1. Early Nutrition Intervention Attenuates Weight Gain for Pediatric Acute Lymphoblastic Leukemia Patients in Maintenance Therapy
- Author
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Lisa Bashore, Kenneth Heym, W. Paul Bowman, Stefanie Rapisand, Kari M. Galipp, Tyler Hamby, and Rachel Hill
- Subjects
Male ,Pediatric Obesity ,Pediatrics ,medicine.medical_specialty ,Antineoplastic Agents ,Weight Gain ,03 medical and health sciences ,0302 clinical medicine ,Maintenance therapy ,Intervention (counseling) ,Humans ,Medicine ,Child ,Retrospective Studies ,business.industry ,Medical record ,Infant ,Retrospective cohort study ,Hematology ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Anthropometry ,medicine.disease ,Obesity ,Oncology ,Child, Preschool ,030220 oncology & carcinogenesis ,Pediatrics, Perinatology and Child Health ,Physical therapy ,Female ,medicine.symptom ,business ,Body mass index ,Weight gain ,Diet Therapy ,030215 immunology - Abstract
Obesity following treatment of pediatric acute lymphoblastic leukemia (ALL) has become a significant long-term concern. Excessive weight gain often occurs during treatment, particularly during induction and the first 6 months of maintenance therapy, and it may be potentially modifiable. This retrospective study aimed to evaluate the impact of an early, 3-visit nutrition intervention on weight gain during maintenance therapy in ALL patients. Medical records of the intervention group were compared with historical controls who were treated on the same ALL treatment protocols during an earlier time period. Anthropometrics were collected throughout intensive therapy and at every monthly visit during the first 12 months of maintenance therapy. In total, 67 patients were evaluated (33 in the intervention group and 34 in the control group). After controlling for significant predictors of body mass index (BMI) z-scores in maintenance therapy-including higher BMI at diagnosis and weight gain throughout intensive therapy-the intervention group demonstrated more controlled weight gain during maintenance therapy (P
- Published
- 2018
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