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16. The effects of ES-62 on DC maturation and effector function

Author

Steiger, Christina Nicola

Subjects
616.079, QR180 Immunology
Abstract

Furthermore, these studies provide a better understanding of the therapeutic potential of this parasite molecule in inflammatory diseases such as CIA and asthma and collectively, they have demonstrated the potent immunomodulatory effects of ES-62.

Published
2008

20. The Kocher–Caird Criteria for Pediatric Septic Arthritis of the Hip: Time for a Change in the Kingella Era?

Author

Valisena, Silvia, De Marco, Giacomo, Vazquez, Oscar, Cochard, Blaise, Steiger, Christina, Dayer, Romain, and Ceroni, Dimitri

Subjects
INFECTIOUS arthritis, LEUCOCYTES, BLOOD sedimentation, CHILD patients, C-reactive protein, FEVER
Abstract

Pediatric septic arthritis of the hip (SAH) in children is a severe pathology, requiring prompt diagnosis and treatment to avoid destructive sequelae of the joint. Its diagnosis can be challenging, however, due to its spectrum of manifestations and differential diagnosis. Last century, multiple research teams studied the curves of systemic inflammation markers to aid the differential diagnosis. Kocher showed that a history of fever >38.5 °C, non-weight bearing, an erythrocyte sedimentation rate >40 mm/h, and serum white blood cells >12,000/mm3 were highly suggestive of SAH, with a predicted probability of 99.6% when all these predictors manifested in pediatric patients. Caird validated these criteria, also adding a C-reactive protein >20 mg/L, reaching a 98% probability of SAH when these five criteria were present. The Kocher and the Caird criteria were then applied in multiple settings, but were never clearly validated. Moreover, they were studied and validated in the years when Kingella kingae was just emerging, and this was probably responsible for false-negative cases in multiple centers. For this reason, the Kocher and the Caird criteria are still at the center of a debate on the diagnostic tools for pediatric SAH. We provide a historical overview of the development of clinical and laboratory test algorithms for pediatric SAH. Further, new perspectives for future research on the prediction rules of pediatric SAH are here proposed. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Transphyseal Hematogenous Osteomyelitis: An Epidemiological, Bacteriological, and Radiological Retrospective Cohort Analysis

Author

Cochard, Blaise, primary, Habre, Céline, additional, Pralong-Guanziroli, Nastassia, additional, Gavira, Nathaly, additional, Di Laura Frattura, Giorgio, additional, Di Marco, Giacomo, additional, Steiger, Christina N., additional, De Coulon, Geraldo, additional, Dayer, Romain, additional, and Ceroni, Dimitri, additional

Published
2023
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35. Pediatric hand injuries – current treatment recommendations for injuries around the finger joints

Author

Steiger, Christina

Subjects
Pediatric hand injuries, Pediatric finger fractures, Pediatric finger trauma
Abstract

Pediatric hand injuries are a frequent worldwide cause for trauma consultations. To properly treat these injuries, physicians must be familiar with the particular anatomy and physiology of the growing skeleton. While many current treatment protocols are based on expert opinions this narrative review examined data from published studies to determine evidenced based treatment recommendations if such exist.

Published
2022
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37. Osteoarticular Infections in Children: Accurately Distinguishing between MSSA and Kingella kingae.

Author

Coulin, Benoit, DeMarco, Giacomo, Vazquez, Oscar, Spyropoulou, Vasiliki, Gavira, Nathaly, Vendeuvre, Tanguy, Tabard-Fougère, Anne, Dayer, Romain, Steiger, Christina, and Ceroni, Dimitri

Subjects
TODDLERS, PLATELET count, INFANTS, RECEIVER operating characteristic curves, BACTERIAL cultures, JOINTS (Anatomy), UNIVARIATE analysis, KRUSKAL-Wallis Test
Abstract

Introduction: Osteoarticular infections (OAIs) constitute serious paediatric conditions that may cause severe complications. Identifying the causative organism is one of the mainstays of the care process, since its detection will confirm the diagnosis, enable adjustments to antibiotic therapy and thus optimize outcomes. Two bacteria account for the majority of OAIs before 16 years of age: Staphylococcus aureus is known for affecting the older child, whereas Kingella kingae affects infants and children younger than 4 years old. We aimed to better define clinical characteristic and biological criteria for prompt diagnosis and discrimination between these two OAI. Materials and methods: We retrospectively studied 335 children, gathering 100 K. kingae and 116 S. aureus bacteriologically proven OAIs. Age, gender, temperature at admission, involved bone or joint, and laboratory data including bacterial cultures were collected for analysis. Comparisons between patients with OAI due to K. kingae and those with OAI due to S. aureus were performed using the Mann–Whitney and Kruskal–Wallis tests. Six cut-off discrimination criteria (age, admission's T°, WBC, CRP, ESR and platelet count) were defined, and their respective ability to differentiate between OAI patients due to K. kingae versus those with S. aureus was assessed by nonparametric receiver operating characteristic (ROC) curves. Results: Univariate analysis demonstrated significant differences between the two populations for age of patients, temperature at admission, CRP, ESR, WBC, and platelet count. AUC assessed by ROC curves demonstrated an exquisite ability to discriminate between the two populations for age of the patients; whereas AUC for CRP (0.79), temperature at admission (0.76), and platelet count (0.76) indicated a fair accuracy to discriminate between the two populations. Accuracy to discriminate between the two subgroups of patients was considered as poor for WBC (AUC = 0.62), and failed for ESR (AUC = 0.58). On the basis of our results, the best model to predict K. kingae OAI included of the following cut-offs for each parameter: age < 43 months, temperature at admission < 37.9 °C, CRP < 32.5 mg/L, and platelet count > 361,500/mm3. Conclusions: OAI caused by K. kingae affects primarily infants and toddlers aged less than 4 years, whereas most of the children with OAI due to MSSA were aged 4 years and more. Considering our experience on the ground, only three variables were very suggestive of an OAI caused by K. kingae, i.e., age of less than 4 years, platelet count > 400,000, and a CRP level below 32.5 mg/L, whereas WBC and ESR were relatively of limited use in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2023
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46. Osteoarticular infection in children

Author

Coulin, Benoit, primary, Demarco, Giacomo, additional, Spyropoulou, Vanessa, additional, Juchler, Celine, additional, Vendeuvre, Tanguy, additional, Habre, Céline, additional, Tabard-Fougère, Anne, additional, Dayer, Romain, additional, Steiger, Christina, additional, and Ceroni, Dimitri, additional

Published
2021
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