Search

Your search keyword '"Steinbok, Paul"' showing total 961 results
Start Over Author "Steinbok, Paul"
961 results on '"Steinbok, Paul"'

4. Comparison of the real‐world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug‐resistant epilepsy: A post hoc analysis of the HOPS study

Author

Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi‐Hong, Harris, William B, Chen, Jia‐Shu, Lin, Kao‐Min, Cai, Li‐Xin, Liu, Qing‐Zhu, Lin, Jiu‐Luan, Zhou, Wen‐Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy WR, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian‐Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong‐Kisiel, Lily, Lapalme‐Remis, Samuel, Tripathi, Manjari, Chandra, Poodipedi Sarat, Hader, Walter, Wang, Feng‐Peng, Yao, Yi, Champagne, Pierre‐Olivier, Brunette‐Clément, Tristan, Guo, Qiang, Li, Shao‐Chun, Budke, Marcelo, Pérez‐Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Malone, Christian Cantillano, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al‐Khateeb, Mashael, Otaibi, Faisal Al, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Weil, Alexander G

Subjects
Neurodegenerative, Clinical Research, Epilepsy, Neurosciences, Brain Disorders, Clinical Trials and Supportive Activities, Child, Drug Resistant Epilepsy, Hemispherectomy, Humans, Pilot Projects, Prospective Studies, Retrospective Studies, Seizures, Treatment Outcome, hemispherectomy, hemispherotomy, seizure outcomes, technique, Clinical Sciences, Neurology & Neurosurgery
Abstract

ObjectiveThis study was undertaken to determine whether the vertical parasagittal approach or the lateral peri-insular/peri-Sylvian approach to hemispheric surgery is the superior technique in achieving long-term seizure freedom.MethodsWe conducted a post hoc subgroup analysis of the HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort study that identified predictors of seizure freedom through logistic regression modeling. Only patients undergoing vertical parasagittal, lateral peri-insular/peri-Sylvian, or lateral trans-Sylvian hemispherotomy were included in this post hoc analysis. Differences in seizure freedom rates were assessed using a time-to-event method and calculated using the Kaplan-Meier survival method.ResultsData for 672 participants across 23 centers were collected on the specific hemispherotomy approach. Of these, 72 (10.7%) underwent vertical parasagittal hemispherotomy and 600 (89.3%) underwent lateral peri-insular/peri-Sylvian or trans-Sylvian hemispherotomy. Seizure freedom was obtained in 62.4% (95% confidence interval [CI] = 53.5%-70.2%) of the entire cohort at 10-year follow-up. Seizure freedom was 88.8% (95% CI = 78.9%-94.3%) at 1-year follow-up and persisted at 85.5% (95% CI = 74.7%-92.0%) across 5- and 10-year follow-up in the vertical subgroup. In contrast, seizure freedom decreased from 89.2% (95% CI = 86.3%-91.5%) at 1-year to 72.1% (95% CI = 66.9%-76.7%) at 5-year to 57.2% (95% CI = 46.6%-66.4%) at 10-year follow-up for the lateral subgroup. Log-rank test found that vertical hemispherotomy was associated with durable seizure-free progression compared to the lateral approach (p = .01). Patients undergoing the lateral hemispherotomy technique had a shorter time-to-seizure recurrence (hazard ratio = 2.56, 95% CI = 1.08-6.04, p = .03) and increased seizure recurrence odds (odds ratio = 3.67, 95% CI = 1.05-12.86, p = .04) compared to those undergoing the vertical hemispherotomy technique.SignificanceThis pilot study demonstrated more durable seizure freedom of the vertical technique compared to lateral hemispherotomy techniques. Further studies, such as prospective expertise-based observational studies or a randomized clinical trial, are required to determine whether a vertical approach to hemispheric surgery provides superior long-term seizure outcomes.

Published
2021

12. Development of an online calculator for the prediction of seizure freedom following pediatric hemispherectomy using the Hemispherectomy Outcome Prediction Scale (HOPS)

Author

Weil, Alexander G., primary, Dimentberg, Evan, additional, Lewis, Evan, additional, Ibrahim, George M., additional, Kola, Olivia, additional, Tseng, Chi‐Hong, additional, Chen, Jia‐Shu, additional, Lin, Kao‐Min, additional, Cai, Li‐Xin, additional, Liu, Qing‐Zhu, additional, Lin, Jiu‐Luan, additional, Zhou, Wen‐Jing, additional, Mathern, Gary W., additional, Smyth, Matthew D., additional, O'Neill, Brent R., additional, Dudley, Roy, additional, Ragheb, John, additional, Bhatia, Sanjiv, additional, Delev, Daniel, additional, Ramantani, Georgia, additional, Zentner, Josef, additional, Wang, Anthony C., additional, Dorfer, Christian, additional, Feucht, Martha, additional, Czech, Thomas, additional, Bollo, Robert J., additional, Issabekov, Galymzhan, additional, Zhu, Hongwei, additional, Connolly, Mary, additional, Steinbok, Paul, additional, Zhang, Jian‐Guo, additional, Zhang, Kai, additional, Hidalgo, Eveline Teresa, additional, Weiner, Howard L., additional, Wong‐Kisiel, Lily, additional, Lapalme‐Remis, Samuel, additional, Tripathi, Manjari, additional, Sarat Chandra, Poodipedi, additional, Hader, Walter, additional, Wang, Feng‐Peng, additional, Yao, Yi, additional, Champagne, Pierre Olivier, additional, Brunette‐Clément, Tristan, additional, Guo, Qiang, additional, Li, Shao‐Chun, additional, Budke, Marcelo, additional, Pérez‐Jiménez, Maria Angeles, additional, Raftopoulos, Christian, additional, Finet, Patrice, additional, Michel, Pauline, additional, Schaller, Karl, additional, Stienen, Martin N., additional, Baro, Valentina, additional, Cantillano Malone, Christian, additional, Pociecha, Juan, additional, Chamorro, Noelia, additional, Muro, Valeria L., additional, von Lehe, Marec, additional, Vieker, Silvia, additional, Oluigbo, Chima, additional, Gaillard, William D., additional, Al Khateeb, Mashael, additional, Al Otaibi, Faisal, additional, Krayenbühl, Niklaus, additional, Bolton, Jeffrey, additional, Pearl, Phillip L., additional, and Fallah, Aria, additional

Published
2023
Full Text
View/download PDF

13. Global trends and decision-making in the management of arachnoid cysts

Author

Kakodkar, Pramath, primary, Ragulojan, Malavan, additional, Hayawi, Lamia, additional, Tsampalieros, Anne, additional, Chee, Sharini Sam, additional, Wu, Mia, additional, Makoshi, Ziyad, additional, Singhal, Ashutosh, additional, Steinbok, Paul, additional, Fallah, Aria, additional, Robison, Richard A., additional, and Tu, Albert, additional

Published
2023
Full Text
View/download PDF

30. Pediatric thalamic tumors in the MRI era: a Canadian perspective

Author

Steinbok, Paul, Gopalakrishnan, Chittur Viswanathan, Hengel, Alexander R., Vitali, Aleksander M., Poskitt, Ken, Hawkins, Cynthia, Drake, James, Lamberti-Pasculli, Maria, Ajani, Olufemi, Hader, Walter, Mehta, Vivek, McNeely, P. Daniel, McDonald, Patrick J., Ranger, Adrianna, Vassilyadi, Michael, Atkinson, Jeff, Ryall, Scott, Eisenstat, David D., and Hukin, Juliette

Published
2016
Full Text
View/download PDF

39. Nonoperative Management of Childhood Calvarial Langerhans-Cell Histiocytosis

Author

Steinbok, Paul, primary, Cheong, Alexander, additional, Dix, David B., additional, Bhatia, Sanjiv, additional, Handler, Michael H., additional, Limbrick, David D., additional, Niazi, Toba, additional, Price, Angela V., additional, Ragheb, John, additional, Souweidane, Mark, additional, Tamber, Mandeep S., additional, and Sandberg, David I., additional

Published
2022
Full Text
View/download PDF

48. Comparison of the real-world effectiveness of vertical versus lateral functional hemispherotomy techniques for pediatric drug-resistant epilepsy: A post hoc analysis of the HOPS study.

Author

UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Centre du cancer, Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Harris, William B, Chen, Jia-Shu, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy W R, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Champagne, Pierre-Olivier, Brunette-Clément, Tristan, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al-Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, Weil, Alexander G, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Centre du cancer, Fallah, Aria, Lewis, Evan, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Harris, William B, Chen, Jia-Shu, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy W R, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connolly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Champagne, Pierre-Olivier, Brunette-Clément, Tristan, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al-Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Weil, Alexander G

Abstract

This study was undertaken to determine whether the vertical parasagittal approach or the lateral peri-insular/peri-Sylvian approach to hemispheric surgery is the superior technique in achieving long-term seizure freedom. We conducted a post hoc subgroup analysis of the HOPS (Hemispheric Surgery Outcome Prediction Scale) study, an international, multicenter, retrospective cohort study that identified predictors of seizure freedom through logistic regression modeling. Only patients undergoing vertical parasagittal, lateral peri-insular/peri-Sylvian, or lateral trans-Sylvian hemispherotomy were included in this post hoc analysis. Differences in seizure freedom rates were assessed using a time-to-event method and calculated using the Kaplan-Meier survival method. Data for 672 participants across 23 centers were collected on the specific hemispherotomy approach. Of these, 72 (10.7%) underwent vertical parasagittal hemispherotomy and 600 (89.3%) underwent lateral peri-insular/peri-Sylvian or trans-Sylvian hemispherotomy. Seizure freedom was obtained in 62.4% (95% confidence interval [CI] = 53.5%-70.2%) of the entire cohort at 10-year follow-up. Seizure freedom was 88.8% (95% CI = 78.9%-94.3%) at 1-year follow-up and persisted at 85.5% (95% CI = 74.7%-92.0%) across 5- and 10-year follow-up in the vertical subgroup. In contrast, seizure freedom decreased from 89.2% (95% CI = 86.3%-91.5%) at 1-year to 72.1% (95% CI = 66.9%-76.7%) at 5-year to 57.2% (95% CI = 46.6%-66.4%) at 10-year follow-up for the lateral subgroup. Log-rank test found that vertical hemispherotomy was associated with durable seizure-free progression compared to the lateral approach (p = .01). Patients undergoing the lateral hemispherotomy technique had a shorter time-to-seizure recurrence (hazard ratio = 2.56, 95% CI = 1.08-6.04, p = .03) and increased seizure recurrence odds (odds ratio = 3.67, 95% CI = 1.05-12.86, p = .04) compared to those undergoing the vertical hemispherotomy technique. This pilot stud

Published
2021

49. Hemispherectomy Outcome Prediction Scale: Development and validation of a seizure freedom prediction tool.

Author

UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, Weil, Alexander G, Lewis, Evan C, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Zhou, Xinkai, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Ojemann, Jeffrey, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connelly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Olivier Champagne, Pierre, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, Fallah, Aria, UCL - SSS/IONS - Institute of NeuroScience, UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - (SLuc) Service de neurochirurgie, Weil, Alexander G, Lewis, Evan C, Ibrahim, George M, Kola, Olivia, Tseng, Chi-Hong, Zhou, Xinkai, Lin, Kao-Min, Cai, Li-Xin, Liu, Qing-Zhu, Lin, Jiu-Luan, Zhou, Wen-Jing, Mathern, Gary W, Smyth, Matthew D, O'Neill, Brent R, Dudley, Roy, Ragheb, John, Bhatia, Sanjiv, Delev, Daniel, Ramantani, Georgia, Zentner, Josef, Ojemann, Jeffrey, Wang, Anthony C, Dorfer, Christian, Feucht, Martha, Czech, Thomas, Bollo, Robert J, Issabekov, Galymzhan, Zhu, Hongwei, Connelly, Mary, Steinbok, Paul, Zhang, Jian-Guo, Zhang, Kai, Hidalgo, Eveline Teresa, Weiner, Howard L, Wong-Kisiel, Lily, Lapalme-Remis, Samuel, Tripathi, Manjari, Sarat Chandra, Poodipedi, Hader, Walter, Wang, Feng-Peng, Yao, Yi, Olivier Champagne, Pierre, Guo, Qiang, Li, Shao-Chun, Budke, Marcelo, Pérez-Jiménez, Maria Angeles, Raftopoulos, Christian, Finet, Patrice, Michel, Pauline, Schaller, Karl, Stienen, Martin N, Baro, Valentina, Cantillano Malone, Christian, Pociecha, Juan, Chamorro, Noelia, Muro, Valeria L, von Lehe, Marec, Vieker, Silvia, Oluigbo, Chima, Gaillard, William D, Al Khateeb, Mashael, Al Otaibi, Faisal, Krayenbühl, Niklaus, Bolton, Jeffrey, Pearl, Phillip L, and Fallah, Aria

Abstract

To develop and validate a model to predict seizure freedom in children undergoing cerebral hemispheric surgery for the treatment of drug-resistant epilepsy. We analyzed 1267 hemispheric surgeries performed in pediatric participants across 32 centers and 12 countries to identify predictors of seizure freedom at 3 months after surgery. A multivariate logistic regression model was developed based on 70% of the dataset (training set) and validated on 30% of the dataset (validation set). Missing data were handled using multiple imputation techniques. Overall, 817 of 1237 (66%) hemispheric surgeries led to seizure freedom (median follow-up = 24 months), and 1050 of 1237 (85%) were seizure-free at 12 months after surgery. A simple regression model containing age at seizure onset, presence of generalized seizure semiology, presence of contralateral 18-fluoro-2-deoxyglucose-positron emission tomography hypometabolism, etiologic substrate, and previous nonhemispheric resective surgery is predictive of seizure freedom (area under the curve = .72). A Hemispheric Surgery Outcome Prediction Scale (HOPS) score was devised that can be used to predict seizure freedom. Children most likely to benefit from hemispheric surgery can be selected and counseled through the implementation of a scale derived from a multiple regression model. Importantly, children who are unlikely to experience seizure control can be spared from the complications and deficits associated with this surgery. The HOPS score is likely to help physicians in clinical decision-making.

Published
2021

Catalog

Books, media, physical & digital resources
See catalog results