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135 results on '"Stelloo, Ellen"'

1. Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential

Author

Zhang, Chunye, Stelloo, Ellen, Barrans, Sharon, Cucco, Francesco, Jiang, Dan, Tzioni, Maria-Myrsini, Chen, Zi, Li, Yan, Swennenhuis, Joost F., Makker, Jasmine, Rásó-Barnett, Lívia, Liu, Hongxiang, El-Daly, Hesham, Soilleux, Elizabeth, Shah, Nimish, Nagumantry, Sateesh Kumar, Kyaw, Maw, Prahladan, Mahesh Panatt, Tooze, Reuben, Westhead, David R., Feitsma, Harma, Davies, Andrew J., Burton, Catherine, Johnson, Peter W. M., and Du, Ming-Qing

Published
2024
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2. Exploiting a subtype-specific mitochondrial vulnerability for successful treatment of colorectal peritoneal metastases

Author

Bootsma, Sanne, Dings, Mark P.G., Kesselaar, Job, Helderman, Roxan F.C.P.A., van Megesen, Kyah, Constantinides, Alexander, Moreno, Leandro Ferreira, Stelloo, Ellen, Scutigliani, Enzo M., Bokan, Bella, Torang, Arezo, van Hooff, Sander R., Zwijnenburg, Danny A., Wouters, Valérie M., van de Vlasakker, Vincent C.J., Galanos, Laskarina J.K., Nijman, Lisanne E., Logiantara, Adrian, Veenstra, Veronique L., Schlingemann, Sophie, van Piggelen, Sterre, van der Wel, Nicole, Krawczyk, Przemek M., Platteeuw, Johannes J., Tuynman, Jurriaan B., de Hingh, Ignace H., Klomp, Jan P.G., Oubrie, Arthur, Snaebjornsson, Petur, Medema, Jan Paul, Oei, Arlene L., Kranenburg, Onno, Elbers, Clara C., Lenos, Kristiaan J., Vermeulen, Louis, and Bijlsma, Maarten F.

Published
2024
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4. Clinicogenomic associations in childhood Langerhans cell histiocytosis: an international cohort study

Author

Kemps, Paul G., Zondag, Timo C. E., Arnardóttir, Helga B., Solleveld-Westerink, Nienke, Borst, Jelske, Steenwijk, Eline C., van Egmond, Demi, Swennenhuis, Joost F., Stelloo, Ellen, Trambusti, Irene, Verdijk, Robert M., van Noesel, Carel J. M., Cleven, Arjen H. G., Scheijde-Vermeulen, Marijn A., Koudijs, Marco J., Krsková, Lenka, Hawkins, Cynthia, Egeler, R. Maarten, Brok, Jesper, von Bahr Greenwood, Tatiana, Svojgr, Karel, Beishuizen, Auke, van Laar, Jan A. M., Pötschger, Ulrike, Hutter, Caroline, Sieni, Elena, Minkov, Milen, Abla, Oussama, van Wezel, Tom, van den Bos, Cor, and van Halteren, Astrid G. S.

Published
2023
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5. Formalin-Fixed, Paraffin-Embedded–Targeted Locus Capture: A Next-Generation Sequencing Technology for Accurate DNA-Based Gene Fusion Detection in Bone and Soft Tissue Tumors

Author

Stelloo, Ellen, Meijers, Ruud W.J., Swennenhuis, Joost F., Allahyar, Amin, Hajo, Karima, Cangiano, Mario, de Leng, Wendy W.J., van Helvert, Sjoerd, Van der Meulen, Joni, Creytens, David, van Kempen, Léon C., Cleton-Jansen, Anne-Marie, Bovee, Judith V.M.G., de Laat, Wouter, Splinter, Erik, and Feitsma, Harma

Published
2023
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6. Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

Author

Bollen, Yannik, Stelloo, Ellen, van Leenen, Petra, van den Bos, Myrna, Ponsioen, Bas, Lu, Bingxin, van Roosmalen, Markus J., Bolhaqueiro, Ana C. F., Kimberley, Christopher, Mossner, Maximilian, Cross, William C. H., Besselink, Nicolle J. M., van der Roest, Bastiaan, Boymans, Sander, Oost, Koen C., de Vries, Sippe G., Rehmann, Holger, Cuppen, Edwin, Lens, Susanne M. A., Kops, Geert J. P. L., Kloosterman, Wigard P., Terstappen, Leon W. M. M., Barnes, Chris P., Sottoriva, Andrea, Graham, Trevor A., and Snippert, Hugo J. G.

Published
2021
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7. Non-IG::MYC in diffuse large B-cell lymphoma confers variable genomic configurations and MYC transactivation potential

Author

Du, Ming-Qing, primary, Zhang, Chunye, additional, Stelloo, Ellen, additional, Barrans, Sharon, additional, Cucco, Francesco, additional, Jiang, Dan, additional, Tzioni, Maria-Myrsini, additional, Chen, Zi, additional, Li, Yan, additional, Swennenhuis, Joost F, additional, Makker, Jasmine, additional, Raso-Barnett, Livia, additional, Liu, Hongxiang, additional, daly, Hesham El, additional, Soilleux, Elizabeth, additional, Shah, Nimish, additional, Nagumantry, Sateesh Kumar, additional, Kyaw, Maw, additional, Prahladan, Mahesh Panatt, additional, Tooze, Reuben, additional, Westhead, David, additional, Feitsma, Harma, additional, Davies, Andrew, additional, Burton, Catherine, additional, and Johnson, Peter, additional

Published
2023
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8. Targeted locus amplification to develop robust patient-specific assays for liquid biopsies in pediatric solid tumors

Author

van Zogchel, Lieke M. J., primary, Lak, Nathalie S. M., additional, Gelineau, Nina U., additional, Sergeeva, Irina, additional, Stelloo, Ellen, additional, Swennenhuis, Joost, additional, Feitsma, Harma, additional, van Min, Max, additional, Splinter, Erik, additional, Bleijs, Margit, additional, Groot Koerkamp, Marian, additional, Breunis, Willemijn, additional, Meister, Michael Torsten, additional, Kholossy, Waleed Hassan, additional, Holstege, Frank C. P., additional, Molenaar, Jan J., additional, de Leng, Wendy W. J., additional, Stutterheim, Janine, additional, van der Schoot, C. Ellen, additional, and Tytgat, Godelieve A. M., additional

Published
2023
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9. Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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10. Abstract 222: High frequency of structural variants in FFPE colorectal cancer tissue detected by targeting selected common fragile site genes and LINE transposable elements

Author

Rubio-Alarcon, Carmen, primary, Stelloo, Ellen, additional, Vessies, Daan C., additional, van ‘t Erve, Iris, additional, Mekkes, Nienke, additional, Swennenhuis, Joost, additional, Lakbir, Soufyan, additional, van Bree, Elise, additional, Tijssen, Marianne, additional, Delis-van Diemen, Pien, additional, Lanfermeijer, Mirthe, additional, Linders, Theodora C., additional, van den Broek, Daan, additional, Punt, Cornelis J., additional, Heringa, Jaap, additional, Meijer, Gerrit A., additional, Abeln, Sanne, additional, Feitsma, Harma, additional, and Fijneman, Remond J., additional

Published
2023
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11. Supplementary Data from Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, primary, Nout, Remi A., primary, Stelloo, Ellen, primary, Kedzierska, Katarzyna, primary, León-Castillo, Alicia, primary, Plat, Annechien, primary, Mertz, Kirsten D., primary, Osse, Michelle, primary, Jürgenliemk-Schulz, Ina M., primary, Lutgens, Ludy C.H.W., primary, Jobsen, Jan J., primary, van der Steen-Banasik, Elzbieta M., primary, Smit, Vincent T., primary, Creutzberg, Carien L., primary, Bosse, Tjalling, primary, Nijman, Hans W., primary, Koelzer, Viktor H., primary, and Church, David N., primary

Published
2023
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12. Supplementary figure 6 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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13. Supplementary figure 1 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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14. Supplementary Table S5 from Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts

Author

Stelloo, Ellen, primary, Nout, Remi A., primary, Osse, Elisabeth M., primary, Jürgenliemk-Schulz, Ina J., primary, Jobsen, Jan J., primary, Lutgens, Ludy C., primary, van der Steen-Banasik, Elzbieta M., primary, Nijman, Hans W., primary, Putter, Hein, primary, Bosse, Tjalling, primary, Creutzberg, Carien L., primary, and Smit, Vincent T.H.B.M., primary

Published
2023
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15. Supplementary figure 4 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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16. Supplementary table 2 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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17. Figure S4 from Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Author

Depreeuw, Jeroen, primary, Stelloo, Ellen, primary, Osse, Elisabeth M., primary, Creutzberg, Carien L., primary, Nout, Remi A., primary, Moisse, Matthieu, primary, Garcia-Dios, Diego A., primary, Dewaele, Michael, primary, Willekens, Karen, primary, Marine, Jean-Christophe, primary, Matias-Guiu, Xavier, primary, Amant, Frédéric, primary, Lambrechts, Diether, primary, and Bosse, Tjalling, primary

Published
2023
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18. Supplementary figure 5 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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19. Supplementary figure 2 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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20. Supplementary figure 3 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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21. Supplementary table 1 from POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., primary, Freeman-Mills, Luke, primary, Stelloo, Ellen, primary, Marchi, Emanuele, primary, de Bruyn, Marco, primary, Palles, Claire, primary, Nout, Remi A., primary, de Kroon, Cor D., primary, Osse, Elisabeth M., primary, Klenerman, Paul, primary, Creutzberg, Carien L., primary, Tomlinson, Ian P.M., primary, Smit, Vincent T.H.B.M., primary, Nijman, Hans W., primary, Bosse, Tjalling, primary, and Church, David N., primary

Published
2023
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22. Molecular Classification Predicts Response to Radiotherapy in the Randomized PORTEC-1 and PORTEC-2 Trials for Early-Stage Endometrioid Endometrial Cancer.

Author

Horeweg, Nanda, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Lutgens, Ludy C.H.W., Jobsen, Jan J., Haverkort, Marie A.D., Mens, Jan Willem M., Slot, Annerie, Wortman, Bastiaan G., de Boer, Stephanie M., Stelloo, Ellen, Verhoeven-Adema, Karen W., Putter, Hein, Smit, Vincent T.H.B.M., Bosse, Tjalling, Creutzberg, Carien L., Creutzberg, C.L., Koper, P.C.M., van Putten, W.L.J., and Dercksen, R.

Published
2023
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23. Abstract A020: Structural variants in the pathogenesis of colorectal cancer: The elephant in the room

Author

van Bree, Elise, primary, Alarcón, Carmen Rubio, additional, Lakbir, Soufyan, additional, Stelloo, Ellen, additional, Buranelli, Caterina, additional, Hondema, Amber, additional, van 't Erve, Iris, additional, Vessies, Daan, additional, Delis-van Diemen, Pien, additional, Tijssen, Marianne, additional, Bolijn, Anne, additional, Lanfermeijer, Mirthe, additional, Linders, Dorothe, additional, Swennenhuis, Joost, additional, van den Broek, Daan, additional, Heringa, Jaap, additional, Meijer, Gerrit, additional, Carvalho, Beatriz, additional, Feitsma, Harma, additional, Abeln, Sanne, additional, and Fijneman, Remond J. A., additional

Published
2022
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26. 2022-RA-450-ESGO Benefit of adjuvant radiotherapy depends on molecular class of early-stage endometrial cancer

Author

Horeweg, Nanda, primary, Nout, Remi A, additional, Stelloo, Ellen, additional, Lutgens, Ludy CHW, additional, Jobsen, Jan J, additional, Jürgenliemk-Schulz, Ina M, additional, van der Steen-Banasik, Elsbieta M, additional, Mens, Jan-Willem M, additional, Slot, Annerie, additional, Smit, Vincent THBM, additional, Bosse, Tjalling, additional, and Creutzberg, Carien L, additional

Published
2022
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27. 2022-RA-809-ESGO Underlying causes and prognosis of mismatch repair deficiency in endometrial cancer other thanMLH1promoter hypermethylation

Author

Kaya, Merve, primary, Post, Cathalijne, additional, Tops, Carli M, additional, Stelloo, Ellen, additional, Nielsen, Maartje, additional, Powell, Melanie E, additional, Leary, Alexandra, additional, Mileshkin, Linda R, additional, Bessette, Paul, additional, de Boer, Stephanie M, additional, Jürgenliemk-Schulz, Ina M, additional, Lutgens, Ludy, additional, Jobsen, Jan J, additional, van der Steen-Banasik, Elzbieta M, additional, Nout, Remi A, additional, Horeweg, Nanda, additional, van Wezel, Tom, additional, Smit, Vincent, additional, Creutzberg, Carien L, additional, and Bosse, Tjalling, additional

Published
2022
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31. Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer

Author

Post, Cathalijne C B, primary, Stelloo, Ellen, additional, Smit, Vincent T H B M, additional, Ruano, Dina, additional, Tops, Carli M, additional, Vermij, Lisa, additional, Rutten, Tessa A, additional, Jürgenliemk-Schulz, Ina M, additional, Lutgens, Ludy C H W, additional, Jobsen, Jan J, additional, Nout, Remi A, additional, Crosbie, Emma J, additional, Powell, Melanie E, additional, Mileshkin, Linda, additional, Leary, Alexandra, additional, Bessette, Paul, additional, Putter, Hein, additional, de Boer, Stephanie M, additional, Horeweg, Nanda, additional, Nielsen, Maartje, additional, Wezel, Tom van, additional, Bosse, Tjalling, additional, and Creutzberg, Carien L, additional

Published
2021
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32. In Vitro Systematic Drug Testing Reveals Carboplatin, Paclitaxel, and Alpelisib as a Potential Novel Combination Treatment for Adult Granulosa Cell Tumors

Author

Roze, Joline, primary, Sendino Garví, Elena, additional, Stelloo, Ellen, additional, Stangl, Christina, additional, Sereno, Ferdinando, additional, Duran, Karen, additional, Groeneweg, Jolijn, additional, Paijens, Sterre, additional, Nijman, Hans, additional, van Meurs, Hannah, additional, van Lonkhuijzen, Luc, additional, Piek, Jurgen, additional, Lok, Christianne, additional, Jonges, Geertruida, additional, Witteveen, Petronella, additional, Verheijen, René, additional, van Haaften, Gijs, additional, Zweemer, Ronald, additional, and Monroe, Glen, additional

Published
2021
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33. Prognostic Integrated Image-Based Immune and Molecular Profiling in Early-Stage Endometrial Cancer

Author

Horeweg, Nanda, primary, de Bruyn, Marco, additional, Nout, Remi A., additional, Stelloo, Ellen, additional, Kedzierska, Katarzyna, additional, León-Castillo, Alicia, additional, Plat, Annechien, additional, Mertz, Kirsten D., additional, Osse, Michelle, additional, Jürgenliemk-Schulz, Ina M., additional, Lutgens, Ludy C.H.W., additional, Jobsen, Jan J., additional, van der Steen-Banasik, Elzbieta M., additional, Smit, Vincent T., additional, Creutzberg, Carien L., additional, Bosse, Tjalling, additional, Nijman, Hans W., additional, Koelzer, Viktor H., additional, and Church, David N., additional

Published
2020
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34. Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses

Author

de Witte, Chris Jenske, primary, Espejo Valle-Inclan, Jose, additional, Hami, Nizar, additional, Lõhmussaar, Kadi, additional, Kopper, Oded, additional, Vreuls, Celien Philomena Henrieke, additional, Jonges, Geertruida Nellie, additional, van Diest, Paul, additional, Nguyen, Luan, additional, Clevers, Hans, additional, Kloosterman, Wigard Pieter, additional, Cuppen, Edwin, additional, Snippert, Hugo Johannes Gerhardus, additional, Zweemer, Ronald Peter, additional, Witteveen, Petronella Oda, additional, and Stelloo, Ellen, additional

Published
2020
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35. Whole Genome Analysis of Ovarian Granulosa Cell Tumors Reveals Tumor Heterogeneity and a High-Grade TP53-Specific Subgroup

Author

Roze, Joline, primary, Monroe, Glen, additional, Kutzera, Joachim, additional, Groeneweg, Jolijn, additional, Stelloo, Ellen, additional, Paijens, Sterre, additional, Nijman, Hans, additional, van Meurs, Hannah, additional, van Lonkhuijzen, Luc, additional, Piek, Jurgen, additional, Lok, Christianne, additional, Jonges, Geertruida, additional, Witteveen, Petronella, additional, Verheijen, René, additional, van Haaften, Gijs, additional, and Zweemer, Ronald, additional

Published
2020
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36. Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses

Author

de Witte, Chris J., primary, Valle-Inclan, Jose Espejo, additional, Hami, Nizar, additional, Lõhmussaar, Kadi, additional, Kopper, Oded, additional, Vreuls, Celien P.H., additional, Jonges, Trudy N., additional, van Diest, Paul, additional, Nguyen, Luan, additional, Clevers, Hans, additional, Kloosterman, Wigard P., additional, Cuppen, Edwin, additional, Snippert, Hugo J.G., additional, Zweemer, Ronald P., additional, Witteveen, Petronella O., additional, and Stelloo, Ellen, additional

Published
2019
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38. Folate receptor-α targeted near-infrared fluorescence imaging in high-risk endometrial cancer patients: a tissue microarray and clinical feasibility study

Author

Boogerd, Leonora S.F., primary, Hoogstins, Charlotte E.S., additional, Gaarenstroom, Katja N., additional, de Kroon, Cornelis D., additional, Beltman, Jogchum J., additional, Bosse, Tjalling, additional, Stelloo, Ellen, additional, Vuyk, Jaap, additional, Low, Philip S., additional, Burggraaf, Jacobus, additional, and Vahrmeijer, Alexander L., additional

Published
2017
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39. Amplification of 1q32.1 Refines the Molecular Classification of Endometrial Carcinoma

Author

Depreeuw, Jeroen, primary, Stelloo, Ellen, additional, Osse, Elisabeth M., additional, Creutzberg, Carien L., additional, Nout, Remi A., additional, Moisse, Matthieu, additional, Garcia-Dios, Diego A., additional, Dewaele, Michael, additional, Willekens, Karen, additional, Marine, Jean-Christophe, additional, Matias-Guiu, Xavier, additional, Amant, Frédéric, additional, Lambrechts, Diether, additional, and Bosse, Tjalling, additional

Published
2017
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42. Improved Risk Assessment by Integrating Molecular and Clinicopathological Factors in Early-stage Endometrial Cancer—Combined Analysis of the PORTEC Cohorts

Author

Stelloo, Ellen, primary, Nout, Remi A., additional, Osse, Elisabeth M., additional, Jürgenliemk-Schulz, Ina J., additional, Jobsen, Jan J., additional, Lutgens, Ludy C., additional, van der Steen-Banasik, Elzbieta M., additional, Nijman, Hans W., additional, Putter, Hein, additional, Bosse, Tjalling, additional, Creutzberg, Carien L., additional, and Smit, Vincent T.H.B.M., additional

Published
2016
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43. Microsatellite instability derived JAK1 frameshift mutations are associated with tumor immune evasion in endometrioid endometrial cancer

Author

Stelloo, Ellen, primary, Versluis, Marco A., additional, Nijman, Hans W., additional, de Bruyn, Marco, additional, Plat, Annechien, additional, Osse, Elisabeth M., additional, van Dijk, Reinhardt H., additional, Nout, Remi A., additional, Creutzberg, Carien L., additional, de Bock, Geertruida H., additional, Smit, Vincent T., additional, Bosse, Tjalling, additional, and Hollema, Harry, additional

Published
2016
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44. POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer

Author

van Gool, Inge C., primary, Eggink, Florine A., additional, Freeman-Mills, Luke, additional, Stelloo, Ellen, additional, Marchi, Emanuele, additional, de Bruyn, Marco, additional, Palles, Claire, additional, Nout, Remi A., additional, de Kroon, Cor D., additional, Osse, Elisabeth M., additional, Klenerman, Paul, additional, Creutzberg, Carien L., additional, Tomlinson, Ian P.M., additional, Smit, Vincent T.H.B.M., additional, Nijman, Hans W., additional, Bosse, Tjalling, additional, and Church, David N., additional

Published
2015
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45. Prognostic Significance of POLE Proofreading Mutations in Endometrial Cancer

Author

Church, David N., primary, Stelloo, Ellen, additional, Nout, Remi A., additional, Valtcheva, Nadejda, additional, Depreeuw, Jeroen, additional, ter Haar, Natalja, additional, Noske, Aurelia, additional, Amant, Frederic, additional, Tomlinson, Ian P. M., additional, Wild, Peter J., additional, Lambrechts, Diether, additional, Jürgenliemk-Schulz, Ina M., additional, Jobsen, Jan J., additional, Smit, Vincent T. H. B. M., additional, Creutzberg, Carien L., additional, and Bosse, Tjalling, additional

Published
2014
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46. Designing a High-Throughput Somatic Mutation Profiling Panel Specifically for Gynaecological Cancers

Author

Spaans, Vivian M., primary, Trietsch, Marjolijn D., additional, Crobach, Stijn, additional, Stelloo, Ellen, additional, Kremer, Dennis, additional, Osse, Elisabeth M., additional, Haar, Natalja T. ter., additional, van Eijk, Ronald, additional, Muller, Susanne, additional, van Wezel, Tom, additional, Trimbos, J. Baptist, additional, Bosse, Tjalling, additional, Smit, Vincent T. H. B. M., additional, and Fleuren, Gert Jan, additional

Published
2014
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48. Proximity ligation-based sequencing for the identification of human papillomavirus genomic integration sites in formalin-fixed paraffin embedded oropharyngeal squamous cell carcinomas.

Author

Demers I, Balaji H, Feitsma H, Stelloo E, Swennenhuis J, Sergeeva I, Wuerdemann N, van den Hout MFCM, Wagner S, Kremer B, Klussmann JP, Huebbers CU, and Speel EM

Subjects
Female, Humans, Male, Cell Line, Tumor, DNA, Viral genetics, Formaldehyde, Paraffin Embedding, Polymerase Chain Reaction methods, Sequence Analysis, DNA, Tissue Fixation, Carcinoma, Squamous Cell genetics, Carcinoma, Squamous Cell virology, Human Papillomavirus Viruses classification, Human Papillomavirus Viruses genetics, Human Papillomavirus Viruses isolation & purification, Oropharyngeal Neoplasms virology, Oropharyngeal Neoplasms genetics, Papillomavirus Infections virology, Papillomavirus Infections diagnosis, Virus Integration genetics
Abstract

Human papillomavirus (HPV) infections are an increasing cause of oropharyngeal squamous cell carcinomas (OPSCC). Integration of the viral genome into the host genome is suggested to affect carcinogenesis, however, the correlation with OPSCC patient prognosis is still unclear. Research on HPV integration is hampered by current integration detection technologies and their unsuitability for formalin-fixed paraffin-embedded (FFPE) tissues. This study aims to develop and validate a novel targeted proximity-ligation based sequencing method (targeted locus amplification/capture [TLA/TLC]) for HPV integration detection in cell lines and FFPE OPSCCs. For the identification of HPV integrations, TLA/TLC was applied to 7 cell lines and 27 FFPE OPSCCs. Following preprocessing steps, a polymerase chain reaction (PCR)-based HPV enrichment was performed on the cell lines and a capture-based HPV enrichment was performed on the FFPE tissues before paired-end sequencing. TLA was able to sequence up to hundreds of kb around the target, detecting exact HPV integration loci, structural variants, and chromosomal rearrangements. In all cell lines, one or more integration sites were identified, in accordance with detection of integrated papillomavirus sequences PCR data and the literature. TLC detected integrated HPV in 15/27 FFPE OPSCCs and identified simple and complex integration patterns. In general, TLA/TLC confirmed PCR data and detected additional integration sites. In conclusion TLA/TLC reliably and robustly detects HPV integration in cell lines and FFPE OPSCCs, enabling large, population-based studies on the clinical relevance of HPV integration. Furthermore, this approach might be valuable for clonality assessment of HPV-related tumors in clinical diagnostics., (© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)

Published
2024
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49. Prevalence and Prognosis of Lynch Syndrome and Sporadic Mismatch Repair Deficiency in Endometrial Cancer.

Author

Post CCB, Stelloo E, Smit VTHBM, Ruano D, Tops CM, Vermij L, Rutten TA, Jürgenliemk-Schulz IM, Lutgens LCHW, Jobsen JJ, Nout RA, Crosbie EJ, Powell ME, Mileshkin L, Leary A, Bessette P, Putter H, de Boer SM, Horeweg N, Nielsen M, Wezel TV, Bosse T, and Creutzberg CL

Subjects
Brain Neoplasms, Colorectal Neoplasms, DNA Methylation, DNA Mismatch Repair genetics, Female, Humans, MutL Protein Homolog 1 genetics, Neoplastic Syndromes, Hereditary, Prevalence, Prognosis, Colorectal Neoplasms, Hereditary Nonpolyposis diagnosis, Colorectal Neoplasms, Hereditary Nonpolyposis epidemiology, Colorectal Neoplasms, Hereditary Nonpolyposis genetics, Endometrial Neoplasms epidemiology, Endometrial Neoplasms genetics
Abstract

Background: Standard screening of endometrial cancer (EC) for Lynch syndrome (LS) is gaining traction; however, the prognostic impact of an underlying hereditary etiology is unknown. We established the prevalence, prognosis, and subsequent primary cancer incidence of patients with LS-associated EC in relation to sporadic mismatch repair deficient (MMRd)-EC in the large combined Post Operative Radiation Therapy in Endometrial Carcinoma-1, -2, and -3 trial cohort., Methods: After MMR-immunohistochemistry, MLH1-promoter methylation testing, and next-generation sequencing, tumors were classified into 3 groups according to the molecular cause of their MMRd-EC. Kaplan-Meier method, log-rank test, and Cox model were used for survival analysis. Competing risk analysis was used to estimate the subsequent cancer probability. All statistical tests were 2-sided., Results: Among the 1336 ECs, 410 (30.7%) were MMRd. A total of 380 (92.7%) were fully triaged: 275 (72.4%) were MLH1-hypermethylated MMRd-ECs; 36 (9.5%) LS MMRd-ECs, and 69 (18.2%) MMRd-ECs due to other causes. Limiting screening of EC patients to 60 years or younger or to 70 years or younger would have resulted in missing 18 (50.0%) and 6 (16.7%) LS diagnoses, respectively. Five-year recurrence-free survival was 91.7% (95% confidence interval [CI] = 83.1% to 100%; hazard ratio = 0.45, 95% CI = 0.16 to 1.24, P = .12) for LS, 95.5% (95% CI = 90.7% to 100%; hazard ratio = 0.17, 95% CI = 0.05 to 0.55, P = .003) for "other" vs 78.6% (95% CI = 73.8% to 83.7%) for MLH1-hypermethylated MMRd-EC. The probability of subsequent LS-associated cancer at 10 years was 11.6% (95% CI = 0.0% to 24.7%), 1.5% (95% CI = 0.0% to 4.3%), and 7.0% (95% CI = 3.0% to 10.9%) within the LS, "other," and MLH1-hypermethylated MMRd-EC groups, respectively., Conclusions: The LS prevalence in the Post Operative Radiation Therapy in Endometrial Carcinoma trial population was 2.8% and among MMRd-ECs was 9.5%. Patients with LS-associated ECs showed a trend towards better recurrence-free survival and higher risk for second cancers compared with patients with MLH1-hypermethylated MMRd-EC., (© The Author(s) 2021. Published by Oxford University Press.)

Published
2021
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50. Prognostic significance of POLE proofreading mutations in endometrial cancer.

Author

Church DN, Stelloo E, Nout RA, Valtcheva N, Depreeuw J, ter Haar N, Noske A, Amant F, Tomlinson IP, Wild PJ, Lambrechts D, Jürgenliemk-Schulz IM, Jobsen JJ, Smit VT, Creutzberg CL, and Bosse T

Subjects
Adult, Disease-Free Survival, Endometrial Neoplasms pathology, Female, Humans, Kaplan-Meier Estimate, Neoplasm Grading, Odds Ratio, Poly-ADP-Ribose Binding Proteins, Predictive Value of Tests, Prognosis, Biomarkers, Tumor genetics, DNA Polymerase II genetics, Endometrial Neoplasms genetics, Endometrial Neoplasms mortality, Mutation
Abstract

Background: Current risk stratification in endometrial cancer (EC) results in frequent over- and underuse of adjuvant therapy, and may be improved by novel biomarkers. We examined whether POLE proofreading mutations, recently reported in about 7% of ECs, predict prognosis., Methods: We performed targeted POLE sequencing in ECs from the PORTEC-1 and -2 trials (n = 788), and analyzed clinical outcome according to POLE status. We combined these results with those from three additional series (n = 628) by meta-analysis to generate multivariable-adjusted, pooled hazard ratios (HRs) for recurrence-free survival (RFS) and cancer-specific survival (CSS) of POLE-mutant ECs. All statistical tests were two-sided., Results: POLE mutations were detected in 48 of 788 (6.1%) ECs from PORTEC-1 and-2 and were associated with high tumor grade (P < .001). Women with POLE-mutant ECs had fewer recurrences (6.2% vs 14.1%) and EC deaths (2.3% vs 9.7%), though, in the total PORTEC cohort, differences in RFS and CSS were not statistically significant (multivariable-adjusted HR = 0.43, 95% CI = 0.13 to 1.37, P = .15; HR = 0.19, 95% CI = 0.03 to 1.44, P = .11 respectively). However, of 109 grade 3 tumors, 0 of 15 POLE-mutant ECs recurred, compared with 29 of 94 (30.9%) POLE wild-type cancers; reflected in statistically significantly greater RFS (multivariable-adjusted HR = 0.11, 95% CI = 0.001 to 0.84, P = .03). In the additional series, there were no EC-related events in any of 33 POLE-mutant ECs, resulting in a multivariable-adjusted, pooled HR of 0.33 for RFS (95% CI = 0.12 to 0.91, P = .03) and 0.26 for CSS (95% CI = 0.06 to 1.08, P = .06)., Conclusion: POLE proofreading mutations predict favorable EC prognosis, independently of other clinicopathological variables, with the greatest effect seen in high-grade tumors. This novel biomarker may help to reduce overtreatment in EC., (© The Author 2014. Published by Oxford University Press.)

Published
2014
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