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263 results on '"Steinke H."'

1. Influence of short-term fixation with mixed formalin or ethanol solution on the mechanical properties of human cortical bone

Author

Mick E., Steinke H., Wolfskämpf T., Wieding J., Hammer N., Schulze M., Souffrant R., and Bader R.

Subjects
human cortical bone, mechanical properties, fixation, ethanol, formalin, 4-point-bendin, Medicine
Abstract

Bone specimens obtained for biomechanical experiments are fresh-frozen for storage to slow down tissue degradation and autolysis in long-term storage. Alternatively, due to infectious risks related to the fresh tissues, fixative agents are commonly used. However, fixatives will likely change the mechanical properties of bone. Existing studies on this issue gave controversial results that are hardly comparable due to a variety of measurement approaches. For this reason, the influence of ethanol and a formalin-based fixative agent was evaluated on the mechanical properties of human cortical bone specimens by means of four-point-bending tests. 127 prismatic specimens with rectangular cross sections (2.5 x 2.5 x 20 mm3) were obtained from different regions of two fresh human femora (medial, lateral, dorsal, ventral). Specimens were either fixed in ethanol or in a mixed formalin solution or frozen following a given scheme. After two weeks of storage the samples were re-hydrated in isotonic saline and subsequently tested mechanically. The elastic bending modulus and ultimate bending strength were computed considering the actual dimensions of each specific specimen. For statistical analysis a one-way-ANOVA and an LSD post-hoc-test were performed. For ultimate bending strength no significant differences due to formalin or ethanol fixation, as compared to unfixed-fresh bone specimens could be found. And only for few cases significant differences in elastic bending modulus were observed when the two bones were evaluated separately. Since more differences of significant level due to the anatomical region of the samples were determined, the original location seems to have more influence on the evaluated mechanical properties than the method of (chemical) fixation. Consequently, ethanol and the mixed formalin solution can be recommended as a fixation agent for samples in biomechanical testing, if these samples are rinsed in isotonic saline prior to static mechanical testing.

Published
2015
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7. MRI-Based Classification Scheme for Degenerative Cervical Spinal Stenosis (DCSS Classification)

Author

Hamann I, Leimert M, von Sachsen S, Schackert G, Steinke H, Bostelmann R, and Meixensberger J

Subjects
medicine.medical_specialty, business.industry, medicine, Classification scheme, Radiology, Degenerative cervical spinal stenosis, business
Abstract

Background: The severity of Degenerative Cervical Spinal Stenosis (DCSS) is currently assessed by determining the sagittal diameter of the spinal canal, the degree of narrowing, and the level of stenosis using magnetic resonance imaging (MRI). The aim of our study was to develop and evaluate an optimized, MRI-based classification of DCSS to support treatment decision-making. Methods: We analyzed preoperative MRI scans of 75 patients to determine key morphological features of DCSS. Based on the features found, a classification was proposed and tested on ten representative image sets by 53 neurosurgeons to determine practicability and inter-observer reliability. Results: DCSS extended over one (13 and 17 % of pat.), two (23 and 31 % of pat.) or three (39 and 52 % of pat.). Thickening of the ligaments was observed in 71%, scoliosis in 3% and grade I spondylolisthesis in 11% of the patients. The DCSS classification has three main Types (A, B, C), which differ in the extent of the stenoses and thickening of the ligaments. Each main class has 2-3 subtypes depending on the position of the stenosis (lateral/medial) and the number of stenotic segments. An additional suffix indicates the presence of concomitant pathology (spondylolisthesis, scoliosis). 26 (49 %) neurosurgeons rated the classification as useful. For the main classes, interobserver reliability was fair (k=0.23). For subtype and concomitant pathology, interobserver reliability was low (k=0.14). Conclusions: In the study a new classification system for degenerative spinal stenoses was developed, which combines anatomical and clinical defect characteristics. Deviations in the classification result from a strict subdivision, so that adjustments are necessary.

Published
2021
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9. Cellular and Molecular Probing of Intact Human Organs.

Author

Wolf E., Lipfert J., Puelles V.G., Bechmann I., Erturk A., Zhao S., Todorov M.I., Cai R., Maskari R.A., Steinke H., Kemter E., Mai H., Rong Z., Warmer M., Stanic K., Schoppe O., Paetzold J.C., Gesierich B., Wong M.N., Huber T.B., Duering M., Bruns O.T., Menze B., Wolf E., Lipfert J., Puelles V.G., Bechmann I., Erturk A., Zhao S., Todorov M.I., Cai R., Maskari R.A., Steinke H., Kemter E., Mai H., Rong Z., Warmer M., Stanic K., Schoppe O., Paetzold J.C., Gesierich B., Wong M.N., Huber T.B., Duering M., Bruns O.T., and Menze B.

Abstract

Zhao et al. present an approach for intact human organ mapping that uses a new tissue permeabilization method to clear and deeply label whole organs followed by light-sheet microscopy imaging and a deep learning-based pipeline for 3D reconstruction and data analysis. Optical tissue transparency permits scalable cellular and molecular investigation of complex tissues in 3D. Adult human organs are particularly challenging to render transparent because of the accumulation of dense and sturdy molecules in decades-aged tissues. To overcome these challenges, we developed SHANEL, a method based on a new tissue permeabilization approach to clear and label stiff human organs. We used SHANEL to render the intact adult human brain and kidney transparent and perform 3D histology with antibodies and dyes in centimeters-depth. Thereby, we revealed structural details of the intact human eye, human thyroid, human kidney, and transgenic pig pancreas at the cellular resolution. Furthermore, we developed a deep learning pipeline to analyze millions of cells in cleared human brain tissues within hours with standard lab computers. Overall, SHANEL is a robust and unbiased technology to chart the cellular and molecular architecture of large intact mammalian organs.Copyright © 2020 Elsevier Inc.

Published
2020

18. Variation der Anordnung von Textilelektroden anhand einer FE-Analyse unter Berücksichtigung anatomischer Gesichtspunkte

Author

Münst, P, Seidel, B, Steinke, H, Heyde, CE, and Voigt, C

Subjects
ddc: 610, 610 Medical sciences, Medicine, Finite Elemente Modell, Transkutane Elektrostimulation
Abstract

Fragestellung: Die Elektrostimulation lässt sich bei Patienten zur Rehabilitation, Wiederherstellung von motorischer Funktionalität und für Trainingszwecke im Sport- und Fitnessbereich einsetzten. Dabei ist die Aktivierung von Muskeln mit Hilfe elektrischer Stimulation durch die Hautoberfläche[zum vollständigen Text gelangen Sie über die oben angegebene URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2017)

Published
2017
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27. A computer-based approach for classification of cervical spine defects in MR images

Author

Daenzer, S, Freitag, S, v. Sachsen, S, Steinke, H, Groll, M, Meixensberger, J, and Leimert, M

Subjects
computer-assisted diagnosis, ddc: 610, spinal stenosis detection, cervical spine, 610 Medical sciences, Medicine
Abstract

Objective: Fully automatic computer-based classification of spinal defects in Magnetic Resonance (MR) images, such as cervical spine stenosis, is an important step towards automatic diagnosis assistance systems. However, defect classification is a challenging task due to natural and pathological anatomical[for full text, please go to the a.m. URL], 65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)

Published
2014
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30. Geschichte der Medizin

Author

Condrau, Flurin, Barras, Vincent, Steinke, Hubert, Condrau, F ( Flurin ), Barras, V ( Vincent ), Steinke, H ( Hubert ), Condrau, Flurin, Barras, Vincent, Steinke, Hubert, Condrau, F ( Flurin ), Barras, V ( Vincent ), and Steinke, H ( Hubert )

Published
2015

33. Experiment und Realität – Experimentelle Testung und klinische Anwendung der navigierten Transiliosakralverschraubung im Vergleich

Author

Behrendt, D, Böhme, J, Maria, M, Steinke, H, and Josten, C

Subjects
ddc: 610, Becken, Transiliosakralverschraubung, 610 Medical sciences, Medicine, Navigation, Computergestützte Chirurgie
Abstract

Fragestellung: Zunehmend werden navigationsgestützte Operationsverfahren in der Unfallchirurgie durchgeführt. Mit der Einführung der intraoperativen 3D-Bildgebung konnte in eigenen experimentellen Studien die Präzision der navigierten transiliosakralen Schraubentransfixation (TISV)[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2012)

Published
2012
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35. Age-dependent biomechanical properties of the iliotibial tract for pelvic Finite Elements Analysis

Author

Hammer, N, Böhme, J, Steinke, H, Lingslebe, U, Hädrich, C, and Josten, C

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Questionnaire: Pelvic Finite Elements Analysis (FEA) lacks in adequate morphological and biomechanical properties of the ligaments. The tissues which are usually subject of materials testing may not reflect the native situation, as regards the mean age of the specimens. The iliotibial tract (IT) ser[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 75. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 97. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 52. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2011
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36. Vergleichende quantitative Anatomie des ovinen und humanen Knies

Author

Osterhoff, G., Löffler, S., Steinke, H., Feja, C., Josten, C., and Hepp, P.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Vergleichende quantitative anatomische Messungen der Kniegelenke von Schaf und Mensch fehlen. Das Ziel dieser Studie war daher, die knöcherne Anatomie des ovinen und des humanen Knies zu beschreiben und zu vermessen. Methodik: 24 Kniegelenke humaner Leichen und 24 Kniegelenke [for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2010

37. Experimentelle Studie zur Anwendung der digitalen fluoroskopiebasierten 3-dimensionalen Navigation von transiliosacral eingebrachten Schrauben in den hinteren Beckenring

Author

Böhme, J., Behrendt, D., Köstler, M., Steinke, H., and Josten, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Der Einsatz der fluoroskopiebasierten 3-dimensionalen (3D) Navigation von transiliosacralen Schrauben gewinnt aufgrund einer verbesserten intraoperativen Darstellung des OP-Gebietes und damit einer geringeren Rate an Schraubenfehllagen im Vergleich zu 2D-navigations- und nicht navigationsgestützten[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2010
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38. The sacro-iliac joint ligaments

Author

Hammer, N, Steinke, H, Slowik, V, Böhme, J, Spanel-Borowski, K, and Josten, C

Subjects
ddc: 610, 610 Medical sciences, Medicine, musculoskeletal system, human activities
Abstract

Objective: The ligaments of the human sacro-iliac joint (SIJ) were investigated morphometrically. A macroscopical study was performed to measure the anterior sacro-iliac ligament (ASL), the interosseous sacro-iliac ligament (ISL) and the posterior sacro-iliac ligament (PSL) applying different methods[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 74. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 96. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 51. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2010
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39. Nachweis von komplexen Instabilitäten nach Applikation eines anterioren Anpralltraumas am Beckenring

Author

Schibur, S., Böhme, J., Steinke, H., Hammer, N., Klink, T., and Josten, C.

Subjects
ddc: 610, 610 Medical sciences, Medicine
Abstract

Fragestellung: Das Vorhandensein und die Richtung der Instabilität einer Beckenfraktur steht im Mittelpunkt der von Tile 1984 eingeführten und von der AO weitgehend übernommenen Klassifikation der Beckenfrakturen in A-, B- und C-Frakturen. Anhand dieser funktionellen Betrachtung leitet[for full text, please go to the a.m. URL], Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie

Published
2009
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47. Albert Schweitzer als Musikforscher und als Musiker

Author

Berlis, Angela, Steinke, Hubert, von Gunten, Fritz, Wagner, Anderas, Berlis, A ( Angela ), Steinke, H ( Hubert ), von Gunten, F ( Fritz ), Wagner, A ( Anderas ), Hinrichsen, Hans-Joachim, Berlis, Angela, Steinke, Hubert, von Gunten, Fritz, Wagner, Anderas, Berlis, A ( Angela ), Steinke, H ( Hubert ), von Gunten, F ( Fritz ), Wagner, A ( Anderas ), and Hinrichsen, Hans-Joachim

Published
2013

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