1. Potassium-43 Myocardial Perfusion Scanning for the Noninvasive Evaluation of Patients with False-Positive Exercise Tests
- Author
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R. L. Mcgowan, Stenson Re, Flamm, H.P. Wells, B.L. Zaret, H.W. Strauss, and N.D. Martin
- Subjects
Adult ,Male ,medicine.medical_specialty ,Rectilinear scanner ,Hemodynamics ,Coronary Disease ,Chest pain ,Electrocardiography ,Myocardial perfusion imaging ,Physiology (medical) ,Internal medicine ,medicine ,Humans ,ST segment ,False Positive Reactions ,Angiocardiography ,Radionuclide Imaging ,Cardiac imaging ,Radioisotopes ,medicine.diagnostic_test ,business.industry ,Myocardium ,Heart ,Middle Aged ,Exercise Test ,Lactates ,Cardiology ,Cineangiography ,Potassium Isotopes ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Twelve patients with false-positive ECG exercise tests presented with ischemic ECG responses (greater than one mm ST segment depression) during graded maximal treadmill exercise testing in the absence of exercise-induced chest pain or clinical coronary heart disease. Coronary arteriography, left ventriculography and hemodynamic evaluation revealed no significant abnormality in these patients. Transmyocardial lactate analysis during atrial pacing revealed a normal extraction (mean 21%) during pacing stress in five patients. Nine of 12 patients were evaluated with exercise potassium-43 myocardial perfusion imaging whereby the radioactive tracer was administered intravenously during exercise at a time when abnormal ECG changes were present. Myocardial images in these nine patients all showed a normal homogeneous pattern of radioisotope distribution. These results are in direct contrast to findings in patients with coronary heart disease in whom reproducibly demonstrable abnormal regions of decreased potassium-43 accumulation have been noted in myocardial images obtained following injection of the radioactive tracer during exercise. Potassium-43 exercise myocardial perfusion scanning thus appears to be an accurate noninvasive method of assessing patients with suspected false-positive exercise tests and provides a means of increasing the specificity of exercise testing.
- Published
- 1973
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