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7 results on '"Stefancova, Dorota"'

1. PDGFRβ+ cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

Author

Sá da Bandeira, Diana, Kilpatrick, Alastair Morris, Marques, Madalena, Gomez-Salazar, Mario, Ventura, Telma, Gonzalez, Zaniah Nashira, Stefancova, Dorota, Rossi, Fiona, Vermeren, Matthieu, Vink, Chris Sebastiaan, Beltran, Mariana, Henderson, Neil Cowan, Jung, Bongnam, van der Linden, Reinier, van de Werken, Harmen Jan George, van Ijcken, Wilfred F.J., Betsholtz, Christer, Forbes, Stuart John, Cuervo, Henar, and Crisan, Mihaela

Published
2022
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3. Aldehyde Dehydrogenase, a Marker of Normal and Malignant Stem Cells, Typifies Mesenchymal Progenitors in Perivascular Niches

Author

Gomez-Salazar, Mario A, primary, Wang, Yiyun, additional, Thottappillil, Neelima, additional, Hardy, Reef W, additional, Alexandre, Manon, additional, Höller, Fabian, additional, Martin, Niall, additional, Gonzalez-Galofre, Zaniah N, additional, Stefancova, Dorota, additional, Medici, Daniele, additional, James, Aaron W, additional, and Péault, Bruno, additional

Published
2023
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5. PDGFR beta(+) cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

Author

da Bandeira, Diana Sa, Kilpatrick, Alastair Morris, Marques, Madalena, Gomez-Salazar, Mario, Ventura, Telma, Gonzalez, Zaniah Nashira, Stefancova, Dorota, Rossi, Fiona, Vermeren, Matthieu, Vink, Chris Sebastiaan, Beltran, Mariana, Henderson, Neil Cowan, Jung, Bongnam, van der Linden, Reinier, van de Werken, Harmen Jan George, van Ijcken, Wilfred F. J., Betsholtz, Christer, Forbes, Stuart John, Cuervo, Henar, Crisan, Mihaela, da Bandeira, Diana Sa, Kilpatrick, Alastair Morris, Marques, Madalena, Gomez-Salazar, Mario, Ventura, Telma, Gonzalez, Zaniah Nashira, Stefancova, Dorota, Rossi, Fiona, Vermeren, Matthieu, Vink, Chris Sebastiaan, Beltran, Mariana, Henderson, Neil Cowan, Jung, Bongnam, van der Linden, Reinier, van de Werken, Harmen Jan George, van Ijcken, Wilfred F. J., Betsholtz, Christer, Forbes, Stuart John, Cuervo, Henar, and Crisan, Mihaela

Abstract

Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requires HSC specification signals from the surrounding microenvironment. In zebrafish, PDGF-B/PDGFR beta signaling controls hematopoietic stem/progenitor cell (HSPC) generation and is required in the HSC specification niche. Little is known about murine HSPC specification in vivo and whether PDGF-B/PDGFR beta is involved. Here, we show that PDGFR beta is expressed in distinct perivascular stromal cell layers surrounding the mid-gestation dorsal aorta, and its deletion impairs hematopoiesis. We demonstrate that PDGFR beta(+) cells play a dual role in murine hematopoiesis. They act in the aortic niche to support HSPCs, and in addition, PDGFR beta(+) embryonic precursors give rise to a subset of HSPCs that persist into adulthood. These findings provide crucial information for the controlled production of HSPCs in vitro.

Published
2022
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6. 3060 – PDGFRΒ+ CELLS PLAY A DUAL ROLE AS HEMATOPOIETIC PRECURSORS AND NICHE CELLS DURING MOUSE ONTOGENY

Author

Crisan, Mihaela, primary, da bandeira, Diana Sa, additional, Kilpatrick, Alastair, additional, Marques, Madalena, additional, Gomez-salazar, Mario, additional, Ventura, Telma, additional, Gonzalez, Zaniah, additional, Stefancova, Dorota, additional, Rossi, Fiona, additional, Vink, Chris, additional, Beltran, Mariana, additional, Henderson, Neil, additional, Jung, Bongnam, additional, Van Der Linden, Reinier, additional, Werken, Harmen Van De, additional, Van IJcken, Wilfred, additional, Betsholtz, Christer, additional, Forbes, Stuart, additional, and Cuervo, Henar, additional

Published
2022
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7. PDGFRβ+cells play a dual role as hematopoietic precursors and niche cells during mouse ontogeny

Author

Sá da Bandeira, Diana, Kilpatrick, Alastair Morris, Marques, Madalena, Gomez-Salazar, Mario, Ventura, Telma, Gonzalez, Zaniah Nashira, Stefancova, Dorota, Rossi, Fiona, Vermeren, Matthieu, Vink, Chris Sebastiaan, Beltran, Mariana, Henderson, Neil Cowan, Jung, Bongnam, van der Linden, Reinier, van de Werken, Harmen Jan George, van Ijcken, Wilfred F.J., Betsholtz, Christer, Forbes, Stuart John, Cuervo, Henar, and Crisan, Mihaela

Abstract

Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requires HSC specification signals from the surrounding microenvironment. In zebrafish, PDGF-B/PDGFRβ signaling controls hematopoietic stem/progenitor cell (HSPC) generation and is required in the HSC specification niche. Little is known about murine HSPC specification in vivoand whether PDGF-B/PDGFRβ is involved. Here, we show that PDGFRβ is expressed in distinct perivascular stromal cell layers surrounding the mid-gestation dorsal aorta, and its deletion impairs hematopoiesis. We demonstrate that PDGFRβ+cells play a dual role in murine hematopoiesis. They act in the aortic niche to support HSPCs, and in addition, PDGFRβ+embryonic precursors give rise to a subset of HSPCs that persist into adulthood. These findings provide crucial information for the controlled production of HSPCs in vitro.

Published
2022
Full Text
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