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3 results on '"Staurianeas NG"'

1. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria

Author

Papadopoulou, N Kalogeromitros, D Staurianeas, NG Tiblalexi, D Theoharides, TC

Subjects
endocrine system, nervous system, integumentary system, polycyclic compounds, hormones, hormone substitutes, and hormone antagonists
Abstract

Certain skin disorders, such as contact dermatitis and chronic urticaria, are characterized by inflammation involving mast cells and worsen by stress. The underlying mechanism of this effect, however, is not known. The skin appears to have the equivalent of a hypothalamic-pituitary-ad renal (HPA) axis, including local expression of corticotropin-releasing hormone (CRH) and its receptors (CRH-R). We have reported that acute stress and intradermal administration of CRH stimulate skin mast cells and increase vascular permeability through CRH-R1 activation. In this study, we investigated the expression of CRH-R1, the main CRH-R subtype in human skin, and the mast cell related gene histidine decarboxylase (HDC), which regulates the production of histamine, in normal and pathological skin biopsies. Quantitative real time PCR revealed that chronic urticaria expresses high levels of CRH-R1 and HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. The lichen simplex samples had high expression of CRH-R1, but low HDC. These results implicate CRH-R in chronic urticaria, which is often exacerbated by stress.

Published
2005

2. Skin corticotropin-releasing hormone receptor expression in psoriasis.

Author

Tagen M, Stiles L, Kalogeromitros D, Gregoriou S, Kempuraj D, Makris M, Donelan J, Vasiadi M, Staurianeas NG, and Theoharides TC

Subjects
Adult, Case-Control Studies, Corticotropin-Releasing Hormone blood, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Psoriasis pathology, RNA, Messenger genetics, RNA, Messenger metabolism, Severity of Illness Index, Skin pathology, Stress, Physiological genetics, Stress, Physiological metabolism, Psoriasis metabolism, Receptors, Corticotropin-Releasing Hormone metabolism, Skin metabolism
Published
2007
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3. Corticotropin-releasing hormone receptor-1 and histidine decarboxylase expression in chronic urticaria.

Author

Papadopoulou N, Kalogeromitros D, Staurianeas NG, Tiblalexi D, and Theoharides TC

Subjects
Adult, Aged, Chronic Disease, Female, Gene Expression, Histamine metabolism, Histidine Decarboxylase genetics, Humans, Infant, Male, Mast Cells metabolism, Middle Aged, Receptors, Corticotropin-Releasing Hormone genetics, Skin metabolism, Up-Regulation, Urticaria enzymology, Urticaria genetics, Histidine Decarboxylase metabolism, Receptors, Corticotropin-Releasing Hormone metabolism, Urticaria metabolism
Abstract

Certain skin disorders, such as contact dermatitis and chronic urticaria, are characterized by inflammation involving mast cells and worsen by stress. The underlying mechanism of this effect, however, is not known. The skin appears to have the equivalent of a hypothalamic-pituitary-adrenal (HPA) axis, including local expression of corticotropin-releasing hormone (CRH) and its receptors (CRH-R). We have reported that acute stress and intradermal administration of CRH stimulate skin mast cells and increase vascular permeability through CRH-R1 activation. In this study, we investigated the expression of CRH-R1, the main CRH-R subtype in human skin, and the mast cell related gene histidine decarboxylase (HDC), which regulates the production of histamine, in normal and pathological skin biopsies. Quantitative real time PCR revealed that chronic urticaria expresses high levels of CRH-R1 and HDC as compared to normal foreskin, breast skin and cultured human keratinocytes. The lichen simplex samples had high expression of CRH-R1, but low HDC. These results implicate CRH-R in chronic urticaria, which is often exacerbated by stress.

Published
2005
Full Text
View/download PDF

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