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2. Fast- and thermal-neutron detection with common NaI(Tl) detectors

Author

Pausch, Guntram, Kreuels, Achim, Scherwinski, Falko, Kong, Yong, Kuester, Mathias, Lentering, Ralf, Wolf, Andreas, and Stein, Juergen

Subjects
Physics - Instrumentation and Detectors, Nuclear Experiment, Physics - Applied Physics, Physics - Geophysics, Physics - Medical Physics
Abstract

Radionuclide Identification Devices (RIDs) or Backpack Radiation Detection Systems (BRDs) are often equipped with NaI(Tl) detectors. We demonstrate that such instruments could be provided with reasonable thermal- and fast-neutron sensitivity by means of an improved and sophisticated processing of the digitized detector signals: Fast neutrons produce nuclear recoils in the scintillation crystal. Corresponding signals are detectible and can be distinguished from that of electronic interactions by pulse-shape discrimination (PSD) techniques as used in experiments searching for weakly interacting massive particles (WIMPs). Thermal neutrons are often captured in iodine nuclei of the scintillator. The gamma-ray cascades following such captures comprise a sum energy of almost 7 MeV, and some of them involve isomeric states leading to delayed gamma emissions. Both features can be used to distinguish corresponding detector signals from responses to ambient gamma radiation. The experimental proof was adduced by offline analyses of pulse records taken with a commercial RID. An implementation of such techniques in commercial RIDs is feasible., Comment: 7 pages, 5 figures; invited paper to be presented at the 2022 SPIE Optics + Photonics Conference in San Diego, CA

Published
2022

3. Modified-Release Phosphatidylcholine (LT-02) for Ulcerative Colitis: Two Double-Blind, Randomized, Placebo-Controlled Trials

Author

Dignass, Axel, Stremmel, Wolfgang, Horyński, Marek, Poyda, Oleksandr, Armerding, Peter, Fellermann, Klaus, Langhorst, Jost, Kuehbacher, Tanja, Uebel, Peter, Stein, Juergen, Novacek, Gottfried, Avalueva, Elena, Oliinyk, Oleksandr, Hasselblatt, Peter, Dorofeyev, Andrey, Heinemann, Heidrun, Mueller, Ralph, Greinwald, Roland, and Reinisch, Walter

Published
2024
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16. Iron therapy supplementation in inflammatory bowel disease patients with iron deficiency anemia: findings from a real-world analysis in Italy

Author

Fiorino, Gionata, primary, Colombel, Jean-Frederic, additional, Katsanos, Kostas, additional, Mearin, Fermín, additional, Stein, Jürgen, additional, Andretta, Margherita, additional, Antonacci, Stefania, additional, Arenare, Loredana, additional, Citraro, Rita, additional, Dell’Orco, Stefania, additional, Degli Esposti, Luca, additional, Ramirez de Arellano Serna, Antonio, additional, Morin, Neige Teldja, additional, and Koutroubakis, Ioannis E., additional

Published
2024
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20. Use of Biomarkers of Inflammation in the Differentiation of Iron Deficiency and Anaemia—Lessons from Inflammatory Bowel Disease.

Author

Farrag, Karima, Aksan, Aysegül, Ademaj-Kospiri, Valëza, Leventi, Eleni, and Stein, Jürgen

Subjects
INFLAMMATORY bowel diseases, IRON deficiency anemia, CROHN'S disease, ULCERATIVE colitis, IRON deficiency
Abstract

Iron deficiency and iron deficiency anaemia are common in inflammatory bowel disease (IBD), to the detriment of the patients' quality of life. Since ferritin, as an acute-phase protein (APP), has limited diagnostic value in IBD, concurrent assessment of C-reactive protein (CRP) is recommended. The World Health Organization suggests using α1-acid glycoprotein (AGP) as an additional biomarker due to its differing half-life. This study aimed to evaluate ferritin levels in patients with IBD using CRP and AGP, individually and in combination. A total of 118 patients with IBD (mean age: 45.48 ± 15.25 years, 47.46% female) were recruited, including 38 with Crohn's disease, 47 with ulcerative colitis, and 33 controls. The results showed that while CRP alone detected an inflammatory increase in ferritin of 29.76%, this increased to 82.14% when AGP or both AGP and CRP were considered (p < 0.05). Elevated AGP levels were more prevalent in patients with ulcerative colitis. However, concordance between high CRP and AGP levels was confirmed in only 55% of cases. Correcting for inflammation using CRP and/or AGP significantly improved the diagnostic accuracy of ferritin levels in patients with IBD, highlighting the challenge posed by inflammation when assessing iron deficiency. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Impact of dose intensified salvage radiation therapy on urinary continence recovery after radical prostatectomy: Results of the randomized trial SAKK 09/10

Author

Ghadjar, Pirus, Hayoz, Stefanie, Bernhard, Jürg, Zwahlen, Daniel R., Stein, Jürgen, Hölscher, Tobias, Gut, Philipp, Polat, Bülent, Hildebrandt, Guido, Müller, Arndt-Christian, Putora, Paul Martin, Papachristofilou, Alexandros, Schär, Corinne, Dal Pra, Alan, Biaggi Rudolf, Christine, Wust, Peter, Aebersold, Daniel M., and Thalmann, George N.

Published
2018
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28. ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease.

Author

Gordon, Hannah, Burisch, Johan, Ellul, Pierre, Karmiris, Konstantinos, Katsanos, Konstantinos, Allocca, Mariangela, Bamias, Giorgos, Acosta, Manuel Barreiro-de, Braithwaite, Tasanee, Greuter, Thomas, Harwood, Catherine, Juillerat, Pascal, Lobaton, Triana, Müller-Ladner, Ulf, Noor, Nurulamin, Pellino, Gianluca, Savarino, Edoardo, Schramm, Christoph, Soriano, Alessandra, and Stein, Jürgen Michael

Published
2024
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38. Entzündliche Erkrankungen des Dünn- und Dickdarms

Author

Lembcke, Bernhard, Schulze, Hermann, Dignaß, Axel, Scheuerlein, Hubert, Settmacher, Utz, Tromm, Andreas, Erckenbrecht, Joachim F., Jonas, Sven, Mirow, Lutz, Hildebrand, Philipp, Caspary, Wolfgang F., Stein, Jürgen, Erckenbrecht, J.F., editor, and Jonas, Sven, editor

Published
2015
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47. ECCO Guidelines on Extraintestinal Manifestations in Inflammatory Bowel Disease

Author

Gordon, Hannah, Burisch, Johan, Ellul, Pierre, Karmiris, Konstantinos, Katsanos, Konstantinos, Allocca, Mariangela, Bamias, Giorgos, Barreiro-de Acosta, Manuel, Braithwaite, Tasanee, Greuter, Thomas, Harwood, Catherine, Juillerat, Pascal, Lobaton, Triana, Müller-Ladner, Ulf, Noor, Nurulamin, Pellino, Gianluca, Savarino, Edoardo, Schramm, Christoph, Soriano, Alessandra, Stein, Jürgen Michael, Uzzan, Mathieu, van Rheenen, Patrick F, Vavricka, Stephan R, Vecchi, Maurizio, Zuily, Stephane, and Kucharzik, Torsten

Subjects
610 Medizin und Gesundheit
Published
2023
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48. sj-docx-1-tag-10.1177_17562848231177153 – Supplemental material for Iron deficiency anemia impacts disease progression and healthcare resource consumption in patients with inflammatory bowel disease: a real-world evidence study

Author

Fiorino, Gionata, Colombel, Jean-Frederic, Katsanos, Kostas, Mearin, Fermín, Stein, Jürgen, Andretta, Margherita, Antonacci, Stefania, Arenare, Loredana, Citraro, Rita, Dell’Orco, Stefania, Degli Esposti, Luca, Ramirez de Arellano Serna, Antonio, Morin, Neige, and Koutroubakis, Ioannis E.

Subjects
FOS: Clinical medicine, 111199 Nutrition and Dietetics not elsewhere classified, FOS: Health sciences, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified, 111299 Oncology and Carcinogenesis not elsewhere classified
Abstract

Supplemental material, sj-docx-1-tag-10.1177_17562848231177153 for Iron deficiency anemia impacts disease progression and healthcare resource consumption in patients with inflammatory bowel disease: a real-world evidence study by Gionata Fiorino, Jean-Frederic Colombel, Kostas Katsanos, Fermín Mearin, Jürgen Stein, Margherita Andretta, Stefania Antonacci, Loredana Arenare, Rita Citraro, Stefania Dell’Orco, Luca Degli Esposti, Antonio Ramirez de Arellano Serna, Neige Morin and Ioannis E. Koutroubakis in Therapeutic Advances in Gastroenterology

Published
2023
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