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244 results on '"Stenwig, A E"'

3. Genomic analysis of prostate carcinoma specimens obtained via ultrasound-guided needle biopsy may be of use in preoperative decision-making

Author

Teixeira, Manuel R., Ribeiro, Franclim R., Eknaes, Mette, Waehre, Hakon, Stenwig, Anna E., Giercksky, Karl E., Heim, Sverre, and Lothe, Ragnhild A.

Subjects
Karyotyping -- Research, Karyotyping -- Analysis, Prostate cancer -- Diagnosis, Prostate cancer -- Prognosis, Prostate cancer -- Care and treatment, Immune system -- Testing, Immune system -- Influence, Health
Published
2004

7. Systemic relapse of patients with osteogenic sarcoma: prognostic factors for long term survival

Author

Saeter, Gunnar, Hoie, Johan, Stenwig, Anna E., Johansson, Anna K., Hannisdal, Einar, and Solheim, Oyvin P.

Subjects
Osteosarcoma -- Care and treatment, Cancer -- Relapse, Cancer survivors -- Patient outcomes, Health
Abstract

Background. A retrospective study of long term outcome after the development of metastases from osteosarcoma was performed, with emphasis on the impact of different treatment strategies and the identification of prognostic factors. Methods. From 1975 to 1993, a population-based series of 60 patients with distant metastases (relapse) from high grade, extremity-localized osteosarcoma was treated at The Norwegian Radium Hospital. Six patients relapsed after surgery alone, 28 patients relapsed after primary chemotherapy of low potency, and 26 patients after modern, intensive chemotherapy. Lung metastases were present in 88% of the patients, 52% had bilateral lesions, and the median number of lesions was three (range, 1-25 lesions). Forty-seven percent of patients had complete surgical excision of all identifiable metastatic nodules and 54% of these had additional second line chemotherapy defined as adequate. Adequate chemotherapy included further dose escalations of methotrexate in approximately half of the patients, usually from 8 to 12 g. The rest were exposed to novel agents such as cisplatin, etoposide, and ifosfamide. Of the operated patients, 43% had additional thoracotomies after subsequent relapses. Results. The projected 5-year survival rate from the first metastatic event was 24% for all patients and 50% for patients who underwent complete metastasectomy. In a multivariate analysis, the factors with independent predictive value for improved overall survival were the presence of a solitary metastasis, the accomplishment of complete metastasectomy, and the administration of adequate salvage chemotherapy. Conclusions. Complete metastasectomy is mandatory for long term survival of patients with metastatic osteosarcoma, and repeated lung resections are necessary in nearly half the patients. Second line chemotherapy and following primary treatment with modern intensive chemotherapy protocols may improve survival further. Cancer 1995;75:1084-93. Key words: osteosarcoma, metastases, chemotherapy, surgery, metastasectomy, survival, prognostic factors.

Published
1995

12. Familial/Bilateral and Sporadic Testicular Germ Cell Tumors Show Frequent Genetic Changes at Loci with Suggestive Linkage Evidence1

Author

Skotheim, Rolf I, Kraggerud, Sigrid M, Fosså, Sophie D, Stenwig, Anna E, Gedde-Dahl, Tobias, Danielsen, Håvard E, Jakobsen, Kjetill S, and Lothe, Ragnhild A

Subjects
Adult, Male, X Chromosome, Genetic Linkage, Loss of Heterozygosity, Allelic Imbalance, Polymerase Chain Reaction, Neoplasms, Multiple Primary, Testicular Neoplasms, Humans, Genetic Predisposition to Disease, Germinoma, Research Article, Microsatellite Repeats
Abstract

Testicular germ cell tumor (TGCT) is the most common tumor type among adolescent and young adult males. Familial clustering and bilateral disease are suggestive of a genetic predisposition among a subgroup of these patients, but susceptibility genes for testicular cancer have not yet been identified. However, suggestive linkage between disease and genetic markers has been reported at loci on chromosome arms 3q, 5q, 12q, 18q, and Xq. We have analyzed primary familial/bilateral (n=20) and sporadic (n=27) TGCTs, including 28 seminomas and 19 nonseminomas, for allelic imbalance (AI) within the autosomal regions. DNA from all tumors were analyzed by fluorescent polymerase chain reaction of 22 polymorphic loci at 3q27-ter, 5q13-35.1, 12q21-ter, and 18q12--ter. All tumor genotypes were evaluated against their corresponding constitutional genotypes. The percentages of TGCTs with genetic changes at 3q, 5q, 12q, and 18q, were 79%, 36%, 53% and 43%, respectively. The frequencies at 3q and 12q in nonseminomas were significantly higher than in seminomas (P=.003 and P=.004). In order to evaluate changes at hemizygous Xq loci, five loci were analyzed by co-amplification with an autosomal reference marker known to reveal retained heterozygosity in the tumor DNA. Gain of Xq sequences was seen in more than 50% of the tumors. The degree of amplification varied among the loci in each of five tumors, and based on these breakpoints, a common region of overlapping gains was found at Xq28. No significant differences were found between the frequencies of genetic changes in familial/bilateral versus sporadic tumors, an observation speaking in disfavor of the existence of a single susceptibility gene for TGCT in any of the analyzed regions. Our data suggest that gain of genetic material at distal Xq and losses at 5q and 18q contribute to establishment of seminomas, whereas imbalances at 3q as well as gain at distal part of 12q are associated with further progression into nonseminomas.

Published
2001

14. Prognostic factors in liposarcoma.

Author

Reitan, Jon B., Kaalhus, Olav, Brennhovd, Ivar O., Sager, Eli Marie, Stenwig, Anna E., Talle, Kristian, Reitan, J B, Kaalhus, O, Brennhovd, I O, Sager, E M, Stenwig, A E, and Talle, K

Published
1985
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22. Chemotherapy in osteosarcoma

Author

Sæter, Gunnar, primary, Wiebe, Thomas, additional, Wiklund, Tom, additional, Monge, Odd, additional, Wahlqvist, Yngve, additional, Engström, Katarina, additional, Forestier, Erik, additional, Holmström, Teddy, additional, Stenwig, Anna E, additional, Willén, Helena, additional, Brosjö, Otte, additional, Follerås, Gunnar, additional, Alvegård, Thor A, additional, and Strander, Hans, additional

Published
1999
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43. False-negative Biopsy for Testicular Intraepithelial Neoplasia and High-risk Features for Testicular Cancer.

Author

Cappelen, Tone, Fosså, Sophie D., Stenwig, Anna E., and Aass, Nina

Subjects
TESTIS, TUMOR growth, DISEASES in men, BIOPSY
Abstract

The purpose of this report is to emphasize the possibility of false-negative biopsies for testicular intraepithelial neoplasia (TIN) in men with high-risk features of testicular cancer and to review the relevant literature. At the Norwegian Radium Hospital patients in this category are offered the chance to undergo a testicular biopsy. A patient is described who had a normal testicular biopsy a decade before presenting with an invasive testicular cancer. Furthermore, this patient is the first case reported with a false-negative biopsy for TIN and a family history of testicular cancer. The evaluation of the biopsies included immunohistochemical staining for c-kit and PlAP (placental-like alkaline phosphatase) in order to diagnose early TIN. Though multifocal or diffuse extension seems to be the most frequent pattern of distribution of TIN, the presented case and another 14 cases from the literature review indicate that the focality of TIN may be a reason for a TIN-negative biopsy. [ABSTRACT FROM AUTHOR]

Published
2000
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44. Chemotherapy in osteosarcoma.

Author

Saeter, Gunnar, Wiebe, Thomas, Wiklund, Tom, Monge, Odd, Wahlqvist, Yngve, Engstrom, Katarina, Forestier, Erik, Holmstrom, Teddy, Stenwig, Anna E., Willen, Helena, Brosio, Otte, Folleras, Gunnar, Alvegard, Thor A., and Strander, Hans

Subjects
OSTEOSARCOMA, DRUG therapy, METHOTREXATE
Abstract

Discusses the development of chemotherapy procedures for use in the treatment of osteosarcoma. Introduction of high doses of methotrexate (MTX); Components of osteosarcoma protocols; Correlation between histologic response and serum levels of MTX.

Published
1999

45. Chemotherapy of Advanced Seminoma: Clinical Significance of Radiological Findings before and after Treatment.

Author

FOSSÅ, SOPHIE D., KULLMANN, G., LIEN, H. H., STENWIG, ANNA E., and OUS, S.

Abstract

- The predictive significance of the mass detected following chemotherapy was assessed in 46 patients with advanced seminoma. Patients with residual viable seminoma in the post-chemotherapy operation specimen or who developed recurrent disease were regarded as chemotherapy failures. This group included 1 of 20 patients in whom the retroperitoneal masses were ≤ 10 cm2 3 to 4 weeks after chemotherapy and 4 of 15 patients whose residual masses were >10cm2. Four of 11 patients with mediastinal tumours achieved a complete remission (mediastinal masses ≤ 1 cm2). However, 2 of these 4 patients relapsed, as did 2 of the 4 who achieved a partial remission. In no case was the original size of the tumour significantly related to treatment failure. Three patients had residual lung masses; 1 of these contained histological evidence of viable tumour. In one-third of the irradiated relapse-free patients, slightly enlarged masses were visible on follow-up computed tomography scans taken several years after treatment, even in patients without tumour activity. There is a 25% risk of relapse in patients with advanced seminoma who have retroperitoneal masses > 10 cm2 following cisplatin-based chemotherapy. They should be followed up regularly for many years. [ABSTRACT FROM AUTHOR]

Published
1989
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