meniscal treatment and subsequent restrictions on strength recovery after ACL reconstruction is unclear. Purpose/Hypothesis: The purpose of this study was to compare strength, jumping performance, and patient-reported outcomes between patients who underwent isolated ACL reconstruction (ACLR) and those who underwent surgical intervention for meniscal pathology at the time of ACLR. Our hypothesis was that patients who underwent concurrent meniscal repair (MR) would have lower strength recovery owing to postoperative restrictions. Study Design: Cohort study; Level of evidence, 3. Methods: Patients with ACLR were stratified into isolated ACLR, ACLR and meniscectomy (ACLR-MS), or ACLR-MR groups and were compared with healthy controls. The ACLR-MR group was restricted to partial weightbearing and to 90° of knee flexion for the first 6 weeks postoperatively. All participants completed patient-reported outcomes (International Knee Documentation Committee [IKDC] and Knee injury and Osteoarthritis Outcome Score [KOOS]) and underwent bilateral isokinetic and isometric strength tests of the knee extensor and flexor groups as part of a return-to-sports test battery at 5 to 7 months postoperatively. Results: A total of 165 patients with ACLR (50 with isolated ACLR, 44 with ACLR-MS, and 71 with ACLR-MR) and 140 healthy controls were included in the study. Follow-up occurred at a mean of 5.96 ± 0.47 months postoperatively. The control group demonstrated higher subjective knee function, unilateral peak extensor torque, and limb symmetry than did the ACLR-MS and ACLR-MR groups combined ( P < .001 for all). There were no differences in IKDC, KOOS subscales, or unilateral or limb symmetry measures of peak knee extensor or flexor torque among the isolated ACLR, ACLR-MS, and ACLR-MR groups. Conclusion: Persistent weakness, asymmetry, and reduced subjective outcome scores at 6-month follow-up after ACLR were not influenced by meniscal treatment. These findings suggested that the weightbearing and range of motion restrictions associated with meniscal repair recovery do not result in loss of early strength or worse patient-reported outcomes.

Background Anterior cruciate ligament injuries and anterior cruciate ligament reconstructions (ACLRs) are common, especially in adolescent patients. Recovery of strength, jumping performance, and perceived/subjective function are often used to make a return to sports decisions after injury. It is unknown how skeletal maturity may influence strength recovery after ACLR. The purpose of this study was to compare the strength and patient-reported outcomes in adolescent ACLR patients with and without open distal femur and proximal tibia physes. Methods One hundred seventeen consecutive patients under the age of 18 were referred for routine strength and subjective outcomes evaluation following ACLR, 100 were included in the final analyses after excluding those with prior injuries, those tested outside for 4 to 12 month postoperative window, and those with incomplete clinical data. All study patients completed patient-reported outcomes, and underwent isometric and isokinetic testing of knee extensor and flexor strength to calculate normalized peak torque and limb symmetry. Statistical analyses were performed on all outcomes data using a 2×2 (physeal status: open, closed; and sex: male, female) with analysis of covariance where age and preoperative activity level were used as covariates. Results A significant interaction between sex and physeal status for isokinetic knee extension peak torque and isometric knee extension peak torque, and limb symmetry index was found. This indicated that males with open physes were stronger and more symmetric than males with closed physes and females with open physes at ~6 months post-ACLR. There were no differences between sexes for patients with closed physes. No interactions were observed for flexion strength. Male patients and patients with open physes had higher perceived knee function compared with their corresponding counterparts. Conclusions After ACLR, adolescent patients with open physes had higher quadriceps strength compared with patients with closed physes. Overall, those skeletally less mature patients actually fared better on the functional strength tests, suggesting that functional recovery is not hindered by the presence of an incompletely closed physis. Level of evidence Level III-retrospective comparative study.

Background Corticospinal adaptations have been observed following anterior cruciate ligament reconstruction around the time of returning to activity. These measures have been related to quadriceps strength deficits. Visuomotor therapy, combining motor control tasks with visual biofeedback, has been shown to increase corticospinal excitability. The purpose of this study was to assess the immediate changes of corticospinal excitability following a single session of visuomotor therapy in patients following anterior cruciate ligament reconstruction. Methods This was a single blinded, sham-controlled crossover study. Ten patients following ACLR (8 Female, 26.1(6.2) years) completed assessments of quadriceps strength at approximately 4- and 6-months following anterior cruciate ligament reconstruction. At 6-months, quadriceps motor evoked potentials were assessed at 80%, 90%, 100%, 110%, 120%, 130%, 140%, and 150% of the patient's active motor threshold. Patients were randomized to receive a single session of visuomotor therapy(active) or passive motion(sham). Quadriceps motor evoked potentials were reassessed for treatment effect. Following a one-week washout period, all patients received the crossover intervention. Findings Moderate to large increases in motor response following visuomotor therapy 90%(P = .008, r = 0.60), 110%(P = .038, r = 0.46), 120%(P = .021, r = 0.52), 130%(P = .021, r = 0.52), 140%(P = .008, r = 0.60) and 150%(P = .021, r = 0.52) of the active motor threshold were found. Moderate increases in motor response was observed following the passive motion at 80% of the active motor threshold(P = .028, r = 0.49). Interpretation A single session of visuomotor therapy was found to increase quadriceps corticospinal motor response greater than the response to sham therapy. Visuomotor therapy is a potential supplement to quadriceps rehabilitation programs when upregulation of corticospinal excitability is indicated.

Individuals following anterior cruciate ligament reconstruction demonstrate quadriceps weakness throughout the post-operative recovery and at the time of returning to sport. This is often accompanied with patterns of quadriceps fatigue resistance. As such, fatigue may be an identifier of individuals with delayed recovery. The purpose was to assess quadriceps fatigue in anterior cruciate ligament reconstructed patients at the time of return to sport in comparison to healthy controls.A total of 215 individuals, 120 following anterior cruciate ligament reconstruction (21.0 (2.9) years, 63 Female, 5.96 (0.48) months post-surgery) and 95 healthy controls (21.5 (8.4) years, 49 Female), participated in this study. All participants completed a 30-s knee extensor maximum voluntary isometric contraction. Knee extensor strength, limb symmetry index, and fatigue (%) were compared between groups. Between-limb fatigue comparisons were made through the Fatigue Index Limb Difference = [(Involved Limb Fatigue Index) - (Uninvolved Limb Fatigue Index)].Individuals following anterior cruciate ligament reconstruction (18.7 (10.9)%, -5.6 (11.2)) demonstrated lower values of unilateral fatigue and Fatigue Index Limb Difference compared to healthy participants (22.5 (8.2)%, P = .002; 2.2 (7.9), P .001). For anterior cruciate ligament reconstructed patients, there was a weak, negative, significant relationship between the involved limb strength and fatigue (r = -0.184, P = .048). There was no relationship between limb symmetry and Fatigue Index Limb Difference (r = 0.137, P = .142). For Healthy individuals, there was a positive, moderate relationship between limb symmetry and Fatigue Index Limb Difference (r = 0.400, P .001).Individuals following anterior cruciate ligament reconstruction demonstrate fatigue resistance compared to healthy active controls and greater resistance to fatigue in their involved limb compared to their contralateral limb.

Context: Individuals following anterior cruciate ligament reconstruction (ACLR) demonstrate altered postural stability and functional movement patterns. It is hypothesized that individuals following ACLR may compensate with sensory adaptations with greater reliance on visual mechanisms during activities. It is unknown if visual compensatory strategies are implemented to maintain postural stability during functional tasks. Objective: To examine visual gaze accuracy during a single-leg balance task in individuals following ACLR compared with healthy, active controls. Design: Case control. Setting: Controlled laboratory. Participants: A total of 20 individuals (10 ACLR and 10 healthy controls) participated in the study. Data Collection and Analysis: Visual gaze patterns were obtained during 20-second single-leg balance trials while participants were instructed to look at presented targets. During the Stationary Target Task, the visual target was presented in a central location for the duration of the trial. The Moving Target Task included a visual target that randomly moved to 1 of 9 target locations for a period of 2 seconds. Targets were stratified into superior, middle, and inferior levels for the Moving Target Task. Results: The Stationary Target Task demonstrated no differences in visual error between groups (P = .89). The Moving Target Task demonstrated a significant interaction between group and target level (F2,36 = 3.76, P = .033). Individuals following ACLR demonstrated greater visual error for the superior targets (ACLR = .70 [.44] m, healthy = .41 [.21] m, Cohen d = 0.83 [0.06 to 1.60]) and inferior targets (ACLR = .68 [.25] m, healthy = .33 [.16] m, Cohen d = 1.67 [0.81 to 2.52]). Conclusion: Individuals following ACLR demonstrate greater visual error during settings of high or low visual stimuli compared with healthy individuals to maintain single-limb postural stability. This population may rely on visual input to compensate for the somatosensory changes following injury.

Background: Patients often have quadriceps or hamstring weakness after anterior cruciate ligament reconstruction (ACLR), despite postoperative physical therapy regimens; however, little evidence exists connecting nerve blocks and ACLR outcomes. Purpose: To compare muscle strength at return to play in patients who received a nerve block with ACLR and determine whether a specific block type affected subjective knee function. Study Design: Cohort study; Level of evidence, 3. Methods: Patients were recruited 5 to 7 months after primary, isolated ACLR and completed bilateral isokinetic strength tests of the knee extensor/flexor groups as a single-session return-to-sport test. Subjective outcomes were assessed with the International Knee Documentation Committee (IKDC) score. Strength was expressed as torque normalized to mass (N·m/kg) and limb symmetry index as involved/uninvolved torque. Chart review was used to determine the type of nerve block and graft used. Nerve block types were classified as knee extensor motor (femoral nerve), knee flexor motor (sciatic nerve), or isolated sensory (adductor canal block/saphenous nerve). A 1-way analysis of covariance controlling for graft type was used. Results: A total of 169 patients were included. Graft type distribution consisted of 102 (60.4%) ipsilateral bone–patellar tendon–bone (BTB) and 67 (39.6%) ipsilateral hamstring tendon. Nerve block type distribution consisted of 38 (22.5%) femoral, 25 (14.8%) saphenous, 45 (26.6%) femoral and sciatic, and 61 (36.1%) saphenous and sciatic. No significant difference was found in knee extensor strength ( P = .113) or symmetry ( P = .860) between patients with knee extensor motor blocks (1.57 ± 0.45 N·m/kg; 70.1% ± 15.3%) and those without (1.47 ± 0.47 N·m/kg; 69.6% ± 18.8%). A significant difference was found between patients with knee flexor motor blocks (0.83 ± 0.26 N·m/kg) and those without (0.92 ± 0.27 N·m/kg) for normalized knee flexor strength ( P = .21) but not knee flexor symmetry ( P = .592). Controlling for graft type, there were no differences in subjective knee function (IKDC score) between all nerve block groups ( P = .57). Conclusion: Our data showed that use of a sciatic nerve block with ACLR in patients with hamstring and BTB grafts influences persistent knee flexor strength deficits at time of return to sports. Although the cause of postoperative muscular weakness is multifactorial, this study adds to the growing body of evidence suggesting that perioperative nerve blocks affect muscle strength and functional rehabilitation after ACLR.

Background: Graft choice in anterior cruciate ligament reconstruction (ACLR) and postoperative rehabilitation may affect strength recovery differently in men than women and therefore affect a timely and successful return to sport. Purpose: To compare knee extensor and flexor strength between men and women who underwent isolated ACLR with either patellar tendon or hamstring tendon (HST) autografts. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 166 patients (87 women, 79 men) with primary unilateral and uncomplicated ACLRs were recruited for participation. A total of 100 patients had bone–patellar tendon–bone (BPTB) autografts and 66 had HST autografts. At 6 months postoperatively, all patients completed the Tegner activity scale and International Knee Documentation Committee Subjective Knee Evaluation as well as underwent bilateral isokinetic (90 deg/s) tests of the knee extensor and flexor groups. Outcomes were recorded in a single session as part of a return-to-sport test battery. Surgical notes were obtained to determine the type of autograft and nerve block used at the time of ACLR. Results: There was a significant sex × graft type interaction for mass-normalized knee flexor torque ( P = .017). Female patients with an HST graft had a significantly lower knee flexor torque compared with female patients with a BPTB graft (0.592 ± 0.49 N·m/kg vs 0.910 ± 0.24 N·m/kg; Cohen d [95% CI] = 0.91 [0.45, 1.36]). They also had a significantly lower knee flexor torque when compared with male patients with an HST graft (0.592 ± 0.49 N·m/kg vs 0.937 ± 0.35 N·m/kg; Cohen d [95% CI]= 0.88 [0.45, 1.31]). There were significant main effects for graft type with knee flexion ( P = .001) and extension ( P = .008) symmetry. Patients with a BPTB graft demonstrated lower knee extensor symmetry (65.7% ± 17.0%) and greater knee flexor symmetry (98.7% ± 18.0%) compared with patients with an HST graft (extension: 77.1% ± 32%, Cohen d [95% CI] = 0.47 [0.16, 0.79]; flexion: 82.9% ± 33.3%, Cohen d [95% CI] = 0.63 [0.31, 0.95]). We also observed a significant main effect for sex ( P = .028) and graft type ( P = .048) for mass-normalized knee extensor strength. Female participants and patients of either sex with BPTB grafts had lower knee extensor strength compared with male participants and patients with HST grafts, respectively. Conclusion: At approximately 6 months after ACLR, female patients reconstructed with HST autografts demonstrated weaker HST strength compared with female patients with a BPTB autograft. There were no differences in HST strength between graft types in male patients. Female patients appear to be recovering HST strength differently than male patients when using an HST autograft. These findings may have implications in surgical planning, postoperative rehabilitation, and return-to-sport decision making.

ContextCurrent clinical assessments used for patients with anterior cruciate ligament reconstruction (ACLR) may not enable clinicians to properly identify functional deficits that have been found in laboratory studies. Establishing muscular-function assessments, through agility and balance tasks, that can properly differentiate individuals with ACLR from healthy, active individuals may permit clinicians to detect deficits that increase the risk for poor outcomes.ObjectiveTo compare lower extremity agility and balance between patients with ACLR and participants serving as healthy controls.DesignCase-control study.SettingControlled laboratory.Patients or Other ParticipantsA total of 47 volunteers in 2 groups, ACLR (9 males, 11 females; age = 23.28 ± 5.61 years, height = 173.52 ± 8.89 cm, mass = 70.67 ± 8.89 kg) and control (13 males, 12 females; age = 23.00 ± 6.44, height = 172.50 ± 9.24, mass = 69.81 ± 10.87 kg).Main Outcome Measure(s)Participants performed 3 timed agility tasks: Agility T Test, 17-hop test, and mat-hopping test. Balance was assessed in single-legged (SL) stance in 3 positions (straight knee, bent knee, squat) on 2 surfaces (firm, foam) with the participants' eyes open or closed for 10-second trials. Agility tasks were measured for time to completion. Eyes-open balance tasks were measured using center-of-pressure average velocity, and eyes-closed balance tasks were measured using the Balance Error Scoring System.ResultsFor the Agility T Test, the ACLR group had slower times than the control group (P = .05). Times on the Agility T Test demonstrated moderate to strong positive relationships for unipedal measures of agility. The ACLR group had greater center-of-pressure average velocity in the SL bent-knee position than the control group. No differences were found between groups for the SL straight-knee and SL-squat balance tasks (P > .05). No differences in errors were present between groups for the eyes-closed balance tasks (P > .05).ConclusionsThe ACLR group demonstrated slower bipedal agility times and decreased postural stability when assessed in an SL bent-knee position compared with the control group.

The ability to detect subtle changes in movement patterns is the most important step towards early and accurate detection of aberrant movement patterns that lead to Anterior Cruciate Ligament (ACL) reinjury which is a common and costly disease resulting in surgical reconstruction and rehabilitation costs well over $3 billion annually. Various types of commercially available wearable motion sensors have been used to assess gait and mobility characteristics in patients performing activities that resemble the demand for sports and in native sport environments. However, the question of to what extent the sensor data could be used to develop predictive models and aid in treatment decision making that may improve care in patients with an ACL injury. Therefore, this paper explores the influences of cross-validation strategies (e.g., record-wise, subject-wise) in developing machine learning models to predict the attributes of an ACL injury that play a significant role in clinical decision-making process including gender, left and right involved limbs, and comparison between patients and healthy controls. Six machine learning models were developed to examine the influences and experimental results demonstrated the performance of the models varied depending on the cross-validation methods and revealed practical implications for clinical decision-making process regarding ACL injury.

Objectives: Graft choice in ACL reconstruction (ACLR) and post-operative rehabilitation may influence strength recovery and return to sports differently in men versus women. Persistent muscle weakness, impaired function, and poor patient reported outcomes are a concern for patients early after reconstruction and impact a timely and successful return to unrestricted physical activity without re-injury. However, little is known about the effect of graft choice and sex on short term ACLR recovery and return-to-play assessment. The purpose of this study was to compare knee extensor and flexor strength between male and female patients in isolated ACLR across both patellar tendon and hamstring autografts. Methods: A total of 166 patients with primary, unilateral and uncomplicated ACL reconstructions (22.6±9.9 years, 87 females, 5.94±.46 months post ACLR) were recruited for participation. There were 100 patients with bone patellar tendon bone (BPTB) autografts and 66 hamstring (HS) autografts. All patients completed the Tegner activity Scale and underwent bilateral isokinetic (90°/sec) tests of the knee extensor and flexor groups. Outcomes were recorded in a single session as part of a return-to-sport test battery. Strength was expressed as torque normalized to mass (Nm/kg) and limb-symmetry was expressed as a percentage of (involved/uninvolved)*100. Surgical Notes were obtained to determine the patient’s sex and type of autograft used at the time of ACLR. Strength measures were compared using 2x2 ANCOVAs (Sex by Graft Type) with the patient’s current activity level as a covariate. Post-hoc Cohen’s D effect sizes and 95% CI were calculated and statistical significance was defined as p-values of .05 or less. Results: There was a significant sex*graft type interaction for normalized knee flexor torque (P=.017) (Figure 1). Females with a HS graft (.592±.49 Nm/kg) had significantly less knee flexor torque compared to females with a BPTB graft (.910±.24 Nm/kg, Cohen’s d= .90[.45, 1.36]) and all males (HS: .937±.35, Cohen’s d=.87 [.45, 1.30]). There were significant main effects for graft type for knee flexor (P=.001) and extensor (P=.008) symmetry. Patients with a BPTB graft demonstrated less knee extensor symmetry (65.7±17%) and greater knee flexor symmetry (98.7±18%) compared to patients with a HS graft (Extension: 77.1±32%, Cohen’s d=.47[.16, .79]) (Flexion: 82.9±33%, Cohen’s d=.63[.31,.95]). We also observed a significant main effect for sex (P=.028) and graft type (P=.048) for normalized knee extensor strength. On average, males (1.67±.60 Nm/kg) demonstrated significantly greater normalized extensor torque than females (1.44±.75 Nm/kg, Cohen’s d= .34 [.03, .64]), and patients with a HS graft (1.66±.34 Nm/kg) demonstrated greater normalized extensor strength than those with a BPTB graft (1.45±.42 Nm/kg, Cohen’s d= .54 [.22, .85]). Conclusion: At approximately 6 months following ACLR, female patients reconstructed with hamstring autografts demonstrated weaker hamstring strength compared to females with a BPTB autograft. There were no differences in hamstring strength between graft types in males. Females appear to be recovering hamstring strength differently than males when using a hamstring autograft. These findings may have implications in surgical planning, post-operative rehabilitation and return to sports decision making. [Figure: see text]

Background: Patellofemoral pain is common in the young and active populations. Nonoperative management is limited and focuses on physical therapy. Hyaluronic acid (HA) is an injectable device that has been used for the treatment of knee osteoarthritis. Hypothesis: A single injection of HA would reduce pain and improve function in patients with patellofemoral pain who had previously failed conservative management. Study Design: Randomized controlled trial; Level of evidence, 2. Methods: A total of 86 patients with patellofemoral pain (65 females, 21 males; mean ± SD age, 27.0 ± 7.7 years; height, 168.6 ± 8.9 cm; weight, 74.6 ± 17.0 kg; body mass index, 26.2 ± 5.2 kg/m2) enrolled in this study after failing conservative management. Patients were randomly allocated to either 6 mL of HA or a sham injection. All patients were prescribed an additional home exercise program, including lower extremity strengthening and flexibility exercises, and were evaluated at 1, 3, and 6 months. Outcome assessments included patellofemoral pain assessment with a visual analog scale during a single-legged squat, KOOS (Knee injury and Osteoarthritis Outcome Score), Kujala score, Tegner activity rating, and normalized isometric knee extension strength. Group assignment was revealed after the 6-month assessment, and crossover treatment was offered to patients in the sham group who were still symptomatic. Linear mixed models were used to compare outcomes between groups and across time. Results: A total of 45 patients were randomized to HA injection and 41 to sham, with 6 patients lost to follow-up (93% follow-up rate). Patients in both groups experienced a significant reduction in visual analog pain ratings and significant improvements in all domains of the KOOS and in Kujala scores at 6 months when compared with baseline measurement ( P < .05); however, there was no significant difference between groups. There were no differences observed over time or between groups for normalized knee extension strength or Tegner activity rating ( P > .05). Conclusion: HA injection had no clinically meaningful effect on pain or functional outcomes in patients diagnosed with patellofemoral pain. Improvements were observed for both groups in patient-reported pain and function, with no change in quadriceps strength or activity rating. Registration: NCT01771952 ( ClinicalTrials.gov identifier).

With the advancement of wearable sensor technology, the use of inertial body sensors in the field of Medicine and Healthcare has increased drastically. Researchers have found that gait data is useful for identifying various motion impairments. Current research in gait analysis is incorporating the features extracted from video data, which is hard to analyze and requires expensive video capture equipment to collect data in slow motion. In this study, we utilized the ability of inertial body sensors to capture gait features of individuals with Anterior Cruciate Ligament (ACL) injury. This study also leverages the causality-based approach to find the coordination between different features of gait data. Gait data during walking, jogging, and running was collected from 131 subjects in which 109 have ACL injury. We then utilized this data to incorporate the gait assessment technique, which uses causality analysis to predict various classes of subjects based on health condition, impacted limb, and impacted limb based on gender. Performance metrics of various machine learning (ML) algorithms were compared to observe the best performing algorithm and used it to evaluate the confidence of individual subjects prediction that aids personalized classification.

Knowledge of research methods and common statistical tests for biomedical research is vital for the evaluating the scientific literature and interpreting the clinical applications of research findings. Conducting impactful research starts with a well-defined question relevant to a patient population and testing outcomes of interest. Data collected in the clinical or basic sciences are analyzed through statistical methods that match the research design and answer specific research questions.

Purpose To investigate relationships between quadriceps strength and neural activity, and to establish a clinical threshold of corticospinal excitability able to discriminate between patients with quadriceps strength indicative of satisfactory and unsatisfactory knee function after ACLR. Methods A total of 29 patients following primary, unilateral ACL-reconstruction (11 female, 23.2 ± 8.1 years of age, 7.3 ± 2.5 months since surgery) participated. Subjective knee function was quantified using the International Knee Documentation Committee (IKDC) subjective evaluation. Peak isokinetic knee extensor torque was assessed at 90°/s. Quadriceps corticospinal excitability was quantified via active motor threshold (AMT, %2-Tesla) using transcranial magnetic stimulation during a 5% maximal voluntary isometric contraction of the quadriceps. Pearson's r correlations were used to assess the relationship between peak knee extensor torque and AMT. Receiver operating characteristic (ROC) curves were used to establish a threshold of (a) mass-normalized peak knee extensor torque to discriminate satisfactory knee function (IKDC ≥ 75.9%), and (b) AMT to discriminate quadriceps strength indicative of satisfactory knee function. Likelihood ratios (LR) and the magnitude of change in pre-post-test probability were calculated for each threshold. Results Active motor threshold was negatively correlated with mass-normalized peak knee extensor torque (r = -0.503, P = 0.005). Knee extensor torque ≥1.23 Nm/kg was an excellent discriminator of satisfactory knee function (AUC = 0.890, P = 0.002; (+)LR = 9.56). An AMT ≤50.5% was an excellent discriminator of quadriceps strength indicative of satisfactory knee function following ACLR (AUC = 0.839, P = 0.005; (+)LR = 23.75). Conclusion Lower corticospinal excitability was associated with lower quadriceps strength. An AMT above 50.5% was found to decrease the probability of having satisfactory knee strength by over 62%.

The purpose was to calculate the incidence of osteoarthritis in individuals following Anterior Cruciate Ligament Reconstruction (ACLR) in a large, national database and to examine the risk factors associated with OA development. A commercially available insurance database was queried to identify new diagnoses of knee OA in patients with ACLR. The cumulative incidence of knee OA diagnoses in patients after ACLR was calculated and stratified by time from reconstruction. Odds ratios were calculated using logistic regression to describe factors associated with a new OA diagnosis including age, sex, BMI, meniscus involvement, osteochondral graft use, and tobacco use. A total of 10,565 patients with ACLR were identified that did not have an existing diagnosis of OA, 517 of which had a documented new diagnosis of knee OA 5 years after ACL reconstruction. When stratified by follow-up time points, the incidence of a new OA diagnosis within 6 months was 2.3%; within a 1-year follow-up was 4.1%; within 2 years, follow-up was 6.2%, within 3 years, follow-up was 8.4%; within 4 years, follow-up was 10.4%; and within 5 years, follow-up was 12.3%. Risk factors for new OA diagnoses were age (OR 2.44, P

Background Following anterior cruciate ligament reconstruction (ACLR), patients undergo a battery of performance assessments to determine progression of return to sport activity. Rates of reinjury following ACLR are high, indicating that current assessments may not accurately identify deficits at the time point of return to sport progression. Research question To assess single-leg postural control in ACLR patients around the time point of return to sport progression and their relationships to subjective function. Study design Descriptive Laboratory Study. Methods 198 individuals (108 ACLR, 90 healthy) participated. All ACLR participants were at the time point of return to play progression. Postural stability was quantified by center of pressure (COP) average velocity measured through a straight-knee single-leg balance assessment for 10-seconds with the participant’s eyes closed. Subjective knee function was measured from the International Knee Documentation Committee (IKDC) Subjective Knee Form and the Knee Osteoarthritis Outcome Score (KOOS) subscales. Results No significant differences existed between COP average velocity between limbs (uninvolved, involved) or groups (ACLR, Healthy). As a secondary aim, no significant relationships existed between measures of subjective knee function and postural stability. Significance Individuals following ACLR demonstrate similar patterns of postural stability as healthy individuals in a straight knee single leg balance task. Single-leg balance in a straight knee position may not be sensitive enough to detect impairments and does not predict subjective function in ACLR patients at the time of return to sport progression.

Background: After anterior cruciate ligament reconstruction (ACLR), relationships between objective measures of muscle function and patient-reported outcomes may change over time. Examining these measures at different time frames after surgery may help develop individualized approaches to improve post-ALCR analysis. Purpose: To examine the associations between subjective knee function and lower-extremity muscle function in individual patients at various time points after ACLR. Study Design: Descriptive laboratory study. Methods: Fifty-one participants who underwent primary, unilateral ACLR (15 males, 36 females; mean age, 22.9 ± 4.5 years; mean height, 172.4 ± 10.1 cm; mean weight, 68.7 ± 13.1 kg) were separated into 3 groups depending on time since surgery (early, 5 years). Subjective knee function was quantified using the International Knee Documentation Committee (IKDC) subjective knee form and the Knee injury and Osteoarthritis Outcome Score (KOOS). Isometric knee extension and flexion strength were collected at 90 deg/s. Single-leg hop performance was measured using the single hop, triple hop, cross-over hop, and 6-m timed hop. Coefficient correlations were calculated between subjective knee function and objective measures of muscle function for each group. Results: The early group demonstrated moderate correlations between the KOOS and unilateral measures of flexion peak torque ( r = 0.514, P = .035) and flexion power ( r = 0.54, P = .027). The middle group demonstrated the strongest correlations between the KOOS and symmetry measures of the single hop ( r = 0.69, P = .002) and extension work ( r = 0.71, P = .002) as well as unilateral measures of the triple hop ( r = 0.52, P = .034) and extension work ( r = 0.66, P = .004). The late group demonstrated strong correlations between the 6-m timed hop symmetry and the IKDC ( r = 0.716, P = .001) and KOOS ( r = 0.71, P = .001). Conclusion: Patients with a post-ACLR status of less than 2 years exhibited stronger relationships with unilateral strength measures to subjective function; graft type was found to change these relationships. Patients at 2 to 5 years postsurgery demonstrated relationships with both unilateral and symmetry measures of muscle function to subjective function. Patients who were more than 5 years after ACLR exhibited strong associations between hopping symmetry and subjective function. Clinical Relevance: Future clinical guidelines for patients after ACLR may need to consider time since surgery as a potential factor.