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Like neocortical structures, the archicortical hippocampus differs in its folding patterns across individuals. Here, we present an automated and robust BIDS-App, HippUnfold, for defining and indexing individual-specific hippocampal folding in MRI, analogous to popular tools used in neocortical reconstruction. Such tailoring is critical for inter-individual alignment, with topology serving as the basis for homology. This topological framework enables qualitatively new analyses of morphological and laminar structure in the hippocampus or its subfields. It is critical for refining current neuroimaging analyses at a meso- as well as micro-scale. HippUnfold uses state-of-the-art deep learning combined with previously developed topological constraints to generate uniquely folded surfaces to fit a given subject’s hippocampal conformation. It is designed to work with commonly employed sub-millimetric MRI acquisitions, with possible extension to microscopic resolution. In this paper, we describe the power of HippUnfold in feature extraction, and highlight its unique value compared to several extant hippocampal subfield analysis methods.

Vision neuroscience has made great strides in understanding the hierarchical organization of object representations along the ventral visual stream (VVS). How VVS representations capture fine-grained visual similarities between objects that observers subjectively perceive has received limited examination so far. In the current study, we addressed this question by focussing on perceived visual similarities among subordinate exemplars of real-world categories. We hypothesized that these perceived similarities are reflected with highest fidelity in neural activity patterns downstream from inferotemporal regions, namely in perirhinal (PrC) and anterolateral entorhinal cortex (alErC) in the medial temporal lobe. To address this issue with functional magnetic resonance imaging (fMRI), we administered a modified 1-back task that required discrimination between category exemplars as well as categorization. Further, we obtained observer-specific ratings of perceived visual similarities, which predicted behavioural discrimination performance during scanning. As anticipated, we found that activity patterns in PrC and alErC predicted the structure of perceived visual similarity relationships among category exemplars, including its observer-specific component, with higher precision than any other VVS region. Our findings provide new evidence that subjective aspects of object perception that rely on fine-grained visual differentiation are reflected with highest fidelity in the medial temporal lobe.

New neurons are continuously produced throughout adulthood in the hippocampus. Here the authors provide evidence that adult hippocampal neurogenesis weakens existing memories, and facilitates the encoding of new, confliction information in mice.

La importancia de la producción de lana ha disminuido en las últimas décadas por la competencia de otras fibras, tanto sintéticas como de origen animal o vegetal. A pesar de los muchos atributos positivos que tiene, la lana ha quedado en un segundo plano dentro de las fibras textiles, en parte debido a la falta de información de los consumidores, desinterés por parte de la industria, márgenes abusivos en los precios finales, falta de transparencia del sector... En España la reducción del valor de la lana ha provocado el cierre de muchas empresas transformadoras tradicionales, disminución de las cabezas de ganado, desinterés de la producción de lana en las explotaciones llegándola a considerar un subproducto, teniendo en cuenta que es una producción obligada en la explotación ovina, es necesario adoptar medidas para obtener el máximo beneficio económico. El estudio de la cadena de valor de la lana de oveja es necesario para conocer la estructura del sector, su conducta y el funcionamiento para así poder proponer posibles usos a la lana que no es de interés para la industria textil. del prototipo sobre PROTEUS, emulando también la electrónica. Además, se grafican los esquemas electrónicos simulados del sistema, se brindan datos de parámetros y el estado de las alarmas.

Peatland restoration can have several objectives, for example re-establishing the natural habitat, supporting unique biodiversity attributes or re-initiating key biogeochemical processes, which can ultimately lead to a reduction in greenhouse gas (GHG) emissions. Every restoration measure, however, is itself a disturbance to the ecosystem.Here, we examine an ecosystem shift in a coastal fen at the southern Baltic Sea which was rewetted by flooding. The analyses are based on one year of bi-weekly closed chamber measurements of methane fluxes gathered at spots located in different vegetation stands. During measurement campaigns, we recorded data on water levels, peat temperatures, and chemical properties of peat water. In addition we analyzed the first 20 cm of peat before and after flooding for dry bulk density (DBD), content of organic matter and total amounts of carbon (C), nitrogen (N), sulfur (S), and other nutrients.Rewetting turned the site from a summer dry fen into a shallow lake with water levels up to 0.60 m. We observed a substantial die-back of vegetation, especially in stands of sedges (Carex acutiformis Ehrh). Concentrations of total organic carbon and nitrogen in the peat water, as well as dry bulk density and concentrations of C, N and S in the peat increased. In the first year after rewetting, the average annual exchange of methane amounted to 0.26 ± 0.06 kg m-2. This is equivalent to a 190-times increase in methane compared to pre-flooding conditions. Highest methane fluxes occurred in sedge stands which suffered from the heaviest die-back. None of the recorded environmental variables showed consistent relationships with the amounts of methane exchanged.Our results suggest that rewetting projects should be monitored not only with regard to vegetation development but also with respect to biogeochemical conditions. Further, high methane emissions that likely occur directly after rewetting by flooding should be considered when forecasting the overall effect of rewetting on GHG exchange.

Managing ecosystems for carbon storage may also benefit biodiversity conservation, but such a potential 'win-win' scenario has not yet been assessed for tropical agroforestry landscapes. We measured above- and below-ground carbon stocks as well as the species richness of four groups of plants and eight of animals on 14 representative plots in Sulawesi, Indonesia, ranging from natural rainforest to cacao agroforests that have replaced former natural forest. The conversion of natural forests with carbon stocks of 227-362 Mg C ha(-1) to agroforests with 82-211 Mg C ha(-1) showed no relationships to overall biodiversity but led to a significant loss of forest-related species richness. We conclude that the conservation of the forest-related biodiversity, and to a lesser degree of carbon stocks, mainly depends on the preservation of natural forest habitats. In the three most carbon-rich agroforestry systems, carbon stocks were about 60% of those of natural forest, suggesting that 1.6 ha of optimally managed agroforest can contribute to the conservation of carbon stocks as much as 1 ha of natural forest. However, agroforestry systems had comparatively low biodiversity, and we found no evidence for a tight link between carbon storage and biodiversity. Yet, potential win-win agroforestry management solutions include combining high shade-tree quality which favours biodiversity with cacao-yield adapted shade levels.

A federal pilot project will explore the role played by economically strong border regions in interaction with European metropolitan and urban regions. Jointly with partners from the Maas-Rhine Euroregion, (SaarLorLux+) Euroregion, Trinational Upper Rhine metropolitan area and Lake Constance region, the regional policy of the federal government is aimed at establishing the particular importance of cross-border metropolitan areas for growth and innovation, as well as for the European target of territorial cohesion, within regional policy discussions in Germany and Europe. Testing the strategic approach of “supra-regional partnerships” in a cross-border context, is one significant aspect. The interests of the partners involved in the project are furthermore focussed on the regions themselves. This means, the project is dedicated to promote a coherent regional development, as well as effective cooperation structures across national borders. The project finally pursues the creation of an initiative in the form of an open alliance of cross-border metropolitan regions, in order to more effectively represent the interests of border regions on a national and European level. The article explores the genesis, objectives and approach of this pilot project against the background provided by current debates on sustainable spatial development in Germany and Europe.

The ARL working group “Climate Change and Spatial Planning” conducted a survey among German regional planning authorities on how they currently treat the issue of climate change in their activities. The survey covered the availability of information on climate change, current possibilities and experiences in the field of mitigation, future challenges regarding adaptation to climate change and subsequent consequences for planning procedures. The results of the survey show that at present, regional planners mostly treat mitigation issues when considering climate change. Few experiences have been made regarding adaptation to climate change. The role of spatial planning in the context of climate change has not been defined clearly so far.

Die rund 120 000 Einwohner zählende Großstadt Heilbronn gilt als markantes Fallbeispiel dafür, daß Städte und Regionen von dem Ausbau des Hochgeschwindigkeitsnetzes der Bahn nicht nur profitieren, sondern hierdurch auch in den „Verkehrsschatten” geraten können. Verantwortlich für letztere Entwicklung ist im Falle von Heilbronn vor allem eine ungünstige Trassierung des Schienennetzes in den mäandrierenden Tallagen des Neckars und seiner Zuflüsse, die historische Entwicklung in Deutschland mit zwischenzeitlicher Teilung und späterer Wiedervereinigung sowie die Konzentration von Investitionen zum Bau von Schnellbahnstrecken in anderen Teilräumen der Bundesrepublik.

Abstract Background The Global Drug Facility (GDF) of the Stop TB Partnership was launched in 2001 with the goal of increasing access to quality-assured tuberculosis (TB) drugs and products. We aimed to describe the TB drugs and prices available from the GDF over time and to assess trends. Methods We searched the internet, including an internet archive, for past and recent GDF Product Catalogs and extracted the listed TB drugs and prices. We calculated the lowest price for the most common drug formulations assuming drugs with similar active pharmaceutical ingredients (APIs) are substitutes for each other. We assessed time trends in the TB drugs and prices offered by the GDF in univariable regressions over the longest possible period. Results We identified 43 different GDF Product Catalogs published between November 2001 and May 2024. These product catalogs included 122 single medicines (31 APIs), 28 fixed-dose combinations (9 API combinations), and 8 patient kits (8 API regimens and other materials). The number of TB drugs listed in the GDF Product Catalog increased from 9 (8 APIs) to 55 (32 APIs). The price decreased for 17, increased for 19, and showed no trend for 12 APIs. The price of 15 (53.6%) of 28 APIs used against drug-resistant TB decreased, including the price of drugs used in new treatment regimens. The decreasing price trend was strongest for linezolid (-16.60 [95% CI: -26.35 to -6.85] percentage points [pp] per year), bedaquiline (-12.61 [95% CI: -18.00 to -7.22] pp per year), cycloserine (-11.20 [95% CI: -17.40 to -4.99] pp per year), pretomanid (-10.47 [95% CI: -15.06 to -5.89] pp per year), and rifapentine (-10.46 [95% CI: -12.86 to -8.06] pp per year). The prices of 16 (61.5%) of 23 APIs for standard drug-susceptible TB treatment increased, including rifampicin (23.70 [95% CI: 18.48 to 28.92] pp per year), isoniazid (20.95 [95% CI: 18.96 to 22.95] pp per year), ethambutol (9.85 [95% CI: 8.83 to 10.88] pp per year), and fixed-dose combinations thereof. Conclusions The number of TB drugs available from the GDF has substantially increased during its first 23 years of operation. The prices of most APIs for new TB treatments decreased or remained stable. The prices of most APIs for standard drug-sensitive TB treatment increased.