Author: "Steinig, Kerstin" - Searchworks@Jio Institute Digital Library Search Results

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Author: Toth, Bettina, Nieuwland, Rienk, Liebhardt, Susanne, Ditsch, Nina, Steinig, Kerstin, Stieber, Petra, Rank, Andreas, Göhring, Peter, Thaler, Christian J., Friese, Klaus, Bauerfeind, Ingo, ACS - Amsterdam Cardiovascular Sciences, CCA -Cancer Center Amsterdam, and Laboratory Specialized Diagnostics & Research
Subjects: hemic and lymphatic diseases, ddc:610
Abstract: BACKGROUND: The aim of the present prospective case-control study was to evaluate the putative relevance of circulating microparticles (MP) as a biomarker in breast cancer patients. MATERIALS AND METHODS: Endothelial cell-(EMP) and leukocyte-derived MP (LMP) were determined by flow cytometry in breast cancer patients (n = 41) and healthy controls (n = 25) and compared to carcinoembryonic antigen (CEA), cancer antigen (CA)15-3 and von Willebrand factor antigen (vWF) levels by specificity-sensitivity profiles. RESULTS: LMP, CEA and CA15-3 levels differed significantly between breast cancer patients and controls, whereas EMP and vWF did not. The specificity-sensitivity profiles of LMP and CA15-3 were similar. CONCLUSION: Increasing levels of circulating LMP (CD45+), CEA and CA15-3 correlated with increasing tumor size, thus reflecting disease stage. LMP showed an equal specificity-sensitivity profile to the established marker CA15-3 and therefore might have the potential to become a new biomarker in breast cancer patients
Published: 2021

Author: Toth, Bettina, primary, Liebhardt, Susanne, primary, Steinig, Kerstin, primary, Ditsch, Nina, primary, Rank, Andreas, primary, Bauerfeind, Ingo, primary, Spannagl, Michael, primary, Friese, Klaus, primary, and Reininger, Armin J., additional
Published: 2008
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Author: Toth B, Nieuwland R, Liebhardt S, Ditsch N, Steinig K, Stieber P, Rank A, Göhring P, Thaler CJ, Friese K, and Bauerfeind I
Subjects: Adult, Aged, Aged, 80 and over, Carcinoembryonic Antigen blood, Case-Control Studies, Female, Humans, Middle Aged, Mucin-1 blood, Prospective Studies, von Willebrand Factor analysis, Biomarkers, Tumor blood, Breast Neoplasms blood
Abstract: Background: The aim of the present prospective case-control study was to evaluate the putative relevance of circulating microparticles (MP) as a biomarker in breast cancer patients., Materials and Methods: Endothelial cell-(EMP) and leukocyte-derived MP (LMP) were determined by flow cytometry in breast cancer patients (n = 41) and healthy controls (n = 25) and compared to carcinoembryonic antigen (CEA), cancer antigen (CA)15-3 and von Willebrand factor antigen (vWF) levels by specificity-sensitivity profiles., Results: LMP, CEA and CA15-3 levels differed significantly between breast cancer patients and controls, whereas EMP and vWF did not. The specificity-sensitivity profiles of LMP and CA15-3 were similar., Conclusion: Increasing levels of circulating LMP (CD45+), CEA and CA15-3 correlated with increasing tumor size, thus reflecting disease stage. LMP showed an equal specificity-sensitivity profile to the established marker CA15-3 and therefore might have the potential to become a new biomarker in breast cancer patients.
Published: 2008

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