671 results on '"Steeghs N"'
Search Results
2. Real-world data on the management of pazopanib-induced liver toxicity in routine care of renal cell cancer and soft tissue sarcoma patients
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Westerdijk, K., Krens, S. D., Steeghs, N., van der Graaf, W. T. A., Tjwa, E. T. T. L., Westdorp, H., Desar, I. M. E., and van Erp, N. P.
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- 2024
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3. Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review
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van Schaik, L.F., Engelhardt, E.G., Wilthagen, E.A., Steeghs, N., Fernández Coves, A., Joore, M.A., van Harten, W.H., and Retèl, V.P.
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- 2024
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4. Interleukin-6 in relation to early recurrence in primary, localized soft tissue sarcoma: An addition for existing risk classification systems?
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van der Laan, P., van der Graaf, W.T.A., van den Broek, D., van Boven, H., Heeres, B.C., Schrage, Y., Haas, R.L., Steeghs, N., and van Houdt, W.J.
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- 2024
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5. Sunitinib for the treatment of metastatic gastrointestinal stromal tumors: the effect of TDM-guided dose optimization on clinical outcomes
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Giraud, E.L., Westerdijk, K., van der Kleij, M.B.A., Guchelaar, N.A.D., Meertens, M., Bleckman, R.F., Rieborn, A., Mohammadi, M., Roets, E., Mathijssen, R.H.J., Huitema, A.D.R., Koolen, S.L.W., Gelderblom, H., Moes, D.J.A.R., Reyners, A.K.L., Touw, D.J., Keizer-Heldens, P., Oosten, A.W., van der Graaf, W.T.A., Steeghs, N., van Erp, N.P., and Desar, I.M.E.
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- 2024
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6. Health-related quality of life in patients with gastrointestinal stromal tumor: data from a real-world cohort compared with a normative population
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van de Wal, D., den Hollander, D., Desar, I.M.E., Gelderblom, H., Oosten, A.W., Reyners, A.K.L., Steeghs, N., van der Graaf, W.T.A., and Husson, O.
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- 2024
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7. Exposure–response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients
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Groenland, Stefanie L., Janssen, J. M., Nijenhuis, C. M., de Vries, N., Rosing, H., Wilgenhof, S., van Thienen, J. V., Haanen, J. B. A. G., Blank, C. U., Beijnen, J. H., Huitema, A. D. R., and Steeghs, N.
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- 2023
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8. Elevated preoperative serum interleukin-6 level is predictive for worse postoperative outcome after soft tissue sarcoma surgery
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van der Laan, P., van der Graaf, W.T.A., Reijers, S.J.M., Schrage, Y.M., Hendriks, J.J.H., Haas, R.L., van den Broek, D., Steeghs, N., and van Houdt, W.J.
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- 2023
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9. Sex differences in patients with gastrointestinal stromal tumours: do they exist and does it affect survival?
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IJzerman, N.S., van Werkhoven, E., Mohammadi, M., Hollander, D. den, Bleckman, R.F., Reyners, A.K.L., Desar, I.M.E., Gelderblom, H., Grünhagen, D.J., Mathijssen, R.H.J., Steeghs, N., and van der Graaf, W.T.A.
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- 2022
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10. Complete genomic characterization in patients with cancer of unknown primary origin in routine diagnostics
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Schipper, L.J., Samsom, K.G., Snaebjornsson, P., Battaglia, T., Bosch, L.J.W., Lalezari, F., Priestley, P., Shale, C., van den Broek, A.J., Jacobs, N., Roepman, P., van der Hoeven, J.J.M., Steeghs, N., Vollebergh, M.A., Marchetti, S., Cuppen, E., Meijer, G.A., Voest, E.E., and Monkhorst, K.
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- 2022
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11. Quality of life with encorafenib plus cetuximab with or without binimetinib treatment in patients with BRAF V600E-mutant metastatic colorectal cancer: patient-reported outcomes from BEACON CRC
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Kopetz, S., Grothey, A., Van Cutsem, E., Yaeger, R., Wasan, H., Yoshino, T., Desai, J., Ciardiello, F., Loupakis, F., Hong, Y.S., Steeghs, N., Guren, T.K., Arkenau, H.-T., Garcia-Alfonso, P., Belani, A., Zhang, X., and Tabernero, J.
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- 2022
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12. Priorities and preferences of advanced soft tissue sarcoma patients starting palliative chemotherapy: baseline results from the HOLISTIC study
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Younger, E., Jones, R.L., den Hollander, D., Soomers, V.L.M.N., Desar, I.M.E., Benson, C., Young, R.J., Oosten, A.W., de Haan, J.J., Miah, A., Zaidi, S., Gelderblom, H., Steeghs, N., Husson, O., and van der Graaf, W.T.A.
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- 2021
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13. Clinical Relevance of High Plasma Trough Levels of the Kinase Inhibitors Crizotinib, Alectinib, Osimertinib, Dabrafenib, and Trametinib in NSCLC Patients
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Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Lin, Lishi, Barkman, HJ, Smit, EF, de Langen, AJ, Steeghs, N, Beijnen, JH, Huitema, ADR, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology, Lin, Lishi, Barkman, HJ, Smit, EF, de Langen, AJ, Steeghs, N, Beijnen, JH, and Huitema, ADR
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- 2024
14. Referral patterns of GIST patients: data from a nationwide study
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Roets, E., Ijzerman, N.S., Ho, V.K., Desar, I.M.E., Reyners, A.K.L., Gelderblom, H., Grünhagen, D.J., Etten, B. van, Houdt, W.J. van, Graaf, W.T.A. van der, Steeghs, N., Roets, E., Ijzerman, N.S., Ho, V.K., Desar, I.M.E., Reyners, A.K.L., Gelderblom, H., Grünhagen, D.J., Etten, B. van, Houdt, W.J. van, Graaf, W.T.A. van der, and Steeghs, N.
- Abstract
Contains fulltext : 305391.pdf (Publisher’s version ) (Open Access), BACKGROUND: This study compares the characteristics, referral and treatment patterns and overall survival (OS) of gastrointestinal stromal tumor (GIST) patients treated in reference and non-reference centers in the Netherlands. PATIENTS AND METHODS: This retrospective cohort study on patients diagnosed between 2016 and 2019, utilises data from the Netherlands Cancer Registry and the Dutch Nationwide Pathology Database. Patients were categorized into two groups: patients diagnosed in or referred to reference centers and patients diagnosed in non-reference centers without referral. RESULTS: This study included 1,550 GIST patients with a median age of 67.0 in reference and 68.0 years in non-reference centers. Eighty-seven per cent of patients were diagnosed in non-reference centers, of which 36.5% (493/1,352) were referred to a reference center. Referral rates were higher for high-risk (62.2% [74/119]) and metastatic patients (67.2% [90/134]). Mutation analysis was performed in 96.9% and 87.6% of these cases in reference and in non-reference centers (p < 0.01), respectively. Systemic therapy was given in reference centers versus non-reference in 89.5% versus 82.0% (p < 0.01) of high-risk and in 94.1% versus 65.9% (p < 0.01) of metastatic patients, respectively. The proportion of positive resection margins and tumor rupture did not differ between reference and non-reference centers. Median OS was not reached. CONCLUSION: A substantial amount of metastatic GIST patients in non-reference centers did not receive systemic treatment. This might be due to valid reasons. However, optimisation of the referral strategy of GIST patients in the Netherlands could benefit patients. Further research is needed to explore reasons for not starting systemic treatment in metastatic GIST patients.
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- 2024
15. Monitoring of EGFR mutations in circulating tumor DNA of non-small cell lung cancer patients treated with EGFR inhibitors
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Verheijen, R. B., van Duijl, T. T., van den Heuvel, M. M., Vessies, D., Muller, M., Beijnen, J. H., Janssen, J. M., Schellens, J. H. M., Steeghs, N., van den Broek, D., and Huitema, A. D. R.
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- 2021
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16. Real-world data on the management of pazopanib-induced liver toxicity in routine care of renal cell cancer and soft tissue sarcoma patients
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Westerdijk, K., primary, Krens, S. D., additional, Steeghs, N., additional, van der Graaf, W. T. A., additional, Tjwa, E. T. T. L., additional, Westdorp, H., additional, Desar, I. M. E., additional, and van Erp, N. P., additional
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- 2023
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17. Exposure–response analyses of abiraterone and its metabolites in real-world patients with metastatic castration-resistant prostate cancer
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van Nuland, M., Groenland, S. L., Bergman, A. M., Steeghs, N., Rosing, H., Venekamp, N., Huitema, A. D. R., and Beijnen, J. H.
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- 2020
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18. Surgical and medical management of small bowel gastrointestinal stromal tumors: A report of the Dutch GIST registry
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Boonstra, P.A., Steeghs, N., Farag, S., van Coevorden, F., Gelderblom, H., Grunhagen, D.J., Desar, I.M.E., van der Graaf, W.T.A., Bonenkamp, J.J., Reyners, A.K.L., and van Etten, B.
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- 2019
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19. Enhancing antitumor response by combining immune checkpoint inhibitors with chemotherapy in solid tumors
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Heinhuis, K.M., Ros, W., Kok, M., Steeghs, N., Beijnen, J.H., and Schellens, J.H.M.
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- 2019
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20. Validation and clinical application of an LC-MS/MS method for the quantification of everolimus using volumetric absorptive microsampling
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Verheijen, R.B., Thijssen, B., Atrafi, F., Schellens, J.H.M., Rosing, H., de Vries, N., Beijnen, J.H., Mathijssen, R.H.J., Steeghs, N., and Huitema, A.D.R.
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- 2019
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21. The use of microtracers in food‐effect trials: An alternative study design for toxic drugs with long half‐lives exemplified by the case for alectinib
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van der Heijden, L. T., primary, Steeghs, N., additional, Beijnen, J. H., additional, Huitema, A. D. R., additional, and Dorlo, T. P. C., additional
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- 2023
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22. Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT‐enhanced estimate of renal function
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Molenaar‐Kuijsten, L., primary, Pieters, T. T., additional, Veldhuis, W. B., additional, Moeskops, P., additional, Rijkhorst, E. J., additional, Dorlo, T. P. C., additional, Beijnen, J. H., additional, Steeghs, N., additional, Rookmaaker, M. B., additional, and Huitema, A. D. R., additional
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- 2023
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23. Author Correction: A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns (Nature Communications, (2020), 11, 1, (728), 10.1038/s41467-019-13825-8)
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Jiao W., Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, Al-Shahrour, F, Bailey, P, Biankin, A, Boutros, P, Campbell, P, Chang, D, Cooke, S, Deshpande, V, Faltas, B, Faquin, W, Garraway, L, Getz, G, Grimmond, S, Haider, S, Hoadley, K, Kaiser, V, Kato, M, Kubler, K, Lazar, A, C. H., L, Louis, D, Margolin, A, Martin, S, Nahal-Bose, H, Nielsen, G, Nik-Zainal, S, Omberg, L, P'Ng, C, Perry, M, Rheinbay, E, Rubin, M, Semple, C, Sgroi, D, Shibata, T, Siebert, R, Smith, J, Stein, L, Stobbe, M, Sun, R, Thai, K, Wright, D, C. -L., W, Yuan, K, Zhang, J, Danyi, A, de Ridder, J, van Herpen, C, Lolkema, M, Steeghs, N, Morris, Q, Aaltonen, L, Abascal, F, Abeshouse, A, Aburatani, H, Adams, D, Agrawal, N, Ahn, K, Ahn, S, Aikata, H, Akbani, R, Akdemir, K, Al-Ahmadie, H, Al-Sedairy, S, Alawi, M, Albert, M, Aldape, K, Alexandrov, L, Ally, A, Alsop, K, Alvarez, E, Amary, F, Amin, S, Aminou, B, Ammerpohl, O, Anderson, M, Ang, Y, Antonello, D, Anur, P, Aparicio, S, Appelbaum, E, Arai, Y, Aretz, A, Arihiro, K, Ariizumi, S, Armenia, J, Arnould, L, Asa, S, Assenov, Y, Aukema, S, Auman, J, Aure, M, Awadalla, P, Aymerich, M, Bader, G, Baez-Ortega, A, Bailey, M, Balasundaram, M, Balu, S, Bandopadhayay, P, Banks, R, Barbi, S, Barbour, A, Barenboim, J, Barnholtz-Sloan, J, Barr, H, Barrera, E, Bartlett, J, Bartolome, J, Bassi, C, Bathe, O, Baumhoer, D, Bavi, P, Baylin, S, Bazant, W, Beardsmore, D, Beck, T, Behjati, S, Behren, A, Niu, B, Bell, C, Beltran, S, Benz, C, Berchuck, A, Bergmann, A, Bergstrom, E, Berman, B, Berney, D, Bernhart, S, Beroukhim, R, Berrios, M, Bersani, S, Bertl, J, Betancourt, M, Bhandari, V, Bhosle, S, Bieg, M, Bigner, D, Binder, H, Birney, E, Birrer, M, Biswas, N, Bjerkehagen, B, Bodenheimer, T, Boice, L, Bonizzato, G, De Bono, J, Boot, A, Bootwalla, M, Borg, A, Borkhardt, A, Boroevich, K, Borozan, I, Borst, C, Bosenberg, M, Bosio, M, Boultwood, J, Bourque, G, Bova, G, Bowen, D, Bowlby, R, Bowtell, D, Boyault, S, Boyce, R, Boyd, J, Brazma, A, Brennan, P, Brewer, D, Brinkman, A, Bristow, R, Broaddus, R, Brock, J, Brock, M, Broeks, A, Brooks, A, Brooks, D, Brors, B, Brunak, S, Bruxner, T, Bruzos, A, Buchanan, A, Buchhalter, I, Buchholz, C, Bullman, S, Burke, H, Burkhardt, B, Burns, K, Busanovich, J, Bustamante, C, Butler, A, Butte, A, Byrne, N, Borresen-Dale, A, Caesar-Johnson, S, Cafferkey, A, Cahill, D, Calabrese, C, Caldas, C, Calvo, F, Camacho, N, Campo, E, Cantu, C, Cao, S, Carey, T, Carlevaro-Fita, J, Carlsen, R, Cataldo, I, Cazzola, M, Cebon, J, Cerfolio, R, Chadwick, D, Chakravarty, D, Chalmers, D, Chan, C, Chan, K, Chan-Seng-Yue, M, Chandan, V, Chanock, S, Chantrill, L, Chateigner, A, Chatterjee, N, Chayama, K, Chen, H, Chen, J, Chen, K, Chen, Y, Chen, Z, Cherniack, A, Chien, J, Chiew, Y, Chin, S, Cho, J, Cho, S, Choi, J, Choi, W, Chomienne, C, Chong, Z, Choo, S, Chou, A, Christ, A, Christie, E, Chuah, E, Cibulskis, C, Cibulskis, K, Cingarlini, S, Clapham, P, Claviez, A, Cleary, S, Cloonan, N, Cmero, M, Collins, C, Connor, A, Cooper, C, Cope, L, Corbo, V, Cordes, M, Cordner, S, Cortes-Ciriano, I, Covington, K, Cowin, P, Craft, B, Craft, D, Creighton, C, Cun, Y, Curley, E, Cutcutache, I, Czajka, K, Czerniak, B, Dagg, R, Danilova, L, Davi, M, Davidson, N, Davies, H, Davis, I, Davis-Dusenbery, B, Dawson, K, De La Vega, F, De Paoli-Iseppi, R, Defreitas, T, Tos, A, Delaneau, O, Demchok, J, Demeulemeester, J, Demidov, G, Demircioglu, D, Dennis, N, Denroche, R, Dentro, S, Desai, N, Deshwar, A, Desmedt, C, Deu-Pons, J, Dhalla, N, Dhani, N, Dhingra, P, Dhir, R, Dibiase, A, Diamanti, K, Ding, L, Ding, S, Dinh, H, Dirix, L, Doddapaneni, H, Donmez, N, Dow, M, Drapkin, R, Drechsel, O, Drews, R, Serge, S, Dudderidge, T, Dueso-Barroso, A, Dunford, A, Dunn, M, Dursi, L, Duthie, F, Dutton-Regester, K, Eagles, J, Easton, D, Edmonds, S, Edwards, P, Edwards, S, Eeles, R, Ehinger, A, Eils, J, Eils, R, El-Naggar, A, Eldridge, M, Ellrott, K, Erkek, S, Escaramis, G, Espiritu, S, Estivill, X, Etemadmoghadam, D, Eyfjord, J, Fan, D, Fan, Y, Farcas, C, Fassan, M, Fatima, A, Favero, F, Fayzullaev, N, Felau, I, Fereday, S, Ferguson, M, Ferretti, V, Feuerbach, L, Field, M, Fink, J, Finocchiaro, G, Fisher, C, Fittall, M, Fitzgerald, A, Fitzgerald, R, Flanagan, A, Fleshner, N, Flicek, P, Foekens, J, Fong, K, Fonseca, N, Foster, C, Fox, N, Fraser, M, Frazer, S, Frenkel-Morgenstern, M, Friedman, W, Frigola, J, Fronick, C, Fujimoto, A, Fujita, M, Fukayama, M, Fulton, L, Fulton, R, Furuta, M, Futreal, P, Fullgrabe, A, Gabriel, S, Gallinger, S, Gambacorti-Passerini, C, Gao, J, Gao, S, Garred, O, Garrison, E, Garsed, D, Gehlenborg, N, Gelpi, J, George, J, Gerhard, D, Gerhauser, C, Gershenwald, J, Gerstein, M, Gerstung, M, Ghori, M, Ghossein, R, Giama, N, Gibbs, R, Gibson, B, Gill, A, Gill, P, Giri, D, Glodzik, D, Gnanapragasam, V, Goebler, M, Goldman, M, Gomez, C, Gonzalez, S, Gonzalez-Perez, A, Gordenin, D, Gossage, J, Gotoh, K, Govindan, R, Grabau, D, Graham, J, Grant, R, Green, A, Green, E, Greger, L, Grehan, N, Grimaldi, S, Grossman, R, Grundhoff, A, Gundem, G, Guo, Q, Gupta, M, Gupta, S, Gut, I, Gut, M, Goke, J, Ha, G, Haake, A, Haan, D, Haas, S, Haase, K, Haber, J, Habermann, N, Hach, F, Hama, N, Hamdy, F, Hamilton, A, Hamilton, M, Han, L, Hanna, G, Hansmann, M, Haradhvala, N, Harismendy, O, Harliwong, I, 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Jang, S, Jayaseelan, J, Jayasinghe, R, Jefferys, S, Jegalian, K, Jennings, J, Jeon, S, Jerman, L, Ji, Y, Johansson, P, Johns, A, Johns, J, Johnson, R, Johnson, T, Jolly, C, Joly, Y, Jonasson, J, Jones, C, Jones, D, Jones, N, Jones, S, Jonkers, J, Y. S., J, Juhl, H, Jung, J, Juul, M, Juul, R, Juul, S, Jager, N, Kabbe, R, Kahles, A, Kahraman, A, Kakavand, H, Kalimuthu, S, von Kalle, C, Kang, K, Karaszi, K, Karlan, B, Karsch, D, Kasaian, K, Kassahn, K, Katai, H, Katoh, H, Kawakami, Y, Kay, J, Kazakoff, S, Kazanov, M, Keays, M, Kebebew, E, Kefford, R, Kellis, M, Kench, J, Kennedy, C, Kerssemakers, J, Khoo, D, Khoo, V, Khuntikeo, N, Khurana, E, Kilpinen, H, Kim, H, Kim, J, Kim, Y, King, T, Klapper, W, Kleinheinz, K, Klimczak, L, Knappskog, S, Kneba, M, Knoppers, B, Koh, Y, Komorowski, J, Komura, D, Komura, M, Kong, G, Kool, M, Korbel, J, Korchina, V, Korshunov, A, Koscher, M, Koster, R, Kote-Jarai, Z, Koures, A, Kovacevic, M, Kremeyer, B, Kretzmer, H, Kreuz, M, Krishnamurthy, S, Kube, D, Kumar, K, Kumar, P, Kumar, S, Kumar, Y, Kundra, R, Kuppers, R, Lagergren, J, Lai, P, Laird, P, Lakhani, S, Lalansingh, C, Lalonde, E, Lamaze, F, Lambert, A, Lander, E, Landgraf, P, Landoni, L, Langerod, A, Lanzos, A, Larsimont, D, Larsson, E, Lathrop, M, Lau, L, Lawerenz, C, Lawlor, R, Lawrence, M, Lazic, A, Le, X, Lee, D, Lee, E, Lee, H, Lee, J, Lee, M, Lee-Six, H, Lehmann, K, Lehrach, H, Lenze, D, Leonard, C, Leongamornlert, D, Leshchiner, I, Letourneau, L, Letunic, I, Levine, D, Lewis, L, Ley, T, Li, C, H. I., L, Li, J, Li, L, Li, S, Li, X, Li, Y, Liang, H, Liang, S, Lichter, P, Lin, P, Lin, Z, Linehan, W, Lingjaerde, O, Liu, D, Liu, E, Liu, F, Liu, J, Liu, X, Livingstone, J, Livitz, D, Livni, N, Lochovsky, L, Loeffler, M, Long, G, Lopez-Guillermo, A, Lou, S, Lovat, L, Lu, Y, Y. -J., L, Luchini, C, Lungu, I, Luo, X, Luxton, H, Lynch, A, Lype, L, Lopez, C, Lopez-Otin, C, E. 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W. 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C., Rabionet R., Rader J. S., Radlwimmer B., Radovic P., Raeder B., Raine K. M., Ramakrishna M., Ramakrishnan K., Ramalingam S., Raphael B. J., Rathmell W. K., Rausch T., Reifenberger G., Reimand J., Reis-Filho J., Reuter V., Reyes-Salazar I., Reyna M. A., Reynolds S. M., Riazalhosseini Y., Richardson A. L., Richter J., Ringel M., Ringner M., Rino Y., Rippe K., Roach J., Roberts L. R., Roberts N. D., Roberts S. A., Robertson A. G., Robertson A. J., Rodriguez J. B., Rodriguez-Martin B., Rodriguez-Gonzalez F. G., Roehrl M. H. A., Rohde M., Rokutan H., Romieu G., Rooman I., Roques T., Rosebrock D., Rosenberg M., Rosenstiel P. C., Rosenwald A., Rowe E. W., Royo R., Rozen S. G., Rubanova Y., Rubio-Perez C., Rudneva V. A., Rusev B. C., Ruzzenente A., Ratsch G., Sabarinathan R., Sabelnykova V. Y., Sadeghi S., Sahinalp S. C., Saini N., Saito-Adachi M., Saksena G., Salcedo A., Salgado R., Salichos L., Sallari R., Saller C., Salvia R., Sam M., Samra J. S., Sanchez-Vega F., Sander C., Sanders G., Sarin R., Sarrafi I., Sasaki-Oku A., Sauer T., Sauter G., Saw R. P. M., Scardoni M., Scarlett C. J., Scarpa A., Scelo G., Schadendorf D., Schein J. E., Schilhabel M. B., Schlesner M., Schlomm T., Schmidt H. K., Schramm S. -J., Schreiber S., Schultz N., Schumacher S. E., Schwarz R. F., Scolyer R. A., Scott D., Scully R., Seethala R., Segre A. V., Selander I., Senbabaoglu Y., Sengupta S., Sereni E., Serra S., Shackleton M., Shah N. C., Shahabi S., Shang C. A., Shang P., Shapira O., Shelton T., Shen C., Shen H., Shepherd R., Shi R., Shi Y., Shiah Y. -J., Shih J., Shimizu E., Shimizu K., Shin S. J., Shiraishi Y., Shmaya T., Shmulevich I., Shorser S. I., Short C., Shrestha R., Shringarpure S. S., Shriver C., Shuai S., Sidiropoulos N., Sieuwerts A. M., Sieverling L., Signoretti S., Sikora K. O., Simbolo M., Simon R., Simons J. V., Simpson J. T., Simpson P. T., Singer S., Sinnott-Armstrong N., Sipahimalani P., Skelly T. J., Smid M., Smith-McCune K., Socci N. D., Sofia H. J., Soloway M. G., Song L., Sood A. K., Sothi S., Sotiriou C., Soulette C. M., Span P. N., Spellman P. T., Sperandio N., Spillane A. J., Spiro O., Spring J., Staaf J., Stadler P. F., Staib P., Stark S. G., Stebbings L., Stefansson O. A., Stegle O., Stenhouse A., Stewart C., Stilgenbauer S., Stratton M. R., Stretch J. R., Struck A. J., Stuart J. M., Stunnenberg H. G., Su H., Su X., Sungalee S., Susak H., Suzuki A., Sweep F., Szczepanowski M., Sultmann H., Yugawa T., Tam A., Tamborero D., Tan B. K. T., Tan D., Tan P., Tanaka H., Taniguchi H., Tanskanen T. J., Tarabichi M., Tarnuzzer R., Tarpey P., Taschuk M. L., Tatsuno K., Tavare S., Taylor D. F., Taylor-Weiner A., Teague J. W., Teh B. T., Tembe V., Temes J., Thayer S. P., Thiessen N., Thomas G., Thomas S., Thompson A., Thompson A. M., Thompson J. F. F., Thompson R. H., Thorne H., Thorne L. B., Thorogood A., Tiao G., Tijanic N., Timms L. E., Tirabosco R., Tojo M., Tommasi S., Toon C. W., Toprak U. H., Torrents D., Tortora G., Tost J., Totoki Y., Townend D., Traficante N., Treilleux I., Trotta J. -R., Trumper L. H. P., Tsao M., Tsunoda T., Tubio J. M. C., Tucker O., Turkington R., Turner D. J., Tutt A., Ueno M., Ueno N. T., Umbricht C., Umer H. M., Underwood T. J., Urban L., Urushidate T., Ushiku T., Uuskula-Reimand L., Valencia A., Van Den Berg D. J., Van Laere S., Van Loo P., Van Meir E. G., Van den Eynden G. G., Van der Kwast T., Vasudev N., Vazquez M., Vedururu R., Veluvolu U., Vembu S., Verbeke L. P. C., Vermeulen P., Verrill C., Viari A., Vicente D., Vicentini C., VijayRaghavan K., Viksna J., Vilain R. E., Villasante I., Vincent-Salomon A., Visakorpi T., Voet D., Vyas P., Vazquez-Garcia I., Waddell N. M., Waddell N., Wadelius C., Wadi L., Wagener R., Wala J. A., Wang J., Wang L., Wang Q., Wang W., Wang Y., Wang Z., Waring P. M., Warnatz H. -J., Warrell J., Warren A. Y., Waszak S. M., Wedge D. C., Weichenhan D., Weinberger P., Weinstein J. N., Weischenfeldt J., Weisenberger D. J., Welch I., Wendl M. C., Werner J., Whalley J. P., Wheeler D. A., Whitaker H. C., Wigle D., Wilkerson M. D., Williams A., Wilmott J. S., Wilson G. W., Wilson J. M., Wilson R. K., Winterhoff B., Wintersinger J. A., Wiznerowicz M., Wolf S., Wong B. H., Wong T., Wong W., Woo Y., Wood S., Wouters B. G., Wright A. J., Wright M. H., Wu D. -Y., Wu G., Wu J., Wu K., Wu Y., Wu Z., Xi L., Xia T., Xiang Q., Xiao X., Xing R., Xiong H., Xu Q., Xu Y., Xue H., Yachida S., Yakneen S., Yamaguchi R., Yamaguchi T. N., Yamamoto M., Yamamoto S., Yamaue H., Yang F., Yang H., Yang J. Y., Yang L., Yang S., Yang T. -P., Yang Y., Yao X., Yaspo M. -L., Yates L., Yau C., Ye C., Ye K., Yellapantula V. D., Yoon C. J., Yoon S. -S., Yousif F., Yu J., Yu K., Yu W., Yu Y., Yuan Y., Yuen D., Yung C. K., Zaikova O., Zamora J., Zapatka M., Zenklusen J. C., Zenz T., Zeps N., Zhang C. -Z., Zhang F., Zhang H., Zhang X., Zhang Y., Zhang Z., Zhao Z., Zheng L., Zheng X., Zhou W., Zhou Y., Zhu B., Zhu H., Zhu J., Zhu S., Zou L., Zou X., deFazio A., van As N., van Deurzen C. H. M., van de Vijver M. J., van't Veer L., and von Mering C.
- Abstract
In the published version of this paper, the members of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortiumwere listed in the Supplementary Information; however, these members shouldhave been included in themainpaper.The originalArticle has been corrected to include the members and affiliations of the PCAWG Consortium in the main paper; the corrections have been made to the HTML version of the Article but not the PDF version. Additional corrections to affiliations and author names have been made to the PDF and HTML versions of the original Article for consistency of information between the PCAWG list and the main paper.
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- 2022
24. Patient-reported outcome measures in a pharmacokinetic study with sunitinib, a prospective cohort study
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Koldenhof, J. J., Lankheet, N. A. G., Steeghs, N., Teunissen, S. C. C. M., and Witteveen, P. O.
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- 2018
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25. Remarkable effects of imatinib in a family with young onset gastrointestinal stromal tumors and cutaneous hyperpigmentation associated with a germline KIT-Trp557Arg mutation: case report and literature overview
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Farag, S., van der Kolk, L. E., van Boven, H. H., van Akkooi, A. C. J., Beets, G. L., Wilmink, J. W., and Steeghs, N.
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- 2018
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26. Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization
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Verheijen, R. B., Swart, L. E., Beijnen, J. H., Schellens, J. H. M., Huitema, A. D. R., and Steeghs, N.
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- 2017
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27. Local recurrence in primary localised resected gastrointestinal stromal tumours: A registry observational national cohort study including 912 patients.
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Bleckman, R.F., Roets, E., Ijzerman, N.S., Mohammadi, M., Bonenkamp, H., Gelderblom, H., Mathijssen, R.H., Steeghs, N., Reyners, A.K., Etten, B. van, Bleckman, R.F., Roets, E., Ijzerman, N.S., Mohammadi, M., Bonenkamp, H., Gelderblom, H., Mathijssen, R.H., Steeghs, N., Reyners, A.K., and Etten, B. van
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01 juni 2023, Item does not contain fulltext, BACKGROUND AND OBJECTIVES: Previous literature showed a high risk of recurrence following surgical treatment in patients with gastrointestinal stromal tumours (GISTs). However, little is known about the patient- and treatment characteristics of local recurrences (LRs) in GIST patients. Therefore, this study aimed to better understand patterns of LR in surgically treated localised GIST and to describe treatment options based on our Dutch GIST Registry (DGR). METHODS: Data of primary surgically treated localised GIST between January 2009 until July 2021 were retrospectively retrieved from the DGR. RESULTS: Of 1452 patients registered in the DGR, 912 patients were included in this study. Only 3.8% (35/912) of patients developed LR, including 20 patients with LR only and 15 patients with simultaneous LR and distant metastases (DM). Median time to LR was 30 (interquartile range 8-53) months from date of surgery. Eleven percent (100/912) of patients developed only DM. A total of 2.3% (6/259) of patients treated with adjuvant treatment developed an LR during adjuvant therapy. Seventy percent of patients with LR only (14/20) were treated with surgery (85.7% R0), which was mostly combined with systemic treatment. CONCLUSIONS: Patients with primary surgically treated localised GIST have a limited risk of developing recurrence. Fifteen percent developed recurrence, of which one quarter developed an LR. Therefore, less intensified follow-up schedules could be considered, especially during treatment with adjuvant imatinib. In patients with LR only, potentially curative treatment strategies, including surgical (re-)resection, are often possible as treatment for LR.
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- 2023
28. Improved Efficacy of First-Line Imatinib in Advanced Gastrointestinal Stromal Tumors (GIST): The Dutch GIST Registry Data.
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Mohammadi, M., Ijzerman, N.S., Hollander, D. den, Bleckman, R.F., Oosten, A.W., Desar, I.M.E., Reyners, A.K., Steeghs, N., Gelderblom, H., Mohammadi, M., Ijzerman, N.S., Hollander, D. den, Bleckman, R.F., Oosten, A.W., Desar, I.M.E., Reyners, A.K., Steeghs, N., and Gelderblom, H.
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Item does not contain fulltext, BACKGROUND: Patients with unresectable and metastasized gastrointestinal stromal tumor (GIST) experienced a remarkable improvement of progression-free survival (PFS) and overall survival (OS) after the introduction of imatinib. Our hypothesis is that the outcomes of treatment with imatinib are even better nowadays compared with the registration trials that were performed two decades ago. To study this, we used real-life data from a contemporary registry. METHODS: A multicenter, retrospective study was performed by exploring clinical data from a prospective real-life clinical database, the Dutch GIST Registry (DGR). Patients with advanced GIST treated with first-line imatinib were included and PFS (primary outcome) and OS (secondary outcome) were analyzed. Results of our study were compared with published results of the European Organisation for Research and Treatment of Cancer (EORTC) 62005 trial, which marked the first era of imatinib in the treatment of GIST. RESULTS: Overall, 420 of the 435 patients treated with imatinib in the DGR had recorded response evaluation and were included in the analysis. During a median follow-up of 35.0 months (range 2.0-136.0), progression of GIST was eventually observed in 217 patients (51.2%). The DGR cohort showed a longer median PFS (33.0 months, 95% confidence interval [CI] 28.4-37.6) compared with the EORTC 62005 trial (an estimated PFS of 19.5 months). Additionally, the median OS of 68.0 months (95% CI 56.1-80.0) was longer than the exposed median OS (46.8 months) published in the long-term follow-up results of the EORTC 62005 trial (median follow-up duration 10.9 years). CONCLUSION: This study provides an update on outcomes of imatinib in the treatment of advanced GIST patients and demonstrates improved clinical outcomes since the first randomized studies of imatinib 2 decades ago. Furthermore, these results represent outcomes in real-world clinical practice and can serve as a reference when evaluating effectiveness of imatin
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- 2023
29. A phase 1 open-label study to assess the relative bioavailability of TAK-931 tablets in reference to powder-in-capsule in patients with advanced solid tumors.
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Steeghs, N., Pruis, M., Herpen, C.M.L. van, Lu, V., Redman, J., Zhou, Xiaofei, Steeghs, N., Pruis, M., Herpen, C.M.L. van, Lu, V., Redman, J., and Zhou, Xiaofei
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01 februari 2023, Item does not contain fulltext, In this phase 1 open-label study, we assessed the relative bioavailability of a prototype tablet formulation of TAK-931, a cell division cycle 7 kinase inhibitor, in reference to the current powder-in-capsule (PIC) formulation in patients with advanced solid tumors for whom no effective standard treatment was available. Adult patients were randomized 1:1 in a crossover fashion to receive one dose of TAK-931 80 mg PIC on Day 1 and one dose of TAK-931 80 mg tablet on Day 3 (or the reverse sequence), followed by TAK-931 50 mg PIC once daily (QD) for 12 days starting from Day 5, before a 7-day rest period (Cycle 0). From Cycle 1, all patients received 50 mg PIC QD on Days 1-14 followed by a 7-day rest period. Twenty patients were enrolled. Median T(max) was achieved approximately 2 h post-dose of TAK-931 80 mg for both tablet and PIC. Geometric mean C(max), AUC exposures, and T(1/2z) of TAK-931 were similar for both formulations. Geometric mean C(max), AUC(last), and AUC(inf) ratios were 0.936 (90% confidence interval [CI]: 0.808-1.084), 1.004 (90% CI: 0.899-1.120), and 1.007 (90% CI: 0.903-1.123), respectively, for TAK-931 tablet in reference to PIC. Discontinuation of TAK-931 due to treatment-emergent adverse events (TEAEs) occurred in 1 patient. Four (20%) patients experienced a serious TEAE; none were considered related to TAK-931. Pharmacokinetics and systemic exposure profiles were similar following administration of both formulations, supporting the transition from PIC to tablet in the clinical development of TAK-931. (Trial registration number ClinicalTrials.gov NCT03708211. Registration date October 12, 2018).
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- 2023
30. Therapeutic drug monitoring guided dosing versus standard dosing of alectinib in advanced ALK positive non-small cell lung cancer patients: Study protocol for an international, multicenter phase IV randomized controlled trial (ADAPT ALEC).
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Meertens, M., Muntinghe-Wagenaar, M.B., Sikkema, B.J., Lopez-Yurda, M., Retèl, V.P., Paats, M.S., Heine, R. ter, Schuuring, E., Timens, W., Touw, D.J., Boven, J.F. van, Langen, A.J. de, Hashemi, S.M., Hendriks, L.E., Croes, S., Heuvel, M.M. van den, Dingemans, A.C., Mathijssen, R.H., Smit, E.F., Huitema, A.D., Steeghs, N., Wekken, A.J. van der, Meertens, M., Muntinghe-Wagenaar, M.B., Sikkema, B.J., Lopez-Yurda, M., Retèl, V.P., Paats, M.S., Heine, R. ter, Schuuring, E., Timens, W., Touw, D.J., Boven, J.F. van, Langen, A.J. de, Hashemi, S.M., Hendriks, L.E., Croes, S., Heuvel, M.M. van den, Dingemans, A.C., Mathijssen, R.H., Smit, E.F., Huitema, A.D., Steeghs, N., and Wekken, A.J. van der
- Abstract
Item does not contain fulltext, BACKGROUND: Alectinib is first-line therapy in patients with stage IV non-small cell lung carcinoma (NSCLC) and an anaplastic lymphoma kinase (ALK) fusion. A shorter median progression-free survival (mPFS) was observed when alectinib minimum plasma concentrations during steady state (C(min,SS)) were below 435 ng/mL. This may suggest that patients should have an alectinib C(min,SS) ≥ 435 ng/mL for a more favorable outcome. This potential target could be attained by using therapeutic drug monitoring (TDM), i.e. adjusting the dose based on measured plasma trough concentrations. Hypothetically, this will increase mPFS, but this has not yet been evaluated in a randomized controlled trial (RCT). Therefore, the ADAPT ALEC trial is designed, with the primary objective to prolong mPFS in NSCLC patients treated with alectinib by using TDM. METHODS: ADAPT ALEC is a multicenter, phase IV RCT, in which patients aged ≥ 18 years with advanced ALK positive (+) NSCLC eligible for alectinib in daily care are enrolled. Participants will be randomized (1:1 ratio) into intervention arm A (TDM) or B (control), stratified by brain metastases and prior ALK treatments. Starting dose in both arms is the approved flat fixed dose of alectinib 600 mg taken twice daily with food. In case of alectinib C(min,SS) < 435 ng/mL, arm A will receive increased doses of alectinib till C(min,SS) ≥ 435 ng/mL when considered tolerable. The primary outcome is mPFS, where progressive disease is defined according to RECIST v1.1 or all-cause death and assessed by CT-scans and MRI brain. Secondary endpoints are feasibility and tolerability of TDM, patient and physician adherence, overall response rate, median overall survival, intracranial PFS, quality of life, toxicity, alectinib-M4 concentrations and cost-effectiveness of TDM. Exploratory endpoints are circulating tumor DNA and body composition. DISCUSSION: The ADAPT ALEC will show whether treatment outcomes of patients with advanced ALK+ NSCLC improve when usi
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- 2023
31. Local treatment in metastatic GIST patients: A multicentre analysis from the Dutch GIST Registry.
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Brink, P., Kalisvaart, G.M., Schrage, Y.M., Mohammadi, M., Ijzerman, N.S., Bleckman, R.F., Wal, T., Geus-Oei, L.F. de, Hartgrink, H.H., Grunhagen, D.J., Verhoef, C., Sleijfer, S., Oosten, A.W., Been, L.B., Ginkel, R.J. van, Reyners, A.K.L., Bonenkamp, H., Desar, I.M.E., Gelderblom, H., Houdt, W.J. van, Steeghs, N., Fiocco, M., Hage, J.A. van der, Brink, P., Kalisvaart, G.M., Schrage, Y.M., Mohammadi, M., Ijzerman, N.S., Bleckman, R.F., Wal, T., Geus-Oei, L.F. de, Hartgrink, H.H., Grunhagen, D.J., Verhoef, C., Sleijfer, S., Oosten, A.W., Been, L.B., Ginkel, R.J. van, Reyners, A.K.L., Bonenkamp, H., Desar, I.M.E., Gelderblom, H., Houdt, W.J. van, Steeghs, N., Fiocco, M., and Hage, J.A. van der
- Abstract
01 september 2023, Contains fulltext : 296539.pdf (Publisher’s version ) (Open Access), BACKGROUND: The added value of local treatment in selected metastatic GIST patients is unclear. This study aims to provide insight into the usefulness of local treatment in metastatic GIST by use of a survey study and retrospective analyses in a clinical database. METHODS: A survey study was conducted among clinical specialists to select most relevant characteristics of metastatic GIST patients considered for local treatment, defined as elective surgery or ablation. Patients were selected from the Dutch GIST Registry. A multivariate Cox-regression model for overall survival since time of diagnosis of metastatic disease was estimated with local treatment as a time-dependent variable. An additional model was estimated to assess prognostic factors since local treatment. RESULTS: The survey's response rate was 14/16. Performance status, response to TKIs, location of active disease, number of lesions, mutation status, and time between primary diagnosis and metastases, were regarded the 6 most important characteristics. Of 457 included patients, 123 underwent local treatment, which was associated with better survival after diagnosis of metastases (HR = 0.558, 95%CI = 0.336-0.928). Progressive disease during systemic treatment (HR = 3.885, 95%CI = 1.195-12.627) and disease confined to the liver (HR = 0.269, 95%CI = 0.082-0.880) were associated with worse and better survival after local treatment, respectively. CONCLUSION: Local treatment is associated with better survival in selected patients with metastatic GIST. Locally treated patients with response to TKIs and disease confined to the liver have good clinical outcome. These results might be considered for tailoring treatment, but should be interpreted with care because only specific patients are provided with local treatment in this retrospective study.
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- 2023
32. The association of having a monitoring or blunting coping style with psychological distress, health-related quality of life and satisfaction with healthcare in gastrointestinal stromal tumour (GIST) patients.
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Wal, D. van de, Doorn, B. van, Hollander, D. den, Desar, I.M.E., Gelderblom, H., Oosten, A.W., Reyners, A.K.L., Steeghs, N., Graaf, W.T.A. van der, Husson, O., Wal, D. van de, Doorn, B. van, Hollander, D. den, Desar, I.M.E., Gelderblom, H., Oosten, A.W., Reyners, A.K.L., Steeghs, N., Graaf, W.T.A. van der, and Husson, O.
- Abstract
Contains fulltext : 300113.pdf (Publisher’s version ) (Open Access), BACKGROUND: There are two main coping styles regarding information seeking under medical threat; monitoring (information-seeking) and blunting (information-avoiding). The aim of this study is to (1) determine factors associated with a monitoring or blunting coping style in gastro-intestinal stromal tumour (GIST) patients and (2) investigate its association with psychological distress, cancer-related concerns, health-related quality of life and satisfaction with healthcare. METHODS: In a cross-sectional study, Dutch GIST patients completed the shortened version of the Threatening Medical Situations Inventory to determine their coping style, the Hospital Anxiety and Depression Scale, Cancer Worry Scale, EORTC QLQ-C30 and part of the EORTC QLQ-INFO25. RESULTS: A total of 307 patients were classified as blunters (n = 175, 57%) or monitors (n = 132, 43%). Coping style was not associated with tumour or treatment variables, but being a female (OR 2.5; 95%CI 1.5-4.1; p= <.001) and higher educated (OR 5.5; 95%CI 2.5-11.9, p= <.001) were associated with higher odds of being a monitor. Monitors scored significantly lower on emotional functioning (mean = 86.8 vs mean = 90.9, p=.044), which is considered a trivial difference, more often experienced severe fear of cancer recurrence or progression (53.0% vs 37.7%, p=.007), and had more concerns about dying from GIST in the future (60.6% vs 47.4%, p=.025). Compared to blunters, monitors were less satisfied with the received healthcare and information, and would have liked to receive more information. CONCLUSION: GIST patients with a monitoring coping style experience a higher emotional burden. Additionally, monitors exhibit a greater need for information. Although this need for information could potentially result in fears and concerns, recognising it may also create an opening for tailored communication and information., 01 december 2023
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- 2023
33. The use of microtracers in food-effect trials : An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib
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van Der Heijden, L. T., Steeghs, N., Beijnen, J. H., Huitema, A. D. R., Dorlo, Thomas P. C., van Der Heijden, L. T., Steeghs, N., Beijnen, J. H., Huitema, A. D. R., and Dorlo, Thomas P. C.
- Abstract
The traditional design of food-effect studies has a high patient burden for toxic drugs with long half-lives (e.g., anticancer agents). Microtracers could be used to assess food-effect in patients without influencing their ongoing treatment. The feasibility of a microtracer food-effect study during steady-state of the therapeutic drug was investigated in an in silico simulation study with alectinib as an example for a relative toxic drug with a long half-life. Microtracer pharmacokinetics were simulated based on a previously published population pharmacokinetic model and used for estimation of a model with and a model without food as a covariate on oral bioavailability of alectinib (assuming a 40% food-effect). Power was defined as the fraction of clinical trials where a significant (p < 0.01) food-effect was identified. The proposed study design of 10 patients on steady-state treatment, 10 blood samples collected within 24 h after administration and an assumed food-effect of 40% had a power of 99.9%. The mean estimated food-effect was 39.8% (80% confidence interval: 31.0%-48.6%). The feasibility of microtracer food-effect studies was demonstrated. The design of the microtracer food-effect study allowed estimation of the food-effect with minimal influence on therapeutic treatment and reducing patient burden compared to the traditional study design for toxic drugs with long half-lives.
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- 2023
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34. The use of microtracers in food-effect trials: An alternative study design for toxic drugs with long half-lives exemplified by the case for alectinib
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Arts-assistenten Kinderen, MS Medische Oncologie, Apotheek O&O&O, Cancer, van der Heijden, L. T., Steeghs, N., Beijnen, J. H., Huitema, A. D.R., Dorlo, T. P.C., Arts-assistenten Kinderen, MS Medische Oncologie, Apotheek O&O&O, Cancer, van der Heijden, L. T., Steeghs, N., Beijnen, J. H., Huitema, A. D.R., and Dorlo, T. P.C.
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- 2023
35. Exposure-response analyses of BRAF- and MEK-inhibitors dabrafenib plus trametinib in melanoma patients
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Fysiotherapiewetenschap, Apotheek O&O&O, Cancer, MS Medische Oncologie, Groenland, Stefanie L, Janssen, J M, Nijenhuis, C M, de Vries, N, Rosing, H, Wilgenhof, S, van Thienen, J V, Haanen, J B A G, Blank, C U, Beijnen, J H, Huitema, A D R, Steeghs, N, Fysiotherapiewetenschap, Apotheek O&O&O, Cancer, MS Medische Oncologie, Groenland, Stefanie L, Janssen, J M, Nijenhuis, C M, de Vries, N, Rosing, H, Wilgenhof, S, van Thienen, J V, Haanen, J B A G, Blank, C U, Beijnen, J H, Huitema, A D R, and Steeghs, N
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- 2023
36. Optimizing carboplatin dosing by an improved prediction of carboplatin clearance using a CT-enhanced estimate of renal function
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Nefro Vasculaire Geneeskunde, MS Radiologie, Cancer, Circulatory Health, MS Nefrologie, Regenerative Medicine and Stem Cells, Apotheek O&O&O, Molenaar-Kuijsten, L, Pieters, T T, Veldhuis, W B, Moeskops, P, Rijkhorst, E J, Dorlo, T P C, Beijnen, J H, Steeghs, N, Rookmaaker, M B, Huitema, A D R, Nefro Vasculaire Geneeskunde, MS Radiologie, Cancer, Circulatory Health, MS Nefrologie, Regenerative Medicine and Stem Cells, Apotheek O&O&O, Molenaar-Kuijsten, L, Pieters, T T, Veldhuis, W B, Moeskops, P, Rijkhorst, E J, Dorlo, T P C, Beijnen, J H, Steeghs, N, Rookmaaker, M B, and Huitema, A D R
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- 2023
37. The time to progression ratio: a new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies
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Cirkel, G.A., Weeber, F., Bins, S., Gadellaa-van Hooijdonk, C.G.M., van Werkhoven, E., Willems, S.M., van Stralen, M., Veldhuis, W.B., Ubink, I., Steeghs, N., de Jonge, M.J., Langenberg, M.H.G., Schellens, J.H.M., Sleijfer, S., Lolkema, M.P., and Voest, E.E.
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- 2016
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38. Actualisation des données de phase I de recherche de dose et premières données de la phase d’expansion du tarlatamab, un anticorps bispécifique ciblant la protéine DLL3 et engageant les lymphocytes T, dans le cancer bronchique à petites cellules (CBPC)
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Champiat, S., primary, Izumi, H., additional, Johnson, M., additional, Borghaei, H., additional, Owonikoko, T., additional, Lai, V., additional, Boyer, M., additional, Hummel, H.D., additional, Govindan, R., additional, Steeghs, N., additional, Blackhall, F., additional, Reguart, N., additional, Dowlati, A., additional, Ouali, K., additional, Zhang, Y., additional, Goldrick, A., additional, Mukherjee, S., additional, and Paz-Ares, L., additional
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- 2023
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39. Oncology phase I trial design and conduct: time for a change - MDICT Guidelines 2022
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Araujo, D., primary, Greystoke, A., additional, Bates, S., additional, Bayle, A., additional, Calvo, E., additional, Castelo-Branco, L., additional, de Bono, J., additional, Drilon, A., additional, Garralda, E., additional, Ivy, P., additional, Kholmanskikh, O., additional, Melero, I., additional, Pentheroudakis, G., additional, Petrie, J., additional, Plummer, R., additional, Ponce, S., additional, Postel-Vinay, S., additional, Siu, L., additional, Spreafico, A., additional, Stathis, A., additional, Steeghs, N., additional, Yap, C., additional, Yap, T.A., additional, Ratain, M., additional, and Seymour, L., additional
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- 2023
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40. 147P Characterizing CRS in phase I study of DLL3-targeted T cell engager tarlatamab in small cell lung cancer
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Champiat, S., primary, Boyer, M., additional, Paz-Ares, L., additional, Schoenfeld, A., additional, Izumi, H., additional, Govindan, R., additional, Carlisle, J., additional, Borghaei, H., additional, Johnson, M.L., additional, Steeghs, N., additional, Vokes, E.E., additional, Dowlati, A., additional, Zhang, Y., additional, Pati, A., additional, Ju, C-H., additional, Mukherjee, S., additional, Chen, X., additional, Hashemi Sadraei, N., additional, and Hummel, H-D., additional
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- 2022
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41. Correction to: Exposure-survival analyses of pazopanib in renal cell carcinoma and soft tissue sarcoma patients: opportunities for dose optimization
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Verheijen, R. B., Swart, E. L., Beijnen, J. H., Schellens, J. H. M., Huitema, A. D. R., and Steeghs, N.
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- 2020
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42. Exposure–Response Analysis of Osimertinib in EGFR Mutation Positive Non-Small Cell Lung Cancer Patients in a Real-Life Setting
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Boosman, R.J., Jebbink, M., Veldhuis, W.B., Groenland, S.L., Veggel, B.A.M.H. van, Moeskops, P., Langen, A.J. de, Beijnen, J.H., Smit, E.F., Huitema, A.D.R., Steeghs, N., CCA - Cancer Treatment and quality of life, and CCA - Cancer biology and immunology
- Subjects
Pharmacology ,osimertinib ,Organic Chemistry ,Pharmaceutical Science ,Molecular Medicine ,Pharmacology (medical) ,pharmacokinetics-pharmacodynamics ,NSCLC ,Biotechnology ,exposure-response analysis - Abstract
Background: Osimertinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR) is an important drug in the treatment of EGFR-mutation positive non-small cell lung cancer (NSCLC). Clinical trials with osimertinib could not demonstrate an exposure-efficacy relationship, while a relationship between exposure and toxicity has been found. In this study, we report the exposure–response relationships of osimertinib in a real-life setting. Methods: A retrospective observational cohort study was performed, including patients receiving 40 - 80 mg osimertinib as ≥ 2 line therapy and from whom pharmacokinetic samples were collected during routine care. Trough plasma concentrations (C min,pred) were estimated and used as a measure of osimertinib exposure. A previously defined exploratory pharmacokinetic threshold of 166 µg/L was taken to explore the exposure-efficacy relationship. Results: A total of 145 patients and 513 osimertinib plasma concentration samples were included. Median progression free survival (PFS) was 13.3 (95% confidence interval (CI):10.3 – 19.1) months and 9.3 (95% CI: 7.2 – 11.1) months for patients with C min,pred < 166 µg/L and C min,pred ≥ 166 µg/L, respectively (p = 0.03). In the multivariate analysis, a C min,pred < 166 µg/L resulted in a non-statistically significant hazard ratio of 1.10 (95% CI: 0.60 – 2.01; p = 77). Presence of a EGFR driver-mutation other than the exon 19 del or L858R mutations, led to a shorter PFS with a hazard ratio of 2.89 (95% CI: 1.18 – 7.08; p = 0.02). No relationship between exposure and toxicity was observed (p = 0.91). Conclusion: In our real-life cohort, no exposure–response relationship was observed for osimertinib in the current dosing scheme. The feasibility of a standard lower fixed dosing of osimertinib in clinical practice should be studied prospectively.
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- 2022
43. Therapeutic drug monitoring-based precision dosing of oral targeted therapies in oncology: a prospective multicenter study
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Groenland, S.L., primary, van Eerden, R.A.G., additional, Westerdijk, K., additional, Meertens, M., additional, Koolen, S.L.W., additional, Moes, D.J.A.R., additional, de Vries, N., additional, Rosing, H., additional, Otten, H., additional, Vulink, A.J.E., additional, Desar, I.M.E., additional, Imholz, A.L.T., additional, Gelderblom, H., additional, van Erp, N.P., additional, Beijnen, J.H., additional, Mathijssen, R.H.J., additional, Huitema, A.D.R., additional, and Steeghs, N., additional
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- 2022
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44. OA12.05 Phase 1 Updated Exploration and First Expansion Data for DLL3-targeted T-cell Engager Tarlatamab in Small Cell Lung Cancer
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Borghaei, H., primary, Paz-Ares, L., additional, Johnson, M., additional, Champiat, S., additional, Owonikoko, T., additional, Lai, V., additional, Boyer, M., additional, Hummel, H.-D., additional, Govindan, R., additional, Steeghs, N., additional, Blackhall, F., additional, Reguart, N., additional, Dowlati, A., additional, Zhang, Y., additional, Sadraei, N. Hashemi, additional, Goldrick, A., additional, and Izumi, H., additional
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- 2022
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45. 363P Palbociclib exposure in relation to response and toxicity in patients with advanced breast cancer
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Buijs, S.M., Ali, M.I. Mohmaed, Hoop, E. Oomen-de, Braal, C.L., Wortelboer, N., Van Ommen-Nijhof, A., Sonke, G.S., Konings, I.R., Jager, A., Steeghs, N., Siebinga, H., Mathijssen, R.H., Huitema, A.D.R., and Koolen, S.L.
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- 2024
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46. 1747P Changes in global health status (GHS) in patients with advanced soft tissue sarcoma (STS) treated with first line palliative chemotherapy: Primary outcomes from the HOLISTIC study
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Roets, E., Younger, E., Jones, R.L., Den Hollander, D., Azarang, L., Desar, I., Young, R., Oosten, A., De Haan, J.J., Gelderblom, H., Steeghs, N., Husson, O., and Van Der Graaf, W.T.A.
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- 2024
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47. 607O Interim results of a phase I study of SGN-PDL1V (PF-08046054) in patients with PDL1-expressing solid tumors
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Oliva, M., Ochsenreither, S., Le Tourneau, C., Champiat, S., Saleh, R., Burkitt, K., Nabell, L., Steeghs, N., Spreafico, A., Minchom, A.R., Patnaik, A., Call, J.A., Fontana, E., Kotecki, N., Garralda, E., Zivi, A., Riess, J.W., Gupta, S., Zhang, R., and Gillison, M.
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- 2024
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48. Molecular Tumor Boards: current practice and future needs
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van der Velden, D L, van Herpen, C M L, van Laarhoven, H W M, Smit, E F, Groen, H J M, Willems, S M, Nederlof, P M, Langenberg, M H G, Cuppen, E, Sleijfer, S, Steeghs, N, and Voest, E E
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- 2017
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49. A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns
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Jiao, W, Atwal, G, Polak, P, Karlic, R, Cuppen, E, Al-Shahrour, F, Bailey, P, Biankin, A, Boutros, P, Campbell, P, Chang, D, Cooke, S, Deshpande, V, Faltas, B, Faquin, W, Garraway, L, Getz, G, Grimmond, S, Haider, S, Hoadley, K, Kaiser, V, Kato, M, Kubler, K, Lazar, A, C. H., L, Louis, D, Margolin, A, Martin, S, Nahal-Bose, H, Nielsen, G, Nik-Zainal, S, Omberg, L, P'Ng, C, Perry, M, Rheinbay, E, Rubin, M, Semple, C, Sgroi, D, Shibata, T, Siebert, R, Smith, J, Stein, L, Stobbe, M, Sun, R, Thai, K, Wright, D, C. -L., W, Yuan, K, Zhang, J, Danyi, A, de Ridder, J, van Herpen, C, Lolkema, M, Steeghs, N, Morris, Q, Aaltonen, L, Abascal, F, Abeshouse, A, Aburatani, H, Adams, D, Agrawal, N, Ahn, K, Ahn, S, Aikata, H, Akbani, R, Akdemir, K, Al-Ahmadie, H, Al-Sedairy, S, Alawi, M, Albert, M, Aldape, K, Alexandrov, L, Ally, A, Alsop, K, Alvarez, E, Amary, F, Amin, S, Aminou, B, Ammerpohl, O, Anderson, M, Ang, Y, Antonello, D, Anur, P, Aparicio, S, Appelbaum, E, Arai, Y, Aretz, A, Arihiro, K, Ariizumi, S, Armenia, J, Arnould, L, Asa, S, Assenov, Y, Aukema, S, Auman, J, Aure, M, Awadalla, P, Aymerich, M, Bader, G, Baez-Ortega, A, Bailey, M, Balasundaram, M, Balu, S, Bandopadhayay, P, Banks, R, Barbi, S, Barbour, A, Barenboim, J, Barnholtz-Sloan, J, Barr, H, Barrera, E, Bartlett, J, Bartolome, J, Bassi, C, Bathe, O, Baumhoer, D, Bavi, P, Baylin, S, Bazant, W, Beardsmore, D, Beck, T, Behjati, S, Behren, A, Niu, B, Bell, C, Beltran, S, Benz, C, Berchuck, A, Bergmann, A, Bergstrom, E, Berman, B, Berney, D, Bernhart, S, Beroukhim, R, Berrios, M, Bersani, S, Bertl, J, Betancourt, M, Bhandari, V, Bhosle, S, Bieg, M, Bigner, D, Binder, H, Birney, E, Birrer, M, Biswas, N, Bjerkehagen, B, Bodenheimer, T, Boice, L, Bonizzato, G, De Bono, J, Boot, A, Bootwalla, M, Borg, A, Borkhardt, A, Boroevich, K, Borozan, I, Borst, C, Bosenberg, M, Bosio, M, Boultwood, J, Bourque, G, Bova, G, Bowen, D, Bowlby, R, Bowtell, D, Boyault, S, Boyce, R, Boyd, J, Brazma, A, Brennan, P, Brewer, D, Brinkman, A, Bristow, R, Broaddus, R, Brock, J, Brock, M, Broeks, A, Brooks, A, Brooks, D, Brors, B, Brunak, S, Bruxner, T, Bruzos, A, Buchanan, A, Buchhalter, I, Buchholz, C, Bullman, S, Burke, H, Burkhardt, B, Burns, K, Busanovich, J, Bustamante, C, Butler, A, Butte, A, Byrne, N, Borresen-Dale, A, Caesar-Johnson, S, Cafferkey, A, Cahill, D, Calabrese, C, Caldas, C, Calvo, F, Camacho, N, Campo, E, Cantu, C, Cao, S, Carey, T, Carlevaro-Fita, J, Carlsen, R, Cataldo, I, Cazzola, M, Cebon, J, Cerfolio, R, Chadwick, D, Chakravarty, D, Chalmers, D, Chan, C, Chan, K, Chan-Seng-Yue, M, Chandan, V, Chanock, S, Chantrill, L, Chateigner, A, Chatterjee, N, Chayama, K, Chen, H, Chen, J, Chen, K, Chen, Y, Chen, Z, Cherniack, A, Chien, J, Chiew, Y, Chin, S, Cho, J, Cho, S, Choi, J, Choi, W, Chomienne, C, Chong, Z, Choo, S, Chou, A, Christ, A, Christie, E, Chuah, E, Cibulskis, C, Cibulskis, K, Cingarlini, S, Clapham, P, Claviez, A, Cleary, S, Cloonan, N, Cmero, M, Collins, C, Connor, A, Cooper, C, Cope, L, Corbo, V, Cordes, M, Cordner, S, Cortes-Ciriano, I, Covington, K, Cowin, P, Craft, B, Craft, D, Creighton, C, Cun, Y, Curley, E, Cutcutache, I, Czajka, K, Czerniak, B, Dagg, R, Danilova, L, Davi, M, Davidson, N, Davies, H, Davis, I, Davis-Dusenbery, B, Dawson, K, De La Vega, F, De Paoli-Iseppi, R, Defreitas, T, Tos, A, Delaneau, O, Demchok, J, Demeulemeester, J, Demidov, G, Demircioglu, D, Dennis, N, Denroche, R, Dentro, S, Desai, N, Deshwar, A, Desmedt, C, Deu-Pons, J, Dhalla, N, Dhani, N, Dhingra, P, Dhir, R, Dibiase, A, Diamanti, K, Ding, L, Ding, S, Dinh, H, Dirix, L, Doddapaneni, H, Donmez, N, Dow, M, Drapkin, R, Drechsel, O, Drews, R, Serge, S, Dudderidge, T, Dueso-Barroso, A, Dunford, A, Dunn, M, Dursi, L, Duthie, F, Dutton-Regester, K, Eagles, J, Easton, D, Edmonds, S, Edwards, P, Edwards, S, Eeles, R, Ehinger, A, Eils, J, Eils, R, El-Naggar, A, Eldridge, M, Ellrott, K, Erkek, S, Escaramis, G, Espiritu, S, Estivill, X, Etemadmoghadam, D, Eyfjord, J, Fan, D, Fan, Y, Farcas, C, Fassan, M, Fatima, A, Favero, F, Fayzullaev, N, Felau, I, Fereday, S, Ferguson, M, Ferretti, V, Feuerbach, L, Field, M, Fink, J, Finocchiaro, G, Fisher, C, Fittall, M, Fitzgerald, A, Fitzgerald, R, Flanagan, A, Fleshner, N, Flicek, P, Foekens, J, Fong, K, Fonseca, N, Foster, C, Fox, N, Fraser, M, Frazer, S, Frenkel-Morgenstern, M, Friedman, W, Frigola, J, Fronick, C, Fujimoto, A, Fujita, M, Fukayama, M, Fulton, L, Fulton, R, Furuta, M, Futreal, P, Fullgrabe, A, Gabriel, S, Gallinger, S, Gambacorti-Passerini, C, Gao, J, Gao, S, Garred, O, Garrison, E, Garsed, D, Gehlenborg, N, Gelpi, J, George, J, Gerhard, D, Gerhauser, C, Gershenwald, J, Gerstein, M, Gerstung, M, Ghori, M, Ghossein, R, Giama, N, Gibbs, R, Gibson, B, Gill, A, Gill, P, Giri, D, Glodzik, D, Gnanapragasam, V, Goebler, M, Goldman, M, Gomez, C, Gonzalez, S, Gonzalez-Perez, A, Gordenin, D, Gossage, J, Gotoh, K, Govindan, R, Grabau, D, Graham, J, Grant, R, Green, A, Green, E, Greger, L, Grehan, N, Grimaldi, S, Grossman, R, Grundhoff, A, Gundem, G, Guo, Q, Gupta, M, Gupta, S, Gut, I, Gut, M, Goke, J, Ha, G, Haake, A, Haan, D, Haas, S, Haase, K, Haber, J, Habermann, N, Hach, F, Hama, N, Hamdy, F, Hamilton, A, Hamilton, M, Han, L, Hanna, G, Hansmann, M, Haradhvala, N, Harismendy, O, Harliwong, I, Harmanci, A, Harrington, E, Hasegawa, T, Haussler, D, Hawkins, S, Hayami, S, Hayashi, S, Hayes, D, Hayes, S, Hayward, N, Hazell, S, He, Y, Heath, A, Heath, S, Hedley, D, Hegde, A, Heiman, D, Heinold, M, Heins, Z, Heisler, L, Hellstrom-Lindberg, E, Helmy, M, Heo, S, Hepperla, A, Heredia-Genestar, J, Herrmann, C, Hersey, P, Hess, J, Hilmarsdottir, H, Hinton, J, Hirano, S, Hiraoka, N, Hobolth, A, Hodzic, E, Hoell, J, Hoffmann, S, Hofmann, O, Holbrook, A, Holik, A, Hollingsworth, M, Holmes, O, Holt, R, Hong, C, Hong, E, Hong, J, Hooijer, G, Hornshoj, H, Hosoda, F, Hou, Y, Hovestadt, V, Howat, W, Hoyle, A, Hruban, R, Hu, J, Hu, T, Hua, X, Huang, K, Huang, M, Huang, V, Huang, Y, Huber, W, Hudson, T, Hummel, M, Hung, J, Huntsman, D, Hupp, T, Huse, J, Huska, M, Hutter, B, Hutter, C, Hubschmann, D, Iacobuzio-Donahue, C, Imbusch, C, Imielinski, M, Imoto, S, Isaacs, W, Isaev, K, Ishikawa, S, Iskar, M, Islam, S, Ittmann, M, Ivkovic, S, Izarzugaza, J, Jacquemier, J, Jakrot, V, Jamieson, N, Jang, G, 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S., J, Juhl, H, Jung, J, Juul, M, Juul, R, Juul, S, Jager, N, Kabbe, R, Kahles, A, Kahraman, A, Kakavand, H, Kalimuthu, S, von Kalle, C, Kang, K, Karaszi, K, Karlan, B, Karsch, D, Kasaian, K, Kassahn, K, Katai, H, Katoh, H, Kawakami, Y, Kay, J, Kazakoff, S, Kazanov, M, Keays, M, Kebebew, E, Kefford, R, Kellis, M, Kench, J, Kennedy, C, Kerssemakers, J, Khoo, D, Khoo, V, Khuntikeo, N, Khurana, E, Kilpinen, H, Kim, H, Kim, J, Kim, Y, King, T, Klapper, W, Kleinheinz, K, Klimczak, L, Knappskog, S, Kneba, M, Knoppers, B, Koh, Y, Komorowski, J, Komura, D, Komura, M, Kong, G, Kool, M, Korbel, J, Korchina, V, Korshunov, A, Koscher, M, Koster, R, Kote-Jarai, Z, Koures, A, Kovacevic, M, Kremeyer, B, Kretzmer, H, Kreuz, M, Krishnamurthy, S, Kube, D, Kumar, K, Kumar, P, Kumar, S, Kumar, Y, Kundra, R, Kuppers, R, Lagergren, J, Lai, P, Laird, P, Lakhani, S, Lalansingh, C, Lalonde, E, Lamaze, F, Lambert, A, Lander, E, Landgraf, P, Landoni, L, Langerod, A, Lanzos, A, Larsimont, D, Larsson, E, Lathrop, M, Lau, L, Lawerenz, C, Lawlor, R, Lawrence, M, Lazic, A, Le, X, Lee, D, Lee, E, Lee, H, Lee, J, Lee, M, Lee-Six, H, Lehmann, K, Lehrach, H, Lenze, D, Leonard, C, Leongamornlert, D, Leshchiner, I, Letourneau, L, Letunic, I, Levine, D, Lewis, L, Ley, T, Li, C, H. I., L, Li, J, Li, L, Li, S, Li, X, Li, Y, Liang, H, Liang, S, Lichter, P, Lin, P, Lin, Z, Linehan, W, Lingjaerde, O, Liu, D, Liu, E, Liu, F, Liu, J, Liu, X, Livingstone, J, Livitz, D, Livni, N, Lochovsky, L, Loeffler, M, Long, G, Lopez-Guillermo, A, Lou, S, Lovat, L, Lu, Y, Y. -J., L, Luchini, C, Lungu, I, Luo, X, Luxton, H, Lynch, A, Lype, L, Lopez, C, Lopez-Otin, C, E. 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W. 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- Abstract
In cancer, the primary tumour’s organ of origin and histopathology are the strongest determinants of its clinical behaviour, but in 3% of cases a patient presents with a metastatic tumour and no obvious primary. Here,as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, we train a deep learning classifier to predict cancer type based on patterns of somatic passenger mutations detected in whole genome sequencing (WGS) of 2606 tumours representing 24 common cancer types produced by the PCAWG Consortium. Our classifier achieves an accuracy of 91% on held-out tumor samples and 88% and 83% respectively on independent primary and metastatic samples, roughly double the accuracy of trained pathologists when presented with a metastatic tumour without knowledge of the primary. Surprisingly, adding information on driver mutations reduced accuracy. Our results have clinical applicability, underscore how patterns of somatic passenger mutations encode the state of the cell of origin, and can inform future strategies to detect the source of circulating tumour DNA.
- Published
- 2020
50. Exposure-response analyses of cabozantinib in patients with metastatic renal cell cancer
- Author
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Krens, S.D., Erp, N.P. van, Groenland, S.L., Moes, D., Mulder, S.F., Desar, I.M.E., Steeghs, N., Herpen, C.M.L. van, Krens, S.D., Erp, N.P. van, Groenland, S.L., Moes, D., Mulder, S.F., Desar, I.M.E., Steeghs, N., and Herpen, C.M.L. van
- Abstract
Contains fulltext : 247667.pdf (Publisher’s version ) (Open Access)
- Published
- 2022
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