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Your search keyword '"Stempels, Hilde W."' showing total 9 results
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9 results on '"Stempels, Hilde W."'

3. Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-Shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion.

Author

Stempels, Hilde W., Lehr, A. Mechteld, Delawi, Diyar, Hoebink, Eric A., Wiljouw, Inge A. A. A., Kempen, Diederik H. R., van Susante, Job L. C., and Kruyt, Moyo C.

Subjects
*SPINAL fusion, *COMPACT bone, *BONE substitutes, *CALCIUM phosphate, *SURFACE topography, *POSTEROLATERAL corner
Abstract

Study Design. A multicenter randomized controlled noninferiority trial with intrapatient comparisons. Objective. The aim of this study was to determine noninferiority of a slowly resorbable biphasic calcium phosphate with submicron microporosity (BCP<µm, MagnetOs Granules) as an alternative for autograft in instrumented posterolateral fusion (PLF). Summary of Background Data. Successful spinal fusion with a solid bone bridge between the vertebrae is traditionally achieved by grafting with autologous iliac bone. However, the disadvantages of autografts and unsatisfactory fusion rates have prompted the exploration of alternatives, including ceramics. Nevertheless, clinical evidence for the standalone use of these materials is limited. Methods. Adults indicated for instrumented PLF (1 to 6 levels) were enrolled at 5 participating centers. After bilateral instrumentation and fusion-bed preparation, the randomized allocation side (left or right) was disclosed. Per segment 10 cc of BCP<µm granules (1 to 2 mm) were placed in the posterolateral gutter on one side and 10 cc autograft on the contralateral side. Fusion was systematically scored on 1-year follow-up CT scans. The study was powered to detect >15% inferiority with binomial paired comparisons of the fusion performance score per treatment side. Results. Of the 100 patients (57 ± 12.9 y, 62% female), 91 subjects and 128 segments were analyzed. The overall posterolateral fusion rate per segment (left and/or right) was 83%. For the BCP<µm side only the fusion rate was 79% versus 47% for the autograft side (difference of 32 percentage points, 95% CI, 23-41). Analysis of the primary outcome confirmed the noninferiority of BCP <µm with an absolute difference in paired proportions of 39.6% (95% CI, 26.8-51.2; p < 0.001). Conclusion. This clinical trial demonstrates noninferiority and indicates superiority of MagnetOs Granules as a standalone ceramic when compared to autograft for posterolateral spinal fusion. These results challange the belief that autologous bone is the most optimal graft material. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Health-related quality of life in early onset scoliosis patients treated with the spring distraction system: what to expect in the first 2 years after surgery

Author

MS Orthopaedie Algemeen, KNO Onderzoek, Regenerative Medicine and Stem Cells, Zorgeenheid Orthopaedie Medisch, Lemans, Justin V.C., Top, Anouk, Tabeling, Casper S., Scholten, E. Pauline, Stempels, Hilde W., Schlösser, Tom P.C., Castelein, René M., Kruyt, Moyo C., MS Orthopaedie Algemeen, KNO Onderzoek, Regenerative Medicine and Stem Cells, Zorgeenheid Orthopaedie Medisch, Lemans, Justin V.C., Top, Anouk, Tabeling, Casper S., Scholten, E. Pauline, Stempels, Hilde W., Schlösser, Tom P.C., Castelein, René M., and Kruyt, Moyo C.

Published
2024

5. Efficacy of Biphasic Calcium Phosphate Ceramic With a Needle-shaped Surface Topography Versus Autograft in Instrumented Posterolateral Spinal Fusion: A Randomized Trial

Author

Zorgeenheid Orthopaedie Medisch, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Stempels, Hilde W, Lehr, A Mechteld, Delawi, Diyar, Hoebink, Eric A, Wiljouw, Inge A A A, Kempen, Diederik H R, van Susante, Job L C, Kruyt, Moyo C, Dutch Clinical Spine Research Group, Zorgeenheid Orthopaedie Medisch, MS Orthopaedie Algemeen, Regenerative Medicine and Stem Cells, Stempels, Hilde W, Lehr, A Mechteld, Delawi, Diyar, Hoebink, Eric A, Wiljouw, Inge A A A, Kempen, Diederik H R, van Susante, Job L C, Kruyt, Moyo C, and Dutch Clinical Spine Research Group

Published
2024

7. Surgical treatment of neuromuscular Early Onset Scoliosis with a bilateral posterior one-way rod compared to the Spring Distraction System: study protocol for a limited-efficacy Randomized Controlled Trial (BiPOWR)

Author

MS Orthopaedie Algemeen, Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Lemans, Justin V.C., Tabeling, Casper S., Scholten, E. Pauline, Stempels, Hilde W., Miladi, Lotfi, Castelein, René M., Kruyt, Moyo C., MS Orthopaedie Algemeen, Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Lemans, Justin V.C., Tabeling, Casper S., Scholten, E. Pauline, Stempels, Hilde W., Miladi, Lotfi, Castelein, René M., and Kruyt, Moyo C.

Published
2023

8. The Spring Distraction System for Growth-Friendly Surgical Treatment of Early Onset Scoliosis: A Preliminary Report on Clinical Results and Safety after Design Iterations in a Prospective Clinical Trial

Author

Tabeling, Casper S., primary, Lemans, Justin V. C., additional, Top, Anouk, additional, Scholten, E. Pauline, additional, Stempels, Hilde W., additional, Schlösser, Tom P. C., additional, Ito, Keita, additional, Castelein, René M., additional, and Kruyt, Moyo C., additional

Published
2022
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9. The Spring Distraction System for Growth-Friendly Surgical Treatment of Early Onset Scoliosis: A Preliminary Report on Clinical Results and Safety after Design Iterations in a Prospective Clinical Trial

Author

MS Orthopaedie Algemeen, Orthopaedie Onderzoek, KNO Onderzoek, Cancer, Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Tabeling, Casper S., Lemans, Justin V.C., Top, Anouk, Scholten, E. Pauline, Stempels, Hilde W., Schlösser, Tom P.C., Ito, Keita, Castelein, René M., Kruyt, Moyo C., MS Orthopaedie Algemeen, Orthopaedie Onderzoek, KNO Onderzoek, Cancer, Zorgeenheid Orthopaedie Medisch, Regenerative Medicine and Stem Cells, Tabeling, Casper S., Lemans, Justin V.C., Top, Anouk, Scholten, E. Pauline, Stempels, Hilde W., Schlösser, Tom P.C., Ito, Keita, Castelein, René M., and Kruyt, Moyo C.

Published
2022

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