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4. Disorders of Heme Metabolism

Author

Stölzel, Ulrich, Kubisch, Ilja, Stauch, Thomas, Schuppan, Detlef, Blau, Nenad, editor, Dionisi Vici, Carlo, editor, Ferreira, Carlos R., editor, Vianey-Saban, Christine, editor, and van Karnebeek, Clara D. M., editor

Published
2022
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7. German Porphyria Registry (PoReGer)–Background and Setup

Author

Gerischer, Lea, primary, Mainert, Mona, additional, Wohmann, Nils, additional, Kubisch, Ilja, additional, Stölzel, Ulrich, additional, Stauch, Thomas, additional, von Wegerer, Sabine, additional, Braun, Fabian, additional, Weiler-Normann, Christina, additional, Blaschke, Sabine, additional, Frank, Jorge, additional, Somasundaram, Rajan, additional, and Diehl-Wiesenecker, Eva, additional

Published
2024
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8. Interference From High-Dose Biotin Intake in Immunoassays for Potentially Time-Critical Analytes by Roche: Evaluation of a Countermeasure for Worst-Case Scenarios

Author

Mrosewski, Ingo, Urbank, Matthias, Stauch, Thomas, and Switkowski, Rafael

Subjects
Roche Diagnostics GmbH, ElecSys Inc., Tacrolimus -- Usage -- Dosage and administration, Glycoproteins -- Analysis -- Usage, Chorionic gonadotropins -- Dosage and administration -- Usage, Thyrotropin -- Analysis -- Usage, Thyroxine -- Dosage and administration, Natriuretic peptides -- Analysis -- Usage, Adsorption -- Usage -- Analysis, Immunoglobulin G -- Usage -- Analysis, Biotin -- Analysis -- Usage, Electronic components industry -- Usage -- Analysis, Hormones -- Analysis -- Usage, Troponin -- Usage -- Analysis, Immunoglobulin M -- Usage -- Analysis, Pharmaceutical industry -- Analysis -- Usage, Health
Abstract

Context.--Immunoassays using the interaction between streptavidin and biotin are used for clinical chemical analytes on platforms by many different manufacturers. The design can be susceptible to interference from high-dose biotin intake in patients, which remains an often-overlooked confounder despite recently increased awareness. Objective.--To evaluate an easily implementable method of in vitro biotin depletion for the removal of biotin interference in immunoassays for potentially time-critical analytes. Design.--A biotin stock solution was made and de-identified patient samples were spiked to reach a biotin concentration of 1.126 x [10.sup.6] pg/mL, the maximum reported biotin concentration 1 to 2 hours after a single oral dose of 300 mg biotin. Then, the resulting interference in Elecsys immunoassays for cortisol, cyclosporine A, tacrolimus, digitoxin, thyroid-stimulating hormone, free triiodothyronine, free thyroxine, C-peptide, insulin, Nterminal pro-B-type natriuretic peptide, troponin T high sensitive, human immunodeficiency virus, procalcitonin, [beta] human chorionic gonadotropin, toxoplasma immunoglobulin M, and toxoplasma immunoglobulin G was evaluated before and after biotin depletion using streptavidin particles. Results.--All tested immunoassays, with the exception of toxoplasma immunoglobulin M and toxoplasma immunoglobulin G, suffered from significant biotin interference. The depletion protocol removed assay interference due to biotin and produced results that were close or identical to initial prespike measurements. Conclusions.--Despite an increase in turnaround times, biotin adsorption is a feasible countermeasure for biotin interference in Elecsys immunoassays. Until test kits with an increased resistance to the interference from high-dose biotin intake are distributed, the evaluated protocol can provide results properly reflecting the patient's clinical condition. (Arch Pathol Lab Med. 2020;144:1108-1117; doi: 10.5858/arpa.2019-0425-OA), Laboratory analyses play a paramount role in about 70% of medical decisions and must be highly reliable to avoid false or missed diagnoses or unnecessary diagnostic procedures and treatments. (1) [...]

Published
2020
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10. Autoren

Author

Al-Batran, Salah-Eddin, primary, Allescher, Hans-Dieter, additional, Appenrodt, Beate, additional, Aretz, Stefan, additional, Arnim, Ulrike von, additional, Beuers, Ulrich, additional, Beyer, Georg, additional, Boesecke, Christoph, additional, Borowitzka, Fanny, additional, Caca, Karel, additional, Czauderna, Carolin, additional, Dröge, Carola, additional, Dumoulin, Franz Ludwig, additional, Epple, Hans-Jörg, additional, Feurle, Gerhard E., additional, Fibbe, Christiane, additional, Fischbach, Wolfgang, additional, Frieling, Thomas, additional, Galle, Peter R., additional, Germer, Christoph-Thomas, additional, Gonzalez-Carmona, Maria A., additional, Götze, Thorsten Oliver, additional, Gundling, Felix, additional, Halilbasic, Emina, additional, Hartmann, Franz, additional, Herold, Alexander, additional, Herta, Toni, additional, Höllerich, Jörg, additional, Holtmeier, Wolfgang, additional, Horvatits, Thomas, additional, Hüneburg, Robert, additional, Jüngst, Christoph, additional, Kalff, Jörg C., additional, Kandler, Jennis, additional, Keitel-Anselmino, Verena, additional, Keller, Jutta, additional, Kestler, Angelika, additional, Köpke, Marlies, additional, Koletzko, Sibylle, additional, Kollmar, Otto, additional, Krammer, Heiner, additional, Kubisch, Ilja, additional, Kruis, Wolfgang, additional, Kullak-Ublick, Gerd A., additional, Labenz, Joachim, additional, Lammert, Frank, additional, Lamprecht, Georg, additional, Layer, Peter, additional, Leifeld, Ludger, additional, Lügering, Norbert, additional, Lutz, Philipp L., additional, Malfertheiner, Peter, additional, Mayerle, Julia, additional, Meier, Benjamin, additional, Merle, Uta, additional, Möhler, Markus, additional, Müller-Lissner, Stefan, additional, Munda, Petra, additional, Neubrand, Michael, additional, Neuhaus, Horst, additional, Pehl, Christian, additional, Pischke, Sven, additional, Porschen, Rainer, additional, Pox, Christian, additional, Rahimzai, Rafique, additional, Raithel, Martin, additional, Rockstroh, Jürgen, additional, Roeb, Elke, additional, Sarrazin, Christoph, additional, Sauerbruch, Tilman, additional, Schepke, Michael, additional, Schepp, Wolfgang, additional, Scheyda, Katharina, additional, Schmitt, Annika, additional, Schulz, Christian, additional, Schuppan, Detlef, additional, Seufferlein, Thomas, additional, Siegmund, Britta, additional, Sirtl, Simon, additional, Soysal, Savas D., additional, Spengler, Ulrich, additional, Stallmach, Andreas, additional, Stauch, Thomas, additional, Stindt, Jan, additional, Stölzel, Ulrich, additional, Strassburg, Christian P., additional, Tacke, Frank, additional, Terjung, Birgit, additional, Trauner, Michael, additional, Trebicka, Jonel, additional, Tröger, Hanno, additional, Wege, Henning, additional, Weismüller, Tobias J., additional, and Wolf, Susanna, additional

Published
2021
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11. Porphyrien

Author

Stölzel, Ulrich, primary, Kubisch, Ilja, additional, and Stauch, Thomas, additional

Published
2021
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14. Akute Porphyrien

Author

Doss, Manfred O., Lindner, Uwe, Stölzel, Ulrich, Stauch, Thomas, Marx, Gernot, editor, Muhl, Elke, editor, Zacharowski, Kai, editor, and Zeuzem, Stefan, editor

Published
2015
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16. Detect Acute Porphyrias in Emergency Departments (DePorED) – A pilot study

Author

Diehl-Wiesenecker, Eva, primary, Blaschke, Sabine, additional, Wohmann, Nils, additional, Kubisch, Ilja, additional, Stauch, Thomas, additional, Mainert, Mona, additional, Helm, Franziska, additional, von Wegerer, Sabine, additional, Pittrow, David, additional, Frank, Jorge, additional, Stölzel, Ulrich, additional, and Somasundaram, Rajan, additional

Published
2023
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17. Expert Report on Immune Thrombocytopenia - Current Diagnostics and Treatment Recommendations from an Expert Group from Austria, Germany, and Switzerland

Author

Matzdorff, Axel, primary, Alesci, Sonja R., additional, Gebhart, Johanna, additional, Holzhauer, Susanne, additional, Hütter-Krönke, Marie Luise, additional, Kühne, Thomas, additional, Meyer, Oliver, additional, Ostermann, Helmut, additional, Pabinger, Ingrid, additional, Rummel, Mathias, additional, Sachs, Ulrich J., additional, Stauch, Thomas, additional, Trautmann-Grill, Karolin, additional, and Wörmann, Bernhard, additional

Published
2023
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18. Expertenreport Immunthrombozytopenie - Aktuelle Diagnostik und Therapie

Author

Matzdorff, Axel, primary, Alesci, Sonja R., additional, Gebhart, Johanna, additional, Holzhauer, Susanne, additional, Hütter-Krönke, Marie Luise, additional, Kühne, Thomas, additional, Meyer, Oliver, additional, Ostermann, Helmut, additional, Pabinger, Ingrid, additional, Rummel, Mathias, additional, Sachs, Ulrich J., additional, Stauch, Thomas, additional, Trautmann-Grill, Karolin, additional, and Wörmann, Bernhard, additional

Published
2022
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20. Treatment of Immune Thrombocytopenia (ITP) with Eltrombopag - Results of the 5th Interim Analysis of the Study RISA, with Special Consideration of Treatment Discontinuations

Author

Meyer, Oliver, primary, Schlag, Rudolf, additional, Stauch, Thomas, additional, Fleischmann, Bastian, additional, Reiser, Marcel, additional, Kaempfe, Dietrich, additional, Behlendorf, Timo, additional, Welslau, Manfred, additional, von der Heyde, Eyck, additional, Dörfel, Steffen, additional, Willy, Claudia, additional, and Stauch, Martina, additional

Published
2022
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24. Autoren

Author

Allescher, Hans-Dieter, Andresen, Viola, Aretz, Stefan, Beuers, Ulrich, Beyer, Georg, Boesecke, Christoph, Borowitzka, Fanny, Caca, Karel., Canbay, Ali, Chang, Johannes, Liberto, Alexander di, Dröge, Carola, Dumoulin, Franz Ludwig, Ebert, Matthias P.A., Epple, Hans-Jörg, Feurle, Gerhard E., Fibbe, Chistiane, Fischbach, Wolfgang, Frieling, Thomas, Galle, Peter R., Germer, Christoph-Thomas, González-Carmona, Maria A., Götze, Thorsten Oliver, Gundling, Felix, Halilbasic, Emina, Hartmann, Franz, Herold, Alexander, Herta, Toni, Höllerich, Jörg, Holtmeier, Wolfgang, Horvatits, Thomas, Hüneburg, Robert, Jansen, Christian, Jüngst, Christoph, Kandler, Jennis, Keitel-Anselmino, Verena, Keller, Jutta, Kestler, Angelika, Köhler, Jan Philipp, Koletzko, Sibylle, Kollmar, Otto, Krammer, Heiner, Kreis, Martin, Kruis, Wolfgang, Kubisch, Ilja, Kucharzik, Torsten, Kullak-Ublick, Gerd A., Labenz, Joachim, Lammert, Frank, Lamprecht, Georg, Layer, Peter, Leifeld, Ludger, Lügering, Norbert, Lutz, Philipp, Malfertheiner, Peter, Manekeller, Steffen, Mayerle, Julia, Meier, Benjamin, Merle, Uta, Möhler, Markus, Monin, Malte B., Müller-Lissner, Stefan, Munda, Petra, Neubrand, Michael, Neuhaus, Horst, Nowacki, Tobias, Pascher, Andreas, Pehl, Christian, Pischke, Sven, Pox, Christian C., Praktiknjo, Michael, Rahimzai, Rafique, Raithel, Martin, Reinartz Groba, Sara, Rennebaum, Florian, Repges, Sophie, Rockstroh, Jürgen K., Roeb, Elke, Sarrazin, Christoph, Sauerbruch, Tilman, Schepke, Michael, Schepp, Wolfgang, Scheyda-Yoo, Katharina, Schmitt, Annika, Schöler, David, Schulz, Christian, Schuppan, Detlef, Seufferlein, Thomas, Siegmund, Britta, Sirtl, Simon, Soysal, Savas D., Spengler, Ulrich, Stallmach, Andres, Stauch, Thomas, Stindt, Jan, Stölzel, Ulrich, Strassburg, Christian P., Tacke, Frank, Terjung, Birgit, Trauner, Michael, Trebicka, Jonel, Tröger, Hanno, Dahl, Stephan vom, Arnim, Ulrike von, Schassen, Henrike von, Vornhülz, Marlies, Vorona, Elena, Wege, Henning, Weismüller, Tobias J., Weissenborn, Karin, Wolf, Susanna, Zimpel, Carolin, and Zipprich, Alexander

Published
2024
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25. Akute Porphyrien

Author

Doss, Manfred O., primary, Lindner, Uwe, additional, Stölzel, Ulrich, additional, and Stauch, Thomas, additional

Published
2014
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32. The role of the general practitioner in cancer care in general and with respect to complementary and alternative medicine for patients with cancer.

Author

Vogel, Johanna, Zomorodbakhsch, Bijan, Stauch, Thomas, Josfeld, Lena, and Hübner, Jutta

Subjects
OCCUPATIONAL roles, HOMEOPATHY, ACUPUNCTURE, CANCER patients, SURVEYS, VITAMIN B complex, QUESTIONNAIRES, DESCRIPTIVE statistics, ALTERNATIVE medicine, DATA analysis software, CANCER patient medical care
Abstract

Objective: Cancer patients often use complementary and alternative medicine (CAM). The aim of this study was to assess the expectations of cancer patients towards their general practitioner (GP) regarding information on and offers of CAM procedures. Methods: A standardised anonymous questionnaire was developed and handed out to cancer patients in GP practices and oncology clinics in Germany. Results: One hundred and eighty questionnaires were evaluable. For 88.1% of the patients, it was important that their GP regularly receives information on cancer therapy. Only a minority consulted with the GP regarding diagnosis and therapy of the cancer (32.4%) or approached him about side effects of the therapy (46.9%). About one fifth of the GPs offered CAM. Before the cancer diagnosis, only 7% of the patients received a CAM offer from the GP; after the diagnosis, it was 14%. A large majority wanted the GP to offer more complementary (70.9%) and alternative (54.3%) medicine. Conclusion: Our survey points to a clear mismatch of supply and demand regarding CAM for cancer patients in the primary care sector. Training for GPs on scientific evidence of as well as communication skills on CAM will be indispensable in the future to optimise the care of cancer patients by GPs. [ABSTRACT FROM AUTHOR]

Published
2022
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36. Porphyrien

Author

Stölzel, Ulrich, additional, Stauch, Thomas, additional, and Doss, Manfred, additional

Published
2018
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41. Non-invasive detection of iron deficiency by fluorescence measurement of erythrocyte zinc protoporphyrin in the lip

Author

Hennig, Georg, primary, Homann, Christian, additional, Teksan, Ilknur, additional, Hasbargen, Uwe, additional, Hasmüller, Stephan, additional, Holdt, Lesca M., additional, Khaled, Nadia, additional, Sroka, Ronald, additional, Stauch, Thomas, additional, Stepp, Herbert, additional, Vogeser, Michael, additional, and Brittenham, Gary M., additional

Published
2016
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44. Porphyrien

Author

Stölzel, Ulrich, additional, Stauch, Thomas, additional, and Doss, Manfred, additional

Published
2012
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49. Treatment of Immune Thrombocytopenia (ITP) with Eltrombopag - Results of the 4 thInterim Analysis of the German Non-Interventional Trial RISA

Author

Meyer, Oliver, Schlag, Rudolf, Stauch, Thomas, Fleischmann, Bastian, Reiser, Marcel, Kaempfe, Dietrich, Behlendorf, Timo, Welslau, Manfred, Willy, Claudia, and Stauch, Martina

Abstract

Background:Immune thrombocytopenia (ITP) is an acquired autoimmune disorder with increased platelet destruction and impaired platelet production. Patients present with bleeding complications of various severity. Another common symptom of ITP is fatigue, which can severely affect patient's quality of life. Eltrombopag (EPAG) is an oral thrombopoietin receptor agonist, which is proved to be effective and safe in the treatment of ITP. In Europe, it is approved for the therapy of patients who were diagnosed with ITP at least 6 months ago and who have not responded to other treatments. Here we present data from the 4 thinterim analysis of the RISA study.

Published
2021
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