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169 results on '"Statuto, Teodora"'

1. Image-guided moderately hypofractionated radiotherapy for localized prostate cancer: a multicentric retrospective study (IPOPROMISE)

Author

Ingrosso, Gianluca, Ponti, Elisabetta, Francolini, Giulio, Caini, Saverio, Fondelli, Simona, Santini, Roberto, Valeriani, Maurizio, Rago, Luciana, Duroni, Giacomo, Bruni, Alessio, Augurio, Antonietta, Tramacere, Francesco, Trippa, Fabio, Russo, Donatella, Bottero, Marta, Tamburo, Maria, Parisi, Silvana, Borghesi, Simona, Lancia, Andrea, Gomellini, Sara, Scoccianti, Silvia, Stefanacci, Marco, Vullo, Gianluca, Statuto, Teodora, Miranda, Giulia, Santo, Bianca, Di Marzo, Alessandro, Bellavita, Rita, Vinciguerra, Annamaria, Livi, Lorenzo, Aristei, Cynthia, Bertini, Niccolò, Orsatti, Carolina, and Detti, Beatrice

Published
2024
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2. Worsening of 2-year patient-reported intestinal functionality after radiotherapy for prostate cancer including pelvic node irradiation

Author

Sanguineti, Giuseppe, Pavarini, Maddalena, Munoz, Fernando, Magli, Alessandro, Cante, Domenico, Garibaldi, Elisabetta, Gebbia, Andrea, Noris Chiorda, Barbara, Girelli, Giuseppe, Villa, Elisa, Faiella, Adriana, Magdalena Waskiewicz, Justyna, Avuzzi, Barbara, Pastorino, Alice, Moretti, Eugenia, Rago, Luciana, Statuto, Teodora, Gatti, Marco, Rancati, Tiziana, Valdagni, Riccardo, Luigi Vavassori, Vittorio, Gisella Di Muzio, Nadia, Fiorino, Claudio, and Cozzarini, Cesare

Published
2024
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3. Hypofractionated radiotherapy with simultaneous integrated boost for localized prostate cancer patients: effects on immune system and prediction of toxicity.

Author

D'Auria, Fiorella, Valvano, Luciana, Calice, Giovanni, D'Esposito, Vittoria, Cabaro, Serena, Formisano, Pietro, Bianchino, Gabriella, Traficante, Antonio, Bianculli, Antonella, Lazzari, Grazia, Statuto, Teodora, and Rago, Luciana

Subjects
VOLUMETRIC-modulated arc therapy, LYMPHOCYTE subsets, DOSE fractionation, PROSTATE cancer patients, CANCER radiotherapy, PROSTATE cancer, IMMUNOSUPPRESSION
Abstract

Background: The other side of radiotherapy (RT), in addition to the cytotoxic effect, is the ability to modulate the immune system in terms of activation or suppression, also depending on the dose and fractionation delivered. This immune RT effect can be detected both locally in the irradiated tumor site and in the peripheral blood. The aim of this study was to assess the consequence of pelvic irradiation on peripheral immune cells and cytokine secretions in localized prostate cancer (PC) patients undergoing pelvic irradiation with a simultaneous moderately hypofractionated prostate/prostate bed boost by Volumetric Modulated Arc Therapy (VMAT). Furthermore, we analyzed whether there was a correlation between these peripheral immune parameters and acute and late genitourinary (GU) and gastrointestinal (GI) toxicity. Methods: Thirty-eight PC patients were treated with pelvis irradiation (dose per fraction 1.8 Gy) and simultaneous hypofractionated (median dose per fraction: 2.7 Gy) prostate/prostate bed boost. A longitudinal analysis was performed for 12 months on peripheral blood to assess changes in 9 different lymphocyte subpopulations by flow cytometry and 10 circulating cytokines by Multiplex Luminex assay and ELISA. Results: Our analysis revealed that basal IFN-γ serum values were significantly lower in the definitive (curative intent for patients with prostate) patient group respect to the post-operative one. All the lymphocyte subsets and IFN-α, IFN-β and Il-2 peripheral concentrations displayed significant variations between the different time points considered. The immune cell population that suffers the greatest RT toxicity in the blood was B lymphocyte. We found an interesting correlation between basal TGF-β1 and late GU toxicity. In particular, TGF-β1 concentrations before RT were significantly higher in patients that experienced grade 2-3 of late GU toxicity, respect to grade 0-1. Exploring possible correlations between some clinical/biological findings and radiation planning parameters, we found no statistical significance. Conclusions: Our study analyzed, in the context of hypofractionated radiotherapy in prostate cancer, different parameters of the peripheral immune system. We have highlighted longitudinally the peripheral behavior of the different lymphocyte subpopulations and of a group of 10 cytokines during the first year after RT. One of the analyzed cytokines, such as TGF-β1, has proven to be promising predictive factor of severe late GU toxicity. [ABSTRACT FROM AUTHOR]

Published
2024
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5. What Does Atypical Chronic Lymphocytic Leukemia Really Mean? A Retrospective Morphological and Immunophenotypic Study

Author

D’Arena, Giovanni, primary, Vitale, Candida, additional, Pietrantuono, Giuseppe, additional, Villani, Oreste, additional, Mansueto, Giovanna, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, D’Agostino, Simona, additional, Sabetta, Rosalaura, additional, Tarasco, Angela, additional, Innocenti, Idanna, additional, Autore, Francesco, additional, Fresa, Alberto, additional, Valvano, Luciana, additional, Tomasso, Annamaria, additional, Cafaro, Lorenzo, additional, Lamorte, Daniela, additional, and Laurenti, Luca, additional

Published
2024
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7. T-Large Granular Lymphocytic Leukemia with Hepatosplenic T-Cell Lymphoma? A Rare Case of Simultaneous Neoplastic T-Cell Clones Highlighted by Flow Cytometry and Review of Literature.

Author

Libonati, Rossana, Soda, Michela, Statuto, Teodora, Valvano, Luciana, D'Auria, Fiorella, D'Arena, Giovanni, Pietrantuono, Giuseppe, Villani, Oreste, Mansueto, Giovanna Rosaria, D'Agostino, Simona, Di Somma, Massimo Dante, Telesca, Alessia, and Vilella, Rocchina

Subjects
LYMPHOCYTIC leukemia, T-cell lymphoma, LITERATURE reviews, FLOW cytometry, MOLECULAR cloning
Abstract

Lymphoproliferative diseases are a heterogeneous set of malignant clonal proliferations of lymphocytes. Despite well-established diagnostic criteria, the diagnosis remains difficult due to their variety in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are less common than B-cell entities, and the lack of a clear immunophenotypic characteristic makes their identification hard. Flow cytometry turned out to be a useful tool in diagnosing T-cell disorders and to resolve complicated cases, especially if the number of analyzable neoplastic cells is small. We present a case of a 55-year-old man with simultaneous lymphoproliferative neoplastic T-cell clones, one αβ and the other γδ, identified and characterized by flow cytometry (FC), exploiting the variable expression intensity of specific markers. However, the patient's rapid decline made it impossible to define a differential diagnosis in order to confirm the identity of the γδ clone, which remains uncertain. This case is added to the few other cases already documented in the literature, characterized by the co-existence of T-large granular lymphocytic leukemia (T-LGLL)-αβ and T-LGLL-γδ/Hepatosplenic T-cell lymphoma (HSTCL). Our case underlines the key role of sensitive diagnostic tools in the assessment of potential relationship between the diagnosis, prognosis, and treatment in the two pathologies. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Features, reason for testing, and changes with time of 583 paroxysmal nocturnal hemoglobinuria clones from 529 patients: a multicenter Italian study

Author

Cannizzo, Elisa, Raia, Maddalena, De Propris, Maria Stefania, Triolo, Anna, Scarpati, Barbara, Marfia, Anna, Stacchini, Alessandra, Buccisano, Francesco, Lanza, Francesco, Regazzoli, Antonio, Michelutti, Angela, Cesaro, Simone, Conte, Cinzia Armentano, Vanelli, Laura, Tedone, Elisabetta, Omedè, Paola, Ciriello, Maria Matilde, Caporale, Roberto, Catinella, Virginia, Pantano, Giorgia, De Rosa, Clorinda, Lo Pardo, Catia, Poletti, Giovanni, Ulbar, Francesca, Pavanelli, Maria Cristina, Del Pup, Laura, Ottaviano, Virginia, Santonocito, Anna Maria, Bartocci, Chiara, Boscaro, Elisa, Arras, Marcella, Amodeo, Rachele, Mestice, Anna, Oliva, Bianca, Ferrari, Luisa, Statuto, Teodora, D’Auria, Fiorella, Pianezze, Graziano, Tanca, Donatella, Visconte, Feliciano, Rubba, Fabiana, Musto, Pellegrino, Geuna, Massimo, Gatti, Arianna, Brando, Bruno, and Del Vecchio, Luigi

Published
2019
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9. 2391: Longitudinal assessment of the impact of pelvic nodal radiotherapy on lymphopenia in PCa treatment

Author

Garibaldi, Elisabetta, Pavarini, Maddalena, Alborghetti, Lisa, Munoz, Fernando, Faiella, Adriana, Sanguineti, Giuseppe, Waskiewicz, Justyna M., Statuto, Teodora, Rago, Luciana, Lazzari, Grazia, Cante, Domenico, Piva, Cristina, Avuzzi, Barbara, Chiorda, Barbara Noris, Gatti, Marco, Rancati, Tiziana, Girelli, Giuseppe, Villa, Elisa, Vavassori, Vittorio L., Magli, Alessandro, Pastorino, Alice, De Rosa, Nicola, Di Muzio, Nadia G, Fiorino, Claudio, and Cozzarini, Cesare

Published
2024
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10. 2437: Clinical predictors of late lymphopenia in PCa patients undergoing radical or post-operative WPRT

Author

Magli, Alessandro, Pavarini, Maddalena, Alborghetti, Lisa, Avuzzi, Barbara, Cante, Domenico, Chiorda, Barbara Noris, De Rosa, Nicola, Faiella, Adriana, Garibaldi, Elisabetta, Girelli, Giuseppe, Gatti, Marco, Lazzari, Grazia, Waskiewicz, Justyna M., Munoz, Fernando, Pastorino, Alice, Piva, Cristina, Rago, Luciana, Sanguineti, Giuseppe, Statuto, Teodora, Villa, Elisa, Vavassori, Vittorio L., Rancati, Tiziana, Di Muzio, Nadia G, Fiorino, Claudio, and Cozzarini, Cesare

Published
2024
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11. Preliminary analysis of double‐negative T, double‐positive T, and natural killer T‐like cells in B‐cell chronic lymphocytic leukemia

Author

Valvano, Luciana, primary, Nozza, Filomena, additional, D'Arena, Giovanni, additional, D'Auria, Fiorella, additional, De Luca, Luciana, additional, Pietrantuono, Giuseppe, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, D'Agostino, Simona, additional, Lamorte, Daniela, additional, Calice, Giovanni, additional, and Statuto, Teodora, additional

Published
2023
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12. What Does Atypical Chronic Lymphocytic Leukemia Really Mean? A Retrospective Morphological and Immunophenotypic Study.

Author

D'Arena, Giovanni, Vitale, Candida, Pietrantuono, Giuseppe, Villani, Oreste, Mansueto, Giovanna, D'Auria, Fiorella, Statuto, Teodora, D'Agostino, Simona, Sabetta, Rosalaura, Tarasco, Angela, Innocenti, Idanna, Autore, Francesco, Fresa, Alberto, Valvano, Luciana, Tomasso, Annamaria, Cafaro, Lorenzo, Lamorte, Daniela, and Laurenti, Luca

Subjects
CHRONIC lymphocytic leukemia, FLOW cytometry, RETROSPECTIVE studies, ACQUISITION of data, CANCER patients, GENE expression, SYMPTOMS, MEDICAL records, IMMUNOPHENOTYPING, TUMOR markers, PHENOTYPES
Abstract

Simple Summary: Chronic lymphocytic leukemia (CLL) may be atypical in terms of the cell morphology picture, but also with regard to the surface immunophenotypic profile. Aiming at assessing the impact of morphology and immunophenotype in defining the atypical characteristics of CLL in terms of clinical–biological features and prognosis, a retrospective analysis of a large cohort of CLL patients was performed. We found that morphology better predicts the prognosis of atypical CLL compared to immunophenotypic analysis. Also, discordant cases in terms of immunophenotype and morphology did not identify specific prognostic groups. Overall, the question that still needs to be answered is: does it make sense to focus on morphology and immunophenotypic features in CLL in the era of molecular markers used as prognostic indicators? Atypical chronic lymphocytic leukemia (CLL) is still defined according to morphological criteria. However, deviance from the typical surface immunological profile suggests an atypical immunological-based CLL. A large cohort of patients with CLL was retrospectively evaluated aiming at assessing morphological (FAB criteria), immunophenotypical (two or more discordances from the typical profile), and clinical–biological features of atypical CLL. Compared to typical cases, morphologically atypical CLL showed a greater percentage of unmutated IgVH and CD38 positivity, and a higher expression of CD20. Immunophenotypically atypical CLL was characterized by more advanced clinical stages, higher expression of CD20, higher rate of FMC7, CD79b and CD49d positivity, and by an intermediate–high expression of membrane surface immunoglobulin, compared to typical cases. When patients were categorized based on immunophenotypic and morphologic concordance or discordance, no difference emerged. Finally, morphological features better discriminated patients' prognosis in terms of time-to-first treatment, while concordant atypical cases showed overall a worse prognosis. Discordant cases by immunophenotype and/or morphology did not identify specific prognostic groups. Whether—in the era of molecular markers used as prognostic indicators—it does make sense to focus on morphology and immunophenotype features in CLL is still matter of debate needing further research. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Supplementary Figure 4 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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14. Supplementary Figure 4 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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15. Supplementary Figure 3 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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16. Supplementary Table 2 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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17. Supplementary Figure 2 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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18. Supplementary Figure 1 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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19. Supplementary Table 3 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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20. Supplementary Table 1 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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21. Supplementary Table 2 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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22. Supplementary Table 1 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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23. Supplementary Methods from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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24. Supplementary Figure 1 from Transcriptional Characterization of a Prospective Series of Primary Plasma Cell Leukemia Revealed Signatures Associated with Tumor Progression and Poorer Outcome

Author

Todoerti, Katia, primary, Agnelli, Luca, primary, Fabris, Sonia, primary, Lionetti, Marta, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Lombardi, Luigia, primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Morabito, Fortunato, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Omede', Paola, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, Neri, Antonino, primary, and Musto, Pellegrino, primary

Published
2023
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25. Supplementary Figure 5 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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26. Supplementary Figure 2 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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27. Supplementary Figure 3 from Biological and Clinical Relevance of miRNA Expression Signatures in Primary Plasma Cell Leukemia

Author

Lionetti, Marta, primary, Musto, Pellegrino, primary, Di Martino, Maria Teresa, primary, Fabris, Sonia, primary, Agnelli, Luca, primary, Todoerti, Katia, primary, Tuana, Giacomo, primary, Mosca, Laura, primary, Gallo Cantafio, Maria E., primary, Grieco, Vitina, primary, Bianchino, Gabriella, primary, D'Auria, Fiorella, primary, Statuto, Teodora, primary, Mazzoccoli, Carmela, primary, De Luca, Luciana, primary, Petrucci, Maria Teresa, primary, Offidani, Massimo, primary, Di Raimondo, Francesco, primary, Falcone, Antonietta, primary, Caravita, Tommaso, primary, Omede', Paola, primary, Morabito, Fortunato, primary, Tassone, Pierfrancesco, primary, Boccadoro, Mario, primary, Palumbo, Antonio, primary, and Neri, Antonino, primary

Published
2023
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29. Accurate prediction of long-term risk of biochemical failure after salvage radiotherapy including the impact of pelvic node irradiation

Author

Cozzarini, Cesare, primary, Olivieri, Michela, additional, Magli, Alessandro, additional, Cante, Domenico, additional, Noris Chiorda, Barbara, additional, Munoz, Fernando, additional, Faiella, Adriana, additional, Olivetta, Elisa, additional, Deantoni, Chiara, additional, Fodor, Andrei, additional, Signor, Marco Andrea, additional, Petrucci, Edoardo, additional, Avuzzi, Barbara, additional, Ferella, Letizia, additional, Pastorino, Alice, additional, Garibaldi, Elisabetta, additional, Gatti, Marco, additional, Rago, Luciana, additional, Statuto, Teodora, additional, Rancati, Tiziana, additional, Briganti, Alberto, additional, Montorsi, Francesco, additional, Valdagni, Riccardo, additional, Sanguineti, Giuseppe, additional, Di Muzio, Nadia Gisella, additional, and Fiorino, Claudio, additional

Published
2022
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30. Flow cytometric evaluation of measurable residual disease in chronic lymphocytic leukemia: Where do we stand?

Author

D’Arena, Giovanni, primary, Sgambato, Alessandro, additional, Volpe, Silvestro, additional, Coppola, Giuseppe, additional, Amodeo, Rachele, additional, Tirino, Virginia, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Pietrantuono, Giuseppe, additional, Deaglio, Silvia, additional, Efremov, Dimitar, additional, Laurenti, Luca, additional, and Aiello, Antonella, additional

Published
2022
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31. Modulation of Peripheral Immune Cell Subpopulations After RapidArc/Moderate Hypofractionated Radiotherapy for Localized Prostate Cancer: Findings and Comparison With 3D Conformal/Conventional Fractionation Treatment

Author

D’Auria, Fiorella, primary, Statuto, Teodora, additional, Rago, Luciana, additional, Montagna, Antonietta, additional, Castaldo, Giovanni, additional, Schirò, Irene, additional, Zeccola, Anna, additional, Virgilio, Teresa, additional, Bianchino, Gabriella, additional, Traficante, Antonio, additional, Sgambato, Alessandro, additional, Fusco, Vincenzo, additional, Valvano, Luciana, additional, and Calice, Giovanni, additional

Published
2022
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32. Atypical Mature T-Cell Neoplasms: The Relevance of the Role of Flow Cytometry

Author

Statuto, Teodora, D’Auria, Fiorella, Del Vecchio, Luigi, Mansueto, Giovanna Rosaria, Villani, Oreste, Lalinga, Anna Vittoria, Possidente, Luciana, Nozza, Filomena, Vona, Gabriella, Rago, Luciana, Storto, Giovanni, Gasparini, Vanessa Rebecca, Zambello, Renato, D’Arena, Giovanni, and Valvano, Luciana

Subjects
angioimmunoblastic t-cell lymphoma, diagnosis, peripheral t-cell lymphoma not otherwise specified, Angioimmunoblastic T-cell lymphoma, Diagnosis, Flow cytometry, Immunophenotype, Peripheral T-cell lymphoma not otherwise specified, T-cell prolymphocytic leukemia, flow cytometry, Case Series, t-cell prolymphocytic leukemia, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, OncoTargets and Therapy, immunophenotype
Abstract

Teodora Statuto,1,* Fiorella D’Auria,2,* Luigi Del Vecchio3,4,†, Giovanna Rosaria Mansueto,5 Oreste Villani,5 Anna Vittoria Lalinga6,†, Luciana Possidente,6 Filomena Nozza,1 Gabriella Vona,1 Luciana Rago,7 Giovanni Storto,8 Vanessa Rebecca Gasparini,9 Renato Zambello,10 Giovanni D’Arena,5,* Luciana Valvano1,* 1Laboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 2Unit of Clinical Pathology, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 3CEINGE Biotecnologie Avanzate S.c.a.r.l, Federico II University, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology (DMMBM), Federico II University, Naples, Italy; 5Hematology Department of Basilicata, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 6Pathology Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 7Radiotherapy Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 8Department of Nuclear Medicine, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 9Department of Medicine, University of Padova - Veneto Institute of Molecular Medicine, VIMM, Padova, PD, Italy; 10Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, PD, Italy†Anna Vittoria Lalinga passed away on January 26, 2020 and Luigi Del Vecchio passed away on August 16, 2018*These authors contributed equally to this workCorrespondence: Luciana ValvanoLaboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, ItalyTel +39 0972 726395Fax +39 0972 723509Email luciana.valvano@crob.itAbstract: Lymphoproliferative disorders are a heterogeneous group of malignant clonal proliferations of lymphocytes whose diagnosis remains challenging, despite diagnostic criteria are now well established, due to their heterogeneity in clinical presentation and immunophenotypic profile. Lymphoid T-cell disorders are more rarely seen than B-cell entities and more difficult to diagnose for the absence of a specific immunophenotypic signature. Flow cytometry is a useful tool in diagnosing T-cell lymphoproliferative disorders since it is not only able to better characterize T-cell neoplasms but also to resolve some very complicated cases, in particular those in which a small size population of neoplastic cells is available for the analysis. Here, we report three patients with mature T-cell neoplasms with atypical clinical and biological features in which analysis of peripheral blood and bone marrow specimens by means of multicolor flow cytometry was very useful to identify and characterize three rare T-cell lymphoproliferative disorders, such as angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified and T-cell prolymphocytic leukemia. The aim of this case series report is not only to describe three rare cases of lymphoproliferative neoplasms but also to raise awareness that a fast, highly sensitive, and reproducible procedure, such as flow cytometry immunophenotyping, can have a determinant diagnostic role in these patients.Keywords: flow cytometry, immunophenotype, angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified, T-cell prolymphocytic leukemia, diagnosis

Published
2020

33. Flow cytometric evaluation of measurable residual disease in chronic lymphocytic leukemia: Where do we stand?

Author

D'Arena, Giovanni, Sgambato, Alessandro, Volpe, Silvestro, Coppola, Giuseppe, Amodeo, Rachele, Tirino, Virginia, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Pietrantuono, Giuseppe, Deaglio, Silvia, Efremov, Dimitar, Laurenti, Luca, and Aiello, Antonella

Subjects
CHRONIC lymphocytic leukemia, CHRONIC diseases, CHRONIC leukemia, FLOW cytometry, TREATMENT effectiveness
Abstract

Measurable residual disease (MRD) has emerged as a relevant parameter of response to therapy in chronic lymphocytic leukemia (CLL). Although several methods have been developed, flow cytometry has emerged as the most useful and standardized approach to measure and quantify MRD. The improved sensitivity of MRD measurements has been paralleled by the development of more effective therapeutic strategies for CLL, increasing the applicability of MRD detection in this setting. Chemotherapy and chemoimmunotherapy have firstly demonstrated their ability to obtain a deep MRD. Combined targeted therapies are also demonstrating a high molecular response rate and prospective trials are exploring the role of MRD to guide the duration of treatment in this setting. In this review we briefly summarize what we have learned about MRD with emphasis on its flow cytometric detection. [ABSTRACT FROM AUTHOR]

Published
2022
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34. CD200 Baseline Serum Levels Predict Prognosis of Chronic Lymphocytic Leukemia

Author

D’Arena, Giovanni, primary, Vitale, Candida, additional, Coscia, Marta, additional, Lamorte, Daniela, additional, Pietrantuono, Giuseppe, additional, Perutelli, Francesca, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Tomasso, Annamaria, additional, Griggio, Valentina, additional, Jones, Rebecca, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, D’Agostino, Simona, additional, Viglioglia, Vito, additional, De Feo, Vincenzo, additional, Calapai, Fabrizio, additional, Mannucci, Carmen, additional, Sgambato, Alessandro, additional, Efremov, Dimitar G., additional, and Laurenti, Luca, additional

Published
2021
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35. Analysis of Amount, Size, Protein Phenotype and Molecular Content of Circulating Extracellular Vesicles Identifies New Biomarkers in Multiple Myeloma

Author

Laurenzana, Ilaria, primary, Trino, Stefania, additional, Lamorte, Daniela, additional, Girasole, Marco, additional, Dinarelli, Simone, additional, De Stradis, Angelo, additional, Grieco, Vitina, additional, Maietti, Maddalena, additional, Traficante, Antonio, additional, Statuto, Teodora, additional, Villani, Oreste, additional, Musto, Pellegrino, additional, Sgambato, Alessandro, additional, De Luca, Luciana, additional, and Caivano, Antonella, additional

Published
2021
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36. Analysis of Amount, Size, Protein Phenotype and Molecular Content of Circulating Extracellular Vesicles Identifies New Biomarkers in Multiple Myeloma

Author

Laurenzana,Ilaria, Trino,Stefania, Lamorte,Daniela, Girasole,Marco, Dinarelli,Simone, De Stradis,Angelo, Grieco,Vitina, Maietti,Maddalena, Traficante,Antonio, Statuto,Teodora, Villani,Oreste, Musto,Pellegrino, Sgambato,Alessandro, De Luca,Luciana, Caivano,Antonella, Laurenzana,Ilaria, Trino,Stefania, Lamorte,Daniela, Girasole,Marco, Dinarelli,Simone, De Stradis,Angelo, Grieco,Vitina, Maietti,Maddalena, Traficante,Antonio, Statuto,Teodora, Villani,Oreste, Musto,Pellegrino, Sgambato,Alessandro, De Luca,Luciana, and Caivano,Antonella

Abstract

Ilaria Laurenzana,1,* Stefania Trino,1,* Daniela Lamorte,1 Marco Girasole,2 Simone Dinarelli,2 Angelo De Stradis,3 Vitina Grieco,4 Maddalena Maietti,5 Antonio Traficante,5 Teodora Statuto,4 Oreste Villani,6 Pellegrino Musto,6 Alessandro Sgambato,7 Luciana De Luca,4,* Antonella Caivano4,* 1Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, PZ, Italy; 2Institute for the Study of the Structure of Matter, National Research Council (CNR), Rome, Italy; 3Institute for Sustainable Plant Protection, National Research Council (CNR), Bari, Italy; 4Laboratory of Clinical Research and Advanced Diagnostics, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, PZ, Italy; 5Unit of Clinical Pathology, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, PZ, Italy; 6Hematology and Stem Cell Transplantation Unit, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, PZ, Italy; 7Scientific Direction, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero in Vulture, PZ, Italy*These authors contributed equally to this workCorrespondence: Antonella CaivanoLaboratory of Clinical Research and Advanced Diagnostics, IRCCS CROB, Rionero in Vulture, 85028, Potenza, ItalyTel +39 0972 726395Fax +39 0972 726482Email antonella.caivano@crob.itIntroduction: Extracellular vesicles (EVs) are naturally secreted cellular lipid bilayer particles, which carry a selected molecular content. Owing to their systemic availability and their role in tumor pathogenesis, circulating EVs (cEVs) can be a valuable source of new biomarkers useful for tumor diagnosis, prognostication and monitoring. However, a precise approach for isolation and characterization of cEVs as tumor biomarkers, exportable in a clinical setting, has not been conclusively established.Methods: We developed a novel and laboratory-made procedure based o

Published
2021

37. Modulation of Peripheral Immune Cell Subpopulations After RapidArc/Moderate Hypofractionated Radiotherapy for Localized Prostate Cancer: Findings and Comparison With 3D Conformal/Conventional Fractionation Treatment.

Author

D'Auria, Fiorella, Statuto, Teodora, Rago, Luciana, Montagna, Antonietta, Castaldo, Giovanni, Schirò, Irene, Zeccola, Anna, Virgilio, Teresa, Bianchino, Gabriella, Traficante, Antonio, Sgambato, Alessandro, Fusco, Vincenzo, Valvano, Luciana, and Calice, Giovanni

Subjects
LEUCOCYTES, IMMUNOREGULATION, PROSTATE cancer, PROSTATE cancer patients, KILLER cells
Abstract

Radiotherapy (RT) is an important therapeutic option in patients with localized prostate cancer (PC). Unfortunately, radiation treatment causes a decrease in peripheral lymphocytes and, consequently, influences the patients' immune status. Our aim was to study changes in peripheral blood immune cell subpopulations after RT and during 6 months' follow-up in 2 groups of PC patients irradiated with different techniques and dose fractions with curative intent. We also investigated the presence of correlation between immune cell modulation and genitourinary or gastrointestinal toxicity. We enrolled 44 patients treated with curative RT (RapidArc/hypofractionation regimen or 3D conformal/conventional fractionation) for localized PC. Total white blood cell (WBC), absolute lymphocyte counts (ALCs), and peripheral immune cell subpopulations were analyzed at baseline, at the end of RT, and 3 and 6 months after the end of RT. WBC and ALC greatly decreased at the end of RT with a trend to recover at 6 months' follow-up in the hypofractionation group but not in the conventional one. Furthermore, B, total T, T CD4+, T CD8+, and NK cell values dropped significantly in both groups at the end of RT, with a minor decrease detectable in the hypofractionation group for B, total T, and T CD4+ lymphocytes with respect to the other technique/fractionation group. Double-negative T (DNT), double-positive T (DPT), and NKT cells significantly decreased at the end of RT with a slight tendency to recover values during follow-up, particularly in the hypofractionation group. No correlation with genitourinary or gastrointestinal toxicity was found. In this study, we showed, for the first time, the effects of RapidArc/moderate hypofractionation RT on immune cell subsets in patients treated for localized PC. Due to the growing interest in minority T-cell subpopulations for immunotherapy, we also reported longitudinal monitoring of the effects of RT on DNT, DPT, and NKT, which was never studied before. Our preliminary data highlight the importance of considering the effects of different RT techniques/fractionation regimens on peripheral immune cells, in the era of RT and immunotherapy combination. [ABSTRACT FROM AUTHOR]

Published
2022
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38. Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles

Author

Mosca, Laura, Musto, Pellegrino, Todoerti, Katia, Barbieri, Marzia, Agnelli, Luca, Fabris, Sonia, Tuana, Giacomo, Lionetti, Marta, Bonaparte, Eleonora, Sirchia, Silvia Maria, Grieco, Vitina, Bianchino, Gabriella, DʼAuria, Fiorella, Statuto, Teodora, Mazzoccoli, Carmela, De Luca, Luciana, Petrucci, Maria Teresa, Morabito, Fortunato, Offidani, Massimo, Di Raimondo, Francesco, Falcone, Antonietta, Caravita, Tommaso, Omedè, Paola, Boccadoro, Mario, Palumbo, Antonio, and Neri, Antonino

Published
2013
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39. A shorter time to the first treatment may be predicted by the absolute number of regulatory T-cells in patients with Rai stage 0 chronic lymphocytic leukemia

Author

DʼArena, Giovanni, DʼAuria, Fiorella, Simeon, Vittorio, Laurenti, Luca, Deaglio, Silvia, Mansueto, Giovanna, Principe, Maria Ilaria Del, Statuto, Teodora, Pietrantuono, Giuseppe, Guariglia, Roberto, Innocenti, Idanna, Martorelli, Maria Carmen, Villani, Oreste, De Feo, Vincenzo, Poeta, Giovanni Del, and Musto, Pellegrino

Published
2012
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40. CIRCULATING REGULATORY T-CELL NUMBER DOES NOT PREDICT PROGNOSIS OF MONOCLONAL GAMMOPATHIES OF UNCERTAIN SIGNIFICANCE

Author

Statuto, Teodora, primary, VALVANO, LUCIANA, additional, Calice, Giovanni, additional, Pietrantuono, Giuseppe, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, Marano, Luana, additional, D'Agostino, Simona, additional, D'Auria, Fiorella, additional, Traficante, Antonio, additional, Sgambato, Alessandro, additional, and D'Arena, Giovanni, additional

Published
2021
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42. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance

Author

D’Arena, Giovanni, primary, De Feo, Vincenzo, additional, Pietrantuono, Giuseppe, additional, Seneca, Elisa, additional, Mansueto, Giovanna, additional, Villani, Oreste, additional, La Rocca, Francesco, additional, D’Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Arruga, Francesca, additional, Deaglio, Silvia, additional, Efremov, Dimitar G., additional, Sgambato, Alessandro, additional, and Laurenti, Luca, additional

Published
2020
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43. Atypical Mature T-Cell Neoplasms: The Relevance of the Role of Flow Cytometry

Author

Statuto,Teodora, D'Auria,Fiorella, Del Vecchio,Luigi, Mansueto,Giovanna Rosaria, Villani,Oreste, Lalinga,Anna Vittoria, Possidente,Luciana, Nozza,Filomena, Vona,Gabriella, Rago,Luciana, Storto,Giovanni, Gasparini,Vanessa Rebecca, Zambello,Renato, D'Arena,Giovanni, Valvano,Luciana, Statuto,Teodora, D'Auria,Fiorella, Del Vecchio,Luigi, Mansueto,Giovanna Rosaria, Villani,Oreste, Lalinga,Anna Vittoria, Possidente,Luciana, Nozza,Filomena, Vona,Gabriella, Rago,Luciana, Storto,Giovanni, Gasparini,Vanessa Rebecca, Zambello,Renato, D'Arena,Giovanni, and Valvano,Luciana

Abstract

Teodora Statuto,1,* Fiorella D’Auria,2,* Luigi Del Vecchio3,4,†, Giovanna Rosaria Mansueto,5 Oreste Villani,5 Anna Vittoria Lalinga6,†, Luciana Possidente,6 Filomena Nozza,1 Gabriella Vona,1 Luciana Rago,7 Giovanni Storto,8 Vanessa Rebecca Gasparini,9 Renato Zambello,10 Giovanni D’Arena,5,* Luciana Valvano1,* 1Laboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 2Unit of Clinical Pathology, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 3CEINGE Biotecnologie Avanzate S.c.a.r.l, Federico II University, Naples, Italy; 4Department of Molecular Medicine and Medical Biotechnology (DMMBM), Federico II University, Naples, Italy; 5Hematology Department of Basilicata, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 6Pathology Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 7Radiotherapy Unit, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 8Department of Nuclear Medicine, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, Italy; 9Department of Medicine, University of Padova - Veneto Institute of Molecular Medicine, VIMM, Padova, PD, Italy; 10Hematology and Clinical Immunology, Department of Medicine, Padua School of Medicine, Padova, PD, Italy†Anna Vittoria Lalinga passed away on January 26, 2020 and Luigi Del Vecchio passed away on August 16, 2018*These authors contributed equally to this workCorrespondence: Luciana ValvanoLaboratory of Clinical Research and Advanced Diagnostics, Centro Di Riferimento Oncologico Della Basilicata (IRCCS-CROB), Rionero in Vulture, Pz, ItalyTel +39 0972 726395Fax +39 0972 723509Email luciana.valvano@crob.itAbstract: Lymphoproliferative disorders are a heterogeneous

Published
2020

46. CD200 and Chronic Lymphocytic Leukemia: Biological and Clinical Relevance.

Author

D'Arena, Giovanni, De Feo, Vincenzo, Pietrantuono, Giuseppe, Seneca, Elisa, Mansueto, Giovanna, Villani, Oreste, La Rocca, Francesco, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Arruga, Francesca, Deaglio, Silvia, Efremov, Dimitar G., Sgambato, Alessandro, and Laurenti, Luca

Subjects
CHRONIC lymphocytic leukemia, T cells, B cells, MANTLE cell lymphoma, IMMUNOREGULATION, CHRONIC leukemia
Abstract

CD200, a transmembrane type Ia glycoprotein belonging to the immunoglobulin protein superfamily, is broadly expressed on a wide variety of cell types, such as B lymphocytes, a subset of T lymphocytes, dendritic cells, endothelial and neuronal cells. It delivers immunosuppressive signals through its receptor CD200R, which is expressed on monocytes/myeloid cells and T lymphocytes. Moreover, interaction of CD200 with CD200R has also been reported to play a role in the regulation of tumor immunity. Overexpression of CD200 has been reported in chronic lymphocytic leukemia (CLL) and hairy cell leukemia but not in mantle cell lymphoma, thus helping to better discriminate between these different B cell malignancies with different prognosis. In this review, we focus on the role of CD200 expression in the differential diagnosis of mature B-cell neoplasms and on the prognostic significance of CD200 expression in CLL, where conflicting results have been published so far. Of interest, increasing evidences indicate that anti-CD200 treatment might be therapeutically beneficial for treating CD200-expressing malignancies, such as CLL. [ABSTRACT FROM AUTHOR]

Published
2020
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47. External Validation of the Accuracy of ‘Cllflow Score’

Author

D'Arena, Giovanni, primary, Vitale, Candida, additional, Coscia, Marta, additional, D'Auria, Fiorella, additional, Bellesi, Silvia, additional, Topini, Giuseppe, additional, Panichi, Valentina, additional, Valvano, Luciana, additional, Statuto, Teodora, additional, Corrente, Francesco, additional, and Laurenti, Luca, additional

Published
2018
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48. CD200 included in a 4-marker modified Matutes score provides optimal sensitivity and specificity for the diagnosis of chronic lymphocytic leukaemia

Author

D'Arena, Giovanni, primary, Vitale, Candida, additional, Rossi, Giovanni, additional, Coscia, Marta, additional, Omedè, Paola, additional, D'Auria, Fiorella, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, Ciolli, Stefania, additional, Gilestro, Milena, additional, Molica, Stefano, additional, Bellesi, Silvia, additional, Topini, Giuseppe, additional, Panichi, Valentina, additional, Autore, Francesco, additional, Innocenti, Idanna, additional, Musto, Pellegrino, additional, Deaglio, Silvia, additional, Laurenti, Luca, additional, and Del Vecchio, Luigi, additional

Published
2018
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49. CD200 included in a 4-marker modified Matutes score provides optimal sensitivity and specificity for the diagnosis of chronic lymphocytic leukaemia

Author

D'Arena, Giovanni, Vitale, Candida, Rossi, Giovanni, Coscia, Marta, Omedè, Paola, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Ciolli, Stefania, Gilestro, Milena, Molica, Stefano, Bellesi, Silvia, Topini, Giuseppe, Panichi, Valentina, Autore, Francesco, Innocenti, Idanna, Musto, Pellegrino, Deaglio, Silvia, Laurenti, Luca, Del Vecchio, Luigi, Laurenti, Luca (ORCID:0000-0002-8327-1396), D'Arena, Giovanni, Vitale, Candida, Rossi, Giovanni, Coscia, Marta, Omedè, Paola, D'Auria, Fiorella, Statuto, Teodora, Valvano, Luciana, Ciolli, Stefania, Gilestro, Milena, Molica, Stefano, Bellesi, Silvia, Topini, Giuseppe, Panichi, Valentina, Autore, Francesco, Innocenti, Idanna, Musto, Pellegrino, Deaglio, Silvia, Laurenti, Luca, Del Vecchio, Luigi, and Laurenti, Luca (ORCID:0000-0002-8327-1396)

Abstract

N/A

Published
2018

50. Surface endoglin (CD105) expression on acute leukemia blast cells: an extensive flow cytometry study of 1002 patients

Author

Cosimato, Vincenzo, primary, Scalia, Giulia, additional, Raia, Maddalena, additional, Gentile, Laura, additional, Cerbone, Vincenza, additional, Visconte, Feliciano, additional, Statuto, Teodora, additional, Valvano, Luciana, additional, D’Auria, Fiorella, additional, Calice, Giovanni, additional, Graziano, Daniela, additional, Musto, Pellegrino, additional, and Del Vecchio, Luigi, additional

Published
2018
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