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1. Design and Rationale of the BIOFLOW-DAPT Trial: a Prospective, Randomized, Multicenter Study to Assess the Safety of the Orsiro Mission Stent Compared to the Resolute Onyx Stent in Subjects at High Risk for Bleeding in Combination with 1-Month Dual Antiplatelet Therapy

Author

Landi, Antonio, Wlodarczak, Adrian, Tölg, Ralph, Kelbæk, Henning, Legutko, Jacek, Galli, Stefano, Godin, Matthieu, Toth, Gabor G., Lhermusier, Thibault, Honton, Benjamin, Dietrich, Peter Laurenz, Stammen, Francis, Ferdinande, Bert, Silvain, Johanne, Capodanno, Davide, Cayla, Guillaume, and Valgimigli, Marco

Published
2023
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2. Comparison of two self-expanding transcatheter heart valves for degenerated surgical bioprostheses: the AVENGER multicentre registry

Author

Kim, Won-Keun, primary, Seiffert, Moritz, additional, Rück, Andreas, additional, Leistner, David M., additional, Dreger, Henryk, additional, Wienemann, Hendrik, additional, Adam, Matti, additional, Möllmann, Helge, additional, Blumenstein, Johannes, additional, Eckel, Clemens, additional, Buono, Andrea, additional, Maffeo, Diego, additional, Messina, Antonio, additional, Holzamer, Andreas, additional, Sossalla, Samuel, additional, Costa, Giuliano, additional, Barbanti, Marco, additional, Motta, Silvia, additional, Tamburino, Corrado, additional, von der Heide, Ina, additional, Glasmacher, Julius, additional, Sherif, Mohammad, additional, Seppelt, Philipp, additional, Fischtlscherer, Stephan, additional, Walther, Thomas, additional, Castriota, Fausto, additional, Nerla, Roberto, additional, Frerker, Christian, additional, Schmidt, Tobias, additional, Wolf, Alexander, additional, Adamaszek, Martin M., additional, Giannini, Francesco, additional, Vanhaverbeke, Maarten, additional, Van de Walle, Stefaan, additional, Stammen, Francis, additional, Toggweiler, Stefan, additional, Brunner, Stephanie, additional, Mangieri, Antonio, additional, Gitto, Mauro, additional, Kaleschke, Gerrit, additional, Ninios, Vlasis, additional, Ninios, Ilias, additional, Hübner, Judith, additional, Xhepa, Erion, additional, Renker, Matthias, additional, Charitos, Efstratios I., additional, Joner, Michael, additional, and Rheude, Tobias, additional

Published
2024
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3. Biodegradable-Polymer or Durable-Polymer Stents in Patients at High Bleeding Risk: A Randomized, Open-Label Clinical Trial

Author

Valgimigli, Marco, primary, Wlodarczak, Adrian, additional, Tölg, Ralph, additional, Merkely, Béla, additional, Kelbæk, Henning, additional, Legutko, Jacek, additional, Galli, Stefano, additional, Godin, Matthieu, additional, Toth, Gabor G., additional, Lhermusier, Thibault, additional, Honton, Benjamin, additional, Dietrich, Peter Laurenz, additional, Stammen, Francis, additional, Ferdinande, Bert, additional, Silvain, Johanne, additional, Capodanno, Davide, additional, Cayla, Guillaume, additional, Valgimigli, Marco, additional, Moccetti, Marco, additional, Toth-Gayor, Gabor G., additional, Sanguineti, Francesca, additional, Birkemeyer, Ralf, additional, Schneider, Steffen, additional, Büllesfeld, Lutz, additional, Witzenbichler, Bernhard, additional, Hochadel, Matthias, additional, Collins, Nicolas, additional, Shiekh, Imran, additional, Van Gaal, William, additional, Brandt, Mathias-Christoph, additional, Kefer, Joëlle, additional, Coussement, Patrick, additional, Olsen, Niels Thue, additional, Puymirat, Etienne, additional, Lemesle, Gilles, additional, Romain, Didier, additional, Haude, Michael, additional, Schmitz, Thomas, additional, Sherif, Mohammad, additional, Wöhrle, Jochen, additional, Arthur Yung, See Yue, additional, Yan, Bryan, additional, Vorobcsuk, András, additional, Horvath, Ivan, additional, Ferlini, Marco, additional, Nicolini, Elisa, additional, Erglis, Andrejs, additional, Kalnins, Artis, additional, Azmi, Shaiful, additional, Somi, Samer, additional, Somaratne, Jithendra, additional, Zhi Lin, Deanna Khoo, additional, de la Torre Hernandez, Jose Maria, additional, Bosco, Alfonso Torres, additional, Fores, Juan Sanchis, additional, Fournier, Stéphane, additional, Iglesias, Juan, additional, Rubimbura, Vladimir, additional, and Kehasukcharoen, Wirash, additional

Published
2023
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4. Incidence and Clinical Impact of Device-Associated Thrombus and Peri-Device Leak Following Left Atrial Appendage Closure With the Amplatzer Cardiac Plug

Author

Saw, Jacqueline, Tzikas, Apostolos, Shakir, Samera, Gafoor, Sameer, Omran, Heyder, Nielsen-Kudsk, Jens Erik, Kefer, Joelle, Aminian, Adel, Berti, Sergio, Santoro, Gennaro, Nietlispach, Fabian, Moschovitis, Aris, Cruz-Gonzalez, Ignacio, Stammen, Francis, Tichelbäcker, Tobias, Freixa, Xavier, Ibrahim, Reda, Schillinger, Wolfgang, Meier, Bernhard, Sievert, Horst, and Gloekler, Steffen

Published
2017
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5. Impact of chronic kidney disease on left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

Author

Kefer, Joelle, Tzikas, Apostolos, Freixa, Xavier, Shakir, Samera, Gafoor, Sameer, Nielsen-Kudsk, Jens Erik, Berti, Sergio, Santoro, Gennaro, Aminian, Adel, Landmesser, Ulf, Nietlispach, Fabian, Ibrahim, Reda, Danna, Paolo Luciano, Benit, Edouard, Budts, Werner, Stammen, Francis, De Potter, Tom, Tichelbäcker, Tobias, Gloekler, Steffen, Kanagaratnam, Prapa, Costa, Marco, Cruz-Gonzalez, Ignacio, Sievert, Horst, Schillinger, Wolfgang, Park, Jai-Wun, Meier, Bernhard, and Omran, Heyder

Published
2016
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6. The evolution of the CTO-PCI landscape in Belgium and Luxembourg: a four-year appraisal.

Author

Eertmans, Ward, Kayaert, Peter, Bennett, Johan, Ungureanu, Claudiu, Bataille, Yoann, Saad, Georges, Haine, Steven, Coussement, Patrick, Pereira, Bruno, Agostoni, Pierfrancesco, Janssens, Luc, Vandeloo, Bert, Maréchal, Patrick, Cornelis, Kristoff, de Hemptinne, Quentin, Aminian, Adel, Stammen, Francis, Carlier, Stéphane, Timmermans, Patrick, and Vercauteren, Steven

Published
2021
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7. Impact of COVID-19-related public containment measures on the ST elevation myocardial infarction epidemic in Belgium: a nationwide, serial, cross-sectional study

Author

Claeys, Marc J., primary, Argacha, Jean-François, additional, Collart, Philippe, additional, Carlier, Marc, additional, Van Caenegem, Olivier, additional, Sinnaeve, Peter R., additional, Desmet, Walter, additional, Dubois, Philippe, additional, Stammen, Francis, additional, Gevaert, Sofie, additional, Pourbaix, Suzanne, additional, Coussement, Patrick, additional, Beauloye, Christophe, additional, Evrard, Patrick, additional, Brasseur, Olivier, additional, Fierens, Frans, additional, Marechal, Patrick, additional, Schelfaut, Dan, additional, Floré, Vincent, additional, and Hanet, Claude, additional

Published
2020
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8. Impact of COVID-19-related public containment measures on the ST elevation myocardial infarction epidemic in Belgium: a nationwide, serial, cross-sectional study.

Author

Claeys, Marc J., Argacha, Jean-François, Collart, Philippe, Carlier, Marc, Van Caenegem, Olivier, Sinnaeve, Peter R., Desmet, Walter, Dubois, Philippe, Stammen, Francis, Gevaert, Sofie, Pourbaix, Suzanne, Coussement, Patrick, Beauloye, Christophe, Evrard, Patrick, Brasseur, Olivier, Fierens, Frans, Marechal, Patrick, Schelfaut, Dan, Floré, Vincent, and Hanet, Claude

Published
2021
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9. Assessing the landscape of percutaneous coronary chronic total occlusion treatment in Belgium and Luxembourg

Author

Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlos, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Francis, De Vroey, Frederic, Vercauteren, Steven, Drieghe, Benny, Aminian, Adel, Debrauwere, Jan, Carlier, Stephane, Coosemans, Mark, Van Reet, Bert, Vandergoten, Peter, Dens, Jo Andre, (On behalf of the BWGCTO Investigators), Cardio-vascular diseases, Clinical sciences, Cardiology, Internal Medicine Specializations, Vrije Universiteit Brussel, Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlo, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Franci, De Vroey, Frederic, Vercauteren, Steven, Drieghe, Benny, Aminian, Adel, Debrauwere, Jan, Carlier, Stéphane, Coosemans, Mark, Van Reet, Bert, Vandergoten, Peter, and Dens, Jo Andre

Subjects
Male, medicine.medical_specialty, Percutaneous, Luxembourg, medicine.medical_treatment, Population, 030204 cardiovascular system & hematology, Total occlusion, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Belgium, medicine, Journal Article, Humans, 030212 general & internal medicine, Registries, education, Adverse effect, chronic total occlusion, education.field_of_study, business.industry, Percutaneous coronary intervention, Mean age, General Medicine, Middle Aged, Surgery, Dissection, Treatment Outcome, Conventional PCI, Female, Human medicine, Cardiology and Cardiovascular Medicine, business, in-hospital outcomes
Abstract

Background: Important developments in materials, devices, and techniques have improved outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), and resulted in a growing interest in CTO-PCI. The Belgian Working Group on Chronic Total Occlusions (BWGCTO) working group aims to assess the evolution within the CTO-PCI landscape over the next years. Methods: From May 2016 onwards, patients undergoing CTO-PCI were included in the BWGCTO registry by 15 centres in Belgium and Luxemburg. Baseline, angiographic, and procedural data were collected. Here, we report on the one-year in-hospital outcomes. Results: Over the course of one year, 411 procedures in 388 patients were included with a mean age of 64 ± 11 years. The majority were male (81%). Relatively complex CTOs were treated (Japanese CTO score =2.2 ± 1.2) with a high procedure success rate (82%). Patient- and lesion-wise success rates were 83 and 85%, respectively. Major adverse in-hospital events were acceptably low (3.4%). Antegrade wire escalation technique was applied most frequently (82%). On the other hand, antegrade dissection and re-entry and retrograde strategies were more frequently applied in higher volume centres and successful for lesions with higher complexity. Conclusion: Satisfactory procedural outcomes and a low rate of adverse events were obtained in a complex CTO population, treated by operators with variable experience levels. Antegrade wire escalation was the preferred strategy, regardless of operator volume.

Published
2017

10. Immediate and follow-up results of the conservative coronary angioplasty strategy for unstable angina pectoris

Author

Stammen, Francis, De Scheerder, Ivan, Glazier, James J., Van Lierde, Johan, Vrolix, Matty, Willems, Jos L., De Geest, Hilaire, and Piessens, Jan

Subjects
Unstable angina -- Care and treatment, Transluminal angioplasty -- Health aspects, Coronary arteries, Health
Abstract

To assess the results of a conservative coronary angioplasty strategy in unstable angina pectoris, the records of 1,421 consecutive patients without previous myocardial infarction undergoing a first percutaneous transluminal coronary angioplasty (PTCA) between 1986 and 1990 were reviewed. Of these patients, 631 had unstable and 790 had stable angina pectoris. Only after an intense effort to medically control symptoms, the unstable patients underwent PTCA at an average of 15.4 days (range 1 to 76) after hospital admission. Primary clinical success was achieved in 91.7% of patients with unstable and in 94.4% of those with stable angina pectoris (p = not significant). In-hospital mortality rates were 0.3 and 0.1%, respectively (p = not significant). Nonfatal in-hospital event rates for acute myocardial infarction, cerebrovascular accident and coronary bypass surgery were only slightly higher in patients with unstable angina pectoris; however, the difference from the stable group was significant when all events were combined (9 vs S.9%; p

Published
1992

11. Ridogrel in the setting of percutaneous transluminal coronary angioplasty

Author

Timmermans, Carl, Vrolix, Matty, Vanhaecke, Johan, Stammen, Francis, Piessens, Jan, Vercammen, Els, and De Geest, Hilaire

Subjects
Anticoagulants (Medicine) -- Evaluation, Transluminal angioplasty -- Complications, Health
Abstract

The safety of the combination of heparin and ridogrel therapy and its antiplatelet efficacy was examined in the setting of percutaneous transluminal coronary angioplasty (PTCA). In 32 patients without known aspirin intake for 10 days before PTCA, therapy with ridogrel (300-mg intravenous bolus) was begun just before PTCA and continued orally at a dose of 300 mg twice daily until discharge. Heparin was administered as a 10,000 IU bolus dose before PTCA and followed by an intravenous infusion at a rate of 1,000 IU/hour for 24 hours. Bleeding problems at the arterialentry site occurred in 13 patients, which required a blood transfusion in only 2 patients. One patient underwent emergency bypass surgery without specific problems of hemostasis. Ridogrel virtually eliminated thromboxane [B.sub.2] from the serum (29,2900 [+ or -] 6,555 pg/0.1 ml before vs 63 [+ or -] pg/0.1 ml at 2 hours after ridogrel), with a concomitant increase in serum 6-keto-prostaglandin [F.sub.1[alpha]] (511 [+ or -] 34 pg/0.1 ml before vs 1,190 [+ or -] 146 pg/0.1 ml at 24 hours after ridogrel). There were no acute reocclusions in the ridogrel-treated patients, whereas acute reocclusions occurred in 5.6% of the patients taking the standard aspirin + heparin regimen during the same period. Furthermore, at 6-month clinical follow-up patients treated with ridogrel compared favorably with those receiving standard treatment. (Am J Cardiol 1991;68:463-466), Percutaneous transluminal coronary angioplasty (PTCA) is a technique used to dilate (widen) the coronary arteries, which supply blood to the heart. PTCA is used in the treatment of conditions such as atherosclerosis, in which cholesterol-rich deposits narrow the coronary arteries, diminishing the cardiac blood supply. While this therapy is quite effective, 2 to 11 percent of patients undergoing PTCA suffer reocclusion shortly after the procedure. One strategy for preventing reocclusion after PTCA has been the administration of drugs that prevent adhesion of blood platelets to the arterial wall (the precipitating factor in initiating reocclusion); however, the drugs currently available are not completely effective. A newly available drug, ridogrel, has been proposed as a more effective antiplatelet drug for use in this setting. This agent acts by inhibiting key enzymes involved in the platelet-initiated clotting process. To evaluate the utility and safety of ridogrel, a study involving 32 eligible patients (of 352 potential enrollees) referred for PTCA were administered either ridogrel and heparin or aspirin and heparin immediately after PTCA. (Aspirin and heparin are anticlotting medications.) Biochemical measurements indicated that ridogrel virtually eliminated blood levels of the enzymes on which it works. None of the patients treated with ridogrel suffered reocclusion after PTCA; 5.6 percent of the aspirin and heparin-treated patients did. At six-month follow-up, both groups of patients showed similar (low) levels of disease. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

12. Immediate and short-term results of a 1988-1989 coronary angioplasty registry

Author

Stammen, Francis, Piessens, Jan, Vrolix, Matty, Glazier, James J., DeGeest, Hilaire, and Willems, Jos L.

Subjects
Coronary arteries, Cardiovascular diseases -- Care and treatment, Transluminal angioplasty -- Evaluation, Heart diseases, Health
Abstract

To determine the relevance of recent refinements in angioplasty technology to our particular practice, the records of 507 consecutive patients undergoing a first percutaneous transluminal coronary angioplasty (PTCA) at our center between October 1988 and May 1989 were reviewed. At the time of PTCA, 41% of these patients had class IV angina and 44% were identified as having multivessel disease. Dilatation was attempted in 734 lesions (mean 1.5 per patient), of which 95 (13%) were chronic total occlusions. Overall, 69% of the 734 lesions were judged anatomically complex, and, in dilating these lesions, a rail-type device was used almost exclusively. Successful dilatation was achieved in 659 of the 734 (90%) attempted lesions. There were low incidences of the major complications of death (0.4%), myocardial infarction (1.8%) and emergency bypass surgery (1.8%). Acute rethrombosis occurred in 54 patients (11). in these patients, initial strategy of repeat dilatation was successful in 38 of 47 patients (81%). Overall, primary clinical success at PTCA was achieved in 480 patients (95%). At a mean follow-up of 7.5 [plus or minus] 1.5 months in 497 of the study patients, the event-free rate (freedom from cardiac death, myocardial infarction, repeat PTCA or coronary bypass surgery or recurrence of severe [class ill to IV] angina) was 71%. in conclusion, despite the often complex coronary disease in patients currently presenting to our center, a high initial success rate and acceptable short-term outcome of PTCA was achieved. (Am J Cardiol 1991;67:253-258), Coronary artery disease (CAD) involves stenosis (narrowing) of the arteries supplying the heart with blood, to the extent that cardiac blood flow is compromised. This is usually caused by the formation of fatty atherosclerotic plaques on the inner surface of the arteries. A common treatment for CAD is percutaneous transluminal coronary angioplasty (PTCA), in which a catheter with an inflatable balloon tip is passed through the blood vessels to the occluded region of the coronary arteries, inflated (distending the narrowed region to restore blood flow), and removed. In recent years, improved maneuverability of the catheter system has increased the success rate for this procedure. To obtain an overview of how successful the use of one particular type of angioplasty device (the rail-type dilatation system) has been, the records of 507 consecutive patients undergoing their first PTCA at a Belgian cardiology practice between October 1988 and May 1989 were reviewed. At the time PTCA was performed, 41 percent of the patients had very severe angina pectoris (chest pains resulting from the CAD), and 44 percent had CAD afflicting two or more coronary blood vessels (multivessel CAD). Angioplasty was attempted on 734 narrowed arterial segments (an average of 1.5 per patient); 95 percent of these were total chronic occlusions. Successful restoration of blood flow was obtained in 90 percent of the cases. Low incidence of death (0.4 percent), heart attack (1.8 percent) and the need for emergency bypass surgery (1.8 percent) was noted. Recurrence of the blockage was seen in 11 percent of the patients; 81 percent of these were successfully treated with a repeat PTCA procedure. At 7.5-month (average) follow-up, 71 percent of the procedures were judged to have been successful (i.e. no incidence of cardiac death, heart attack, repeat PTCA, bypass surgery, or recurrence of severe angina pectoris). (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1991

13. CLINICAL OUTCOMES TO 4 YEARS IN PATIENTS IMPLANTED WITH BIOABSORBABLE POLYMER SYNERGY VERSUS PERMANENT POLYMER EVEROLIMUS-ELUTING STENTS: THE EVOLVE II RANDOMIZED TRIAL

Author

Jobe, Robert, primary, Windecker, Stephan, additional, Loli, Akil, additional, Mego, David, additional, Ando, Kenji, additional, Muramatsu, Toshiya, additional, Stammen, Francis, additional, Curtis, Michael, additional, Helqvist, Steffen, additional, Christen, Thomas, additional, Allocco, Dominic, additional, Meredith, Ian, additional, and Kereiakes, Dean, additional

Published
2018
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15. Transcatheter left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: results from the Belgian registry

Author

Kefer, Joelle, primary, Aminian, Adel, additional, Vermeersch, Paul, additional, de Potter, Tom, additional, Stammen, Francis, additional, Benit, Edouard, additional, Budts, Werner, additional, Missault, Luc, additional, Drieghe, Benny, additional, Buysschaert, Ian, additional, Cornelis, Kristoff, additional, Herzet, Jean-Manuel, additional, Guedes, Antoine, additional, Debbas, Nadia, additional, Rivero, Maximo, additional, Lempereur, Mathieu, additional, Lochy, Stijn, additional, Casado-Arroyo, Ruben, additional, Laruelle, Christophe, additional, Debruyne, Philippe, additional, and Ledent, Thierry, additional

Published
2018
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16. Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial

Author

Bhatt, Deepak L, Steg, Philippe Gabriel, Mehta, Shamir R, Leiter, Lawrence A, Simon, Tabassome, Fox, Kim, Held, Claes, Andersson, Marielle, Himmelmann, Anders, Ridderstråle, Wilhelm, Chen, Jersey, Song, Yang, Diaz, Rafael, Goto, Shinya, James, Stefan K, Ray, Kausik K, Parkhomenko, Alexander N, Kosiborod, Mikhail N, McGuire, Darren K, Harrington, Robert A, Santos, Vladimir, Jain, Ashit, Lendel, Irina, Russo, Michael, Haught, W H, Bouza, Manuel, Gogia, Harinder, Banerjee, Supratim, Kichura, George, Kantaros, Louis, Padron, Francisco, Passi, Rakesh, Stone, Jay, Pursley, Michael, D'Urso, Michael, Gardner, Timothy, Bennett, James, Nour, Khaled, Saini, Satinder, Zhang, Wenwu, Kumbhani, Dharam, Thomas, Dustin, Angiolillo, Dominick, Bertolet, Barry, Roman-Miranda, Amaury, Black, Robert, Manshadi, Ramin, Vaca, Carlos, Blanco, Antonio, Napoli, Mark, Brabham, David, Akyea-Djamson, Ayim, Desai, Pratik, Prasada, Sudhir, Khaira, Ajit, Forgosh, Leslie, Lieber, Ira, Umpierrez, Guillermo, Singal, Dinesh, Londono, Juan, Fraser, Neil, Ruiz, Jose, Vega, Damaris, Rodriguez, Lilia, Brown, Christopher, Syed, Faizullah, Aggarwala, Guarav, Eaves, William, Foster, Michael, Gupta, Dinesh, Avino, David, Asfour, Wail, Tonnessen, Glen, Zhao, Xue-Qiao, Singh, Narendra, Brockmyre, Andrew, Lepor, Norman, Shammas, Nicolas, Blick, David, Hearne, Steven, Prodafikas, John, Carell, Edgar, Izzo, Mark, Karim, Amin, Zakhary, Bosh, Atieh, Mahmoud, Leichter, Steven, Meadows, Charles, Hotchkiss, David, Abu-Fadel, Mazen, Wiseman, Alan, Bander, Jeffrey, Shah, Mahesh, Banerjee, Subhash, Ganim, Ricky, Sopko, Karen, Khan, Misal, Lloret, Ramon, Weirick, Troy, Mehta, Rajendra, Thadani, Udho, Bhargava, Anuj, Kosiborod, Mikhail, Moya, Jaynier, Staniloae, Cezar, Guerra, Yamirka D, Chhabra, Anil, Kosmicki, Douglas, Shaheen, Wassim, Mohammed, Akber, Bitters, J'Cinda, Pattanayak, Jan, Javier, Julian, Srivastava, Sunny, Phillips, Roland, Al-Amin, Jessie, Lillestol, Michael, Simpson, Patrick, Hazan, Lydie, Amin, Amit, Shah, Gopi, Korpas, Denes, Platt, Bruce, Dickert, Jim, Puente, Orlando, Hiotis, Louis, Doyle, Timothy, Rajan, Raj, Meholick, Alan, Gring, Christian, Hage-Korban, Elie, Feldman, Robert, Colfer, Harry, Butman, Samuel, Foster, Malcolm, Hart, Terence, Huling, Randall, Eshaghian, Shervin, Quintana, Ofsman, Cheung, Deanna, Handel, Franklin, Rodriguez, Mara, Suh, David, Gordon, Paul, Pressman, Gregg, Bauer, Michael, French, William, Barettella, Mark, Chatrathi, Sridhar, Suresh, Damodhar, Goldberg, Ronald, Huth, Mark, Younis, Liwa, Rahman, Aref, Mascolo, Richard, Welch, Michelle, Suneja, Randeep, Smith, Stephen, Shurmur, Scott, Agaiby, John, Jingo, Ahmad, Johnston, Janice, Beth, Mary, Vlastaris, Anthony, Kemp, Susan, Taheri, Hamid, Pereira, Edward, Deyoung, Michael, Hawa, Zafir, Smith, Ray, Galski, Thomas, Garas, Samer, Reddy, M, Sharma, Susheel, Hargrove, Joeseph, Treasure, Charles, Emerson, Ronald, Haddad, Tariq, Rohr, Kathryn, Levinson, Larry, Gaona, Raul, Uretsky, Barry, Maheshwari, Hiralal, Lee, Denny, Kinnaman, Stephanie, Singal, Robert, Geohas, Jeffrey, Gigliotti, Osvaldo, Raisinghani, Ajit, Khurana, Charanjit, Hella, Brent, Kelberman, Michael, Voyce, Steven, Singh, Sanjay, Lo, Eric, Singh, Pradeep, Goodfellow, Ross, Fischer, Stuart, Lorraine, Richard, Turner, Traci, Shanes, Jeffrey, Busch, Robert, Broker, Robert, Zaniewski, Michelle, Pounds, Kevin, Debs-Perez, Giselle, Ong, Stephen, Frandsen, Brad, Fullington, Douglas, Jaffrani, Naseem, Khan, Ahtaram, Lee, Marcus, Pouzar, Joe, Revtyak, George, Gonzalez, Julian, Nakhle, Samer, Murillo, Abel, Young, Douglas, Makam, Sashi, Syed, Mushtaq, Woolf, Kevin, Grena, Paul, Alfata, Sarab, Mahal, Sharan, Hoffman, David, Kizhakekuttu, Tinoy, Deering, Joseph, Bhavsar, Janak, Mikesell, Scott, Wilson, William, Wilson, Vance, El, Salah, Spinale, Francis, Kannarkat, Vinod, Rao, Sunder, Hanson, Lenita, Bertsch, John, Gonzalez-Ortiz, Elena, Severino, Norma, Willis, John, Schock, Joel, Bakhtari, Ladan, Gazmuri, Raul, Ansari, Saadat, Hall, Jason, Mehta, Arvind, Shealy, Neal, Zarich, Stuart, Singh, Deovrat, Vora, Kishor, Andrawis, Nabil, Molter, Darron, Maron, David, Cardona, Jose, D'Agostino, Ronald, Arshad, Tamjeed, Samaan, Rodney, Jones, David, Presser, Dale, Heath, John, Green, Sandy, Bittar, George, Henry, Sheldon, Korn, David, Schmedtje, John, Nadar, Venkatesh, Graham, Bruce, Labroo, Ajay, Clavijo, Leonardo, Roseman, Hal, Ledesma, Gilbert, Rosen, Robert, Dor, Isaac, Kirby, William, Sutton, Jennefer, Eder, Frank, Iteld, Bruce, Gomez-Cortes, Jose, Buchbinder, Maurice, Kasper, Joseph, Terrelonge, Antonio, Torres, Gustavo, Jagielo, Ted, Alvarez, Jose, Handelsman, Yehuda, Guillen, Mario, Richwine, Randall, Lewy-Alterbaum, Lorena, Corder, Clinton, Arvind, Moogali, Bolshoun, David, Mikhail, Magdy, Minton, Stephen, Alvarado, Odilon, Abbott, J, Cauthen, Brett, Welter, Ryan, Mintz, Randy, Cox, John, Quick, Annette, Weiss, Melvin, Dy, Johnny, Zebrack, James, Gandelman, Glenn, Hegde, Vinayak, Silver, Marc, DeGregorio, Michele, Lawson, William, Paa, Christopher, Bortnick, Anna, Krolick, Merrill, Sotolongo, Rodolfo, Cheirif, Jorge, Kumar, Priya, Nadar, Venkatesh, Jetty, Preetham, Patel, Ambar, Kruk, Mariusz, Kobielusz-Gembala, Iwona, Rewerska, Barbara, Madrzejewski, Adam, Milewski, Krzysztof, Cygler, Jerzy, Petryka-Mazurkiewicz, Joanna, Jastrzebski, Waldemar, Korecki, Janusz, Fil, Wojciech, Prokopczuk, Janusz, Bochenek, Anna, Wujkowski, Marek, Witek, Robert, Konczakowski, Piotr, Miekus, Pawel, Szczasny, Marcin, Musial, Wlodzimierz, Cymerman, Krzysztof, Lampart, Jacek, Mikosinski, Jacek, Szynal, Slawomir, Fares, Issa, Opolski, Grzegorz, Mazur, Stanislaw, Wozakowska-Kaplon, Beata, Bijata-Bronisz, Renata, Wierucki, Lukasz, Losa, Beata, Drelich, Grzegorz, Konieczny, Marek, Starczewski, Pawel, Pawlowicz, Lidia, Jesionowski, Pawel, Jurowiecki, Jaroslaw, Gniot, Jacek, Czyzycki, Mariusz, Stania, Karol, Kucharczyk-Bauman, Izabela, Busz-Papiez, Benita, Karczmarczyk, Agnieszka, Sudnik, Wanda, Koszek, Alina, 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Anders, Leonsson-Zachrisson, Maria, and Ridderstråle, Wilhelm

Abstract

Patients with stable coronary artery disease and diabetes with previous percutaneous coronary intervention (PCI), particularly those with previous stenting, are at high risk of ischaemic events. These patients are generally treated with aspirin. In this trial, we aimed to investigate if these patients would benefit from treatment with aspirin plus ticagrelor.

Published
2019
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18. Assessing the landscape of percutaneous coronary chronic total occlusion treatment in Belgium and Luxembourg: the Belgian Working Group on Chronic Total Occlusions (BWGCTO) registry.

Author

Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlos, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Francis, and De Vroey, Frederic

Published
2018
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19. Left atrial appendage occlusion with the Amplatzer Cardiac Plug could improve survival and prevent thrombo-embolic and major bleeding events in atrial fibrillation patients with increased bleeding risk

Author

Budts, Werner, primary, Laenens, Dorien, additional, Calenbergh, Frank Van, additional, Vermeersch, Paul, additional, Potter, Tom De, additional, Aminian, Adel, additional, Benit, Edouard, additional, Stammen, Francis, additional, and Kefer, Joelle, additional

Published
2016
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20. Long-term follow-up after percutaneous coronary intervention with polytetrafluoroethylene-covered <tex>Symbiot^{TM}$</tex> stents compared to bare metal stents, with and without <tex>FilterWire^{TM}$</tex> embolic protection, in diseased saphenous vein grafts

Author

Bennett, Johan, Dens, Jo, Stammen, Francis, Coussement, Patrick, Janssens, Luc, Claeys, Marc J., Vrolix, Mathias, Sinnaeve, Peter, Dubois, Christophe, and Desmet, Walter

Subjects
Human medicine
Abstract

OBJECTIVES: The long-term clinical outcome of covered stents in the percutaneous treatment of diseased saphenous vein graft (SVG) has been disappointing. The single self-expanding polytetrafluoroethylene (PTFE)-covered Symbiot stent with a unique profile may present advantages that translate into superior long-term clinical outcomes. This study evaluated the safety, effectiveness and clinical outcome of the Symbiot covered stent system (Boston Scientific, Natick, Mass.) and FilterWire EX (Boston Scientific, Natick, Mass.) versus bare metal stents (BMS) in SVG intervention. METHODS AND RESULTS: Between January 2003 and August 2005, 90 patients with degenerative SVG lesions were prospectively randomized at 6 study sites to Symbiot implantation (n = 30), BMS with FilterWire as embolic protection device (EPD, n = 30), or BMS without EPD (control group, n = 30). The primary end point was reduction in peri-procedural cardiac enzyme rise. The major secondary end points were in-hospital, 6-month and long-term target vessel failure rates, defined as the cumulative of death, myocardial infarction and clinically driven target lesion revascularization. There was no significant reduction in median [IQR] post-procedural troponin-I rise in the Symbiot group compared to the FilterWire or the control group (0.08 [0-1.40] microg/l; 0.06 [0-0.28] microg/l; and 0.04 [0-0.31] microg/l, P = 0.58). At 7.4 +/- 1.3 (mean +/- SD) years, there were numerically less deaths in the Symbiot group, although this did not reach statistical significance (P = 0.20). There was no significant difference in TVF-free survival between the treatment groups (P = 0.98). CONCLUSION: This study failed to show a procedural or long-term clinical advantage for the Symbiot PTFE-covered stent in the treatment of degenerated SVG.

Published
2013

21. Peri-procedural use of rivaroxaban in elective percutaneous coronary intervention to treat stable coronary artery disease

Author

Vranckx, Pascal, primary, Leebeek, Frank, primary, Tijssen, Jan, primary, Koolen, Jacques, primary, Stammen, Francis, primary, Herman, Jean-Paul, primary, de Winter, Robbert, primary, van t Hof, Arnout, primary, Backx, Bianca, primary, Lindeboom, Wietze, primary, Kim, So-Young, primary, Kirsch, Bodo, primary, van Eickels, Martin, primary, Misselwitz, Frank, primary, and Verheugt, Freek, additional

Published
2015
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23. Long-term follow-up after percutaneous coronary intervention with polytetrafl uoroethylene-covered Symbiot™ stents compared to bare metal stents, with and without FilterWire™ embolic protection, in diseased saphenous vein grafts

Author

Bennett, Johan, primary, Dens, Jo, additional, Stammen, Francis, additional, Coussement, Patrick, additional, Janssens, Luc, additional, Claeys, Marc, additional, Vrolix, Mathias, additional, Sinnaeve, Peter, additional, Dubois, Christophe, additional, and Desmet, Walter, additional

Published
2013
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24. Effect of intravenous diltiazem on myocardial ischemia occurring during percutaneous transluminal coronary angioplasty

Author

Piessens, Jan, Brzostek, Tomasz, Stammen, Francis, Vanhaecke, Johan, Vrolix, Matty, and De Geest, Hilaire

Subjects
Transluminal angioplasty -- Complications, Calcium channel blockers -- Health aspects, Diltiazem -- Health aspects, Coronary heart disease -- Care and treatment, Ischemia -- Drug therapy, Health
Abstract

To investigate the antiischemic efficacy of intravenously administered diltiazem, 42 patients were randomlY allocated to receive placebo or active treatment before 1-vessel percutaneous transluminal coronary angioplasty (PTCA). The development of myocardial ischemia was studied using subjective (pain) and objective electrocardiography) parameters. Pretreatment with intravenous diltiazem resulted in a significantly delayed onset of ischemic pain and ST-segment elevation; these variables also returned to baseline earlier after balloon deflation. Thus, intravenous diltiazem prevents or delays the onset of myocardial ischemia during repetitive transient coronary occlusions; improvement of the myocardial blood flow distal to the coronary occlusion or impedance of calcium entry into the ischemic cell are considered as possible mechanisms. Because PTCA is increasingly used in patients with poor left ventricular function and more extensive disease, and because recent evidence suggests that better PTCA results could be obtained by the use of longer inflation times, the addition of diltiazem to the classic armamentarium could be beneficial. (Am J Cardiol 1989;64:1103-1107), Percutaneous transluminal coronary angioplasty (PTCA) is a procedure for treating narrowed coronary arteries, which are the major blood vessels that bring blood to the heart. A catheter or tube-like structure with a small inflatable balloon is inserted into the narrowed portion of the artery, and the balloon is inflated, thereby mechanically dilating the narrowed coronary artery. In PTCA, inflation of the balloon causes transient occlusion, or blockage, of the coronary artery. This leads to regional ischemia, or insufficient blood flow to specific portions of the heart. Medications can be given before PTCA to reduce or prevent regional ischemia. The anti-ischemic effect of the drug diltiazem was assessed in 42 patients who were scheduled to undergo PTCA; half the patients received pretreatment with diltiazem while the other half received an inert placebo. During the PTCA procedure, chest pain and changes in the electrocardiogram, a recording of the electrical activity of the heart, were used as indicators of ischemia. Pretreatment with diltiazem delayed the onset of pain and ECG changes associated with ischemia, and both of these indicators returned to normal after deflation of the balloon more quickly with diltiazem than without. The results show that intravenous diltiazem delays the onset of myocardial ischemia during repetitive and brief blockage of the coronary arteries. Diltiazem may exert its effects by improving blood flow beyond the blocked portion of the coronary artery, or by blocking the entry of calcium into the ischemic cell; diltiazem is a calcium blocking agent. Thus, diltiazem may be a useful medication for delaying the onset of ischemia in patients undergoing PTCA; it may be particularly helpful if longer balloon inflation periods (which may prove to be more effective than briefer periods) are utilized in the future. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1989

34. Incidence and Clinical Impact of Device-Associated Thrombus and Peri-Device Leak Following Left Atrial Appendage Closure With the Amplatzer Cardiac Plug

Author

Saw, Jacqueline, Tzikas, Apostolos, Shakir, Samera, Gafoor, Sameer, Omran, Heyder, Nielsen-Kudsk, Jens Erik, Kefer, Joelle, Aminian, Adel, Berti, Sergio, Santoro, Gennaro, Nietlispach, Fabian, Moschovitis, Aris, Cruz-Gonzalez, Ignacio, Stammen, Francis, Tichelbäcker, Tobias, Freixa, Xavier, Ibrahim, Reda, Schillinger, Wolfgang, Meier, Bernhard, Sievert, Horst, and Gloekler, Steffen

Subjects
cardiovascular system, cardiovascular diseases, 610 Medicine & health, 3. Good health
Abstract

OBJECTIVES Routine device surveillance after successful left atrial appendage closure is recommended to evaluate for intermediate to late complications. The aim of this study was to assess the incidence and clinical impact of these complications on cardiovascular events. METHODS Centers participating in the Amplatzer Cardiac Plug multicenter study were requested to submit their post-procedural transesophageal echocardiograms for independent adjudication. Thirteen of 22 centers contributed all their post-procedural echocardiograms, which included 344 from 605 consecutive patients. These images were submitted to a core laboratory and reviewed by 2 independent experts for peri-device leak, device-associated thrombus, device embolization, device migration, left atrial appendage thrombus, and left atrial thrombus. Clinical events were prospectively collected by each center. RESULTS Of the 344 transesophageal echocardiograms, 339 were deemed analyzable. Patients' mean age was 74.4 ± 7.5 years, and 67.3% were men. The mean CHADS2 score was 2.7 ± 1.3, the mean CHA2DS2-VASc score was 4.3 ± 1.5, and the mean HAS-BLED score was 3.0 ± 1.2. Amplatzer Cardiac Plug implantation was successful in all patients. Periprocedural major adverse events occurred in 2.4%. Median clinical follow-up duration was 355 days (range 179 to 622 days). Follow-up transesophageal echocardiography was performed after a median of 134 days (range 88 to 227 days). Device-associated thrombus was observed in 3.2% and peri-device leak in 12.5% (5.5% minimal, 5.8% mild, 0.6% moderate, 0.6% severe). Neither device-associated thrombus nor peri-device leak was associated with an increased risk for cardiovascular events. Independent predictors of device-associated thrombus were smoking (odds ratio: 5.79; p = 0.017) and female sex (odds ratio: 4.22; p = 0.027). CONCLUSIONS Following successful left atrial appendage closure with the Amplatzer Cardiac Plug, the presence of peri-device leak was relatively low, and device-associated thrombus was infrequent. Neither was associated with increased risk for thromboembolism.

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