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Unlabelled: The aim of this study was to search to the factors favouring the earlier revealing of a coronary artery disease by comparing selected immunological, hormonal and biochemical parameters between two groups--younger and older men with coronary artery disease and with responding control groups., Material and Methods: In the study were included 93 men--60 with stable angina, confirmed by coronarography (at least 6 months after CABG, PTCA or myocardial infraction, with EF > 40%) and 33 men without atherosclerotic changes in the coronary vessels, as the control group. The two groups were divided depending on age: the younger subgroups [under 60-ty years old--group A with CAD (n=30) and B without CAD (n=18)] and the older subgroup [over 70-ty years old group C with CAD (n=30) and D without CAD (n=15)]., Results: Significantly lower concentration were noted for TNF-alpha--in control groups--by about 50% in the younger and 23% in the older group (r = 0.49) and homocysteine (by about 20% and 22% respectively, r = 0.40). Patients with CAD had higher concentration of CRP then in the control groups (by 52% and 54%, r = 0.28). Weak but positive correlation with the presence of a coronary heart disease was show for IgE and anti-gliadin antibodies (r = 0. 22-0.29)., Conclusion: The younger and older men with CAD statistically significantly differed in concentration of TNF-alpha and homocysteine.

The aim of this study was to search for the factors favouring the revealing of a coronary artery disease by comparing selected lipids and carbohydrate parameters between two groups--younger and older men with coronary artery disease. Into the study were included 60 men with stable angina confirmed by coronarography (at least 6 months after CABG, PTC A or myocardial infraction, with EF > 40%) and 33 men without atherosclerotic changes in the coronary vasseles as the control group. The two groups were divided depending on age: the younger subgroup [(under 60-ty years old-group: A with CAD, n = 30) and (B without CAD, n = l8)] and older subgroup [(over 70 years old-group: C with CAD, n = 30) and (D without CAD, n = 15)]. Men of middle age were not included. Serum semples were analyzed for the concentration of lipids parameters including apolipoprotein AI and B. The oral glucose tolerance test was carried out for all patients. In control groups (B and C) in comparison to the groups with CAD (A and C) was observed significantly higher concentration of the HDL cholesterol (by abouth 28% in younger men and 16% in older men (r with CAD = 0.40) and ApoAI (respectively by about 17% and 12.5%, r = 0.47). Weak, but positive corelation with the presence of coronary heart disease was shown for fasting glucose concentration. The younger and older men with CAD (A vs C) statistically significantly differed in concentration of HDL (a.v. 9.1 +/- 6.2 vs 46.7 +/- 11,7 ng/dl) and strongly correlated with HDL ApoAI (av. 137.6 +/- 12.6 vs 146.6 +/- 21.5 ng/dl). The negative family history was more often in younger patients.