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2. Post-Lockdown Abatement of COVID-19 by Fast Periodic Switching

Author

Bin, M., Cheung, P., Crisostomi, E., Ferraro, P., Lhachemi, H., Murray-Smith, R., Myant, C., Parisini, T., Shorten, R., Stein, S., and Stone, L.

Subjects
Physics - Physics and Society, Electrical Engineering and Systems Science - Systems and Control, Quantitative Biology - Populations and Evolution
Abstract

COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show -- as proof of concept grounded on rigorous mathematical evidence -- that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn -- while not eliminating the virus -- this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github (https://github.com/V4p1d/FPSP_Covid19). A software tool has also been developed so that interested parties can explore the proof-of-concept system., Comment: Version 6: title slightly changed and extended mathematical results underpinning the mitigation strategy provided, revised sensitivity analysis and discussion given

Published
2020
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5. Analysis of Short-Term Stability of Miniature 171Yb+ Buffer Gas Cooled Trapped Ion Clock

Author

Scherer, David R., Boschen, C. Daniel, Noble, Jay, Silveira, Michael, Taylor, Dwayne, Tallant, Jonathan, Overstreet, K. Richard, and Stein, S. R.

Subjects
Physics - Atomic Physics
Abstract

We demonstrate an improvement in short-term stability by a factor of 10 over a previous generation miniature buffer gas cooled trapped ion clock. We describe the enhancement to detection SNR that has enabled this improvement, the method of clock operation, and the measurement of clock short-term stability. Additionally, we numerically investigate the magnitude of the Dick effect in our pulsed ion clock., Comment: submitted to ION Precise Time and Time Interval Meeting, Reston, VA, 2018

Published
2018
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6. A Population of Human Leukocyte Antigen - DR Isotype Expressing Low Density Granulocytes in Critical Illness

Author

Teague, H.L., primary, Wigerblad, G., additional, Kardava, L., additional, Warner, S., additional, Allen, K.C., additional, Platt, A.P., additional, Stein, S., additional, Ramos-Benitez, M.J., additional, Ramelli, S.C., additional, Curran, S., additional, Lach, I., additional, Adetola, H., additional, Stantliff, T., additional, Kendall, H., additional, Vannella, K.M., additional, Suffredini, A.F., additional, Herbert, R., additional, Moir, S., additional, Kaplan, M., additional, Chertow, D.S., additional, and Strich, J.R., additional

Published
2024
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8. Atezolizumab with or without bevacizumab in unresectable hepatocellular carcinoma (GO30140): an open-label, multicentre, phase 1b study

Author

Bang, Y-J, Bendell, J, Chao, Y, Chen, J-S, Chung, H C, Davis, S L, Dev, A, Gane, E, George, B, He, A R, Hochster, H, Hsu, C-H, Ikeda, M, Lee, J, Lee, M, Mahipal, A, Manji, G, Morimoto, M, Numata, K, Pishvaian, M, Qin, S, Ryan, D, Ryoo, B-Y, Sasahira, N, Stein, S, Strickler, J, Tebbutt, N, Lee, Michael S, Ryoo, Baek-Yeol, Hsu, Chih-Hung, Numata, Kazushi, Stein, Stacey, Verret, Wendy, Hack, Stephen P, Spahn, Jessica, Liu, Bo, Abdullah, Heba, Wang, Yulei, He, Aiwu Ruth, and Lee, Kyung-Hun

Published
2020
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16. High dose NAD+ boosting as pan-sirtuin activation increases atherosclerotic plaques and systemic inflammation in Apoe knockout mice

Author

Wang, Y, primary, Gaul, D S, additional, Pahla, J, additional, Dahlby, T, additional, Dietrich, E, additional, Osto, E, additional, Gariani, K, additional, Costantino, S, additional, Paneni, F, additional, Winnik, S, additional, Stein, S, additional, Ruschitzka, F, additional, Auwerx, J, additional, and Matter, C M, additional

Published
2023
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20. The NIF Integrated Timing System - Design and Performance

Author

Lerche, R. A., Coutts, G. W., Lagin, L. J., Nyholm, R. A., Sewall, N. R., Stever, R. D., Wiedwald, J. D., Larkin, J., Stein, S., and Martin, R.

Subjects
Physics - Instrumentation and Detectors
Abstract

The National Ignition Facility (NIF) will contain the world's most powerful laser. NIF requires more than 1500 precisely timed trigger pulses to control the timing of laser and diagnostic equipment. The Integrated Timing System applies new concepts to generate and deliver triggers at preprogrammed times to equipment throughout the laser and target areas of the facility. Trigger pulses during the last 2 seconds of a shot cycle are required to have a jitter of less than 20 ps (rms) and a wander of less than 100 ps (max). Also, the Timing System allows simultaneous, independent use by multiple clients by partitioning the system hardware into subsets that are controlled via independent software keys. The hardware necessary to implement the Integrated Timing System is commercially available. -- This work is performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under contract No. W-7405-Eng-48., Comment: Contributed conference paper for International Conference on Accelerators & Large Experimental Physics Control Systems ICALEPCS 2001, San Jose, California, November 27-30, 2001 (TUAP069) 3 pages, PDF

Published
2001

21. Testing and Implementation Progress on the Advanced Photon Source (APS) Linear Accelerator (Linac) High-Power S-band Switching System

Author

Grelick, A. E., Arnold, N., Berg, S., Dohan, D., Goeppner, G., Kang, Y. W., Nassiri, A., Pasky, S., Pile, G., Smith, T., and Stein, S. J.

Subjects
Physics - Accelerator Physics
Abstract

An S-band linear accelerator is the source of particles and the front end of the Advanced Photon Source injector. In addition, it supports a low-energy undulator test line (LEUTL) and drives a free-electron laser (FEL). A waveguide-switching and distribution system is now under construction. The system configuration was revised to be consistent with the recent change to electron-only operation. There are now six modulator-klystron subsystems, two of which are being configured to act as hot spares for two S-band transmitters each, so that no single failure will prevent injector operation. The two subsystems are also used to support additional LEUTL capabilities and off-line testing. Design considerations for the waveguide-switching subsystem, topology selection, control and protection provisions, high-power test results, and current status are described, Comment: Linac 2000 paper No. THE07 3 pages with 3 figures

Published
2000

24. O FUTURO DA FILOSOFIA

Author

PERUZZO JÚNIOR, L., primary, VALVERDE, A. J. R., additional, VALLE, B., additional, DALL ´AGNOL, DARLEI, additional, PINTO, P. R. M., additional, SMITH, P. J., additional, STEIN, S. I. A., additional, and de Castro, Susana, additional

Published
2019
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25. International Consensus Definition of Low Anterior Resection Syndrome

Author

Keane, Celia, Fearnhead, Nicola S., Bordeianou, Liliana G., Christensen, Peter, Basany, Eloy Espin, Laurberg, Søren, Mellgren, Anders, Messick, Craig, Orangio, Guy R., Verjee, Azmina, Wing, Kirsty, Bissett, Ian, An, V, Bryant, A, Byrne, C, Chen, T, Croft, S, Clark, D, Gladman, M, Heriot, A, Kariappa, S, Keck, J, Lubowski, D, Dinning, P, Khera, A, Kirkwood, K, Petersen, D, Sloots, K, Totten, B, Weston, M, Andersen, P, Bachmann, C, Barht, H, Emmertsen, K, Faaborg, P, Gögenur, I, Ingerslev, P, Isaksen, D, Iversen, H, Iversen, L, Jacobsen, K, Jansen, T, Jocobsen, I, Juul, T, Kjar, D, Krogh, K, Majgaard, M, Mynster, A, Neuenschwander, A, Nielsen, C, Nielsen, R, Nielsen, M, Nielsen, T, Olsen, J, Poulsen, B, Rahr, H, Snedker, B, Sørensen, G, Stolzenburg, T, Vaabengaard, P, Acheson, A, Andreyev, J, Bach, S, Battersby, N, Bradbury, J, Brown, S, Cecil, T, Chapman, S, Chapman, M, Chave, H, Cook, T, Cuffy, L, Davies, J, Dawson, C, Dixon, J, Duff, S, Edwards, C, Geh, I, Hamilton, C, Hancock, L, Harji, D, Hill, J, Holtham, S, Jenkins, J, Johnston, R, Kapur, S, Maxwell-Armstrong, C, McArthur, D, Moran, B, Norton, C, Nugent, K, Pateman, L, Perston, Y, Rockall, T, Sagar, P, Saunders, M, Sebag-Montefiore, D, Senapati, A, Singh, B, Skaife, P, Sykes, H, Smart, N, Taylor, C, Thorpe, G, Tierney, G, Voyce, S, Walsh, C, Warren, O, Wheeler, J, Woodward, A, Winter, D, Abbott, S, Beban, V, Bennett, M, Chadwick, T, Collinson, R, Corbett, S, Dennett, E, Eglinton, T, Fraser, A, Glue, J, Hohaia, D, Menzi, E, O’Connor, M, Stevenson, D, Wells, C, Wolyncewicz, S, Woodfield, J, Bence, K, Boutros, M, Brueseke, M, DeKorte, J, Floruta, C, Francone, T, Frederick, F, Grasso, J, Gurland, B, Higgins, K, Hull, T, Keller, D, Laffan, A, Lovett, S, Marlatt, J, McAdams, D, McCarthy, C, Milch, H, Natale, S, Pappou, E, Paquette, I, Pulskamp, S, Rich, M, Savitt, L, Shafi, M, Steele, S, Stein, S, Tolbert, M, Varma, M, Vogler, S, Vuong, T, Wells, K, Wexner, S, Wo, J, Wright, J, Wunderlich, C, Campbell, K, Lim, M, Moug, S, Oliphant, R, Labaka-Aretaga, I, Ballester, C, Belen-Bueno, A, Vaquer-Casas, G, Jerez, J, Castillo, J, Paniagua-Cayetano, G, Codina-Cazador, A, Blanco-Colino, R, de la Portilla, F, Pascual-Damieta, M, Enriquez-Navascuez, JM, Martin-Fernández, M, Araujo-Ferreiro, M, Sanchez-García, C, Vico-García, E, Gallego-García, M, Jimenez, LM, Martinez-Sanchez, C, Carrillo-Moreno, J, Muñoz, A, Ramirez, L, Vigorita, V, Adams, R, Cornish, J, Davies, M, Evans, M, Torkington, J, and Turner, J

Published
2020
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26. Electromechanical vortex filaments during cardiac fibrillation

Author

Christoph, J., Chebbok, M., Richter, C., Schrder-Schetelig, J., Bittihn, P., Stein, S., Uzelac, I., Fenton, F. H., Hasenfu, G., Gilmour Jr., R. F., and Luther, S.

Subjects
Waves -- Physiological aspects, Heart -- Physiological aspects -- Mechanical properties -- Electric properties, Fibrillation -- Physiological aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): J. Christoph (corresponding author) [1, 2, 3]; M. Chebbok [2, 4]; C. Richter [1, 2, 4]; J. Schrder-Schetelig [1, 2, 3]; P. Bittihn [5]; S. Stein [1, 3]; I. [...]

Published
2018
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27. P32 MAJESTEC-1: CORRELATIVE ANALYSES OF TECLISTAMAB, A B-CELL MATURATION ANTIGEN (BCMA) X CD3 BISPECIFIC ANTIBODY, IN PATIENTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA (RRMM)

Author

van de Donk, N., primary, Cortes-Selva, D., additional, Casneuf, T., additional, Vishwamitra, D., additional, Stein, S., additional, Perova, T., additional, Ramos, E., additional, Van Steenbergen, L., additional, Boominathan, R., additional, Lau, O., additional, Davis, C., additional, Banerjee, A., additional, Stephenson, T., additional, Uhlar, C., additional, Kobos, R., additional, Goldberg, J., additional, Pei, L., additional, Trancucci, D., additional, Girgis, S., additional, Lin, S.X.W., additional, Wu, L.S., additional, Moreau, P., additional, Usmani, S., additional, Bahlis, N.J., additional, and Verona, R., additional

Published
2023
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28. News and Letters

Author

Jones, Dixon J., Stein, S. K., and Callan, David

Published
1996

42. Stammzellen

Author

Eblenkamp, Markus, Neuss-Stein, S., Salber, S., Jacobs, Volker R., Wintermantel, Erich, Wintermantel, Erich, editor, and Ha, Suk-Woo, editor

Published
2009
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43. Development of a core descriptor set for Crohn's anal fistula

Author

Lee M. J., Williams K. M., Lamidi S., Coe P. O., Bordeianou L. G., Hart A. L., Hind D., Lindsay J. O., Lobo A. J., Myrelid P., Raine T., Sebastian S., Fearnhead N. S., Adams K., Almer S., Ananthakrishnan A., Bethune R. M., Block M., Brown S. R., Cirocco W. C., Cooney R., Davies J., Atici S. D., Dhar A., Din S., Drobne D., Espin-Basany E., Evans J. P., Fleshner P. R., Folkesson J., Fraser A., Graf W., Hahnloser D., Hager J., Hancock L., Hanzel J., Hargest R., Hedin C. R. H., Hill J., Ihle C., Jongen J., Kader R., Karmiris K., Katsanos K. H., Keller D. S., Kopylov U., Koutrabakis I. E., Lamb C. A., Landerholm K., Lee G. C., Litta F., Limdi J. K., Lopes E. W., Madoff R. D., Martin S. T., Martin-Perez B., Michalopoulos G., Millan M., Munch A., Nakov R., Noor N. M., Oresland T., Paquette I. M., Pellino G., Perra T., Porcu A., Roslani A. C., Samaan M. A., Sebepos-Rogers G. M., Segal J. P., de Silva S., Soderholm M., Spinelli A., Speight A., Steinhagen R. M., Stenstrom P., Tsimogiannis K. E., Varma M. G., Verma A. M., Verstockt B., Warden C., Yassin N., Zawadzki A., Carr P., Devlin B., Mannick S., Avery P., Gecse K. B., Goren I., Hellstrom P. M., Kotze P. G., McWhirter D., Naik A. S., Sammour T., Selinger C. P., Stein S. L., Torres J., Wexner S. D., Younge L. C., Lee, M. J., Williams, K. M., Lamidi, S., Coe, P. O., Bordeianou, L. G., Hart, A. L., Hind, D., Lindsay, J. O., Lobo, A. J., Myrelid, P., Raine, T., Sebastian, S., Fearnhead, N. S., Adams, K., Almer, S., Ananthakrishnan, A., Bethune, R. M., Block, M., Brown, S. R., Cirocco, W. C., Cooney, R., Davies, J., Atici, S. D., Dhar, A., Din, S., Drobne, D., Espin-Basany, E., Evans, J. P., Fleshner, P. R., Folkesson, J., Fraser, A., Graf, W., Hahnloser, D., Hager, J., Hancock, L., Hanzel, J., Hargest, R., Hedin, C. R. H., Hill, J., Ihle, C., Jongen, J., Kader, R., Karmiris, K., Katsanos, K. H., Keller, D. S., Kopylov, U., Koutrabakis, I. E., Lamb, C. A., Landerholm, K., Lee, G. C., Litta, F., Limdi, J. K., Lopes, E. W., Madoff, R. D., Martin, S. T., Martin-Perez, B., Michalopoulos, G., Millan, M., Munch, A., Nakov, R., Noor, N. M., Oresland, T., Paquette, I. M., Pellino, G., Perra, T., Porcu, A., Roslani, A. C., Samaan, M. A., Sebepos-Rogers, G. M., Segal, J. P., de Silva, S., Soderholm, M., Spinelli, A., Speight, A., Steinhagen, R. M., Stenstrom, P., Tsimogiannis, K. E., Varma, M. G., Verma, A. M., Verstockt, B., Warden, C., Yassin, N., Zawadzki, A., Carr, P., Devlin, B., Mannick, S., Avery, P., Gecse, K. B., Goren, I., Hellstrom, P. M., Kotze, P. G., Mcwhirter, D., Naik, A. S., Sammour, T., Selinger, C. P., Stein, S. L., Torres, J., Wexner, S. D., Younge, L. C., Gastroenterology and Hepatology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Crohn's disease, anal fistula, consensus, methodology, Gastroenterologi, Gastroenterology, consensu, Gastroenterology and Hepatology
Abstract

Aim: Crohn's anal fistula (CAF) is a complex condition, with no agreement on which patient characteristics should be routinely reported in studies. The aim of this study was to develop a core descriptor set of key patient characteristics for reporting in all CAF research.Method: Candidate descriptors were generated from published literature and stakeholder suggestions. Colorectal surgeons, gastroenterologists and specialist nurses in inflammatory bowel disease took part in three rounds of an international modified Delphi process using nine-point Likert scales to rank the importance of descriptors. Feedback was provided between rounds to allow refinement of the next ratings. Patterns in descriptor voting were assessed using principal component analysis (PCA). Resulting PCA groups were used to organize items in rounds two and three. Consensus descriptors were submitted to a patient panel for feedback. Items meeting predetermined thresholds were included in the final set and ratified at the consensus meeting.Results: One hundred and thirty three respondents from 22 countries completed round one, of whom 67.0% completed round three. Ninety seven descriptors were rated across three rounds in 11 PCA-based groups. Forty descriptors were shortlisted. The consensus meeting ratified a core descriptor set of 37 descriptors within six domains: fistula anatomy, current disease activity and phenotype, risk factors, medical interventions for CAF, surgical interventions for CAF, and patient symptoms and impact on quality of life.Conclusion: The core descriptor set proposed for all future CAF research reflects characteristics important to gastroenterologists and surgeons. This might aid transparent reporting in future studies.

Published
2022

45. Stammzellen

Author

Eblenkamp, M., Neuss-Stein, S., Salber, S., Jacobs, V., Wintermantel, E., Wintermantel, Erich, and Ha, Suk-Woo

Published
2008
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