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Objective We tested the hypothesis that a single-phase neck computed tomography (CT) is not inferior to multiphase neck CT (MPNCT), ultrasound, or nuclear medicine sestamibi scan in identifying parathyroid adenomas (PAs). Methods A total of 29 patients who had an MPNCT for the evaluation of a PA were identified; 11 patients met the inclusion criteria. During the 30-second arterial phase CT (APNCT), a normalized Hounsfield unit of suspected PA was compared to Hounsfield unit of a normal-appearing level I and a level II lymph node. A PA was defined as a lesion with a ratio of greater than 1.4 when compared to the level I and level II lymph node. This cutoff was determined based on the normalized ratios between level II and level I lymph nodes. Results of intraoperative parathyroid hormone assays and surgical pathology were used to validate the accuracy of this technique. Results The sensitivity of this method in APNCT is 90.9% whereas positive predictive value is 100%. The sensitivity or positive predictive value of ultrasound and nuclear medicine are 60% or 100% and 90% or 100%, respectively. Conclusion The sensitivity of APNCT is equivalent to that of MPNCT in identifying PA.

Objectives/Hypothesis To determine the effect of preoperative parathyroid hormone (PTH) level on the extent of surgery and the accuracy of parathyroid imaging in primary hyperparathyroidism. Study Design Retrospective cohort. Methods Final diagnosis of single-gland adenoma and its location versus multigland disease was established in this retrospective cohort study. Positive predictive value, negative predictive value, and accuracy of imaging were analyzed in relation to preoperative PTH levels. Results Eighty-seven percent of the 218 patients enrolled in the study underwent unilateral targeted operation and had a 97.9% (95% confidence interval: 95.8%–100%) success rate. However, in patients with PTH

BACKGROUND Surgical Morbidity and Mortality (M&M) conference lacks a standardized structure across institutions. We compared implementation of structure and National Surgical Quality Improvement Program's (NSQIP) definitions to organize our M&M and identify cases for discussion versus the usually used method at many centers of case identification by an attending surgeon or resident. METHODS AND MATERIALS A prospective study was performed, over a 10-wk period, to compare the identification of adverse events and the educational value of our M&M conference before and after implementation of structured NSQIP-defined presentations. Chart review was performed by a trained surgical clinical reviewer and trained NSQIP resident of all cases over the study period to identify NSQIP-defined occurrences. All presented M&Ms were evaluated for adequate reporting of adverse events and areas for improvement on a three-point scale. Surveys were administered before and after intervention to assess educational value to resident and faculty on a five-point Likert scale. Survey and presentation data were compared using Student's t-tests. P-values

Femoral hernias occur less frequently than inguinal hernias, but are often more challenging to repair surgically. Femoral hernias constitute between 2% and 8% of groin hernias, with the majority afflicting women. Because of the narrow neck and unyielding surrounding structures, femoral hernias are more likely to incarcerate or strangulate than their inguinal counterparts. They commonly present with incarceration of fat or intra-peritoneal contents. There has been extensive controversy in the last several decades concerning optimal approaches to femoral hernia repair, beginning with inguinal vs femoral approaches initially, to current debates about open vs laparoscopic and mesh vs tissue. Annandale is credited with the first inguinal approach to femoral hernia repair. Many other techniques have been described, but the contributions of Chester McVay established the fundamental basis for understanding femoral hernia repair. The McVay repair requires a relaxing incision to obtain a tension-free repair. Since Lichtenstein and colleagues described the use of prosthetic mesh for tension-free herniorrhaphy, many have turned to mesh to address the difficulties of femoral hernia repair, obviating the need for a relaxing incision. The use of prosthetic mesh is not universally applicable to femoral or inguinal hernia repair due to the incidence of strangulation and necrosis causing a potentially contaminated field. In addition, mesh can lead to other complications, such as chronic pain, infection, migration, and erosion. An effective primary tissue repair for femoral hernia is a useful procedure in the armamentarium of the general surgeon. During two recent humanitarian missions to Guatemala, surgeons from the George Washington University Department of Surgery encountered an unusually large incidence of femoral hernias. A technique developed at George Washington University, which combines a classic McVay (Cooper’s ligament [CL]) repair with a

To determine the effect of preoperative parathyroid hormone (PTH) level on the extent of surgery and the accuracy of parathyroid imaging in primary hyperparathyroidism.Retrospective cohort.Final diagnosis of single-gland adenoma and its location versus multigland disease was established in this retrospective cohort study. Positive predictive value, negative predictive value, and accuracy of imaging were analyzed in relation to preoperative PTH levels.Eighty-seven percent of the 218 patients enrolled in the study underwent unilateral targeted operation and had a 97.9% (95% confidence interval: 95.8%-100%) success rate. However, in patients with PTH65 pg/mL, 28.6% had bilateral exploration compared to 10.3% in those with PTH ≥65 pg/mL (P = .042). In patients with PTH65 pg/mL, 7/21 (33.3%) had inaccurate sestamibi findings compared to 24/174 (13.8%) in patients with PTH ≥65 pg/mL (P = .047).Accuracy of sestamibi drops significantly, by threefold, in patients with mild primary hyperparathyroidism and PTH65 pg/mL. Patients with PTH 65 pg/mL have a 2.5-fold higher rate of bilateral operation to identify the hypersecreting gland(s) compared to patients with PTH ≥65 pg/mL.4. Laryngoscope, 128:1016-1021, 2018.

Objective: The objective of this study is to assess the effectiveness of selective parathyroid exploration, using preoperative image localization and intraoperative rapid-parathormone (rPTH) assay. The kinetics of intraoperative rPTH in parathyroid adenoma vs. multiglandular disease is assessed. Design: This is a prospective noncontrolled study of a cohort of 100 patients with primary hyperparathyroidism, at a single academic institution. The patients underwent selective parathyroidectomy after preoperative localization, including sestamibi scan and ultrasonography. Intraoperative rPTH assay was used to determine the extent and success of parathyroidectomy. Frozen sections were used as additional confirmation. Follow-up serum calcium levels were used to assess the effectiveness of selective parathyroidedcomy. Results: Mean preoperative serum calcium (Ca) and baseline intact-parathormone were 11.6 mg/dL and 136, respectively. Data were available in 96 cases: 87 single-gland adenoma with two in ectopic mediastinal position, two double adenoma and seven cases of hyperplasia. Ten percent of patients with adenoma needed bilateral exploration for nonlocalizing or false negative imaging, or for intraoperative rPTH failure to decay. All of the patients undergoing unilateral targeted exploration were normocalcemic on follow up. There were only one failed exploration and two cases of recurrent mild hypercalcemia, all three in bilateral exploration cases. Intraoperative rPTH reduction by standard curves was predictive of successful excision of all of the abnormal glands, as confirmed by postoperative serum calcium levels. More than one postexcision rPTH measurement was useful by showing failure of a decaying slope in multiglandular disease. Conclusion: Targeted parathyroidectomy, when appropriately selected and carried out, is an effective treatment of primary hyperparathyroidism in most cases. Intraoperative rPTH can correctly guide removal of hyperfunctioning glands. Targeted parathyroidectomy offers the advantage of less invasive surgery with less tissue dissection confined to one side and avoids surgically disturbing the remainder of the neck. This should reduce postoperative complications and allow for easier and safer re-exploration in the few cases with persistent or recurrent disease.

Objective: 1) To evaluate the outcome of minimally invasive targeted parathyroidectomy (TP) in managing primary hyperparathyroidism. 2) To report on the predictive value of preoperative imaging in success of targeted parathyroid exploration.Method: Prospective noncontrolled cohort study of 208 patients with primary hyperparathyroidism managed in a single academic institution from 2002 to 2011. Patients underwent targeted parathyroidectomy based on preoperative parathyroid sestamibi scan and sonography. Intraoperative rPTH assay was used to determine success and extent of exploration. Follow-up serum calcium levels were obtained.Results: Of the 208 patients with primary hyperparathyroidism, data were available for 202. One hundred seventy-seven underwent targeted parathyroidectomy (89%), 25 underwent bilateral exploration (11%). Of the 202 patients, follow-up calcium data were available for 170 (162 targeted, 8 bilateral explorations). There was a total of 4 out of 170 (2%) recurrences or failed exploratio...

Thyroid carcinoma is an uncommon form of human cancer, with an outstanding overall cure rate. This excellent prognosis is based on the fact that well over 99% of thyroid cancers are primary tumors. Metastatic cancer to the thyroid remains very rare. We report a case of clear cell renal carcinoma metastatic to the thyroid gland 23 years after nephrectomy.

Twenty-eight ganglion cysts in 21 patients were diagnosed by fine needle aspiration (FNA) in the Cytopathology Service of The George Washington University Medical Center from January 1979 to December 1984. Twenty-four of these were aspirated by a pathologist. One patient had two ganglions. Seven of the 21 patients had recurrences and six were reaspirated. In five of those patients the cysts never attained their original size or interfered with function. Follow-up ranged from three to 71 months. Based upon our experience, we believe that FNA is a simple, fast, effective, nontraumatic, inexpensive method of treating ganglion cysts.