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7. CORRESPONDENCE

Author

Eliezer, Jack, Silcox, Hugh B., Whalen, Tim, Mahoney, Jack, O'Neill, Mike, Cuthbertson, Barbara T., Levinson, Mark, Browne, John D., Cook, Laurel, Bernfeld, Gerald E., Murray, Melba (Jerry), Stein, Richard S., Towers, Michael P., Schwartz, A. J., Tarbet, Glen F., and Ogawa, Nobuo

Published
1982

26. Results of treatment with high intensity, brief duration chemotherapy in poor prognosis non-Hodgkin's lymphoma

Author

McMaster, Mary L., Greer, John P., Wolff, Steven N., Johnson, David H., Greco, F. Anthony, Stein, Richard S., Cousar, John B., Flexner, John M., and Hainsworth, John D.

Subjects
Non-Hodgkin's lymphomas, Chemotherapy -- Management, Health
Abstract

Intermediate and high-grade non-Hodgkin's lymphomas still pose a serious problem for the clinician. Prior to 1965, these tumors were virtually incurable. Although improvements in treatment have been made in the following years, only one-half of the patients treated experienced long-term survival. Furthermore, the effective treatments at present are so toxic that more intensive treatments are not possible without bone marrow transplantation. A study was conducted to determine if delivering high intensity chemotherapy for only a brief period would be any better. For this type of preliminary evaluation, the only patients selected for the experimental treatment were those estimated to have less than 25 percent chance of responding to conventional treatment. A total of 56 such patients were treated with a high-intensity chemotherapeutic protocol including cyclophosphamide, etoposide, doxorubicin, vincristine, and bleomycin, as well as methotrexate, leucovorin, and prednisone. The toxicity of the treatment was high, resulting in five patient deaths. However, the complete response rate was 77 percent, and these responses were long-lived for many patients. After a median follow-up of three years, 52 percent of the patients were alive without relapse of disease. The results indicate that the intensive treatment improves the survival of patients with poor-prognosis non-Hodgkin's lymphomas. The high rate of toxicity of the treatment protocol, which killed 9 percent of the patients, is alarming. However, many of the patients included in the study were severely ill to begin with, which may account for at least a part of this high mortality. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

27. CORRESPONDENCE

Author

Benson, Philippa Jane, Poulson, Marcia Riefer, Klammer, Carol, De Sevo, William, Miller, Carl C., Lewis, William, Nigro, Ralph, DuBay, William H., Weisman, Herman M., Lear, Peter J., Stein, Richard S., Ioven, Anthony, Barry, Alyce, Ingalls, Leonidas T., Beedon, David, and Eliezer, Jack

Published
1991

34. Small-angle light scattering of polymer liquid crystals under shear flow.

Author

Takebe, Tomoaki, Hashimoto, Takeji, Ernst, Benoit, Navard, Patrick, and Stein, Richard S.

Subjects
LIQUID crystals, POLYMERS, LIGHT scattering, SHEAR flow
Abstract

We presented some experimental results on flow small-angle light scattering (‘‘flow SALS’’) of lyotropic polymer liquid crystals which involved real-time, in situ, and simultaneous measurements of mechanical properties and small-angle light scattering (SALS) of a complex structured fluid. The flow-SALS studies were conducted under steady-state Couette flow and during relaxation process occurring after the cessation of the steady-state shear flow. We found the following universal behavior on the structure and properties for two kinds of the liquid crystal systems, i.e., poly(γ-benzyl L-glutamate) in m-cresol and hydroxypropyl cellulose in water. (i) Upon increasing shear rate γ, the ‘‘polydomain’’ structure gradually tends to be transformed to the essentially ‘‘monodomain’’ texture through annihilation of the disclinations. On the top of this general tendency, we found more specific characteristic of the fluid systems with γ, (ii) at γ<γc, a critical shear rate above which a remarkable shear thinning occurs, the disclinations are more or less uniformly distributed in space, while at γ>γc the disclinations are localized into domains and dispersed in the more or less uniform medium with a high degree of orientation, (iii) the relaxation after cessation of the steady state shear depends on its γ before the cessation and is quite different below and above γc, and (iv) the cessation from γ>γc involves formation of the ‘‘band texture’’ during the relaxation process of the fluids. [ABSTRACT FROM AUTHOR]

Published
1990
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