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Your search keyword '"Stanca B. D. C."' showing total 2 results
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2 results on '"Stanca B. D. C."'

1. Beyond Plastic: Oleogel as gel-state biodegradable thermoplastics

Author

Lamanna, L, Corigliano, G, Narayanan, A, Villani, S, Friuli, M, Chietera, F, Stanca, B, Giannotti, L, Siculella, L, Colella, R, Catarinucci, L, Athanassiou, A, Cataldi, P, Demitri, C, Caironi, M, Sannino, A, Lamanna L., Corigliano G., Narayanan A., Villani S., Friuli M., Chietera F. P., Stanca B. D. C., Giannotti L., Siculella L., Colella R., Catarinucci L., Athanassiou A., Cataldi P., Demitri C., Caironi M., Sannino A., Lamanna, L, Corigliano, G, Narayanan, A, Villani, S, Friuli, M, Chietera, F, Stanca, B, Giannotti, L, Siculella, L, Colella, R, Catarinucci, L, Athanassiou, A, Cataldi, P, Demitri, C, Caironi, M, Sannino, A, Lamanna L., Corigliano G., Narayanan A., Villani S., Friuli M., Chietera F. P., Stanca B. D. C., Giannotti L., Siculella L., Colella R., Catarinucci L., Athanassiou A., Cataldi P., Demitri C., Caironi M., and Sannino A.

Abstract

The crisis of plastic waste highlights the urgent need for sustainable alternatives. Bioplastics are seen as a potential solution; however, challenges persist as many are still derived from petroleum, lack biodegradability, or fall short in essential properties such as mechanical strength, chemical stability, and ease of processing. This study pioneers the use of ethyl cellulose-based oleogels as bioderived and biodegradable thermoplastics. These groundbreaking bioplastics, obtained from renewable sources and waste oils, represent an environmentally friendly and high-performance alternative to traditional plastics. The bioplastic named OleoPlast is processed at temperatures ranging from 130 to 165 degrees C, utilizing different biobased oils and adjusting the oil-to-polymer ratio from 10:3.5 to 1:2. This process yields a high level of versatility, offering broad opportunities for customized applications in both research and industry. Remarkable stability under harsh environmental conditions and biocompatibility pave the way for the adoption of such bioplastics in biocomposite structures, food packaging, green electronics, and tissue engineering. Scalability is ensured by compatibility with both large-scale and highresolution manufacturing processes, including injection and compression molding, computer numeric control (CNC) milling, and 3D fusion deposition modeling. Overall, this work lays the foundation for a new class of gel-state bioplastics, favoring the transition from traditional thermoplastics to sustainable options with vast perspectives of further exploration and customization in both laboratory and industrial environments.

Published
2024

2. Analysis of CGF Biomolecules, Structure and Cell Population: Characterization of the Stemness Features of CGF Cells and Osteogenic Potential

Author

Benedetta Di Chiara Stanca, Giuseppe E. De Benedetto, Laura Giannotti, Franco Ferrante, Alessio Rochira, Nadia Calabriso, Christian Demitri, Andrea Palermo, Paola Nitti, Luisa Siculella, Eleonora Stanca, Fabrizio Damiano, Maria Annunziata Carluccio, Stanca, E., Calabriso, N., Giannotti, L., Nitti, P., Damiano, F., Stanca, B. D. C., Carluccio, M. A., De Benedetto, G. E., Demitri, C., Palermo, A., Ferrante, F., Siculella, L., and Rochira, A.

Subjects
Male, QH301-705.5, blood-derived biomaterials, Blood-derived biomaterial, medicine.medical_treatment, Population, Cell, osteogenic differentiation, Stem cells, Matrix (biology), Matrix metalloproteinase, Regenerative medicine, Article, Catalysis, Flow cytometry, Inorganic Chemistry, Osteogenesis, stem cells, Osteogenic differentiation, medicine, Humans, Physical and Theoretical Chemistry, Biology (General), education, Molecular Biology, QD1-999, CGF, Cells, Cultured, Spectroscopy, Cell Proliferation, education.field_of_study, Osteoblasts, medicine.diagnostic_test, Chemistry, Growth factor, Organic Chemistry, Cell Differentiation, growth factor, General Medicine, Computer Science Applications, Cell biology, medicine.anatomical_structure, Intercellular Signaling Peptides and Proteins, Female, Stem cell
Abstract

Concentrated Growth Factors (CGF) represent new autologous (blood-derived biomaterial), attracting growing interest in the field of regenerative medicine. In this study, the chemical, structural, and biological characterization of CGF was carried out. CGF molecular characterization was performed by GC/MS to quantify small metabolites and by ELISA to measure growth factors and matrix metalloproteinases (MMPs) release, structural CGF characterization was carried out by SEM analysis and immunohistochemistry, CGF has been cultured, and its primary cells were isolated for the identification of their surface markers by flow cytometry, Western blot, and real-time PCR, finally, the osteogenic differentiation of CGF primary cells was evaluated through matrix mineralization by alizarin red staining and through mRNA quantification of osteogenic differentiation markers by real-time PCR. We found that CGF has a complex inner structure capable of influencing the release of growth factors, metabolites, and cells. These cells, which could regulate the production and release of the CGF growth factors, show stem features and are able to differentiate into osteoblasts producing a mineralized matrix. These data, taken together, highlight interesting new perspectives for the use of CGF in regenerative medicine.

Published
2021
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