443 results on '"Stavrinou, P."'
Search Results
2. Correction: Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta‑analysis protocol
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Ballesteros, Soledad, Audifren, Michel, Badache, Andreea, Belkin, Vera, Giannaki, Christoforos D., Kaltsatou, Antonia, Marusic, Uros, Ziaaldini, Mohammad Mosaferi, Peskar, Manca, Reales, Jose M., Rieker, Jennifer A., Stavrinou, Pinelopi S., Tortosa‑Martinez, Juan, Voelcker‑Rehage, Claudia, and Netz, Yael
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- 2024
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3. Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta-analysis protocol
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Ballesteros, Soledad, Audifren, Michel, Badache, Andreea, Belkin, Vera, Giannaki, Christoforos D., Kaltsatou, Antonia, Marusic, Uros, Ziaaldini, Mohammad Mosaferi, Peskar, Manca, Reales, José M., Rieker, Jennifer A., Stavrinou, Pinelopi S., Tortosa-Martinez, Juan, Voelcker-Rehage, Claudia, and Netz, Yael
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- 2024
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4. Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta-analysis protocol
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Soledad Ballesteros, Michel Audifren, Andreea Badache, Vera Belkin, Christoforos D. Giannaki, Antonia Kaltsatou, Uros Marusic, Mohammad Mosaferi Ziaaldini, Manca Peskar, José M. Reales, Jennifer A. Rieker, Pinelopi S. Stavrinou, Juan Tortosa-Martinez, Claudia Voelcker-Rehage, and Yael Netz
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Diseased older adults ,Episodic memory ,Executive functions ,Healthy older adults ,Three-level meta-analysis ,Exercise ,Medicine - Abstract
Abstract Background Executive functions (EFs) and episodic memory are fundamental components of cognition that deteriorate with age and are crucial for independent living. While numerous reviews have explored the effect of exercise on these components in old age, these reviews screened and analyzed selected older adult populations, or specific exercise modes, thus providing only limited answers to the fundamental question on the effect of exercise on cognition in old age. This article describes the protocol for a systematic review and multilevel meta-analytic study aiming at evaluating the effectiveness of different types of chronic exercise in improving and/or maintaining EFs and long-term episodic memory in older adults. Methods and analysis The study protocol was written in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Several databases will be searched. Randomized controlled trials (RCTs) conducted in older adults aged ≥ 60 years providing any kind of planned, structured, and repetitive exercise interventions, and EFs and/or episodic memory measures as outcomes, published in English in peer-reviewed journals and doctoral dissertations will be included. Two independent reviewers will screen the selected articles, while a third reviewer will resolve possible conflicts. The Cochrane risk-of-bias tool will be used to assess the quality of the studies. Finally, data will be extracted from the selected articles, and the formal method of combining individual data from the selected studies will be applied using a random effect multilevel meta-analysis. The data analysis will be conducted with the metafor package in R. Discussion and conclusion This review will synthesize the existing evidence and pinpoint gaps existing in the literature on the effects of exercise on EFs and episodic memory in healthy and unhealthy older adults. Findings from this meta-analysis will help to design effective exercise interventions for older adults to improve and/or maintain EFs and episodic memory. Its results will be useful for many researchers and professionals working with older adults and their families. Systematic review registration PROSPERO CRD42022367111.
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- 2024
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5. Transradial versus transfemoral access for endovascular therapy of intracranial aneurysms: a systematic review and meta-analysis of cohort studies
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Huang, Xinyue, Xiong, Yu, Guo, Xiumei, Kang, Xiaodong, Chen, Chunhui, Zheng, Hanlin, Pan, Zhigang, Wang, Lingxing, Zheng, Shuni, Stavrinou, Pantelis, Goldbrunner, Roland, Stavrinou, Lampis, Hu, Weipeng, and Zheng, Feng
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- 2022
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6. Overcoming Resistance to Temozolomide in Glioblastoma: A Scoping Review of Preclinical and Clinical Data
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Dimitra Smerdi, Myrto Moutafi, Ioannis Kotsantis, Lampis C. Stavrinou, and Amanda Psyrri
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glioblastomas ,temozolomide resistance ,resistance mechanisms ,chemoresistance ,therapeutic agents ,Science - Abstract
Glioblastoma (GB) is the most common and most aggressive primary brain tumor in adults, with an overall survival almost 14.6 months. Optimal resection followed by combined temozolomide chemotherapy and radiotherapy, also known as Stupp protocol, remains the standard of treatment; nevertheless, resistance to temozolomide, which can be obtained throughout many molecular pathways, is still an unsurpassed obstacle. Several factors influence the efficacy of temozolomide, including the involvement of other DNA repair systems, aberrant signaling pathways, autophagy, epigenetic modifications, microRNAs, and extracellular vesicle production. The blood–brain barrier, which serves as both a physical and biochemical obstacle, the tumor microenvironment’s pro-cancerogenic and immunosuppressive nature, and tumor-specific characteristics such as volume and antigen expression, are the subject of ongoing investigation. In this review, preclinical and clinical data about temozolomide resistance acquisition and possible ways to overcome chemoresistance, or to treat gliomas without restoration of chemosensitinity, are evaluated and presented. The objective is to offer a thorough examination of the clinically significant molecular mechanisms and their intricate interrelationships, with the aim of enhancing understanding to combat resistance to TMZ more effectively.
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- 2024
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7. Correction: Effects of chronic physical exercise on executive functions and episodic memory in clinical and healthy older adult populations: a systematic review and meta‑analysis protocol
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Soledad Ballesteros, Michel Audifren, Andreea Badache, Vera Belkin, Christoforos D. Giannaki, Antonia Kaltsatou, Uros Marusic, Mohammad Mosaferi Ziaaldini, Manca Peskar, Jose M. Reales, Jennifer A. Rieker, Pinelopi S. Stavrinou, Juan Tortosa‑Martinez, Claudia Voelcker‑Rehage, and Yael Netz
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Medicine - Published
- 2024
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8. Chronic exercise effects on overall depression severity and distinct depressive symptoms in older adults: A protocol of a systematic and meta-analytic review.
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Melanie Mack, Andreea Badache, Arzu Erden, Christoforos D Giannaki, Sandra Haider, Antonia Kaltsatou, Burcu Kömürcü Akik, Yaël Netz, Iuliia Pavlova, Pinelopi S Stavrinou, Claudia Voelcker-Rehage, Michel Audiffren, and PhysAgeNet
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Medicine ,Science - Abstract
IntroductionThere is high evidence that chronic exercise benefits overall depression severity in older adults. However, late-life depression is characterized by considerable heterogeneity in clinical manifestation emphasizing the need for more individualized exercise intervention programs. Therefore, the objective of the proposed review is to investigate the effects of chronic exercise on overall depression severity and on different symptoms of depression in randomized controlled trials (RCTs) including older adults with a mean age of at least 60 years, and by considering the moderating effects of intervention characteristics and individual characteristics.MethodsThis protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols (PRISMA-P). We will use the Population-Intervention-Comparator-Outcomes-Study design (PICOS) criteria for study inclusion and will search the following database sources for relevant RCTs: Web of Science, Academic Search Complete, CINAHL, APA Psycinfo, SPORTDiscuss, Cochrane. Two independent reviewers will conduct the study selection, data extraction, and quality assessment. Disagreement will be solved by a third reviewer. Primary outcome will be changes in overall depression severity and secondary outcomes will encompass changes in symptoms of depression as defined by the DSM-5, such as sleep quality, fatigue, anxiety, mood, apathy, changes in weight, information processing speed, and executive functions, from baseline until the end of the intervention and to any available intermediary measurement or follow up. Meta-analysis will be undertaken to synthesize the effects of chronic exercise on primary and secondary outcomes. Subgroup analysis will investigate the moderating effects of intervention characteristics (frequency, intensity, duration, type of exercise, cognitive demand, social interactions, exercise supervision, behavioral change techniques, compliance, study design, dropout-rate, type of control group) and individual characteristics (age, sex, education, functional capacity, global cognition, population) on primary and secondary outcomes. Additionally, we plan to assess quality of evidence and publication bias, and to carry out sensitivity analysis.ConclusionThe results of the proposed review are anticipated to have a substantial impact on research and clinical practice. On the one hand, the review's conclusions could form the foundation for developing evidence-based recommendations for individualized exercise programs that alleviate depression in older adults. On the other hand, by revealing research gaps, the review results could encourage the formulation of research questions for further RCTs.Protocol registration numberThis protocol has been published in the Prospero repository (PROSPERO 2022 CRD42022361418, available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022361418).
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- 2024
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9. Posterior spinal decompression in adults with spinal cord injury without traumatic compromise of the spinal canal: what is the data?
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Mary Solou, Anastasios A. Politis, Ιoannis Ydreos, Evangelos K. Papadopoulos, Stamatios Banos, Georgios Savvanis, Maria M. Gavra, Efstathios J. Boviatsis, and Lampis C. Stavrinou
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spinal cord injury (SCI) ,SCI ,laminectomy ,laminoplasty ,durotomy ,duroplasty ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
BackgroundSpinal cord injury (SCI) can be caused by a variety of factors and its severity can range from a mild concussion to a complete severing of the spinal cord. Τreatment depends on the type and severity of injury, the patient’s age and overall health. Reduction of dislocated or fractured vertebrae via closed manipulation or surgical procedures, fixation and removal of bony fragments and debris that compromise the spinal canal are indicated for decompression of the spinal cord and stabilization of the spine. However, when there is no obvious traumatic obstruction of spinal canal, the question arises as to whether laminectomy is needed to be performed to improve neurological outcome.MethodsA literature review covering all indexed studies published between 2013 and 2023 was performed using keywords to identify the patient group of interest (spinal cord injury, SCI, spinal cord trauma, cervical, thoracic, lumbar, thoracolumbar),central cord syndrome (CCS) and the interventions (laminectomy, laminoplasty, decompression, duroplasty).ResultsThis review includes6 observational studies investigating the outcome of posterior spinal decompression in patients suffering from spinal cord injury without traumatic spinal cord stenosis. Most patients already had degenerative stenosis. From a total of 202, 151 patients (74.7%) improved neurologically by at least one grade at ASIA scale, after being treated with either laminectomy, laminoplasty, duroplasty or a combination of these techniques.ConclusionEarly decompression in SCI patients remains a reasonable practice option and can be performed safely, but no specific evidence supports the use of laminectomy alone. There is emerging evidence that intended durotomy followed by extended meningoplasty may improve the neurological outcome in patients suffering from SCI when meta-traumatic edema is apparent. However, the lack of high-quality evidence and results support the need for further research.
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- 2023
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10. Report on the first Combat Sports Special Interest Group meeting at the 28th Annual Congress of the European College of Sport Science, and call for action
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Emerson Franchini, Pinelopi S. Stavrinou, Fábio Y. Nakamura, and Gregory Bogdanis
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Martial arts ,combat sports ,conference ,science ,education ,training ,Sports ,GV557-1198.995 - Abstract
This short report describes the process of creating the Combat Sports Special Interest Group (CSSIG), its first meeting at the 28th Annual Congress of the European College of Sport Science (ECSS, Paris 4-7 July, 2023), and to make a call for action for the next events. The first contact between the group that proposed the creation of the CSSIG was made after a session of the Annual Congress of the ECSS held in 2022, but the idea and format of the proposal was initiated in January 2023. After its approval the CSSIG set the topics for the first meeting. During the 2023 edition the ECSS event had eight special interest groups, including the CSSIG. The first meeting of the CSSIG included the presentation of its goals, and two short presentations: one related to combat sports athletes’ health, and the other on testing and training monitoring of judo athletes. The aim of the CSSIG is to establish a sustainable network fostering evidence-based research and practice of combat sports, in order to: (a) promote health and safety of combat sports participants, (b) enhance their performance, and (c) improve training and competition practices. Thus, this report is also a call for action for the next events.
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- 2023
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11. Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
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Jian-feng Zhou, Yu Xiong, Xiaodong Kang, Zhigang Pan, Qiangbin Zhu, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, and Pantelis Stavrinou
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Intracerebral hemorrhage ,Exosomes ,Neuroprotection ,Stem cells ,Mesenchymal stem cells ,Medicine (General) ,R5-920 ,Biochemistry ,QD415-436 - Abstract
Abstract Non-traumatic intracerebral hemorrhage is a highly destructive intracranial disease with high mortality and morbidity rates. The main risk factors for cerebral hemorrhage include hypertension, amyloidosis, vasculitis, drug abuse, coagulation dysfunction, and genetic factors. Clinically, surviving patients with intracerebral hemorrhage exhibit different degrees of neurological deficits after discharge. In recent years, with the development of regenerative medicine, an increasing number of researchers have begun to pay attention to stem cell and exosome therapy as a new method for the treatment of intracerebral hemorrhage, owing to their intrinsic potential in neuroprotection and neurorestoration. Many animal studies have shown that stem cells can directly or indirectly participate in the treatment of intracerebral hemorrhage through regeneration, differentiation, or secretion. However, considering the uncertainty of its safety and efficacy, clinical studies are still lacking. This article reviews the treatment of intracerebral hemorrhage using stem cells and exosomes from both preclinical and clinical studies and summarizes the possible mechanisms of stem cell therapy. This review aims to provide a reference for future research and new strategies for clinical treatment.
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- 2022
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12. Use of double skin façade with building integrated solar systems for an energy renovation of an existing building in Limassol, Cyprus: Energy performance analysis
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Christos Italos, Michalis Patsias, Andriani Yiangou, Stylianos Stavrinou, and Constantinos Vassiliades
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Building energy renovation ,Building integration ,Double façade ,Life cycle cost ,Sustainable architecture ,Electrical engineering. Electronics. Nuclear engineering ,TK1-9971 - Abstract
The high percentage of energy consumption by fossil fuels in the building sector in combination with climate change across the globe increased the need to move into more sustainable building practices. Thus, the integration of sustainable strategies and active solar energy systems into the design process is becoming a tool for the reduction of the energy demand and improvement of the energy performance of existing and new buildings.This study investigates the energy performance of an existing residential apartment building in Limassol, Cyprus before and after its energy renovation, using a double skin façade combined with building integration of active solar energy systems. The proposed research starts with the analysis of the existing building energy performance, focusing on the energy loads for cooling, heating, and artificial lighting. Subsequently, the results of the existing situation are evaluated using digital energy simulations, and the process moves on to the renovation and energy upgrade of the building by integrating the aforementioned systems. Energy-Plus simulations are performed where the proposed systems’ contribution to the energy reduction is investigated including their energy reduction potential. The before and after simulations are compared, with the focus to prove whether the systems can be viable in terms of decreasing the energy demands of the building. Finally, a life cycle cost (LCC) analysis is performed, to determine the viability of the enterprise. The performed research proves that the application of the double façade, consisting of three main features — a building integrated photovoltaic system (BIPV), glazing system and rambling planting, can combine the positive effects of each individual system, if there is a combined systematic approach on the architectural design of the building envelope. The combination of the above led to a reduction of 83.5% in the energy consumption of the building, from 94,321 kWh of the existing situation to the 15,563 kWh of the proposed one. This reduction includes the contribution from BIPV system, which amounts to 26,706 kWh/ year of primary energy — thus covering the 63% of the proposed consumption of the building. On the other hand, the LCC analysis sums that a careful combination of bioclimatic design and active solar systems, can have a viable payback period, which in this case is 13 years.The overall aim of this research is to determine whether the use of a double skin façade combined with integrated active solar systems constitute an energy and cost-efficient solution for the viable refurbishment of an existing building in the south-eastern Mediterranean area.
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- 2022
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13. Application of stem cells and exosomes in the treatment of intracerebral hemorrhage: an update
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Zhou, Jian-feng, Xiong, Yu, Kang, Xiaodong, Pan, Zhigang, Zhu, Qiangbin, Goldbrunner, Roland, Stavrinou, Lampis, Lin, Shu, Hu, Weipeng, Zheng, Feng, and Stavrinou, Pantelis
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- 2022
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14. Efficacy and safety of tranexamic acid in intracranial haemorrhage: A meta-analysis.
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Yu Xiong, Xiumei Guo, Xinyue Huang, Xiaodong Kang, Jianfeng Zhou, Chunhui Chen, Zhigang Pan, Linxing Wang, Roland Goldbrunner, Lampis Stavrinou, Pantelis Stavrinou, Shu Lin, Yuping Chen, Weipeng Hu, and Feng Zheng
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Medicine ,Science - Abstract
BackgroundAlthough some studies have shown that tranexamic acid is beneficial to patients with intracranial haemorrhage, the efficacy and safety of tranexamic acid for intracranial haemorrhage remain controversial.MethodThe PubMed, EMBASE, and Cochrane Library databases were systematically searched. The review followed PRISMA guidelines. Data were analyzed using the random-effects model.ResultsTwenty-five randomized controlled trials were included. Tranexamic acid significantly inhibited hematoma growth in intracranial hemorrhage (ICH) and traumatic brain injury (TBI) patients. (ICH: mean difference -1.76, 95%CI -2.78 to -0.79, I2 = 0%, P < .001; TBI: MD -4.82, 95%CI -8.06 to -1.58, I2 = 0%, P = .004). For subarachnoid hemorrhage (SAH) patients, it significantly decreased the risk of hydrocephalus (OR 1.23, 95%CI 1.01 to 1.50, I2 = 0%, P = .04) and rebleeding (OR, 0.52, 95%CI 0.35 to 0.79, I2 = 56% P = .002). There was no significance in modified Rankin Scale, Glasgow Outcome Scale 3-5, mortality, deep vein thrombosis, pulmonary embolism, or ischemic stroke/transient ischemic.ConclusionTranexamic acid can significantly reduce the risk of intracranial haemorrhage growth in patients with ICH and TBI. Tranexamic acid can reduce the incidence of complications (hydrocephalus, rebleeding) in patients with SAH, which can indirectly improve the quality of life of patients with intracranial haemorrhage.
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- 2023
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15. Multiple Quintets via Singlet Fission in Ordered Films at Room Temperature
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Lubert-Perquel, Daphné, Salvadori, Enrico, Dyson, Matthew, Stavrinou, Paul N., Montis, Riccardo, Nagashima, Hiroki, Kobori, Yasuhiro, Heutz, Sandrine, and Kay, Christopher W. M.
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Condensed Matter - Materials Science - Abstract
The growing interest in harnessing singlet fission for photovoltaic applications stems from the possibility of generating two excitons from a single photon. Quantum efficiencies above unity have been reported, yet the correlation between singlet fission and intermolecular geometry is poorly understood. To address this, we investigated ordered solid solutions of pentacene in p-terphenyl grown by organic molecular beam deposition. Two classes of dimers are expected from the crystal structure - parallel and herringbone - with intrinsically distinctive electronic coupling. Using electron paramagnetic resonance spectroscopy, we provide compelling evidence for the formation of distinct quintet excitons at room temperature. These are assigned to specific pentacene pairs according to their angular dependence. This work highlights the importance of controlling the intermolecular geometry and the need to develop adequate theoretical models to account for the relationship between structure and electronic interactions in strongly-coupled, high-spin molecular systems., Comment: 12 pages, 5 figures, 1 table
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- 2018
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16. Bout duration in high-intensity interval exercise modifies hematologic, metabolic and antioxidant responses
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Gregory C. Bogdanis, George Mastorakos, Spyridon Tsirigkakis, Pinelopi S. Stavrinou, Athanasios Kabasakalis, Aimilia Mantzou, and Vassilis Mougios
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Glucose ,Glutathione ,Immune ,Total antioxidant capacity ,Uric acid ,White blood cells ,Sports ,GV557-1198.995 - Abstract
Background/Objectives: This study compared hematologic, metabolic and antioxidant responses between three high-intensity interval exercise (HIIE) trials of different bout duration and a continuous exercise trial (CON), all with equal average intensity, total work, and duration. Methods: Eleven healthy young males performed four trials involving 20 min of cycling, either continuously (49% of power at VO2max, PPO), or intermittently with 48 10-s bouts (HIIE10), 16 30-s bouts (HIIE30) or 8 60-s bouts (HIIE60) at 100% PPO, with a 1:1.5 work-to-recovery ratio at 15% PPO. Venous blood was obtained before, immediately after, and 1 h post-exercise to evaluate hematologic, metabolic and antioxidant responses. Blood lactate concentration was measured in capillary blood during exercise, while urine lactate was measured before and 1 h post-exercise. Results: Post-exercise leukocyte count (mean ± SD; 9.7 ± 2.8 k μL−1), uric acid concentration (0.35 ± 0.10 mmol L−1), glucose concentration (6.56 ± 1.44 mmol L−1), and plasma volume change (−13.5 ± 4.4%) were greater in HIIE60 compared to all other trials (p
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- 2022
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17. Physiological, perceptual and affective responses to high-intensity interval training using two work-matched programs with different bout duration in obese males
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Spyridon Tsirigkakis, Yiannis Koutedakis, George Mastorakos, Pinelopi S. Stavrinou, Vassilis Mougios, and Gregory C. Bogdanis
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Enjoyment ,High-intensity interval training (HIIT) ,Obesity ,Perceptual responses ,Pleasure-displeasure ,Sports ,GV557-1198.995 - Abstract
Background/Objectives: This study compared physiological, perceptual, and affective responses to high-intensity interval training (HIIT) between two work-matched programs with different bout durations in obese males. Methods: Sixteen low-to-moderately active obese men completed an eight-week cycling program of supervised HIIT (3 days/week) using either short bouts [48 × 10 s at 100% of peak power output (PPO) with 15 s of recovery (HIIT10)] or long bouts [8 × 60 s at 100% PPO with 90 s of recovery (HIIT60)]. Workload was progressively adjusted, to maintain high intensity (100% PPO), throughout training. Blood lactate (BLa), heart rate (HR), ratings of perceived exertion (RPE), and feeling scale ratings (pleasure/displeasure) were measured in each HIIT session. Results: Average HR decreased in the last 2 weeks of training in both groups by 2.2 ± 1.8% of peak HR (p
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- 2022
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18. Excitonic coupling dominates the homogeneous photoluminescence excitation linewidth in semicrystalline polymeric semiconductors
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Grégoire, Pascal, Vella, Eleonora, Dyson, Matthew, Bazán, Claudia M., Leonelli, Richard, Stingelin, Natalie, Stavrinou, Paul N., Bittner, Eric R., and Silva, Carlos
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Condensed Matter - Materials Science ,Physics - Chemical Physics - Abstract
We measure the homogeneous excitation linewidth of regioregular poly(3-hexylthiophene), a model semicrystalline polymeric semiconductor, by means of two-dimensional coherent photoluminescence excitation spectroscopy. At a temperature of 8\,K, we find a linewidth that is always $\gtrsim 110$\,meV full-width-at-half-maximum, which is a significant fraction of the total linewidth. It displays a spectral dependence and is minimum near the 0--0 origin peak. We interpret this spectral dependence of the homogeneous excitation linewidth within the context of a weakly coupled aggregate model., Comment: 13 pages, 4 figures, Supplementary Material
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- 2017
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19. Exosomes Derived From Mesenchymal Stem Cells: Novel Effects in the Treatment of Ischemic Stroke
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Yu Xiong, Jianping Song, Xinyue Huang, Zhigang Pan, Roland Goldbrunner, Lampis Stavrinou, Shu Lin, Weipeng Hu, Feng Zheng, and Pantelis Stavrinou
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exosomes ,ischemic stroke ,miRNAs ,mesenchymal stem cells ,treatment ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Ischemic stroke is defined as an infarction in the brain, caused by impaired cerebral blood supply, leading to local brain tissue ischemia, hypoxic necrosis, and corresponding neurological deficits. At present, revascularization strategies in patients with acute ischemic stroke include intravenous thrombolysis and mechanical endovascular treatment. However, due to the short treatment time window (
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- 2022
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20. Radiation-induced meningiomas (RIM) in adults: A single-centre retrospective experience
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Stamatios Banos, Mary Solou, Ioannis Ydreos, Evangelos K. Papadopoulos, Georgios Savvanis, Anastasios A. Politis, Lampis C. Stavrinou, Maria M. Gavra, and Efstathios J. Boviatsis
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Meningioma ,Radiation-induced meningioma ,RIM ,Radiotherapy ,Irradiation ,Acute lymphoblastic leukaemia ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Introduction: Radiotherapy of central nervous system (CNS) is treatment against many paediatric cancers, even if it is a well-recognized risk factor for meningioma formation. An increased risk of developing secondary brain tumors like radiation-induced meningiomas (RIM) is related to irradiated patients. Research question: This retrospective study aims to present RIM cases treated in a single tertiary-hospital in Greece and compare the results with international literature and cases of sporadic meningiomas. Materials and methods: A single-centre retrospective study of all patients diagnosed between January 2012 and September 2022 with RIM after having been irradiated in CNS for paediatric cancer was undertaken through hospital’s electronic record and clinical notes, identifying baseline demographics and latency period. Results: Thirteen patients were identified with RIM diagnosis after receiving irradiation for Acute Lymphoblastic Leukaemia (69.2%), Premature Neuro-Ectodermal Tumour (23.1%), and Astrocytoma (7.7%). Median age at irradiation was 5 years old and 32 years old at RIM’s presentation. The latent period from irradiation to meningioma diagnosis was 26.23 ± 5.96 years. After surgical excision, histopathologic results showed grade I meningiomas in 12 out of thirteen cases, while only one atypical meningioma was diagnosed. Conclusion: Patients who underwent CNS-radiotherapy in childhood for any condition have an increased risk of developing secondary brain tumors such as radiation-induced meningiomas. RIMs resemble sporadic meningiomas in symptomatology, location, treatment, and histologic grade. However, long-term follow-up and regular check-ups are recommended in irradiated patients due to short latency period from irradiation to RIM development, which means younger age patients than those with sporadic meningiomas cases.
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- 2023
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21. Hybrid scheme for modeling local field potentials from point-neuron networks
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Hagen, Espen, Dahmen, David, Stavrinou, Maria L., Lindén, Henrik, Tetzlaff, Tom, van Albada, Sacha J, Grün, Sonja, Diesmann, Markus, and Einevoll, Gaute T.
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Quantitative Biology - Neurons and Cognition - Abstract
Due to rapid advances in multielectrode recording technology, the local field potential (LFP) has again become a popular measure of neuronal activity in both basic research and clinical applications. Proper understanding of the LFP requires detailed mathematical modeling incorporating the anatomical and electrophysiological features of neurons near the recording electrode, as well as synaptic inputs from the entire network. Here we propose a hybrid modeling scheme combining the efficiency of commonly used simplified point-neuron network models with the biophysical principles underlying LFP generation by real neurons. The scheme can be used with an arbitrary number of point-neuron network populations. The LFP predictions rely on populations of network-equivalent, anatomically reconstructed multicompartment neuron models with layer-specific synaptic connectivity. The present scheme allows for a full separation of the network dynamics simulation and LFP generation. For illustration, we apply the scheme to a full-scale cortical network model for a $\sim$1 mm$^2$ patch of primary visual cortex and predict laminar LFPs for different network states, assess the relative LFP contribution from different laminar populations, and investigate the role of synaptic input correlations and neuron density on the LFP. The generic nature of the hybrid scheme and its publicly available implementation in \texttt{hybridLFPy} form the basis for LFP predictions from other point-neuron network models, as well as extensions of the current application to larger circuitry and additional biological detail.
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- 2015
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22. Correction: Zhang et al. Admission Serum Iron as an Independent Risk Factor for Postoperative Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Propensity-Matched Analysis. Brain Sci. 2022, 12, 1183
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Yi-Bin Zhang, Feng Zheng, Lampis Stavrinou, Hao-Jie Wang, Wen-Jian Fan, Pei-Sen Yao, Yuan-Xiang Lin, Roland Goldbrunner, Shu-Fa Zheng, Pantelis Stavrinou, and De-Zhi Kang
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n/a ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
We would like to submit the following corrections to our recently published paper [...]
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- 2022
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23. Admission Serum Iron as an Independent Risk Factor for Postoperative Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Propensity-Matched Analysis
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Yi-Bin Zhang, Feng Zheng, Lampis Stavrinou, Hao-Jie Wang, Wen-Jian Fan, Pei-Sen Yao, Yuan-Xiang Lin, Roland Goldbrunner, Shu-Fa Zheng, Pantelis Stavrinou, and De-Zhi Kang
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stroke ,intracranial aneurysm ,subarachnoid hemorrhage ,delayed cerebral ischemia ,hemoglobin ,iron ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
This study aimed to investigate the association between serum iron (SI) and postoperative delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage (aSAH). We retrospectively analyzed 985 consecutive adult patients diagnosed with aSAH. Demographic, clinical, and laboratory data were recorded. Univariate and multivariate analyses were employed to assess the association between SI and DCI. Propensity-score matching (PSM) analysis was implemented to reduce confounding. Postoperative DCI developed in 14.38% of patients. Lower SI upon admission was detected in aSAH patients with severe clinical conditions and severe aSAH. SI was negatively correlated with WFNS grade (r = −0.3744, p < 0.001) and modified Fisher (mFisher) grade (r = −0.2520, p < 0.001). Multivariable analysis revealed lower SI was independently associated with DCI [odds ratios (OR) 0.281, 95% confidence interval (CI) 0.177–0.448, p < 0.001], while WFNS grade and mFisher grade were not. The receiver-operating characteristics (ROC) curve analysis of SI for DCI gave an area under the curve (AUC) of 0.7 and an optimal cut-off of 7.5 μmol/L (95% CI 0.665 to 0.733, p < 0.0001). PSM demonstrated the DCI group had a significantly lower SI than the non-DCI group (10.91 ± 6.86 vs. 20.34 ± 8.01 μmol/L, p < 0.001). Lower SI remained a significant independent predictor for DCI and an independent poor prognostic factor of aSAH in multivariate analysis (OR 0.363, 95% CI 0.209–0.630, p < 0.001). The predictive performance of SI for poor outcome had a corresponding AUC of 0.718 after PSM. Lower SI upon admission is significantly associated with WFNS grade, mFisher grade, and predicts postoperative DCI and poor outcome at 90 days following aSAH.
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- 2022
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24. KLF4 K409Q –mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment
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Niklas von Spreckelsen, Natalie Waldt, Rebecca Poetschke, Christoph Kesseler, Hildegard Dohmen, Hui-Ke Jiao, Attila Nemeth, Stefan Schob, Cordula Scherlach, Ibrahim Erol Sandalcioglu, Martina Deckert, Frank Angenstein, Boris Krischek, Pantelis Stavrinou, Marco Timmer, Marc Remke, Elmar Kirches, Roland Goldbrunner, E. Antonio Chiocca, Stefan Huettelmaier, Till Acker, and Christian Mawrin
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Meningioma ,Mutation ,K409Q ,Hypoxia ,HIF ,Edema ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations in meningioma have been identified and correlated with certain pathological subtypes, locations and clinical observations. Alterations of cellular pathways due to these mutations, however, have largely remained elusive. Here we report that the Krueppel like factor 4 (KLF4)-K409Q mutation in skull base meningiomas triggers a distinct tumor phenotype. Transcriptomic analysis of 17 meningioma samples revealed that KLF4 K409Q mutated tumors harbor an upregulation of hypoxia dependent pathways. Detailed in vitro investigation further showed that the KLF4 K409Q mutation induces HIF-1α through the reduction of prolyl hydroxylase activity and causes an upregulation of downstream HIF-1α targets. Finally, we demonstrate that KLF4 K409Q mutated tumors are susceptible to mTOR inhibition by Temsirolimus. Taken together, our data link the KLF4K409Q mediated upregulation of HIF pathways to the clinical and biological characteristics of these skull base meningiomas possibly opening new therapeutic avenues for this distinct meningioma subtype.
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- 2020
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25. A Pilot Study of a Parent Emotion Socialization Intervention: Impact on Parent Behavior, Child Self-Regulation, and Adjustment
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Evalill Bølstad, Sophie S. Havighurst, Christian K. Tamnes, Egil Nygaard, Rune Flaaten Bjørk, Maria Stavrinou, and Thomas Espeseth
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emotion socialization ,parent intervention ,self-regulation ,externalizing ,AX-CPT ,Psychology ,BF1-990 - Abstract
Adequate emotion regulation in children is crucial for healthy development and is influenced by parent emotion socialization. The current pilot study aimed to test, for the first time in a Scandinavian population, whether an emotion-focused intervention, Tuning in to Kids (TIK), had positive effects on parent emotion-related socialization behaviors (ERSBs), and children's self-regulation, anxiety, and externalizing behavior problems. We conducted a controlled trial of the 6-week evidence-based TIK parenting program with 20 parents of preschool children aged 5–6 years and 19 wait-list controls. Assessments at baseline and 6 months after the intervention included parent-report questionnaires on parent ERSBs and child adjustment, as well as aspects of children's self-regulation assessed with two behavioral tasks, the Emotional Go/No-Go task (EGNG) and the AX-Continuous Performance Task (AX-CPT). Results showed a significant increase in reported parent emotion coaching behavior and an uncorrected significant decrease in parents' report of child externalizing problems in intervention participants compared to controls. The behavioral data showed an uncorrected significant improvement in child emotion discrimination in the control condition compared to the intervention condition, while measures of children's executive control improved from baseline to follow-up for both conditions but were not significantly different between conditions. These findings suggest that this emotion-focused parenting intervention contributed to improvement in parents' emotion coaching and their appraisal of child externalizing problems, while children's self-regulation showed mainly normative developmental improvements. Further research with a larger sample will be the next step to determine if these pilot findings are seen in an adequately powered study.
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- 2021
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26. Controversies in the Surgical Treatment of Chronic Subdural Hematoma: A Systematic Scoping Review
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Mary Solou, Ioannis Ydreos, Maria Gavra, Evangelos K. Papadopoulos, Stamatis Banos, Efstathios J. Boviatsis, Georgios Savvanis, and Lampis C. Stavrinou
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chronic subdural hematoma ,treatment ,surgery ,burr hole ,craniotomy ,twist drill craniotomy ,Medicine (General) ,R5-920 - Abstract
Chronic subdural hematoma (cSDH) is one of the most common neurosurgical entities, especially in the elderly population. Diagnosis is usually established via a head computed tomography, while an increasing number of studies are investigating biomarkers to predict the natural history of cSDH, including progression and recurrence. Surgical evacuation remains the mainstay of treatment in the overwhelming majority of cases. Nevertheless, many controversies are associated with the nuances of surgical treatment. We performed a systematic review of the literature between 2010 and 2022, aiming to identify and address the issues in cSDH surgical management where consensus is lacking. The results show ambiguous data in regard to indication, the timing and type of surgery, the duration of drainage, concomitant membranectomy and the need for embolization of the middle meningeal artery. Other aspects of surgical treatment—such as the use of drainage and its location and number of burr holes—seem to have been adequately clarified: the drainage of hematoma is strongly recommended and the outcome is considered as independent of drainage location or the number of burr holes.
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- 2022
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27. Increased Sclerostin, but Not Dickkopf-1 Protein, Is Associated with Elevated Pulse Wave Velocity in Hemodialysis Subjects
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Eirini Stavrinou, Pantelis A. Sarafidis, Charalampos Koumaras, Charalampos Loutradis, Panagiotis Giamalis, Konstantinos Tziomalos, Asterios Karagiannis, and Aikaterini Papagianni
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Sclerostin ,Dickkopf-1 protein ,Hemodialysis ,Pulse wave velocity ,Arterial stiffness ,Dermatology ,RL1-803 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Background: Sclerostin and Dickkopf-1 (Dkk-1) proteins are inhibitors of the canonical Wnt/β-catenin bone pathway. Pilot data suggest that sclerostin may be involved in vascular changes in chronic kidney disease (CKD), but data on the effects of Dkk-1 are scarce. This is the first study investigating simultaneously the associations of sclerostin and Dkk-1 with arterial stiffness in hemodialysis patients. Methods: A total of 80 patients on chronic hemodialysis had carotid-femoral pulse wave velocity (PWV), central blood pressure (BP), and wave reflections evaluated with applanation tonometry (Sphygmocor) on a midweek non-dialysis day. Serum levels of sclerostin and Dkk-1 were measured with ELISA. A large set of demographic, comorbid, laboratory, and drug parameters were used in the analyses. Results: Subjects with PWV >9.5 m/s (high arterial stiffness group, n = 40) were older, had higher BMI, higher prevalence of hypertension, diabetes, and coronary heart disease, and higher peripheral systolic BP, central systolic BP, C-reactive protein, and serum sclerostin (p = 0.02), but similar Dkk-1, compared to subjects with low PWV. When dichotomizing the population by sclerostin levels, those with high sclerostin had higher PWV than patients with low sclerostin levels (10.63 ± 2.71 vs. 9.77 ± 3.13, p = 0.048). Increased sclerostin (>200 pg/mL) was significantly associated with increased PWV (>9.5 m/s; HR 2.778, 95% CI 1.123–6.868 per pg/mL increase); this association remained significant after stepwise adjustment for Dkk-1, intact parathyroid hormone, and calcium × phosphate product. In contrast, no association was noted between Dkk-1 and PWV (HR 1.000, 95% CI 0.416–2.403). Conclusion: Serum sclerostin is associated with PWV independently of routine markers of CKD-MBD in hemodialysis patients. In contrast, Dkk-1 has no association with arterial stiffness and is not pathophysiologically involved in relevant vascular changes.
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- 2019
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28. Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma
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Sotirios Katsigiannis, Boris Krischek, Stefanie Barleanu, Stefan Grau, Norbert Galldiks, Marco Timmer, Christoph Kabbasch, Roland Goldbrunner, and Pantelis Stavrinou
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Glioblastoma ,Timing of radiotherapy ,Prognostic factors ,Survival ,Progression free survival ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background and purpose To evaluate the effect of timing of radiotherapy (RT) on survival in patients with newly diagnosed primary glioblastoma (GBM) treated with the same therapeutical protocol. Materials and methods Patients with newly diagnosed primary GBM treated with the same therapeutical scheme between 2010 and 2015 in our institution were retrospectively reviewed. The population was trichotomized based on the time interval from surgery till initiation of RT ( 33 days). Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis. Results One-hundred-fifty-one patients met the inclusion criteria. Between the three groups no significant difference in PFS (p = 0.516) or OS (p = 0.902) could be demonstrated. Residual tumor volume (RTV) and midline structures involvement were identified as independent prognostic factors of PFS while age, O-6-Methylguanine Methyltransferase (MGMT) status, Ki67 index, RTV and midline structures involvement represented independent predictors of OS. Patients starting RT after a prolonged delay (> 48 days) exhibited a significantly shorter OS (p = 0.034). Conclusion Initiation of RT within a timeframe of 48 days is not associated with worsened survival. A prolonged delay (> 48 days) may be associated with worse OS. RT should neither be delayed, nor forced, but should rather start timely, as soon as the patient has recovered from surgery.
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- 2019
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29. Exploring the Associations between Functional Capacity, Cognitive Function and Well-Being in Older Adults
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Pinelopi S. Stavrinou, George Aphamis, Marios Pantzaris, Giorgos K. Sakkas, and Christoforos D. Giannaki
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aging ,cognition ,executive function ,quality of life ,fatigue ,sleep ,Science - Abstract
Background: The present study aimed to explore the associations between functional capacity and global cognition, executive function and well-being in older adults. Methods: Ninety-seven older adults (age 80.6 ± 8.2 years) were examined for global cognitive function (Mini-Mental State Examination), executive function (symbol cancellation test), functional capacity (sit-to-stand tests, 6 min walk test, timed up-and-go test and handgrip strength test) and well-being (quality of life, fatigue levels, sleep quality and daily sleepiness). Adjusted partial correlations were computed to examine the associations between variables. Mediation analyses were conducted to evaluate whether functional capacity would mediate the relationships between age and cognitive or executive function. Results: Greater levels of functional capacity were associated with better performance in cognitive and executive function tests (p < 0.05). Mediation analyses revealed that functional capacity partially mediated the effects of age on global cognition and executive function (indirect effect: β = −0.11, 95% CI = −0.20 to −0.03; β = 0.34, 95% CI = 0.13 to 0.57, respectively). Increased levels of functional capacity were also associated with higher quality of life (p < 0.05, r = 0.32 to 0.41), lower fatigue levels (p < 0.05, r = 0.23 to 0.37), and better sleep quality (p < 0.05, r = 0.23 to 0.24). Conclusions: Functional capacity can mediate the effects of age on global cognition and executive function in older adults and greater levels of functional capacity are associated with improved quality of life, better sleep quality, and lower fatigue levels.
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- 2022
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30. Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency—Features of CT and 18F-FDG Positron Emission Tomography/CT in Clinically Progressive Disease
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Mai Sasaki Aanensen Fraz, Natasha Moe, Mona-Elisabeth Revheim, Maria L. Stavrinou, Michael T. Durheim, Ingvild Nordøy, Magnhild Eide Macpherson, Pål Aukrust, Silje Fjellgård Jørgensen, Trond Mogens Aaløkken, and Børre Fevang
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GLILD ,Interstitial lung disease (ILD) ,Primary immumunodeficiencies ,DLCO ,rituximab ,CVID- Common Variable Immunodeficiency Disorders ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Common variable immunodeficiency (CVID) is characterized not only by recurrent bacterial infections, but also autoimmune and inflammatory complications including interstitial lung disease (ILD), referred to as granulomatous-lymphocytic interstitial lung disease (GLILD). Some patients with GLILD have waxing and waning radiologic findings, but preserved pulmonary function, while others progress to end-stage respiratory failure. We reviewed 32 patients with radiological features of GLILD from our Norwegian cohort of CVID patients, including four patients with possible monogenic defects. Nineteen had deteriorating lung function over time, and 13 had stable lung function, as determined by pulmonary function testing of forced vital capacity (FVC), and diffusion capacity of carbon monoxide (DLCO). The overall co-existence of other non-infectious complications was high in our cohort, but the prevalence of these was similar in the two groups. Laboratory findings such as immunoglobulin levels and T- and B-cell subpopulations were also similar in the progressive and stable GLILD patients. Thoracic computer tomography (CT) scans were systematically evaluated and scored for radiologic features of GLILD in all pulmonary segments. Pathologic features were seen in all pulmonary segments, with traction bronchiectasis as the most prominent finding. Patients with progressive disease had significantly higher overall score of pathologic features compared to patients with stable disease, most notably traction bronchiectasis and interlobular septal thickening. 18F-2-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/CT (PET/CT) was performed in 17 (11 with progressive and six with stable clinical disease) of the 32 patients and analyzed by quantitative evaluation. Patients with progressive disease had significantly higher mean standardized uptake value (SUVmean), metabolic lung volume (MLV) and total lung glycolysis (TLG) as compared to patients with stable disease. Nine patients had received treatment with rituximab for GLILD. There was significant improvement in pathologic features on CT-scans after treatment while there was a variable effect on FVC and DLCO.ConclusionPatients with progressive GLILD as defined by deteriorating pulmonary function had significantly greater pathology on pulmonary CT and FDG-PET CT scans as compared to patients with stable disease, with traction bronchiectasis and interlobular septal thickening as prominent features.
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- 2021
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31. Optical coherence properties of planar microcavity emission
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Oulton, R. F., Stavrinou, P. N., and Parry, G.
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Physics - Optics - Abstract
An analytical expression for the self coherence function of a microcavity and partially coherent source is derived from first principles in terms of the component self coherence functions. Excellent agreement between the model and experimental measurements of two Resonant Cavity LEDs (RCLEDs) is evident. The variation of coherence length as a function of numerical aperture is also described by the model. This is explained by a microcavity's angular sensitivity in filtering out statistical fluctuations of the underlying light source. It is further demonstrated that the variable coherence properties of planar microcavities can be designed by controlling the underlying coherences of microcavity and emitter whereby coherence lengths ranging over nearly an order of magnitude could be achieved., Comment: 8 Pages, 3 Figures, Submitted to Optics Letters, Novemeber 2004
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- 2004
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32. Effects of Oral Creatine Supplementation on Power Output during Repeated Treadmill Sprinting
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Gregory C. Bogdanis, Mary E. Nevill, George Aphamis, Pinelopi S. Stavrinou, David G. Jenkins, Christoforos D. Giannaki, Henryk K. A. Lakomy, and Clyde Williams
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creatine supplementation ,repeated sprints ,phosphocreatine ,running sprints ,blood ammonia ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The aim of the present study was to examine the effects of creatine (Cr) supplementation on power output during repeated sprints on a non-motorized treadmill. Sixteen recreationally active males volunteered for this study (age 25.5 ± 4.8 y, height 179 ± 5 cm, body mass 74.8 ± 6.8 kg). All participants received placebo supplementation (75 mg of glucose·kg−1·day−1) for 5 days and then performed a baseline repeated sprints test (6 × 10 s sprints on a non-motorised treadmill). Thereafter, they were randomly assigned into a Cr (75 mg of Cr monohydrate·kg−1·day−1) or placebo supplementation, as above, and the repeated sprints test was repeated. After Cr supplementation, body mass was increased by 0.99 ± 0.83 kg (p = 0.007), peak power output and peak running speed remained unchanged throughout the test in both groups, while the mean power output and mean running speed during the last 5 s of the sprints increased by 4.5% (p = 0.005) and 4.2% to 7.0%, respectively, during the last three sprints (p = 0.005 to 0.001). The reduction in speed within each sprint was also blunted by 16.2% (p = 0.003) following Cr supplementation. Plasma ammonia decreased by 20.1% (p = 0.037) after Cr supplementation, despite the increase in performance. VO2 and blood lactate during the repeated sprints test remained unchanged after supplementation, suggesting no alteration of aerobic or glycolytic contribution to adenosine triphosphate production. In conclusion, Cr supplementation improved the mean power and speed in the second half of a repeated sprint running protocol, despite the increased body mass. This improvement was due to the higher power output and running speed in the last 5 s of each 10 s sprint.
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- 2022
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33. FET PET reveals considerable spatial differences in tumour burden compared to conventional MRI in newly diagnosed glioblastoma
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Lohmann, Philipp, Stavrinou, Pantelis, Lipke, Katharina, Bauer, Elena K., Ceccon, Garry, Werner, Jan-Michael, Neumaier, Bernd, Fink, Gereon R., Shah, Nadim J., Langen, Karl-Josef, and Galldiks, Norbert
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- 2019
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34. Impact of aneurysm shape on morbidity after clipping of unruptured intracranial aneurysms
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Goertz, Lukas, Kasuya, Hidetoshi, Hamisch, Christina, Kabbasch, Christoph, von Spreckelsen, Niklas, Ludyga, Dagmar, Timmer, Marco, Stavrinou, Pantelis, Goldbrunner, Roland, Brinker, Gerrit, and Krischek, Boris
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- 2018
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35. An unusual cause of large bowel obstruction: are we aware of this?
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Maria Sotiropoulou, Nikolina Stavrinou, Michail Vailas, Paraskevi Alexakou, Michail Psarologos, Panagiotis Metaxas, Michael Economou, Christine Vourlakou, and Stylianos Kapiris
- Subjects
burkitt lymphoma ,lymphoma ,obstruction ,surgery ,Medicine - Abstract
Primary lymphomas of the colon account for 0.5% of all primary colon malignancies. Burkitt’s lymphoma is a B-cell lymphoma with aggressive clinical behavior. Herein, we describe a case of a male patient who presented with signs of large bowel obstruction, underwent surgery and found to suffer from Burkitt’s lymphoma of the ileocecal region. The histopathological examination was indicative for Burkitt’s lymphoma. To the best of our insight this is one of the few reported cases of such type of lymphoma in an adult patient presenting with bowel obstruction. Burkitt’s lymphoma is a rare malignancy in adults affecting gastrointestinal tract. It has a high proliferation potential and can rapidly progress to advanced disease. Early diagnosis is necessary to prevent complications and improve overall prognosis.
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- 2020
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36. Identifying triplet pathways in dilute pentacene films
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Daphné Lubert-Perquel, Enrico Salvadori, Matthew Dyson, Paul N. Stavrinou, Riccardo Montis, Hiroki Nagashima, Yasuhiro Kobori, Sandrine Heutz, and Christopher W. M. Kay
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Science - Abstract
Singlet fission results in the formation of a pair of triplets, known as a quintet. Here, the authors identify long-lived quintets in dilute pentacene films at room temperature, with lifetimes influenced by intermolecular geometry having implications for the design of triplet-harvesting films.
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- 2018
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37. Treatment of Intracranial Aneurysms with the Pipeline Embolization Device Only: a Single Center Experience
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Maus Volker, Mpotsaris Anastasios, Borggrefe Jan, Abdullayev Nuran, Liebig Thomas, Dorn Franziska, Stavrinou Pantelis, Chang De-Hua, and Kabbasch Christoph
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intracranial aneurysms ,flow diverter ,pipeline embolization device ,incomplete occlusion ,Medicine (General) ,R5-920 ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
PurposeThe aim of this study was to evaluate the technical feasibility and rate of mid-term occlusion in aneurysms treated solely with the Pipeline Embolization Device (PED) in a German tertiary care university hospital.Materials and MethodsForty-nine non-consecutive intracranial aneurysms underwent endovascular treatment using the PED exclusively between March 2011 and May 2017 at our institution. Primary endpoint was a favorable aneurysm occlusion defined as OKM C1-3 and D (O'Kelly Marotta Scale). Secondary endpoints were retreatment rate and delayed complications. Median follow-up was 200 days.ResultsThe mean aneurysm size was 7.1 ± 5.3 mm. Forty-four aneurysms were located in the anterior circulation (90%). Ten aneurysms were ruptured (20%). Branching vessels from the sac were observed in 11 aneurysms (22%). Favorable obliteration immediately after PED placement was seen in 13/49 aneurysms (27%), of those nine aneurysms were completely occluded (18%). Angiographic and clinical follow-up was available for 45 cases (92%); 36/45 aneurysms (80%) were occluded completely and 40/45 aneurysms (89%) showed a favorable occlusion result. A branching vessel arising from the aneurysm sac was associated with incomplete occlusion (P < .05). All electively treated patients had good outcome (mRS 0). Three aneurysms (6%) required additional treatment due to aneurysm recurrence.ConclusionIn our series, treatment of intracranial aneurysms with the PED was associated with favorable occlusion rates and low complication rates at mid-term follow-up. The presence of branching vessels arising from the aneurysms sac was predictive for an incomplete occlusion.
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- 2018
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38. KLF4K409Q–mutated meningiomas show enhanced hypoxia signaling and respond to mTORC1 inhibitor treatment
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von Spreckelsen, Niklas, Waldt, Natalie, Poetschke, Rebecca, Kesseler, Christoph, Dohmen, Hildegard, Jiao, Hui-Ke, Nemeth, Attila, Schob, Stefan, Scherlach, Cordula, Sandalcioglu, Ibrahim Erol, Deckert, Martina, Angenstein, Frank, Krischek, Boris, Stavrinou, Pantelis, Timmer, Marco, Remke, Marc, Kirches, Elmar, Goldbrunner, Roland, Chiocca, E. Antonio, Huettelmaier, Stefan, Acker, Till, and Mawrin, Christian
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- 2020
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39. Ocular signatures of proactive versus reactive cognitive control in young adults
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Mäki-Marttunen, Verónica, Hagen, Thomas, Aminihajibashi, Samira, Foldal, Maja, Stavrinou, Maria, Halvorsen, Jens H., Laeng, Bruno, and Espeseth, Thomas
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- 2018
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40. Preoperative neurocognitive function as an independent survival prognostic marker in primary glioblastoma
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Liouta, Evangelia, Koutsarnakis, Christos, Komaitis, Spyridon, Kalyvas, Aristotelis V, Drosos, Evangelos, García-Gómez, Juan M, Juan-Albarracín, Javier, Katsaros, Vasileios, Stavrinou, Lampis, and Stranjalis, George
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- 2023
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41. Impact of time to initiation of radiotherapy on survival after resection of newly diagnosed glioblastoma
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Katsigiannis, Sotirios, Krischek, Boris, Barleanu, Stefanie, Grau, Stefan, Galldiks, Norbert, Timmer, Marco, Kabbasch, Christoph, Goldbrunner, Roland, and Stavrinou, Pantelis
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- 2019
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42. Chrono-nutrition behaviours and cognitive outcomes in 45–65-year-old adults living in Cyprus: the NUTRICO study
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Demetriou, C.A., primary, Onisiphorou, E., additional, Kazafanioti, C., additional, Alogakos, M., additional, Vardakastani, D., additional, Hileti, D., additional, Christofidou, E., additional, Papaioannou, M., additional, Philippou, P., additional, Andreou, E., additional, Giannaki, C., additional, Stavrinou, P., additional, Constantinidou, F., additional, and Philippou, E., additional
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- 2023
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43. Effects of Dehydration on Archery Performance, Subjective Feelings and Heart Rate during a Competition Simulation
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Alexandros Savvides, Christoforos D. Giannaki, Angelos Vlahoyiannis, Pinelopi S. Stavrinou, and George Aphamis
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hydration ,urine specific gravity ,athletes ,heart rate ,fatigue ,alertness ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
This study aimed to investigate the effect of dehydration on archery performance, subjective feelings and heart rate response. Ten national level archers performed two archery competition simulations, once under euhydration (EUH) and once in a dehydrated state (DEH), induced by 24-h reduced fluid intake. Hydration status was verified prior to each trial by urine specific gravity (USG ≥ 1.025). Archery score was measured according to official archery regulations. Subjective feelings of thirst, fatigue and concentration were recorded on a visual analogue scale. Heart rate was continuously monitored during the trials. Archery performance was similar between trials (p = 0.155). During DEH trial (USG 1.032 ± 0.005), the athletes felt thirstier (p < 0.001), more fatigued (p = 0.041) and less able to concentrate (p = 0.016) compared with the EUH trial (USG 1.015 ± 0.004). Heart rate during DEH at baseline (85 ± 5 b∙min−1) was higher (p = 0.021) compared with EUH (78 ± 6 b∙min−1) and remained significantly higher during the latter stages of the DEH compared to EUH trial. In conclusion, archery performance over 72 arrows was not affected by dehydration, despite the induced psychological and physiological strain, revealed from decreased feeling of concentration, increased sensation of fatigue and increased heart rate during the DEH trial.
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- 2020
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44. The Effects of a 6-Month High Dose Omega-3 and Omega-6 Polyunsaturated Fatty Acids and Antioxidant Vitamins Supplementation on Cognitive Function and Functional Capacity in Older Adults with Mild Cognitive Impairment
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Pinelopi S. Stavrinou, Eleni Andreou, George Aphamis, Marios Pantzaris, Melina Ioannou, Ioannis S. Patrikios, and Christoforos D. Giannaki
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antioxidant vitamins ,cognitive function ,elderly ,functional capacity ,mild cognitive impairment ,pufas ,supplementation ,Nutrition. Foods and food supply ,TX341-641 - Abstract
The aim of the present study was to examine the effects of a high-dose omega-3 and omega-6 fatty acids supplementation, in combination with antioxidant vitamins, on cognitive function and functional capacity of older adults with mild cognitive impairment (MCI), over a 6-month period in a randomized, double-blind, placebo-controlled trial. Forty-six older adults with MCI (age: 78.8 ± 7.3 years) were randomized 1:1 to receive either a 20 mL dose of a formula containing a mixture of omega-3 (810 mg Eicosapentaenoic acid and 4140 mg Docosahexaenoic acid) and omega-6 fatty acids (1800 mg gamma-Linolenic acid and 3150 mg Linoleic acid) (1:1 w/w), with 0.6 mg vitamin A, vitamin E (22 mg) plus pure γ-tocopherol (760 mg), or 20 mL placebo containing olive oil. Participants completed assessments of cognitive function, functional capacity, body composition and various aspects of quality of life at baseline and following three and six months of supplementation. Thirty-six participants completed the study (eighteen from each group). A significant interaction between supplementation and time was found on cognitive function (Addenbrooke’s Cognitive Examination -Revised (ACE-R), Mini-Mental State Examination (MMSE) and Stroop Color and Word Test (STROOP) color test; p < 0.001, p = 0.011 and p = 0.037, respectively), functional capacity (6-min walk test and sit-to-stand-60; p = 0.028 and p = 0.032, respectively), fatigue (p < 0.001), physical health (p = 0.007), and daily sleepiness (p = 0.007)—showing a favorable improvement for the participants receiving the supplement. The results indicate that this nutritional modality could be promising for reducing cognitive and functional decline in the elderly with MCI.
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- 2020
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45. Early or late cranioplasty following decompressive craniotomy for traumatic brain injury: A systematic review and meta-analysis
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Feng Zheng, Hao Xu, Niklas von Spreckelsen, Pantelis Stavrinou, Marco Timmer, Roland Goldbrunner, Fang Cao, Qishan Ran, Gang Li, Ruiming Fan, Qiang Zhang, Wei Chen, Shengtao Yao, and Boris Krischek
- Subjects
Medicine (General) ,R5-920 - Abstract
Objective To evaluate the effectiveness of early (3 months) on post-operative complications in patients receiving decompressive craniotomy (DC) for traumatic brain injury (TBI). Methods The Cochrane Library, PubMed and EMBASE databases were systematically searched for studies published prior to May 21, 2017. A meta-analysis examined post-operative overall complication rates, infection rates, subdural fluid collection and operating times according to early and late CP. Results Of the initial 1675 references, five studies, all cohort, involving a total of 413 patients, were selected for the review. There was no difference between early and late CP in post-operative overall complication rate (RR=0.68, 95%CI [0.36, 1.29]) and the post-operative infection rate (RR=0.50, 95%CI [0.20, 1.24]) in patients receiving DC for TBI. However, there was a significant difference in post-operative subdural effusion (RR=0.24, 95%CI [0.07, 0.78]) and mean operative time (mean difference = −33.02 min, 95%CI [−48.19, −17.84]) both in favour of early CP. Conclusions No differences were found between early and late CP in post-operative overall complications and procedural related infections in patients receiving DC for TBI, but early CP reduced the complication of subdural effusion and the mean operating time. These findings need to be confirmed by large, randomised controlled trials.
- Published
- 2018
- Full Text
- View/download PDF
46. The opsis of Helen: Performative Intertextuality in Euripides
- Author
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Aspasia Skouroumouni Stavrinou
- Subjects
History of Greece ,DF10-951 - Abstract
Features of the play’s staging, costume, and gestures achieve a series of allusions to comparable features in the genre of comedy and thus reinforce the comic elements of the plot and characters of Helen.
- Published
- 2015
47. P‐16.1: Fully Inkjet‐Printed Organic Light‐Emitting Diodes based on a Thermally Activated Delayed Fluorescent Emitter
- Author
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Tao, Wen-wen, Hu, Yun, Huang, Jing-song, and Stavrinou, Paul N
- Abstract
Using a fully solution‐processed cross‐linking method, we demonstrate a technique for fabricating multilayer OLEDs based on Thermally Activated Delayed Fluorescence (TADF). Our approach addresses the challenge of interfacial miscibility frequently encountered during fabrication and remains compatible with industrial printing and coating technologies. Multilayer TADF‐based OLEDs utilizing fully inkjet‐printed organic layers are successfully manufactured. The fully printed devices exhibit a maximum luminance of 2830 cd/m², a maximum current efficiency of 6.52 cd/A, and a maximum external quantum efficiency (EQE) of 1.98%.
- Published
- 2024
- Full Text
- View/download PDF
48. Identifying triplet pathways in dilute pentacene films
- Author
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Lubert-Perquel, Daphné, Salvadori, Enrico, Dyson, Matthew, Stavrinou, Paul N., Montis, Riccardo, Nagashima, Hiroki, Kobori, Yasuhiro, Heutz, Sandrine, and Kay, Christopher W. M.
- Published
- 2018
- Full Text
- View/download PDF
49. Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans
- Author
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Bogdanis, G.C., Stavrinou, P., Fatouros, I.G., Philippou, A., Chatzinikolaou, A., Draganidis, D., Ermidis, G., and Maridaki, M.
- Published
- 2013
- Full Text
- View/download PDF
50. Polymers with Exceptional Photoluminescence by Homoconjugation
- Author
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Andreas Braendle, Aleksandr Perevedentsev, Nathan J. Cheetham, Paul N. Stavrinou, Jörg A. Schachner, Nadia C. Mösch-Zanetti, Markus Niederberger, and Walter Caseri
- Subjects
Fluorescence ,Homoconjugation ,Light emission ,Optical spectroscopy ,Poly(phenylene methylene)s ,Chemistry ,QD1-999 - Published
- 2017
- Full Text
- View/download PDF
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