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ObjectiveMechanisms of neurocognitive injury as post-operative sequelae of coronary artery bypass grafting (CABG) are not understood. The systemic inflammatory response to surgical stress causes skeletal muscle impairment, and this is also worsened by immobility. Since evidence supports a link between muscle vitality and neuroprotection, there is a need to understand the mechanisms by which promotion of muscle activity counteracts the deleterious effects of surgery on long-term cognition.MethodsWe performed a clinical trial to test the hypothesis that adding neuromuscular electrical stimulation (NMES) to standard rehabilitation care in post-CABG patients promotes the maintenance of skeletal muscle strength and the expression of circulating neuroprotective myokines.ResultsWe did not find higher serum levels of neuroprotective myokines, except for interleukin-6, nor better long-term cognitive performance in our intervention group. However, a greater increase in functional connectivity at brain magnetic resonance was seen between seed regions within the default mode, frontoparietal, salience, and sensorimotor networks in the NMES group. Regardless of the treatment protocol, patients with a Klotho increase 3 months after hospital discharge compared to baseline Klotho values showed better scores in delayed memory tests.SignificanceWe confirm the potential neuroprotective effect of Klotho in a clinical setting and for the first time post-CABG.

Previous literature suggested that individuals increase temporal and risk discounting at the presence of a proposer whose face is perceived as untrustworthy, suggesting the activation of protective choice patterns. By the way, the COVID-19 pandemic has substantially transformed the way we interact with other people, even bringing us into situations where the face of the person making a proposal is not fully visible, because of the mask. With the current study, we aimed at verifying if the effect of proposer’s facial (un)trustworthiness on discounting behavior is modulated by mask wearing. In two different experiments, participants performed traditional delay and probability discounting tasks with masked proposers manipulated across trustworthiness levels. Results highlighted that, even after checking for subject-specific emotion recognition ability with masked faces, the presence of a masked untrustworthy proposer increases both delay and probability discounting parameters, although the effect is not statistically significant and smaller than the one detected at the presence of an untrustworthy proposer without a mask. These results suggest that the ability to perceive the proposer’s (un)trustworthiness is affected by the mask, with a consequent less strong effect of proposer’s (un)trustworthiness on choice behavior on both intertemporal and risky choices. Limits and possible implications are outlined and discussed.

Abstract After the COVID-19 worldwide spread, evidence suggested a vast diffusion of negative consequences on people's mental health. Together with depression and sleep difficulties, anxiety symptoms seem to be the most diffused clinical outcome. The current contribution aimed to examine attentional bias for virus-related stimuli in people varying in their degree of health anxiety (HA). Consistent with previous literature, it was hypothesized that higher HA would predict attentional bias, tested using a visual dot-probe task, to virus-related stimuli. Participants were 132 Italian individuals that participated in the study during the lockdown phase in Italy. Results indicated that the HA level predicts attentional bias toward virus-related objects. This relationship is double mediated by the belief of contagion and by the consequences of contagion as assessed through a recent questionnaire developed to measure the fear for COVID-19. These findings are discussed in the context of cognitive-behavioral conceptualizations of anxiety suggesting a risk for a loop effect. Future research directions are outlined.

The current study examines the association of individual hoarding levels with temporal discounting of different commodities during the COVID-19 pandemic. Based on their hoarding level, participants were assigned to the Hoarding Group (HG) or the Non-Hoarding Group (NHG). Participants performed two delay discounting tasks: a traditional task with monetary options and a modified task, where money was replaced with disposable surgical masks, a needed commodity during the pandemic. Results revealed a stronger preference for immediate commodity, therefore a higher discount rate, when evaluating surgical masks compared to money in the whole sample, and an overall higher tendency in discounting both type of rewards in the NHG compared to the HG. Moreover, non-hoarders discounted money significantly more than hoarders, while no significant differences were detected in the surgical mask version of the task. Possible explanations for this result are discussed in the light of a situational frame that makes salient the notion of scarcity, like the one induced by the COVID-19 pandemic. The hoarding dimension of cluttering was found to be the only dimension to significantly correlate with the discount rate on surgical masks. Altogether, these findings shed light on the role of general hoarding level and specific hoarding dimensions on intertemporal preferences with different commodities by contributing to the theoretical debate about impulsivity in hoarders' behavior. Furthermore, the present results help to understand the general population's preferences during times of crisis, thus contributing to the investigation of the effects of COVID-19 on consumers' behavior.

Facial mimicry is described by embodied cognition theories as a human mirror system-based neural mechanism underpinning emotion recognition. This could play a critical role in the Self-Mirroring Technique (SMT), a method used in psychotherapy to foster patients’ emotion recognition by showing them a video of their own face recorded during an emotionally salient moment. However, dissociation in facial mimicry during the perception of own and others’ emotions has not been investigated so far. In the present study, we measured electromyographic (EMG) activity from three facial muscles, namely, the zygomaticus major (ZM), the corrugator supercilii (CS), and the levator labii superioris (LLS) while participants were presented with video clips depicting their own face or other unknown faces expressing anger, happiness, sadness, disgust, fear, or a neutral emotion. The results showed that processing self vs. other expressions differently modulated emotion perception at the explicit and implicit muscular levels. Participants were significantly less accurate in recognizing their own vs. others’ neutral expressions and rated fearful, disgusted, and neutral expressions as more arousing in the self condition than in the other condition. Even facial EMG evidenced different activations for self vs. other facial expressions. Increased activation of the ZM muscle was found in the self condition compared to the other condition for anger and disgust. Activation of the CS muscle was lower for self than for others’ expressions during processing a happy, sad, fearful, or neutral emotion. Finally, the LLS muscle showed increased activation in the self condition compared to the other condition for sad and fearful expressions but increased activation in the other condition compared to the self condition for happy and neutral expressions. Taken together, our complex pattern of results suggests a dissociation at both the explicit and implicit levels in emotional processing of self vs. other emotions that, in the light of the Emotion in Context view, suggests that STM effectiveness is primarily due to a contextual–interpretative process that occurs before that facial mimicry takes place.

Individual differences in temporal and probabilistic discounting are associated with a wide range of life outcomes in literature. Traditional approaches have focused on impulsiveness and cognitive control skills, on goal-oriented personality traits as well as on the psychological perception of time. More recently, literature started to consider the role of social and contextual factors in discounting behavior. Between others, higher generalized trust in human beings and specific trust in people who will deliver the future/probabilistic rewards have been related to a stronger willingness to wait and to assume risk. Moreover, the tendency to trust others has been associated with the oxytocin receptor gene regulation that can be modified by life experiences. In this perspective, we hypothesized that differences in the tendency to wait and to take risks for a more desirable reward according to the proposer’s trustworthiness could be related to a different level of DNA methylation at the oxytocin receptor gene. Findings confirmed that participants are less willing to wait and to risk when the proposer is considered highly untrustworthy and revealed how higher oxytocin receptor gene DNA methylation is associated with a stronger effect due to the presence of an untrustworthy proposer. Limits and future directions are outlined.