339 results on '"Stauffer, Shaun R."'
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2. Acetylation of the NS3 helicase by KAT5γ is essential for flavivirus replication
3. A PAM of the α1A-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure
4. Characterization of a novel positive allosteric modulator of the α1A-Adrenergic receptor
5. Discovery of VU0467319: an M1 Positive Allosteric Modulator Candidate That Advanced into Clinical Trials.
6. WD repeat domain 5 (WDR5) inhibitors: a patent review (2016-present).
7. Aminopyridine analogs selectively target metastatic pancreatic cancer
8. Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
9. Supplementary Figure 2 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
10. Supplementary Figure 7 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
11. Supplementary Figure 4 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
12. Supplementary Figure 5 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
13. Supplementary Figure 3 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
14. Supplementary Figure 6 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
15. Supplementary Figure 1 from Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
16. Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase
17. Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets
18. A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
19. TheSLC1A1/EAAT3 Dicarboxylic Amino Acid Transporter is an Epigenetically Dysregulated Nutrient Carrier that Sustains Oncogenic Metabolic Programs
20. VU0477573: Partial Negative Allosteric Modulator of the Subtype 5 Metabotropic Glutamate Receptor with In Vivo Efficacy
21. Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen–Fluorogen Activating Protein Binding Pair
22. Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase.
23. 361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
24. Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death
25. Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
26. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes
27. Biased mGlu5-Positive Allosteric Modulators Provide In Vivo Efficacy without Potentiating mGlu5 Modulation of NMDAR Currents
28. WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
29. Biotransformation of a Novel Positive Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Contributes to Seizure-Like Adverse Events in Rats Involving a Receptor Agonism-Dependent Mechanism
30. Probing the Metabotropic Glutamate Receptor 5 (mGlu5) Positive Allosteric Modulator (PAM) Binding Pocket: Discovery of Point Mutations That Engender a “Molecular Switch” in PAM Pharmacology
31. Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity
32. Modulation of pyramidal cell output in the medial prefrontal cortex by mGluR5 interacting with CB1
33. Functional Impact of Allosteric Agonist Activity of Selective Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 in Regulating Central Nervous System Function
34. Discovery of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Reveals Chemical and Functional Diversity and In Vivo Activity in Rat Behavioral Models of Anxiolytic and Antipsychotic Activity
35. Characterization of a Novel Positive Allosteric Modulator of the α1A-Adrenergic Receptor
36. WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
37. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro)
38. Discovery and Structure-Based Optimization of Potent and Selective WDR5 Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core
39. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro).
40. The discovery of VU0486846: steep SAR from a series of M1 PAMs based on a novel benzomorpholine core
41. Identification of second-generation P2X3 antagonists for treatment of pain
42. Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
43. Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core
44. In Vitro to in Vivo Translation of Allosteric Modulator Concentration-Effect Relationships: Implications for Drug Discovery
45. Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5–MYC Protein–Protein Interaction
46. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding
47. Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV-2 3CLpro)
48. Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor
49. Triarylpyrazoles with basic side chains: development of pyrazole-based estrogen receptor antagonists
50. Acyclic amides as estrogen receptor ligands: Synthesis, binding, activity and receptor interaction
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