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28 results on '"Stazi, M.A."'

2. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Author

Skytthe, A., Valensin, S., Jeune, B., Cevenini, E., Balard, F., Beekman, M., Bezrukov, V., Blanche, H., Bolund, L., Broczek, K., Carru, C., Christensen, K., Christiansen, L., Collerton, J.C., Cotichini, R., de Craen, A.J.M., Dato, S., Davies, K., De Benedictis, G., Deiana, L., Flachsbart, F., Gampe, J., Gilbault, C., Gonos, E.S., Haimes, E., Hervonen, A., Hurme, M.A., Janiszewska, D., Jylhä, M., Kirkwood, T.B.L., Kristensen, P., Laiho, P., Leon, A., Marchisio, A., Masciulli, R., Nebel, A., Passarino, G., Pelicci, G., Peltonen, L., Perola, M., Poulain, M., Rea, I.M., Remacle, J., Robine, J.M., Schreiber, S., Scurti, M., Sevini, F., Sikora, E., Skouteri, A., Slagboom, P.E., Spazzafumo, L., Stazi, M.A., Toccaceli, V., Toussaint, O., Törnwall, O., Vaupel, J.W., Voutetakis, K., and Franceschi, C.

Published
2011
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3. Concordance, disease progression, and heritability of coeliac disease in Italian twins

Author

Nistico, L., Fagnani, C., Coto, I., Percopo, S., Cotichini, R., Limongelli, M.G., Paparo, F., D'Alfonso, S., Giordano, M., Sferlazzas, C., Magazzu, G., Momigliano-Richiardi, P., Greco, L., and Stazi, M.A.

Subjects
Celiac disease -- Development and progression, Celiac disease -- Genetic aspects, Celiac disease -- Risk factors, Twins -- Health aspects, Twins -- Genetic aspects, Twins -- Research, Health
Published
2006

4. The first large population based twin study of coeliac disease. (Small Intestine)

Author

Greco, L., Romino, R., Coto, I., Cosmo, N. Di, Percopo, S., Maglio, M., Paparo, F., Gasperi, V., Limongelli, M.G., Cotichini, R., D'Agate, C., Tinto, N., Sacchetti, L., Tosi, R., and Stazi, M.A.

Subjects
Celiac disease -- Genetic aspects -- Research, Familial diseases -- Research -- Genetic aspects, Twin studies -- Research, Twins -- Research -- Diseases -- Genetic aspects, Health, Diseases, Research, Genetic aspects
Abstract

Background and aims: The genetic load in coeliac disease has hitherto been inferred from case series or anecdotally referred twin pairs. We have evaluated the genetic component in coeliac disease [...]

Published
2002

6. Greater Risk of Asthma and Allergic Rhinitis, But Not Eczema, Associated with Living Close to Green Space in European Children. The Heals Project

Author

Annesi-Maesano, I., primary, Maesano, C.N., additional, Baldacci, S., additional, Bono, R., additional, Brescianini, S., additional, D'Ippolito, C., additional, Hanke, W., additional, Horvat, M., additional, Liedes, H., additional, Maio, S., additional, Marchetti, P., additional, Marcon, A., additional, Medda, E., additional, Molinier, M., additional, Panunzi, S., additional, Pärkkä, J., additional, Polańska, K., additional, Prud'homme, J., additional, Ricci, P., additional, Sabel, C.E., additional, Snoj Tratnik, J., additional, Squillacioti, G., additional, Stazi, M.A., additional, Parmes, E., additional, and Pesce, G., additional

Published
2020
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7. Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Author

Beekman, M., Blanche, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., Craen, A.J.M. de, Kirkwood, T.B.L., Rea, I.M., Poulain, M., Robine, J.M., Valensin, S., Stazi, M.A., Passarino, G., Deiana, L., Gonos, E.S., Paternoster, L., Sorensen, T.I.A., Tan, Q.H., Helmer, Q., Akker, E.B. van den, Deelen, J., Martella, F., Cordell, H.J., Ayers, K.L., Vaupel, J.W., Tornwall, O., Johnson, T.E., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, R.G.J., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, J.J., Slagboom, P.E., Franceschi, C., GEHA Consortium, Leiden University Medical Center (LUMC), Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris] (CEPH), National Institute for Health and Welfare [Helsinki], Tampere School of Public Health, Institute of Gerontology [Kiev], Nencki Institute of Experimental Biology, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Christian-Albrechts University of Kiel, University of Southern Denmark (SDU), Netherlands Consortium for Healthy Ageing, Newcastle University [Newcastle], The Queen’s University of Belfast, Université Catholique de Louvain = Catholic University of Louvain (UCL), CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS), University of Bologna, Istituto Superiore di Sanita [Rome], Università della Calabria [Arcavacata di Rende] (Unical), Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Theoretical and Physical Chemistry Institute NHRF, National Hellenic Research Foundation, University of Bristol [Bristol], Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Odense University Hospital (OUH), Institute for Ageing and Health, Newcastle University, Max Planck Institute for Demographic Research (MPIDR), Max-Planck-Gesellschaft, University of Colorado [Boulder], Leiden University Medical Centre [Leyde, Pays-Bas], Leiden University, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Institute for Ageing and Health, École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Sassari, Danish Aging Research Center, Institute of Public Health, and Institute for Behavioral Genetics

Subjects
Aging, Genetic Linkage, APOE gene, Genome-wide association study, Association analysis, Human familial longevity, [SHS]Humanities and Social Sciences, 0302 clinical medicine, Mitochondrial Precursor Protein Import Complex Proteins, Cluster Analysis, Nonagenarian sibling pairs, media_common, Aged, 80 and over, Genetics, 0303 health sciences, Longevity, Chromosome Mapping, Middle Aged, Europe, genome-wide linkage analysis, association analysis, nonagenarian sibling pairs, apoe gene, human familial longevity, congenital, hereditary, and neonatal diseases and abnormalities, media_common.quotation_subject, Locus (genetics), Biology, Article, 03 medical and health sciences, Apolipoproteins E, SDG 3 - Good Health and Well-being, Genetic linkage, Humans, Allele, Alleles, Aged, 030304 developmental biology, Genetic association, Chromosomes, Human, Pair 14, Apolipoprotein C-I, Genome, Human, Siblings, Membrane Transport Proteins, Cell Biology, Heritability, Apoe gene, Genetic Loci, Human genome, Lod Score, Chromosomes, Human, Pair 19, Genome-wide linkage analysis, 030217 neurology & neurosurgery, Chromosomes, Human, Pair 17, Genome-Wide Association Study
Abstract

Clear evidence exists for heritability of humanlongevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage scan thus far reported. Linkage analyses included 2118nonagenarian Caucasian sibling pairs that have been enrolled in 15 study centers of 11 European countries as part of the Genetics of Healthy Aging (GEHA) project. In the joint linkage analyses, we observed four regions that show linkage with longevity; chromosome 14q11.2 (LOD = 3.47), chromosome 17q12-q22 (LOD = 2.95), chromosome 19p13.3-p13.11 (LOD = 3.76), and chromosome 19q13.11-q13.32 (LOD = 3.57). To fine map these regions linked to longevity, we performed association analysis using GWAS data in a subgroup of 1228 unrelated nonagenarian and 1907 geographically matched controls. Using a fixed-effect meta-analysis approach, rs4420638 at the TOMM40/ APOE/APOC1 gene locus showed significant association with longevity (P-value = 9.6 × 10 -8). By combined modeling of linkage and association, we showed that association of longevity with APOEe4 and APOEe2 alleles explain the linkage at 19q13.11-q13.32 with P-value = 0.02 and P-value = 1.0 × 10 -5, respectively. In the largest linkage scan thus far performed for human familial longevity, we confirm that the APOE locus is a longevity gene and that additional longevity loci may be identified at 14q11.2, 17q12-q22, and 19p13.3-p13.11. As the latter linkage results are not explained by common variants, we suggest that rare variants play an important role in human familial longevity.

Published
2013

8. 1A.12

Author

Tarnoki, A., primary, Tarnoki, D.L., additional, Fejer, B., additional, Godor, E., additional, Molnar, A.A., additional, Horvat, P. Maurovich, additional, Medda, E., additional, Fagnani, C., additional, Stazi, M.A., additional, Merkely, B., additional, Farina, F., additional, Baracchini, C., additional, Pucci, G., additional, Schillaci, G., additional, and Jermendy, G., additional

Published
2015
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9. PP.18.25

Author

Tarnoki, D., primary, Tarnoki, A.D., additional, Fejer, B., additional, Godor, E., additional, Molnar, A.A., additional, Kovacs, A., additional, Horvat, P. Maurovich, additional, Medda, E., additional, Fagnani, C., additional, Stazi, M.A., additional, Merkely, B., additional, Farina, F., additional, Baracchini, C., additional, Pucci, G., additional, Jermendy, G.Y., additional, and Schillaci, G., additional

Published
2015
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10. PP.04.17

Author

Pucci, G., primary, Medda, E., additional, Tarnoki, A.D., additional, Tarnoki, D.L., additional, Kovacs, A., additional, Molnar, A.A., additional, Battista, F., additional, Abu Shrkihe, B., additional, Salemi, M., additional, Stazi, M.A., additional, and Schillaci, G., additional

Published
2015
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11. Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study

Author

Medda, E., primary, Fagnani, C., additional, Schillaci, G., additional, Tarnoki, A.D., additional, Tarnoki, D.L., additional, Baracchini, C., additional, Meneghetti, G., additional, Fanelli, F., additional, Alaeddin, A., additional, Pucci, G., additional, Alviti, S., additional, Cotichini, R., additional, Brescianini, S., additional, Boatta, E., additional, Lucatelli, P., additional, Nisticò, L., additional, Penna, L., additional, Salemi, M., additional, Toccaceli, V., additional, Zini, C., additional, Garami, Z., additional, and Stazi, M.A., additional

Published
2014
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12. Serum elements and oxidative status in clinically isolated syndromes

Author

Ristori, G., primary, Brescianini, S., additional, Pino, A., additional, Visconti, A., additional, Vittori, D., additional, Coarelli, G., additional, Cotichini, R., additional, Bocca, B., additional, Forte, G., additional, Pozzilli, C., additional, Pestalozza, I., additional, Stazi, M.A., additional, Alimonti, A., additional, and Salvetti, M., additional

Published
2011
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13. P8.12 GENETIC INFLUENCES ON THE RELATION BETWEEN EXHALED NITRIC OXIDE AND ARTERIAL STIFFNESS: A TWIN STUDY

Author

Tarnoki, D.L., primary, Tarnoki, A.D., primary, Medda, E., primary, Littvay, L., primary, Lazar, Z.S., primary, Cotichini, R., primary, Fagnani, C., primary, Stazi, M.A., primary, Nisticó, L., primary, Fanelli, F., primary, Baracchini, C., primary, Meneghetti, G., primary, Jermendy, Gy., primary, Preda, I., primary, Lannert, A., primary, Molnar, A.A., primary, Garami, Z., primary, Kiss, R.G., primary, Berczi, V., primary, and Horvath, I., primary

Published
2011
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14. P11.30 HERITABILITY OF CENTRAL BLOOD PRESSURE AND PULSE PRESSURE – A TWIN STUDY

Author

Tarnoki, A.D., primary, Tarnoki, D.L., primary, Stazi, M.A., primary, Medda, E., primary, Cotichini, R., primary, Nistico, L., primary, Lucatelli, P., primary, Boatta, E., primary, Zini, C., primary, Fanelli, F., primary, Baracchini, C., primary, Meneghetti, G., primary, Schillaci, G., primary, Jermendy, G., primary, Osztovits, J., primary, Lannert, A., primary, Molnar, A.A., primary, Littvay, L., primary, Garami, Z., primary, and Berczi, V., primary

Published
2011
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15. Heritability of adult body height: a comparative study of twin cohorts in eight countries

Author

Silventoinen, K., Sammalisto, S., Perola, M., Boomsma, D.I., Cornes, B., Davis, C., Dunkel, L., de Lange, M., Harris, J.R., Hjemborg, J.V.B., Luciano, M, Martin, N.G., Mortensen, J., Nistico, L., Pedersen, N.L., Skytthe, A., Spector, T.D., Stazi, M.A., Willemsen, G., Kaprio, J, Silventoinen, K., Sammalisto, S., Perola, M., Boomsma, D.I., Cornes, B., Davis, C., Dunkel, L., de Lange, M., Harris, J.R., Hjemborg, J.V.B., Luciano, M, Martin, N.G., Mortensen, J., Nistico, L., Pedersen, N.L., Skytthe, A., Spector, T.D., Stazi, M.A., Willemsen, G., and Kaprio, J

Abstract

A major component of variation in body height is due to genetic differences, but environmental factors have a substantial contributory effect. In this study we aimed to analyse whether the genetic architecture of body height varies between affluent western societies. We analysed twin data from eight countries comprising 30,111 complete twin pairs by using the univariate genetic model of the Mx statistical package. Body height and zygosity were self-reported in seven populations and measured directly in one population. We found that there was substantial variation in mean body height between countries; body height was least in Italy (177 cm in men and 163 cm in women) and greatest in the Netherlands (184 cm and 171 cm, respectively). In men there was no corresponding variation in heritability of body height, heritability estimates ranging from 0.87 to 0.93 in populations under an additive genes/unique environment (AE) model. Among women the heritability estimates were generally lower than among men with greater variation between countries, ranging from 0.68 to 0.84 when an additive genes/shared environment/unique environment (ACE) model was used. In four populations where an AE model fit equally well or better, heritability ranged from 0.89 to 0.93. This difference between the sexes was mainly due to the effect of the shared environmental component of variance, which appears to be more important among women than among men in our study populations. Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men.

Published
2003
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18. Epidemiology of acute promyelocytic leukemia in Italy

Author

Avvisati, G., primary, Mele, A., additional, Stazi, M.A., additional, Vegna, M.L., additional, Pasquini, P., additional, Mandelli, F., additional, Rotoli, B., additional, De Rosa, G., additional, Papa, G., additional, Venditti, A., additional, Citarrella, P., additional, Tambone Reyes, M., additional, Ascari, E., additional, Invernizzi, R., additional, Cajozzo, A., additional, Musso, M., additional, Alberti, A., additional, Peta, A., additional, Rossi Ferrini, P., additional, Leoni, F., additional, Caronia, F., additional, Mirto, S., additional, Nobile, F., additional, Iacopino, P., additional, Resegotti, L., additional, Allione, B., additional, Monfardini, S., additional, Zagonel, V., additional, Liso, V., additional, Specchia, G., additional, Tura, S., additional, Visani, G., additional, Broccia, G., additional, Deplano, W., additional, Ricciuti, F., additional, Pizzuti, M., additional, Longinotti, M., additional, Bonfigli, S., additional, De Laurenzi, A., additional, Pacilli, L., additional, Deriu, L., additional, Chierichini, A., additional, Bizzi, B., additional, Leone, G., additional, De Biasi, R., additional, Miraglia, E., additional, Bruzzese, L., additional, and Abbadessa, A., additional

Published
1991
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21. Prophylaxis of Hepatitis C with Intramuscular Immunoglobulin: Clinical and Economic Appraisal.

Author

Palumbo, F., Piazza, M., Manzin, A., Sagliocca, L., Clementi, M., Tosone, G., Guadagnino, V., Stazi, M.A., Orlando, R., Borgia, G., Rosa, D., and Abrignani, S.

Subjects
HEPATITIS C, IMMUNOGLOBULINS
Abstract

Hepatitis C virus (HCV) affects millions of individuals worldwide. In most cases, HCV infection progresses to chronic liver disease and, subsequently, to liver cirrhosis and hepatocellular carcinoma. HCV is transmitted by the parenteral route, for example by transfusion of blood or blood products, injection during drug abuse, etc., and by the inapparent parenteral route (penetration of the virus through difficult-to-identify microlesions present on the skin or mucosae), for example, sexual exposure or household exposure to infected contacts, etc. The cost of chronic hepatitis C and its sequelae is high in both financial and human terms. At present, only anti-HCV screening of blood/organ/tissue donors and universal precautions for the prevention of blood-borne infections are recommended for HCV prevention. Before the discovery of the main aetiological agent of non-A, non-B hepatitis (HCV), several randomised controlled clinical trials demonstrated that standard intramuscular immunoglobulin exerted a preventive effect on post-transfusional and sexual and /or horizontal transmission of non-A, non-B hepatitis. When serological tests for HCV infection became available, bimonthly inoculation of standard unscreened intramuscular immunoglobulin (prepared from plasma pools containing about 2% of anti-HCV-positive units) was demonstrated to significantly prevent sexually transmitted HCV infection. The immunoglobulin used contained high titres of anti-HCV neutralising antibodies (anti-E2 neutralisation of binding assay), whereas currently available commercial screened immunoglobulin (prepared from anti-HCV-negative blood units) did not. This finding suggested that anti-HCV neutralising antibodies are concentrated only in anti-HCV-positive units (which are currently discarded). Thus, anti-HCV hyperimmune globulin (HCIg) can be produced only from anti-HCV-positive units. The neutralising titre can be increased by the exclusive use of units with higher titres of neutralising antibodies. Unlike other hyperimmune globulins, which are produced from a limited number of selected donors, HCIg should be produced from a large number of units so as to contain neutralising antibodies to the different HCV strains. HCIg will have a number of advantages: (i) it is easy to produce and inexpensive; (ii) it has a long half-life, allowing infrequent administration; (iii) new additional viral inactivation procedures have been introduced to eradicate transmission of infection, and (iv) it may be possible to neutralise all the emerging HCV strains. HCIg could be used in all individuals at risk of HCV infection (sexual partners, haemodialysis patients, etc), in preventing reinfection of transplanted livers, and perhaps also in the treatment of chronic hepatitis C, alone or associated with other drugs. [ABSTRACT FROM AUTHOR]

Published
1999

22. Epidemiological surveillance of diseases following the earthquake of 23rd November 1980 in Southern Italy

Author

Greco, D., primary, Faustini, A., additional, Forastiere, F., additional, Galanti, M.R., additional, Magliola, M.E., additional, Moro, M.L., additional, Piergentili, P., additional, Rosmini, F., additional, Stazi, M.A., additional, Luzi, S., additional, Fantozzi, L., additional, Capocaccia, R., additional, Conti, S., additional, and Zampieri, A., additional

Published
1981
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23. An Independent Evaluation of the Lens Opacities Classification system II (LOCS II)

Author

Maraini, Giovanni, primary, Pasquini, Paolo, additional, Tomba, Maria C., additional, Bonacini, Mirka, additional, Stazi, Maria A., additional, Rosmini, Francesco, additional, Sperduto, Robert D., additional, Maraini, G., additional, Pasquini, P., additional, Bonacini, M., additional, Cantarelli, R., additional, Preti, S., additional, Tencani, C., additional, Tomba, M.C., additional, Williams, S.L., additional, Corona, R.M., additional, Rosmini, F., additional, Stazi, M.A., additional, Raschetti, R., additional, Rossi, G.L., additional, Damiani, G., additional, Meazza, M., additional, Volta, S., additional, Bolchi, A., additional, Sperduto, R.D., additional, Mowery, R.L., additional, Leske, M.C., additional, and Kahn, H., additional

Published
1989
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24. Epidemiology of acute promyelocytic leukemia in Italy

Author

Rotoli, B., De Rosa, G., Papa, G., Venditti, A., Citarrella, P., Tambone Reyes, M., Ascari, E., Invernizzi, R., Cajozzo, A., Musso, M., Alberti, A., Peta, A., Rossi Ferrini, P., Leoni, F., Caronia, F., Mirto, S., Nobile, F., Iacopino, P., Resegotti, L., Allione, B., Monfardini, S., Zagonel, V., Liso, V., Specchia, G., Tura, S., Visani, G., Broccia, G., Deplano, W., Ricciuti, F., Pizzuti, M., Longinotti, M., Bonfigli, S., De Laurenzi, A., Pacilli, L., Deriu, L., Chierichini, A., Bizzi, B., Leone, G., De Biasi, R., Miraglia, E., Bruzzese, L., Abbadessa, A., Avvisati, G., Mele, A., Stazi, M.A., Vegna, M.L., Pasquini, P., and Mandelli, F.

Published
1991
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27. Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

Author

C. Gilbault, G. Pelicci, Marian Beekman, Axel Skytthe, Serena Dato, A. Skouteri, Konstantinos Voutetakis, Luca Deiana, Ciriaco Carru, Ewa Sikora, Claudio Franceschi, Friederike Flachsbart, Leena Peltonen, James W. Vaupel, P. Laiho, Joanna Collerton, V. Bezrukov, Stefan Schreiber, Michel Poulain, Karen Davies, Irene Maeve Rea, Mikko Hurme, Giuseppe Passarino, Federica Sevini, Katarzyna Broczek, Outi Törnwall, Antti Hervonen, Elisa Cevenini, Hélène Blanché, Bernard Jeune, Maria Scurti, Rodolfo Cotichini, Jean-Marie Robine, Erica Haimes, A.J.M. de Craen, Thomas B. L. Kirkwood, R. Masciulli, José Remacle, Lene Christiansen, Dorota Janiszewska, F. Balard, Almut Nebel, A. Leon, P.E. Slagboom, Lars Bolund, A. Marchisio, Liana Spazzafumo, Marja Jylhä, Virgilia Toccaceli, G. De Benedictis, Markus Perola, Olivier Toussaint, Jutta Gampe, M A Stazi, Silvana Valensin, Peter Kristensen, Kaare Christensen, Efstathios S. Gonos, University of Southern Denmark (SDU), University of Bologna/Università di Bologna, Laboratoire Lorrain de Sciences Sociales (2L2S), Université de Lorraine (UL), Institut National de la Santé et de la Recherche Médicale (INSERM), Netherlands Consortium for Healthy Ageing, Leiden University Medical Center (LUMC), Universiteit Leiden-Universiteit Leiden, Institute of Gerontology [Kiev], Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris] (CEPH), Beijing Genomics Institute [Shenzhen] (BGI), Institute of Human Genetics [Aarhus], Nencki Institute of Experimental Biology, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Medical University of Warsaw - Poland, Università degli Studi di Sassari = University of Sassari [Sassari] (UNISS), Odense University Hospital (OUH), Newcastle University [Newcastle], Istituto Superiore di Sanità (ISS), Universiteit Leiden, Università della Calabria [Arcavacata di Rende] (Unical), Institute of Clinical Molecular Biology, Kiel University, Max Planck Institute for Demographic Research (MPIDR), Max-Planck-Gesellschaft, Université Catholique de Louvain = Catholic University of Louvain (UCL), National Hellenic Research Foundation [Athens], Tampere School of Public Health, University of Tampere [Finland], University of Aarhus, The National Institute for Health and Welfare, National Institute for Health and Welfare [Helsinki], Research Innovation [Italy], IFOM Institute of Milan, Queen's University [Belfast] (QUB), Eppendorf Array Technologies, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Istituto Nazionale Ricovero e Cura Anziani, Université de Namur [Namur] (UNamur), European Project: 26813,GEHA, University of Bologna, Istituto Superiore di Sanita [Rome], University of Calabria, The Queen’s University of Belfast, Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-École des hautes études en sciences sociales (EHESS), Skytthe A., Valensin S., Jeune B., Cevenini E., Balard F., Beekman M., Bezrukov V., Blanche H., Bolund L., Broczek K., Carru C., Christensen K., Christiansen L., Collerton J.C., Cotichini R., de Craen A.J., Dato S., Davies K., De Benedictis G., Deiana L., Flachsbart F., Gampe J., Gilbault C., Gonos E.S., Haimes E., Hervonen A., Hurme M.A., Janiszewska D., Jylha M., Kirkwood T.B., Kristensen P., Laiho P., Leon A., Marchisio A., Masciulli R., Nebel A., Passarino G., Pelicci G., Peltonen L., Perola M., Poulain M., Rea I.M., Remacle J., Robine J.M., Schreiber S., Scurti M., Sevini F., Sikora E., Skouteri A., Slagboom P.E., Spazzafumo L., Stazi M.A., Toccaceli V., Toussaint O., Tornwall O., Vaupel J.W., Voutetakis K., Franceschi C., GEHA consortium [Pini Elisa, Palmas Maria Giustina, Panourgia Maria Panagiota], balard, frédéric, and GEnetics for Healthy Aging - GEHA - 26813 - OLD

Subjects
Research design, Gerontology, Male, Questionnaires, Aging, Genetic Linkage, [SDV]Life Sciences [q-bio], Genome-wide association study, Biochemistry, Nonagenarian sib pairs, [SHS]Humanities and Social Sciences, 0302 clinical medicine, Endocrinology, Cognition, Surveys and Questionnaires, 80 and over, Medicine, ComputingMilieux_MISCELLANEOUS, media_common, Genetics, Aged, 80 and over, 0303 health sciences, Life style, Longevity, Middle Aged, HEALTHY AGING, [SDV] Life Sciences [q-bio], Europe, Research Design, Extreme longevity tracking, Female, [SHS] Humanities and Social Sciences, media_common.quotation_subject, Article, 03 medical and health sciences, Healthy ageing, Humans, Family, Molecular Biology, Life Style, 030304 developmental biology, Genetic association, Aged, nonagenarian sib pair, business.industry, Patient Selection, Cell Biology, Multicenter study, business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract

In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7years the number of families with all participating siblings aged 95years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity. In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7years the number of families with all participating siblings aged 95years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.

Published
2011

28. Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging)

Author

Olivier Toussaint, Bernard Jeune, Thomas B. L. Kirkwood, M A Stazi, James W. Vaupel, P.E. Slagboom, Hélène Blanché, Michel Poulain, Jean-Marie Robine, Ewa Sikora, Pier Giuseppe Pelicci, Antti Hervonen, Lars Bolund, V. Bezrukov, Liana Spazzafumo, Irene Maeve Rea, A. Leon, Luca Deiana, José Remacle, Huanning Yang, Stefan Schreiber, Peter Kristensen, Kaare Christensen, Efsthatios Gonos, Giovanna De Benedictis, Claudio Franceschi, Leena Peltonen, Franceschi C., Bezrukov V., Blanché H., Bolund L., Christensen K., de Benedictis G., Deiana L., Gonos E., Hervonen A., Yang H., Jeune B., Kirkwood T.B., Kristensen P., Leon A., Pelicci P.G., Peltonen L., Poulain M., Rea I.M., Remacle J., Robine J.M., Schreiber S., Sikora E., Slagboom P.E., Spazzafumo L., Stazi M.A., Toussaint O., and Vaupel J.W.

Subjects
Adult, medicine.medical_specialty, Linkage disequilibrium, Aging, Genetic Linkage, Genomics, Biology, Genetic analysis, DNA, Mitochondrial, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Linkage Disequilibrium, History and Philosophy of Science, Genetic linkage, Molecular genetics, Genotype, medicine, media_common.cataloged_instance, Animals, Humans, European Union, European union, media_common, Aged, Genetics, Aged, 80 and over, Genome, Models, Genetic, General Neuroscience, Linkage Disequilibrium Mapping, Linkage (Genetics), Middle Aged, Europe
Abstract

Udgivelsesdato: 2007-Apr The aim of the 5-year European Union (EU)-Integrated Project GEnetics of Healthy Aging (GEHA), constituted by 25 partners (24 from Europe plus the Beijing Genomics Institute from China), is to identify genes involved in healthy aging and longevity, which allow individuals to survive to advanced old age in good cognitive and physical function and in the absence of major age-related diseases. To achieve this aim a coherent, tightly integrated program of research that unites demographers, geriatricians, geneticists, genetic epidemiologists, molecular biologists, bioinfomaticians, and statisticians has been set up. The working plan is to: (a) collect DNA and information on the health status from an unprecedented number of long-lived 90+ sibpairs (n = 2650) and of younger ethnically matched controls (n = 2650) from 11 European countries; (b) perform a genome-wide linkage scannning in all the sibpairs (a total of 5300 individuals); this investigation will be followed by linkage disequilibrium mapping (LD mapping) of the candidate chromosomal regions; (c) study in cases (i.e., the 2650 probands of the sibpairs) and controls (2650 younger people), genomic regions (chromosome 4, D4S1564, chromosome 11, 11.p15.5) which were identified in previous studies as possible candidates to harbor longevity genes; (d) genotype all recruited subjects for apoE polymorphisms; and (e) genotype all recruited subjects for inherited as well as epigenetic variability of the mitochondrial DNA (mtDNA). The genetic analysis will be performed by 9 high-throughput platforms, within the framework of centralized databases for phenotypic, genetic, and mtDNA data. Additional advanced approaches (bioinformatics, advanced statistics, mathematical modeling, functional genomics and proteomics, molecular biology, molecular genetics) are envisaged to identify the gene variant(s) of interest. The experimental design will also allow (a) to identify gender-specific genes involved in healthy aging and longevity in women and men stratified for ethnic and geographic origin and apoE genotype; (b) to perform a longitudinal survival study to assess the impact of the identified genetic loci on 90+ people mortality; and (c) to develop mathematical and statistical models capable of combining genetic data with demographic characteristics, health status, socioeconomic factors, lifestyle habits.

Published
2007

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