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1. 2,2,2-Trifluoroethyl Chlorooxoacetate--Universal Reagent for One-Pot Parallel Synthesis of N(1)-Aryl-N(2)-alkyl-Substituted Oxamides.

Author

Bogolubsky AV, Moroz YS, Mykhailiuk PK, Pipko SE, Zhemera AV, Konovets AI, Stepaniuk OO, Myronchuk IS, Dmytriv YV, Doroschuk RA, Zaporozhets OA, and Tolmachev A

Subjects
Amides chemical synthesis, Amines chemical synthesis, Amines chemistry, HIV Fusion Inhibitors chemical synthesis, Indicators and Reagents, Small Molecule Libraries, Amides chemistry, Glyoxylates chemistry, Oxalates chemistry
Abstract

A one-pot parallel synthesis of N(1)-aryl-N(2)-alkyl-substituted oxamides with 2,2,2-trifluoroethyl chlorooxoacetate was developed. The synthesis of a library of 45 oxamides revealed higher efficiency of this reagent over the known ethyl chlorooxoacetate. The reagent was successfully used to prepare the known oxamide-containing HIV entry inhibitors.

Published
2015
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