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9. DEPRESSION OF LYMPHOCYTE TRANSFORMATION BY DRUGS IN VITRO

Author

SCHWARTZ, G. H., STENZEL, K. H., and RUBIN, A. L.

Abstract

Cinanserin, an antiserotonin agent with no bone marrow toxicity, has been evaluated in human lymphocyte cultures. Cinanserin, 7 × 10-5M, inhibits phytohemagglutinin-stimulated protein and deoxyribonucleic acid synthesis by greater than 60; 1.4 × 10-4M is more than 90 inhibitory. At equivalent molar concentrations, Cinanserin is more active than azathioprine. When added late in culture, the drug is not effective. Other drugs have been evaluated by lymphocyte cultures, and their effects arc described. Cinanserin appears to be a promising immunosuppressive agent.

Published
2022

21. Constitutive and inducible expression of CYP enzymes in immortal hepatocytes derived from SV40 transgenic mice

Author

Donato, M.T., Klocke, R., Castell, J.V., Stenzel, K., Paul, D., Gomez-Lechon, M.J., and Publica

Subjects
transgenic mouse, hepatocyte
Abstract

1. The expression of liver-specific transcription factors and cytochrome P450 (CYP) enzymes have been studied in three new hepatocyte-like cell lines derived from SV Delta 202 transgenic mice: AMH-Delta 202 (adult mouse hepatocytes), TAMH-Delta 202 (tumour-derived adult mouse hepatocytes) and NMH-Delta 202 (newborn mouse hepatocytes). 2. mRNA levels of liver-enriched transcription factors such as D-element binding protein (DBP), liver-enriched transcription activating protein (LAP) and the hepatic nuclear factors (HNF) 1, 2 and 3 in all Delta 202 transgenic hepatocyte lines were similar to those in the wild-type liver and in primary mouse hepatocytes. 3. Analysis of basal CYP activities and testosterone metabolism revealed that Delta 202 cells showed higher similarities to mouse hepatocytes than Hepa 1c1c7 hepatoma cells. All three Delta 202 cell lines exhibited substantial active CYP1A1/2, CYP2A4/5 and CYP3A11 activities and lower levels of CYP2B, CYP2C and CYP2E1 activities. 4. The Delta 202 cells also responded to model inducers. 3-Methylcholanthrene induced CYP1A1/2 (7-ethoxyresorufin O-deethylation); phenobarbital induced CYP2B (7-benzoxyresorufin O-debenzylation), CYP2A4/5 (testosterone 7alpha -hydroxylation) and CYP3A11(testosterone 6beta -hydroxylation); and rifampicin and dexamethasone induced CYP3A11 activities in the three Delta 202 cell lines, whereas only AMH-Delta 202 cells reproduced to a limited extent the response of CYP2E1 to ethanol observed in hepatocytes. 5. The results suggest that generation of hepatocyte lines from transgenic animals constitutes a successful approach to obtain in vitro models alternative to primary hepatocytes for drug metabolism and CYP inducibility studies.

Published
2003

33. Deceased-donor kidney transplantation: improvement in long-term survival

Author

Serur, D., primary, Saal, S., additional, Wang, J., additional, Sullivan, J., additional, Bologa, R., additional, Hartono, C., additional, Dadhania, D., additional, Lee, J., additional, Gerber, L. M., additional, Goldstein, M., additional, Kapur, S., additional, Stubenbord, W., additional, Belenkaya, R., additional, Marin, M., additional, Seshan, S., additional, Ni, Q., additional, Levine, D., additional, Parker, T., additional, Stenzel, K., additional, Smith, B., additional, Riggio, R., additional, and Cheigh, J., additional

Published
2010
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36. Separation of lymphocytes by electrophoresis under terrestrial conditions and at zero gravity, phase 3

Author

Rubin, A. L, Stenzel, K. H, Cheigh, J. S, Seaman, G. V. F, and Novogrodsky, A

Subjects
Aerospace Medicine
Abstract

Electrophoretic mobilities (EPM) of peripheral lymphocytes were studied from normal subjects, chronic hemodialysis patients and kidney transplant recipients. A technique to separate B lymphocytes and null cells from non-T lymphocyte preparation was developed. The experiments were designed to determine which subpopulation of the non-T lymphocytes is primarily affected and shows a decreased EPM in chronic hemodialysis patients and kidney transplant recipients.

Published
1977

48. EXCELLENT OUTCOME WITH A CALCIUM CHANNEL BLOCKER—SUPPLEMENTED IMMUNOSUPPRESSIVE REGIMEN IN CADAVERIC RENAL TRANSPLANTATION

Author

SUTHANTHIRAN, M., primary, HASCHEMEYER, R. H., additional, RIGGIO, R. R., additional, ADUBOR, C., additional, FRIEDMAN, G. S., additional, CHEIGH, J. S., additional, WANG, J. C., additional, FOTINO, M., additional, STUBENBORD, W. T., additional, SAAL, S. D., additional, STENZEL, K. H., additional, and RUBIN, A. L., additional

Published
1993
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