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1. Cardiac Hamartomas: Report of Two Rare Primary Cardiac Tumors (Rhabdomyoma and Hamartoma of Mature Cardiomyocytes) with Review of the Literature

Author

Metodiev D., Gegova A., Ruseva M., Ganeva R., Parvanov D., Marinov R., Georgiev D., Staneva-Mitkova D., and Stamenov G.

Subjects
tuberous sclerosis, rhabdomyoma, hamartoma of mature cardiomyocytes, histiocytoid cardiomyopathy, Medicine
Abstract

The most common primary cardiac tumors are myxomas, while cardiac hamartomas are rare. Cardiac hamartomas may constitute manifestation of a genetic disorder such as tuberous sclerosis, or could be diagnosed independently as a solitary lesion. We present two rare cases of primary cardiac tumors detected via diagnostic imaging and subsequent histopathology examination. The first described case is that of a male preterm foetus with multiple rhabdomyomas in the heart, discovered during foetal echocardiography. The finding was later confirmed by autopsy, which also revealed presence of cortical tubers with typical balloon cells constituting well known epileptogenic lesions in the foetal brain. The second case describes an even rarer benign cardiac lesion – a hamartoma of mature cardiomyocytes – which was discovered by chance in a 49-year old female patient during echocardiography. The performed CT scan revealed a 37 x 16 x 12 mm tumor in the right atrium obstructing the superior vena cava inlet. The malformation was surgically removed and examined histologically revealing disorganized hypertrophic mature cardiomyocytes, partly separated by fibrous strands and admixed with mature adipocytes. Differential diagnosis was performed to rule out other benign tumors with myocyte differentiation – cardiac rhabdomyoma, histiocytoid cardiomyopathy and adult cellular rhabdomyoma.

Published
2023
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2. Genome-Wide Methylation Profiling of Schizophrenia

Author

Rukova B., Staneva R., Hadjidekova S., Stamenov G., Milanova V., and Toncheva D.

Subjects
dna methylation, schizophrenia, whole genome arrays, Genetics, QH426-470
Abstract

Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution.

Published
2014
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6. P-715 NGS-based metagenome analysis of endometrial microbiome in women with implantation failure after in vitro fertilization: results of a prospective cohort study

Author

Hadjidekova, S, primary, Parvanov, D, additional, Tihomirova, T, additional, Chapanova, S, additional, Staneva, R, additional, Rukova, B, additional, Pancheva, M, additional, Serafimova, M, additional, Ganeva, R, additional, Ruseva, M, additional, Handzhiyska, M, additional, Vidolova, N, additional, Metodiev, D, additional, and Stamenov, G, additional

Published
2023
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7. P-323 Associations between endometrial microbiome and the local immune cell composition during the mid-secretory phase

Author

Ganeva, R, primary, Stamenov, G, additional, Parvanov, D, additional, Moskova-Doumanova, V, additional, Ruseva, M, additional, Handzhiyska, M, additional, Vidolova, N, additional, Tihomirova, T, additional, Chapanova, S, additional, Metodiev, D, additional, Pancheva, M, additional, Serafimova, M, additional, Rukova, B, additional, Staneva, R, additional, and Hadjidekova, S, additional

Published
2023
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11. 1318P Neutrophil extracellular traps as a potential predictive marker for treatment with pembrolizumab alone or with chemotherapy as a first-line in patients with metastatic non-small cell lung cancer

Author

Petrova, M., primary, Parvanov, D., additional, Ganeva, R., additional, Metodiev, D., additional, Bachurska, S., additional, Stamenov, G., additional, Eneva, M., additional, Penkova, P., additional, Sarbianova, I., additional, Popov, T., additional, Nikolov, K., additional, Radanova, M., additional, Taushanova, M., additional, Megdanova, V., additional, and Donev, I., additional

Published
2021
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17. Poster session 1: Wednesday 3 December 2014, 09:00-16:00Location: Poster area

Author

Tong, L., Huang, C., Ramalli, A., Tortoli, P., Luo, J., D'Hooge, J., Tzemos, N., Mordi, I., Bishay, T., Negishi, T., Hristova, K., Kurosawa, K., Bansal, M., Thavendiranathan, P., Yuda, S., Popescu, B., Vinereanu, D., Penicka, M., Marwick, T., Hamed, W., Kamel, M., Yaseen, R., El Barbary, H., Nemes, A., Kis, O., Gavaller, H., Kanyo, E., Forster, T., Angelis, A., Vlachopoulos, C., Ioakimidis, N., Felekos, I., Chrysohoou, C., Aznaouridis, K., Abdelrasoul, M., Terentes, D., Ageli, K., Stefanadis, C., Kurnicka, K., Domienik Karlowicz, J., Lichodziejewska, B., Goliszek, S., Grudzka, K., Krupa, M., Dzikowska Diduch, O., Ciurzynski, M., Pruszczyk, P., Capllonch, F. G., Ayerbe, J. L., Teis, A., Ferrer, E., Vallejo, N., Junca, G., Pla, R., Bayes Genis, A., Schwaiger, J., Knight, D., Gallimore, A., Schreiber, B., Handler, C., Coghlan, J., Bruno, R. M., Giardini, G., Malacrida, S., Catuzzo, B., Armenia, S., Brustia, R., Ghiadoni, L., Cauchy, E., Pratali, L., Kim, K., Lee, K., Cho, J., Yoon, H., Ahn, Y., Jeong, M., Park, J., Cho, S., Nastase, O., Enache, R., Mateescu, A., Botezatu, D., Ginghina, C., Gu, H., Sinha, M., Simpson, J., Chowienczyk, P., Fazlinezhad, A., Behesthi, A. T., Homaei, F., Mostafavi, H., Hosseini, G., Bakaeiyan, M., Boutsikou, M., Petrou, E., Dimopoulos, A., Dritsas, A., Leontiadis, E., Karatasakis, G., Sahin, S. T., Yurdakul, S., Yilmaz, N., Cengiz, B., Cagatay, Y., Aytekin, S., Yavuz, S., Karlsen, S., Dahlslett, T., Grenne, B., Sjoli, B., Smiseth, O., Edvardsen, T., Brunvand, H., Nasr, G., Nasr, A., Eleraki, A., Elrefai, S., Sonecki, P., Gustafsson, U., Naar, J., Stahlberg, M., Cerne, A., Capotosto, L., Rosato, Edoardo, D'Angeli, I., Azzano, A., Truscelli, G., Maio, M. D., Salsano, F., Terzano, C., Mangieri, E., Vitarelli, A., Renard, S., Najih, H., Mancini, J., Jacquier, A., Haentjens, J., Gaubert, J., Habib, G., Caminiti, G., D'Antoni, V., Cardaci, V., Conti, V., Volterrani, M., Ahn, J., Kim, D., Lee, H., Iliuta, L., Kim, S., Ryu, S., Ko, C., Pyun, Y., Yoon, S., Iudice, F. L., Esposito, R., Lembo, M., Santoro, C., Ballo, P., Mondillo, S., Simone, G. D., Galderisi, M., Hwang, Y., Kim, J., Moon, K., Yoo, K., Kim, C., Tagliamonte, E., Rigo, F., Cirillo, T., Caruso, A., Astarita, C., Cice, G., Quaranta, G., Romano, C., Capuano, N., Calabro', R., Zagatina, A., Zhuravskaya, N., Guseva, O., Huttin, O., Benichou, M., Voilliot, D., Venner, C., Micard, E., Girerd, N., Sadoul, N., Moulin, F., Juilliere, Y., Selton Suty, C., Baron, T., Christersson, C., Johansson, K., Flachskampf, F., Lee, S., Lee, J., Hur, S., Yun, J., Song, S., Kim, W., Ko, J., Nyktari, E., Bilal, S., Ali, S., Izgi, C., Prasad, S., Aly, M., Kleijn, S., Kandil, H., Kamp, O., Beladan, C., Calin, A., Rosca, M., Craciun, A., Gurzun, M., Calin, C., Mornos, C., Mornos, A., Ionac, A., Cozma, D., Crisan, S., Popescu, I., Ionescu, G., Petrescu, L., Camacho, S., Chulian, S. G., Carmona, R., Diaz, E., Giraldez, A., Gutierrez, A., Toro, R., Benezet, J., Antonini Canterin, F., Vriz, O., Carrubba, S. L., Poli, S., Leiballi, E., Zito, C., Careri, S., Caruso, R., Pellegrinet, M., Nicolosi, G., Kong, W., Kyu, K., Wong, R., Tay, E., Yip, J., Yeo, T., Poh, K., Correia, M., Delgado, A., Marmelo, B., Correia, E., Abreu, L., Cabral, C., Gama, P., Santos, O., Rahman, M., Borges, I. P., Peixoto, E., Peixoto, R., Marcolla, V., Okura, H., Kanai, M., Murata, E., Kataoka, T., Stoebe, S., Tarr, A., Pfeiffer, D., Hagendorff, A., Generati, G., Bandera, F., Pellegrino, M., Alfonzetti, E., Labate, V., Guazzi, M., Kuznetsov, V., Yaroslavskaya, E., Pushkarev, G., Krinochkin, D., Zyrianov, I., Carigi, S., Baldazzi, F., Bologna, F., Amati, S., Venturi, P., Grosseto, D., Biagetti, C., Fabbri, E., Arlotti, M., Piovaccari, G., Rahbi, H., Abdulhaq, A. B., Tleyjeh, I., Costantino, M., Tarsia, G., Innelli, P., Dores, E., Esposito, G., Matera, A., Trimarco, B., Mukred, K., Ashurov, R., Tanzilli, G., Merlo, M., Gigli, M., Stolfo, D., Pinamonti, B., Canterin, F. A., Muca, M., D'Angelo, G., Scapol, S., Nucci, M. D., Sinagra, G., Behaghel, A., Feneon, D., Fournet, M., Thebault, C., Martins, R., Mabo, P., Leclercq, C., Daubert, C., Donal, E., Pal, S. D., Chand, N. P., Sanjeev, A., Rajeev, M., Ankur, D., Gopal, S. R., Mzoughi, K., Zairi, I., Jabeur, M., Moussa, F. B., Chaabene, A. B., Kamoun, S., Mrabet, K., Fennira, S., Zargouni, A., Kraiem, S., Demkina, A., Hashieva, F., Krylova, N., Kovalevskaya, E., Potehkina, N., Zaroui, A., Said, R. B., Smaali, S., Rekik, B., Hlima, M. B., Mizouni, H., Mechmeche, R., Mourali, M., Malhotra, A., Sheikh, N., Dhutia, H., Siva, A., Narain, R., Merghani, A., Millar, L., Walker, M., Sharma, S., Papadakis, M., Siam Tsieu, V., Mansencal, N., Arslan, M., Deblaise, J., Dubourg, O., Boudiche, S., Larbi, N., Tababi, N., Hannachi, S., Chalbia, T., Halima, M. B., Boussada, R., Chistyakova, M. V., Govorin, A., Radaeva, E., Lipari, P., Bonapace, S., Valbusa, F., Rossi, A., Zenari, L., Lanzoni, L., Targher, G., Canali, G., Molon, G., Barbieri, E., Novo, G., Giambanco, S., Sutera, M., Bonomo, V., Giambanco, F., Rotolo, A., Evola, S., Assennato, P., Novo, S., Budnik, M., Piatkowski, R., Kochanowski, J., Opolski, G., Chatzistamatiou, E., Vagena, I. M., Manakos, K., Moustakas, G., Konstantinidis, D., Memo, G., Mitsakis, O., Kasakogias, A., Syros, P., Kallikazaros, I., Park, S., Kim, M., Shim, W., Marketou, M., Parthenakis, F., Kalyva, N., Pontikoglou, C., Maragkoudakis, S., Zacharis, E., Patrianakos, A., Maragoudakis, F., Papadaki, H., Vardas, P., Rodrigues, A., Perandini, L. A., Souza, T., Sa Pinto, A., Borba, E., Arruda, A., Furtado, M., Carvalho, F., Bonfa, E., Andrade, J., Hlubocka, Z., Malinova, V., Palecek, T., Danzig, V., Kuchynka, P., Dostalova, G., Zeman, J., Linhart, A., Trachanas, K., Vergi, N., Feretou, A., Corut, H., Sade, L. E., Ozin, B., Atar, I., Turgay, O., Muderrisoglu, H., Ledakowicz Polak, A., Polak, L., Krauza, G., Zielinska, M., Szulik, M., Streb, W., Wozniak, A., Lenarczyk, R., Sliwinska, A., Kalarus, Z., Kukulski, T., Nogueira, M., Branco, L., Agapito, A., Galrinho, A., Borba, A., Teixeira, P., Monteiro, A., Ramos, R., Cacela, D., Ferreira, R. C., Guala, A., Camporeale, C., Tosello, F., Canuto, C., Ridolfi, L., Traxanas, K., Marinov, R., Stamenov, G., Mihova, M., Persenska, S., Racheva, A., Plaskota, K., Trojnarska, O., Bartczak, A., Grajek, S., Bejiqi, R. R., Retkoceri, R., Bejiqi, H., Beha, A., Surdulli, S., Seya, M., Sasaoka, T., Hirasawa, K., Yoshikawa, S., Maejima, Y., Ashikaga, T., Hirao, K., Isobe, M., Dreyfus, J., Durand Viel, G., Cimadevilla, C., Brochet, E., Vahanian, A., Messika Zeitoun, D., Jin, C., Fang, F., Meng, F., Kam, K., Sun, J., Tsui, G., Wong, K., Wan, S., Yu, C., Lee, A., Cho, I. J., Chung, H., Heo, R., Ha, S., Hong, G., Shim, C., Chang, H., Ha, J., Chung, N., Moral, S., Gruosso, D., Galuppo, V., Teixido, G., Rodriguez Palomares, J., Gutierrez, L., Evangelista, A., Alexopoulos, A., Dawson, D., Nihoyannopoulos, P., Zainal, H. A., Ismail, J., Arshad, K., Ibrahim, Z., Lim, C., Rahman, E. A., Kasim, S., Peteiro, J., Barrio, A., Escudero, A., Bouzas Mosquera, A., Yanez, J., Martinez, D., Castro Beiras, A., Scali, M., Simioniuc, A., Mandoli, G., Lombardo, A., Massaro, F., Bello, V. D., Marzilli, M., Dini, F., Adachi, H., Tomono, J., Oshima, S., Ortega, G. M., Bustos, D. B., Garcia, R. L., Espino, A. S., Quinones, J. M., Ikuta, I., Lopez, M. R., Serrano, F. V., Gonzalez, J. B., Recio, M. G., Romano, G., D'Ancona, G., Pilato, G., Gesaro, G. D., Clemenza, F., Raffa, G., Scardulla, C., Sciacca, S., Lancellotti, P., Pilato, M., Addetia, K., Takeuchi, M., Maffessanti, F., Weinert, L., Hamilton, J., Mor Avi, V., Lang, R., Sugano, A., Seo, Y., Watabe, H., Kakefuda, Y., Aihara, H., Nishina, H., Ishizu, T., Fumikura, Y., Noguchi, Y., Aonuma, K., Luo, X., Shang, Q., Sammut, E. C., Chabinok, R., Jackson, T., Siarkos, M., Lee, L., Carr White, G., Rajani, R., Kapetanakis, S., Byrne, D., Walsh, J., Ellis, L., Mckiernan, S., Norris, S., King, G., Murphy, R., Katova, T., Simova, I., Kostova, V., Shuie, I., Ferferieva, V., Bogdanova, V., Castelon, X., Sasi, V., Domsik, P., Kalapos, A., Lengyel, C., Orosz, A., Grapsa, J., Demir, O., Sharma, R., Senior, R., Pilichowska, E., Zaborska, B., Baran, J., Stec, S., Kulakowski, P., Budaj, A., Herrera, J. E., Palacios, I. F., Mendoza, I., Marquez, J. A., Herrera, J. A., Octavio, J. A., Dempaire, G., Rotolo, M., Kosmala, W., Kaye, G., Saito, M., Negishi, K., Maceira, A. M., Ripoll, C., Cosin Sales, J., Igual, B., Salazar, J., Belloch, V., Dulai, R. S., Taylor, A., Gupta, S., and S. U. C., None

Published
2014

18. P1270Effects of blood pressure variability on layer-specific longitudinal strain in hypertensionP1271 Left atrial dynamics and diastolic function in hypertensive patientsP1272Echocardiographic evaluation of right ventricular function in patients with chronic obstructive pulmonary disease in comparison with healthy groupP1273The impact of preeclampsia on myocardial recovery in women with peripartum cardiomyopahty - speckle tracking studyP1274Diagnostic accuracy of bedside lung ultrasonography in emergency (BLUE) protocol in discriminating cardiovascular causes of acute dyspneaP1275Heart failure with preserved and reduced ejection fraction - the mysterious role of ghrelin in the improvement of cardiac mechanicsP1276Prolonged atrial electromechanical coupling interval in patients with vitamin d deficiencyP1277Early detection of cardiotoxicity induced by new target therapy by strain echocardiography and arterial stiffnessP1278Long term course of bicuspid aortic valve in patients with and without associated cardiac malformations. A single-centre, retrospective cohort studyP1279Left ventricular mechanics in ALCAPA patients post successful repair: really normal?P1280Next generation stress echo computerized software (SECS)P1281Non invasive hemodynamic profile of patients developing inducible ischemia at dobutamine stress echocardiography: a global longitudinal strain investigation P1282Silent myocardial ischaemia is highly prevalent in patients with chronic obstructive pulmonary disease referred for dobutamine stress echocardiographyP1283Silent chronic obstructive pulmonary disease is highly prevalent in patients referred for dobutamine stress echocardiography with shortness of breathP1284Exercise echocardiography for the prediction of mortality after coronary artery by-pass surgery.P1285Exercise echocardiography reveals higher LV myocardial performance efficiency in adolescent elite athletes compared to non-athlete controlsP1287Impact of subclinical left ventricular myocardial dysfunction on exercise capacity in young patients with type 1 diabetes mellitusP1288Mitral annular plane systolic excursion as additional evaluation for left ventricular ejection fractionP12892 dimensional global longitudinal strain and mitral annular plane systolic?excursion as additional evaluation for left ventricular ejection fractionP1290Assessment of the left atrial appendage systolic function by 3 dimensional transoesophageal echocardiographyP1291Functional anatomy of mitral valve in obstructive hypertrophic cardiomyopathy patientsP1292Right ventricle deformation indices discriminate better than left ventricle deformation indices and fractional shortening between healthy and hypothermia treated asphyxiated neonatesP1293Determinants of myocardial strain in chronic myocardial infarction

Author

Tsai, W-C, primary, Chamodraka, E., primary, Behzadnia, N., primary, Hristova, K., primary, Ledakowicz-Polak, A., primary, Kupczynska, K., primary, Hacioglu, Y., primary, Novo, G., primary, Lamy, J., primary, Di Salvo, G., primary, Ciampi, Q., primary, Santoro, C., primary, O'driscoll, J., primary, Peteiro Vazquez, JC., primary, Pieles, GE., primary, Ruisanchez Villar, C., primary, Cho, EJ., primary, Garcia Martin, A., primary, Pavlyukova, EN., primary, Nestaas, E., primary, Ballo, H., primary, Lee, W-H, additional, Liu, Y-W, additional, Kallistratos, E., additional, Athanasiou, D., additional, Giannitsi, S., additional, Manetos, C., additional, Athanasiadis, G., additional, Asonitis, M., additional, Kouremenos, N., additional, Tsoukas, A., additional, Manolis, A., additional, Asadpour-Piranfar, M., additional, Sharif-Kashani, BABAK, additional, Ameli, N., additional, Marinov, R., additional, Stamenov, G., additional, Chacheva, K., additional, Michova, M., additional, Persenska, S., additional, Dimova, N., additional, Racheva, A., additional, Krauza, G., additional, Stokfisz, K., additional, Zielinska, M., additional, Michalski, BW., additional, Trzcinski, P., additional, Miskowiec, D., additional, Peczek, L., additional, Lipiec, P., additional, Kasprzak, JD., additional, Karabag, T., additional, Piskinpasa, ME., additional, Sametoglu, F., additional, Yuksel, Y., additional, Di Lisi, D., additional, Meschisi, M., additional, Cosentino, F., additional, Bonomo, V., additional, Mazzola, G., additional, D'angelo, F., additional, Vella, I., additional, Bronte, E., additional, Badalamenti, G., additional, Russo, A., additional, Chopard, R., additional, Ecarnot, F., additional, Tchaoussoff, C., additional, Schiele, F., additional, Bernard, YF., additional, Al Qweai, N., additional, Issa, Z., additional, Muhanna, N., additional, Habdan, M., additional, Pergola, V., additional, Fadel, B., additional, Siblini, G., additional, Paterni, M., additional, Cortigiani, L., additional, Citro, R., additional, Sicari, R., additional, Galderisi, M., additional, Bossone, E., additional, Colonna, P., additional, Picano, E., additional, Ilardi, F., additional, Schiano-Lomoriello, V., additional, Esposito, R., additional, Cocozza, S., additional, Lo Iudice, F., additional, Lembo, M., additional, Trimarco, B., additional, Madden, B., additional, Giannoglou, D., additional, Peresso, V., additional, Marciniak, A., additional, Nazir, S., additional, Sharma, R., additional, Bouzas-Mosquera, A., additional, Pardo, P., additional, Broullon-Molanes, F., additional, Vazquez-Rodriguez, JM., additional, Luszczak, J., additional, Gowing, L., additional, Stuart, AG., additional, Williams, CA., additional, Gonzalez Vilchez, FJ., additional, Piedra Leon, M., additional, Marigomez Estrada, M., additional, Pesquera Gonzalez, C., additional, Ruano Calvo, J., additional, Zarauza Navarro, J., additional, Martin Duran, R., additional, Amado Senaris, JA., additional, Jeong, MY., additional, Kim, HJ., additional, Kwak, MH., additional, Moya Mur, JL., additional, Fernandez-Golfin, C., additional, Casas Rojo, E., additional, Del Val Martin, D., additional, Pardo Sanz, A., additional, Gonzalez Gomez, A., additional, Hinojar, R., additional, Berlot, B., additional, Zamorano, JL., additional, Evtushenko, AV., additional, Smushlyaev, KA., additional, Karpov, RS., additional, Stoylen, A., additional, Fugelseth, D., additional, Tarkia, M., additional, Haavisto, M., additional, Stark, C., additional, Vahasilta, T., additional, Strandberg, M., additional, Saukko, P., additional, Savunen, T., additional, Knuuti, J., additional, and Saraste, A., additional

Published
2016
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22. Survival role of superoxide dismutase 1 on human granulosa luteinized cells in vitro

Author

Dineva J, Vangelov I, Abrashev R, Krassimira Todorova, Gulenova D, Nikolov D, Rangelov I, Stamenov G, Angelova M, and Ivanova M

Subjects
Granulosa Cells, Caspase 3, Cell Survival, Superoxide Dismutase, Cell Culture Techniques, Apoptosis, Fertilization in Vitro, Culture Media, Oxidative Stress, Superoxide Dismutase-1, Humans, Female, Ditiocarb, Chelating Agents
Abstract

Deleterious effects of free radicals do not only result from the amount of free radicals produced but also are related to the efficiency and to the activities of enzymatic antioxidant systems. We investigated the effect of exogenous superoxide dismutase (SOD1) or Cu-chelating agent diethyldithiocarbamate (DDC) on the apoptosis (caspase-3 activity) of human granulosa luteinized cells (hGLC) in vitro.The effects of SOD1 and DDC were studied using in vitro culture system, caspase-3 and the total SOD activity in hGLCs were measured using AcDEVD-PNA substrate and Beaushap and Fridovich methods, respectively, after 48 h of the culture period.The activity of SOD1 was the lowest in GLCs treated with 100 µM DDC as compared to control cells and to the cells supplemented with Cu, Zn-SOD or DDC (10 µM). The effect of DDC was associated with elevated caspase-3 activity as compared to control cells.It was demonstrated for the first time that the supplementation of cultured hGLCs with Cu2+, Zn2+-SOD (200 U/ml) maintains the viability of hGLCs via caspase-3 suppression.

Published
2011

23. Poster session 1GENERAL PRINCIPLESP194Ultrasound indexes of adipose tissue and lipid goals attainment in high and very high cardiovascular risk patientsTHE IMAGING EXAMINATIONP195Right ventricular global longitudinal strain provides higher prognostic value than right free wall longitudinal strain in patients with left heart diseaseP196Normal values of echocardiographlc left and right cardiac chambers dimensions as multifactorially determined by sex, level of physical activity, age, BMI, systolic blood pressure and heart rateAnatomy and physiology of the heart and great vesselsP197Echocardiographic phenotypes according to levels of oxygen consumption at peak exercise: findings from the EURO(pean) EX(ercise) population-based studyAnatomy and physiology of the heart and great vesselsP198Systemic vascular resistance and central arterial stiffness in relation to left ventricular geometry and diastolic function in essential hypertensionAssessment of diameters, volumes and massP199Left atrial diameter predicts a new diagnosis of paroxysmal atrial fibrillation in a population presenting with palpitationsP200Interventricular septum thickness and acute coronary syndromes: small differences, big prognostic influence?P201Detection of abdominal aortic aneurysm in a population referred for an ultrasonographyAssessments of haemodynamicsP202The ultrasound vector velocity method transverse oscillation validated in a flowrig with constant and pulsatile flow and in-vivo of blood flow in the ascending aortaASSESSMENT OF SYSTOLIC FUNCTIONP203Different types of left ventrical remodeling in children with arterial hypertensionP204Assessment of myocardial performance index in hypertensive patients with or without hyperuricemiaP205Strain echocardiography detects mild impairment of systolic function in patients with frequent premature ventricular contractionsP206Speckle tracking strain correlates better with functional capacity and hemodynamic burden than ejection fraction in patients with severe heart failureP207Prognostic value of 2D and 3D echocardiographic volumes, ejection fraction and strain as markers of abnormal left ventricular performanceP208Long-term prognostic value of left ventricular ejection fraction assessed by echocardiography and magnetic resonance imaging after acute STEMIP209Assessment of left ventricular function after percutaneous coronary intervention of chronic total occluded coronary artery by speckle tracking and cardiac magnetic resonanceP210Physiologic variations of tricuspid annular plane systolic excursion in healthy subjects: clinical and echocardiographic correlatesP211Predictors of incipient ventricular dysfunction with tyrosine kinase inhibitors in metastatic renal cell carcinomaAssessment of diastolic functionP212Disagreement between the American Society of Echocardiography (ASE) and gastroenterology-based guidelines for the diagnosis of diastolic dysfunction among patients with advanced liver diseaseP213Nomograms for mitral inflow doppler and tissue doppler velocities in caucasian childrenP215Diastolic function is impaired in women with angina pectoris and no obstructive coronary artery disease independently of coronary microvascular functionP216Clinical value of myocardial performance index in patients with isolated diastolic dysfunctionIschemic heart diseaseP217Cardiac imaging strategy is clinically more effective and at lower cost than traditional ETT strategy for the diagnosis of stable coronary artery diseaseP218Does the ESC clinical pretest probability score stratify our patients correctly? Validation with stress echocardiographyP219Incremental value of exercise echocardiography over exercise electrocardiography in a chest pain unit: a decision curve analysisP220A bedside echocardiographic score for risk stratification of ST-elevation myocardial infarction patients undergoing primary percutaneous coronary interventionP221Interventricular and intraventricular dyssynchrony in patients with Q-wave acute myocardial infarctionP222Comparison of tagging and tissue tracking for myocardial strain assessment at 1.5T and 3.0T following ST-segment elevation myocardial infarctionP223Left atrial strain rate evaluated by two-dimensional speckle tracking is predictor of left ventricular arrhythmias in STEMI patients treated by primary PCIP224Impact of percutaneous coronary intervention of chronic total oclussion on left ventricular function using speckle tracking and cardiac magnetic resonanceHeart valve DiseasesP225Clinical and echocardiographic characteristics of patients with low flow severe aortic stenosis and preserved ejection fractionP226Ventricular-arterial interplay in patients with severe aortic stenosis: additional role of wave intensity analysisP227Degenerative aortic stenosis: don't forget the vascular componentP228Reclassifying low gradient aortic stenosis with 3D transesophageal echocardiography and global longitudinal strainP229Importance of mitral regurgitation on pre- and postoperative clinical status and echocardiographic findings in patients with severe aortic stenosis admitted for aortic valve replacementsP230Aorto-septal angle and degenerative aortic stenosis: a case-control study stenosisP231Difference of sST2 level in mitral stenosis compare with control subjectsP232Velocity-time integral of aortic regurgitation: a novel echocardiographic marker in the evaluation of aortic regurgitation severityP233Color doppler 3D echocardiography-derived regurgitant volume in primary mitral regurgitation: a comparison of different techniques with magnetic resonanceP234Outcome of surgery for degenerative mitral regurgitationP235Mitral valve repair or replacement for functional regurgitation and left ventricular dysfunction: clinical and echocardiographic outcomeP236Prevalence, characteristics and prognosis of moderate to severe tricuspid regurgitation in patients with precapillary pulmonary hypertensionP237Management of late bioprosthetic mitral valve thrombosisP238Relationship between pulmonary venous flow and prosthetic mitral valve thrombosisP239Transcatheter aortic valve implantation does not reduce acutely valvuloarterial impedance in an elderly population with degenerative calcific aortic valve stenosisP240Influence of type of prosthesis on mitral regurgitation change after transcatheter aortic valve replacement for aortic stenosisP241The prevalence of valve disease in patients undergoing atrial fibrillation ablationCardiomyopathiesP242The prognostic value of lung ultrasound at discharge in heart failureP243Prognostic value of global longitudinal strain in non-ischaemic dilated cardiomyopathyP244Additional effect of high intensity exercise training to cardiac resynchronization in heart failure: the reduction on left venticular massP245Dobutamine-induced changes of longitundinal strain predicts longterm mortality in severe heart failureP246Myocardial fibrosis is not related to two-dimensional longitudinal strain in dilated cardiomyopathyP247Echocardiographic parameters are predictors of positive genetic study in a Portuguese population with hypertrophic cardiomyopathy: a multicentre studyP248Myocardial deformation techniques for the evaluation of the right ventricle in fabry diseaseP249Borderline hypertrophic cardiomyopathy or athlete's heart: what is the role for genetic testing in athletes?P250Isolated papillary muscle hypertrophy. Clinical, electrocardiographic and morphologic characteristicsP251Prognostic value of the assessment of left atrial deformation in hypertrophic cardiomyopathyP252Assessment of subtle echocardiographic changes may improve risk stratification of arrhythmias in early stages of arrhythmogenic right ventricular cardiomyopathy (ARVC)P253Long-term correlation of electrocardiography with structural echocardiography changes in patients with arrhythmogenic right ventricular cardiomyopathyP254Right ventricular strain and dyssynchrony assessment in arrhythmogenic right ventricular cardiomyopathy: a cardiac magnetic resonance feature-tracking studyP255Association of non compaction and hypertrophic cardiomyopathies, Noonan and long QT syndromesP256Predictors of mortality in patients with acute myocarditisP257Clinical characteristics and natural history of acute myocarditisP258One-beat 3dimensional echocardiography for the assessment of right ventricular function in heart transplant recipientsP259Hemodynamically irrelevant, non-surgery related pericardial effusion is a predictor of mortality in heart transplanted patientsSystemic diseases and other conditionsP260Left ventricular function as a cardiac marker of target organ damage in non-diabetic, never treated hypertensive patients: Camparison with microalbuminuriaP261Subclinical myocardial dysfunction in hypertensive patients with hyperuricemiaP262Can deformation indices (strain/strain rate) establish differential diagnosis in infiltrative cardiomyopathies?P263Prevalence and factors associated with inappropriately high left ventricular mass in patients with rheumatoid arthritisP264Echocardiographic evaluation of patients with end-stage liver disease, the importance of follow up after liver transplantationP265Cardiovasclular involvement in asymptomatic juvenile localized scleroderma patientsP267Can the left ventricular mechanics using speckle tracking echocardiography in pregnancy predict the new onset heart failure?P268What causes impaired exercise tolerance in HFpEF? Relative contribution from LV filling pressure and other factorsCongenital heart diseaseP269Pregnancy in patients with Ebsteins anomaly - echocardiographic and clinical studyP270Double aortic arch anomalies in clinical practiceP271Echocardiography as the essential imaging modality in congenital heart disease - first one to begin with and the one who staysMasses, tumors and sources of embolismP272Can the reduction of wall shear stress in diskinetic myocardial wall segments be used to predict trombogenicity?Diseases of the aortaP273The role of modified transoesophageal echocardiography for optimal access decision making for transcatheter aortic valve replacement proceduresStress echocardiographyP274Is aortic valve resistance different in patients with severe aortic stenosis and left ventricular fraction below 40% with low or high gradient?P275Does wall motion score index in dobutamine stress echocardiography predict syntax score in catheterization lab?P276Sex-related differences in peak stress left ventricular global longitudinal strain during dobutamine stress echocardiography in patients with significant coronary artery diseaseP277Exercise stress echocardiography complications: a 4-year single center experienceP278Reduced baseline left ventricular longitudinal systolic function is a marker of inducible myocardial ischemia in patients undergoing exercise echocardiographyP279Estimation of mean pulmonary arterial pressure based on right ventricle systolic pressure observed from exercise echocardiography among non-pulmonary hypertension with systemic sclerosisTransesophageal echocardiographyP280Transoesophageal echocardiography in patients with neuroendocrine tumour and carcinoid symptoms is safe without intravenous octreotideP281The feasibility and the clinical benefit of the cognitive-behavioral intervention for preparing patients for transesophageal echocardiographic studyP282Dynamic changes of mitral annulus shape in different types of mitral valve prolapse. A three-dimensional transoesophageal studyReal-time three-dimensional TEEP283Severe aortic stenosis: evaluation of effective and anatomy valve by 2D transthoracic echocardiography and 3D transesophageal echocardiographyP2843D-transeosphageal echocardiography usefulness for assessment of cardiac output in intensive care unit: an ultrasound versus thermodilution comparative study for patients under mechanical ventilationP285The predictive value of three-dimensional vena-contracta in determining the number of MitraClip devices needed during the procedure in functional mitral regurgitationTissue Doppler and speckle trackingP286Should the septum be included in the assessment of right ventricular longitudinal strain?P287Can machine learning help to identify heart failure with preserved ejection fraction?P288Concordance of atrial function measurement by 3D volumetric echocardiography and speckle tracking deformation imagingP289Heterogonous regional diastolic function revealed by 2D speckle tracking echocardiography identifies patients with ischemic etiology of left ventricular systolic dysfunctionP290The values from Real time 3-dimensional strain is not independent from preload changesP291Risk stratification in hypertrophic cardiomyopathy. a potential role for speckle-tracking parameters by cardiac magnetic resonanceP292Abnormal longitudinal peak systolic strain in asymptomatic patients with type-I diabetes mellitusP294Strain evaluation of subclinical cardiac dysfunction in patients with myotonic dystrophy type 1P295Heart function assessment in perinatal asphyxia; speckle tracking indices from greyscale recordings perform better than from tissue Doppler recordings, fractional shortening and tissue Doppler indicesP297Longitudinal strain assessed by automatic function imaging - a useful tool in significant coronary artery disease detection in patients with low risk anginaP298Global 2-Dimensional strain as a predictor of mortality in heart transplant patients with cardiac allograft vasculopathyP299Two-dimensional longitudinal strain and strain rate in asymptomatic middle-aged patients with type 2 diabetes mellitus - a pilot study resultsP300Limited accuracy of myocardial deformation imaging in diagnosis of left ventricular segmental dysfunction in patients with acute myocardial infarction: is it only a limitation of the strain software?Computed Tomography & Nuclear CardiologyP301Evaluation of the actual prevalence of myocardial ischemia in patients prior to performing a peripheral vascular surgeryP302Prognostic value of myocardial ischemia detected by myocardial perfusion imaging in asymptomatic patients with diabetes type 2P303Economic cost analysis derived by coronary computed tomography angiography inappropriate indications to rule out coronary heart disease

Author

Haberka, M, primary, Garcia Martin, A, primary, Barbier, P, primary, Pellegrino, M, primary, Angelis, A, primary, Howlett, PJ, primary, Madeira, M, primary, Carrero, PJ, primary, Hansen, KL, primary, Trunina, I, primary, Basar, C, primary, Lie, OH, primary, Sade, LE, primary, Gopal, A S, primary, Klug, G, primary, Rodriguez Gonzalez, E, primary, Ferrara, F, primary, Moustafa, S, primary, Naksuk, N, primary, Cantinotti, M, primary, Michelsen, MM, primary, Fernandes, JMG, primary, Demir, OM, primary, Cano Carrizal, R, primary, Bouzas-Mosquera, A, primary, Leao, S, primary, Kuznetsov, VA, primary, Nazir, S A, primary, Trifunovic, D, primary, Spampinato, RA, primary, Antonini-Canterin, F, primary, Ribeiro, JM, primary, Morgado, GJ, primary, Reis, L, primary, Naratrekoon, B, primary, Soto-Ruiz, RM, primary, Penicka, M, primary, Zilberszac, R, primary, De Chiara, B, primary, Rifai, R, primary, Gunduz, S, primary, Cersit, S, primary, Devecchi, C, primary, Ancona, F, primary, Smith, D, primary, Gargani, L, primary, Asmarats Serra, L, primary, Abreu, A, primary, Ikonomidis, I, primary, Biernacka, B, primary, Gomes, AC, primary, Caballero, L, primary, Mansencal, N, primary, Venturini, C, primary, Zaroui, A, primary, Leren, I S, primary, Astrom Aneq, M, primary, Nucifora, G, primary, Rocon, CRLA, primary, Cho, J Y, primary, Stampfli, S F, primary, Cho, EJ, primary, Stevanovic, A, primary, Pena, J L, primary, Ognibeni, F, primary, Colunga, S, primary, Borowiec, A, primary, Hristova, K, primary, Kosmala, W, primary, Lesniak-Sobelga, A M, primary, Kaldararova, M, primary, Stanojevic, D, primary, Carbonell San Roman, A, primary, Hoetink, A, primary, Ferreira, R, primary, Rohani, A, primary, Wierzbowska-Drabik, K, primary, Carvalho, J F, primary, Cherubini, A, primary, Teramoto, K, primary, May, CJH, primary, Wejner-Mik, P, primary, Gurzun, M M, primary, Perea, GO, primary, Laveau, F, primary, Mahmoud, HM, primary, Sanz, M, primary, Sanchez-Martinez, S, primary, Montserrat, S, primary, Kowalczyk, E, primary, Park, CS, primary, Hinojar, R, primary, Van Berendoncks, A M, primary, Guedes, H, primary, Nestaas, E, primary, Onut, R, primary, Moran, L, primary, Kisko, A, primary, Agmon, Y, primary, Corneli, M, primary, Peovska Mitevska, IPM, primary, Barreiro Perez, M, primary, Banska, K, additional, Gasior, Z, additional, Moya-Mur, JL, additional, Carbonell-San Roman, S-A, additional, Rodriguez-Munoz, D, additional, Garcia-Lledo, A, additional, Casas-Rojo, E, additional, Hinojar, R, additional, Jimenez-Nacher, JJ, additional, Fernandez-Golfin, C, additional, Zamorano-Gomez, JL, additional, Ravani, A, additional, Cefalu, C, additional, Maltagliati, A, additional, Frigerio, B, additional, Sansaro, D, additional, Amato, M, additional, Baldassarre, D, additional, Bandera, F, additional, Generati, G, additional, Labate, V, additional, Alfonzetti, E, additional, Guazzi, M, additional, Aggeli, K, additional, Ioakeimidis, N, additional, Abdelrasoul, M, additional, Felekos, I, additional, Gourgouli, I, additional, Aznaouridis, K, additional, Rousakis, G, additional, Vlachopoulos, C, additional, Tousoulis, D, additional, Darasz, K, additional, Mahmoudi, M, additional, Shah, N, additional, Jabr, RI, additional, Hickman, M, additional, Leatham, EW, additional, Fry, CH, additional, Teixeira, R, additional, Almeida, I, additional, Caetano, F, additional, Fernandes, A, additional, Cassandra, M, additional, Reis, L, additional, Costa, M, additional, Goncalves, L, additional, Nielsen, AJ, additional, Carrero, MC, additional, Saubidet, GL, additional, Peralta, SP, additional, Moeller-Soerensen, H, additional, Kjaergaard, J, additional, Jensen, MB, additional, Lund, JT, additional, Pedersen, MM, additional, Olesen, JB, additional, Jensen, JA, additional, Nielsen, MB, additional, Sharykin, AS, additional, Karelina, EV, additional, Telezhnikova, ND, additional, Ozhan, H, additional, Kayapinar, O, additional, Albayrak, ES, additional, Saberniak, J, additional, Dejgaard, L, additional, Nestaas, E, additional, Edvardsen, T, additional, Haugaa, KH, additional, Bal, U, additional, Eroglu, S, additional, Pirat, B, additional, Muderrisoglu, H, additional, Muthukumar, L, additional, Saha, SK, additional, Toole, RS, additional, Reinstadler, S, additional, Feistritzer, HJ, additional, Pernter, B, additional, Mayr, A, additional, Franz, WM, additional, Mueller, S, additional, Metzler, B, additional, Mingo Santos, S, additional, Palomero Monivas, V, additional, Gonzalez Mirelis, J, additional, Goirigolzarri Artaza, J, additional, Zorita Gil, B, additional, Fernandez Diaz, JA, additional, Goicolea Ruigomez, J, additional, Restrepo Cordoba, MA, additional, Alonso Pulpon, L, additional, Gargani, L, additional, D'alto, M, additional, Ghio, S, additional, Acri, E, additional, Carannante, L, additional, Argiento, P, additional, D'andrea, A, additional, Vriz, O, additional, Bossone, E, additional, Ho, TH, additional, Shah, P, additional, Murphy, K, additional, Nelluri, BK, additional, Lee, H, additional, Wilansky, S, additional, Mookadam, F, additional, Peeraphatdit, T, additional, Chaiteerakij, R, additional, Klarich, KW, additional, Scalese, M, additional, Melo, M, additional, Assanta, N, additional, Marotta, M, additional, Crocetti, M, additional, Spadoni, I, additional, Giordano, R, additional, Kutty, S, additional, Iervasi, I, additional, Mygind, ND, additional, Pena, A, additional, Frestad, D, additional, Hoest, N, additional, Prescott, E, additional, Romao, BO, additional, Rivera, IR, additional, Mendonca, MA, additional, Carvalho, AC, additional, Campos, O, additional, Amato, A, additional, Moises, VA, additional, Bashir, A, additional, Marshall, K, additional, Douglas, M, additional, Wasan, B, additional, Plein, S, additional, Alfakih, K, additional, Casanova Rodriguez, C, additional, Cadenas Chamorro, R, additional, Iglesias Del Valle, D, additional, Martin-Penato Molina, A, additional, De Juan Baguda, J, additional, Prieto Moriche, E, additional, Garcia Garcia, A, additional, De La Cruz Berlanga, E, additional, Plaza Perez, I, additional, Peteiro, J, additional, Broullon, FJ, additional, Alvarez-Garcia, N, additional, Barbeito-Caamano, C, additional, Larranaga-Moreira, JM, additional, Maneiro-Melon, N, additional, Martinez-Ruiz, D, additional, Yanez, JC, additional, Vazquez-Rodriguez, JM, additional, Cordeiro, F, additional, Magalhaes, P, additional, Moz, M, additional, Trigo, J, additional, Mateus, P, additional, Fontes, P, additional, Moreira, I, additional, Krinochkin, DV, additional, Plusnin, AV, additional, Soldatova, AM, additional, Shetye, A, additional, Khan, JN, additional, Singh, A, additional, Kanagala, P, additional, Swarbrick, DJ, additional, Graham-Brown, M, additional, Mccann, GP, additional, Krljanac, G, additional, Savic, L, additional, Asanin, M, additional, Aleksandric, S, additional, Lasica, R, additional, Srdic, M, additional, Zlatic, N, additional, Petrovic, M, additional, Mrdovic, I, additional, Monivas Palomero, V, additional, Rivero Arribas, B, additional, Dobrovie, M, additional, Da Rocha E Silva, JG, additional, Bonamigo Thome, F, additional, Kluttig, R, additional, Schloma, V, additional, Dmitrieva, Y, additional, Strotdrees, E, additional, Mohr, FW, additional, Luzza, G, additional, Caruso, R, additional, Belfiore, R, additional, Della Mattia, A, additional, Poli, S, additional, Zito, C, additional, La Carrubba, S, additional, Carerj, S, additional, Carvalho, JF, additional, Gomes, AC, additional, Caldeira, D, additional, Cruz, IR, additional, Stuart, B, additional, Maia, R, additional, Fazendas, P, additional, Pereira, H, additional, Rakocevic, I, additional, Tutos, V, additional, Petrovic, O, additional, Boricic-Kostic, M, additional, Stepanovic, J, additional, Jovanovic, I, additional, Banovic, M, additional, Vujisic-Tesic, B, additional, Leite, L, additional, Madeira, M, additional, Botelho, A, additional, Santos, M, additional, Nascimento, J, additional, Yingchoncharoen, T, additional, Vathesatogkit, P, additional, Yamwong, S, additional, Sritara, P, additional, Bonaque Gonzalez, J C, additional, Abellan-Huerta, J, additional, Rubio-Paton, R, additional, Soria, F, additional, Ramos, JL, additional, Egea, S, additional, Garcia-Gomez, J, additional, Martinez Diaz, JJ, additional, Castillo, JA, additional, Vecera, J, additional, Mirica, C, additional, Kotrc, M, additional, Kockova, R, additional, Gabriel, H, additional, Maurer, G, additional, Rosenhek, R, additional, Botta, L, additional, Musca, F, additional, Belli, O, additional, Costetti, A, additional, Trolese, I, additional, Spano, F, additional, Russo, C, additional, Giannattasio, C, additional, Moreo, A, additional, Berthelot, E, additional, Le, MT, additional, Hilpert, L, additional, Montani, D, additional, Sitbon, O, additional, Jais, X, additional, Humbert, M, additional, Assayag, P, additional, Yesin, M, additional, Kalcik, M, additional, Gursoy, MO, additional, Cersit, S, additional, Astarcioglu, MA, additional, Karakoyun, S, additional, Aykan, AC, additional, Ozkan, M, additional, Gunduz, S, additional, Tabakci, M, additional, Bayam, E, additional, Degiovanni, A, additional, Di Ruocco, MV, additional, Marino, P, additional, Rosa, I, additional, Stella, S, additional, Barletta, M, additional, Marini, C, additional, Latib, A, additional, Montorfano, M, additional, Colombo, A, additional, Margonato, A, additional, Agricola, E, additional, Ray, R, additional, Gallagher, M, additional, Nazir, M, additional, Perreso, V, additional, Sharma, R, additional, Pang, PS, additional, Miglioranza, M, additional, Landi, P, additional, Dini, FL, additional, Picano, E, additional, Pons Llinares, J, additional, Macaya Ten, F, additional, Pericas Ramis, P, additional, Caldes Llull, O, additional, Grau Sepulveda, A, additional, Frontera, G, additional, Bethencourt, A, additional, Santa Clara, H, additional, Santos, V, additional, Oliveira, M, additional, Cunha, P, additional, Portugal, G, additional, Rio, P, additional, Branco, L, additional, Ferreira, R, additional, Mota Carmo, M, additional, Paraskevaidis, I, additional, Papadopoulos, C, additional, Stasinos, V, additional, Parissis, J, additional, Lekakis, J, additional, Rubis, P, additional, Gackowski, A, additional, Wisniowska-Smialek, S, additional, Lesniak-Sobelga, A, additional, Kostkiewicz, M, additional, Bento, D, additional, Correia, E, additional, Teles, L, additional, Picarra, B, additional, Lourenco, C, additional, Faria, R, additional, Domingues, K, additional, Azevedo, O, additional, Climent Paya, V, additional, Martinez Moreno, M, additional, Gimeno, JR, additional, Oliva, MJ, additional, Saura, D, additional, Sanchez Quinones, J, additional, Garcia Honrubia, A, additional, Valdes, M, additional, De La Morena, G, additional, Richard, P, additional, Guerard, S, additional, Brion, R, additional, Paul, P, additional, Dubourg, O, additional, Komajda, M, additional, Isnard, R, additional, Arslan, M, additional, Charron, P, additional, Avegliano, G, additional, Andres, S, additional, Costabel, JP, additional, Kuschnir, P, additional, Sciancalepore, A, additional, Mendoza, O, additional, Perea, G, additional, Ronderos, R, additional, Ben Said, RYM, additional, EL Chalbia, TEJ, additional, Wali, SANA, additional, Mourali, MS, additional, Mechmeche, RACHID, additional, Haland, TF, additional, Svetlichnaya, J S, additional, Shikha, SS, additional, Scheinmann, MS, additional, Klein, LK, additional, Prati, G, additional, Vitrella, G, additional, Allocca, G, additional, Cukon Buttignoni, S, additional, Muser, D, additional, Morocutti, G, additional, Pinamonti, B, additional, Sinagra, G, additional, Proclemer, A, additional, Melo, MDTM, additional, Bocchi, EAB, additional, Araujo, JABAF, additional, Demarchi, LMMFD, additional, Mady, CM, additional, Biselli, BB, additional, Kalil, RKF, additional, Salemi, VMCS, additional, Tuma, RT, additional, Kim, K H, additional, Yoon, H J, additional, Lee, K J, additional, Park, H, additional, Kim, J H, additional, Ahn, Y, additional, Jeong, M H, additional, Cho, J G, additional, Park, J C, additional, Park, H J, additional, Kozan, H, additional, Sezgin, A, additional, Aydinalp, A, additional, Oezkartal, T, additional, Bernhart, S, additional, Flammer, AJ, additional, Vecchiati, A, additional, Froehlich, GM, additional, Ruschitzka, F, additional, Tanner, FC, additional, Choi, KY, additional, Kim, DB, additional, Jang, SW, additional, Cho, JS, additional, Park, CS, additional, Jung, HO, additional, Jeon, HK, additional, Youn, HJ, additional, Dekleva, M, additional, Fortes, PRL, additional, Passos, BR, additional, Rodrigues, AB, additional, Sampaio, IH, additional, Oliveira, MCN, additional, Silva, MG, additional, Cardoso, RAF, additional, Tofani, FA, additional, Moreira, MCV, additional, Cioffi, G, additional, Viapiana, O, additional, Dalbeni, A, additional, Fracassi, E, additional, Di Nora, C, additional, Cherubini, A, additional, Mazzone, C, additional, Di Lenarda, A, additional, Rossini, M, additional, Corros, C, additional, Garcia-Campos, A, additional, Martin, M, additional, Rodriguez-Suarez, M, additional, Leon, V, additional, Fidalgo, A, additional, Lopez-Iglesias, F, additional, Moris, C, additional, De La Hera, JM, additional, Dabrowski, R, additional, Wozniak, J, additional, Jasek, S, additional, Chwyczko, T, additional, Kowalik, I, additional, Musiej-Nowakowska, E, additional, Szwed, H, additional, Marinov, R, additional, Stamenov, G, additional, Mihova, M, additional, Chacheva, K, additional, Persenska, S, additional, Racheva, A, additional, Przewlocka-Kosmala, M, additional, Rojek, A, additional, Karolko, B, additional, Mysiak, A, additional, Marwick, TH, additional, Biernacka, B, additional, Tittel, P, additional, Kardos, M, additional, Vrsanska, V, additional, Ondriska, M, additional, Hraska, V, additional, Nosal, M, additional, Masura, J, additional, Simkova, I, additional, Apostolovic, S, additional, Salinger-Martinovic, S, additional, Jankovic-Tomasevic, R, additional, Djordjevic-Radojkovic, D, additional, Stanojlovic, T, additional, Atanaskovic, V, additional, Pavlovic, M, additional, Tahirovic, E, additional, Dungen, HD, additional, Moya Mur, JL, additional, Lozano Granero, C, additional, Jimenez Nacher, JJ, additional, Gonzalez Gomez, A, additional, Fraile Sanz, C, additional, Segura De La Cal, T, additional, Zamorano Gomez, JL, additional, Jansen Klomp, WW, additional, Van 'T Hof, AWJ, additional, Brandon Bravo Bruinsma, GJ, additional, Spanjersberg, AJ, additional, Grandjean, J, additional, Nierich, AP, additional, Ferreira, J, additional, Lazaro Mendes, S, additional, Martins, R, additional, Monteiro, S, additional, Pego, M, additional, Khamene Bagheri, R, additional, Peruga, JZ, additional, Sobczak, M, additional, Plewka, M, additional, Wcislo, T, additional, Krecki, R, additional, Kasprzak, JD, additional, Morgado, G, additional, Cruz, I, additional, Almeida, AR, additional, Joao, I, additional, Lopes, L, additional, Cotrim, C, additional, Faganello, G, additional, Pandullo, C, additional, Russo, G, additional, Stefenelli, C, additional, Furlanello, F, additional, Tarantini, L, additional, Suzuki, K, additional, Satoh, Y, additional, Minami, K, additional, Mizukoshi, K, additional, Kamijima, R, additional, Kou, S, additional, Takai, M, additional, Izumo, M, additional, Akashi, YJ, additional, Ayuk, J, additional, Geh, I, additional, Shah, T, additional, Edwards, NC, additional, Steeds, RP, additional, Miskowiec, D, additional, Wdowiak-Okrojek, K, additional, Lipiec, P, additional, Rosca, M, additional, Calin, A, additional, Beladan, C, additional, Serban, M, additional, Ginghina, C, additional, Popescu, BA, additional, Lombardero, M, additional, Henquin, R, additional, Corneli, M, additional, Tinetti, M, additional, Hekimian, G, additional, Achkar, M, additional, Combes, A, additional, Hammoudi, N, additional, Al-Ghamdi, M, additional, Ghabashi, A, additional, Ezzat, M H, additional, Al-Amin, A, additional, Giraldeau, G, additional, Sarvari, SI, additional, Marin, J, additional, Brambila, C, additional, Gabrielli, L, additional, Bijnens, B, additional, Sitges, M, additional, Duchateau, N, additional, Erdei, T, additional, Fraser, A, additional, Bijnens, B H, additional, Piella, G, additional, Sanchis, L, additional, Borras, R, additional, Vidal, B, additional, Prat, S, additional, Azqueta, M, additional, Pare, C, additional, Grazioli, G, additional, Sanz, M, additional, Wejner-Mik, P, additional, Jung, MH, additional, Ahn, HS, additional, Kim, JH, additional, Megias, A, additional, Alonso, GL, additional, Gonzalez-Gomez, A, additional, Rincon, LM, additional, Esteban, A, additional, Fernandez Mendez, MA, additional, Barrios, V, additional, Zamorano, JL, additional, Van Gaal, L, additional, De Block, C, additional, Salgado, R, additional, Vrints, C, additional, Shivalkar, B, additional, Pereira, A, additional, Santos, R, additional, Marques, L, additional, Moreno, N, additional, Carvalho, R, additional, Pires, M, additional, Sousa, R, additional, Andrade, A, additional, Pinto, P, additional, Stoylen, A, additional, Fugelseth, D, additional, Tautu, O, additional, Onciul, S, additional, Marinescu, C, additional, Zamfir, D, additional, Dorobantu, M, additional, Sanchez Sanchez, V, additional, Navas, P, additional, Garcia-Cosio, D, additional, Diaz, B, additional, Carballo-Alzola, L, additional, Lombera, F, additional, Delgado, J, additional, Babcak, M, additional, Kishko, N, additional, Eitan, A, additional, Mutlak, D, additional, Kehat, I, additional, Meretta, AH, additional, Perea, GO, additional, Belcastro, F, additional, Aguirre, E, additional, Rosa, D, additional, Zaefferer, P, additional, Masoli, O, additional, Srbinovska, ES, additional, Bosevski, MB, additional, Antova, EA, additional, Pop Gorceva, DPG, additional, Martin Fernandez, M, additional, Costilla Garcia, SM, additional, Diaz Pelaez, E, additional, and Moris De La Tassa, C, additional

Published
2015
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25. Poster session 1

Author

Haberka, M, Banska, K, Gasior, Z, Garcia Martin, A, Moya-Mur, JL, Carbonell-San Roman, S-A, Rodriguez-Munoz, D, Garcia-Lledo, A, Casas-Rojo, E, Hinojar, R, Jimenez-Nacher, JJ, Fernandez-Golfin, C, Zamorano-Gomez, JL, Barbier, P, Ravani, A, Cefalu, C, Maltagliati, A, Frigerio, B, Sansaro, D, Amato, M, Baldassarre, D, Pellegrino, M, Bandera, F, Generati, G, Labate, V, Alfonzetti, E, Guazzi, M, Angelis, A, Aggeli, K, Ioakeimidis, N, Abdelrasoul, M, Felekos, I, Gourgouli, I, Aznaouridis, K, Rousakis, G, Vlachopoulos, C, Tousoulis, D, Howlett, PJ, Darasz, K, Mahmoudi, M, Shah, N, Jabr, RI, Hickman, M, Leatham, EW, Fry, CH, PREDICT-PAF, Madeira, M, Teixeira, R, Almeida, I, Caetano, F, Fernandes, A, Cassandra, M, Reis, L, Costa, M, Goncalves, L, Carrero, PJ, Nielsen, AJ, Carrero, MC, Saubidet, GL, Peralta, SP, Argentina, Aorta Abdominal, Hansen, KL, Moeller-Soerensen, H, Kjaergaard, J, Jensen, MB, Lund, JT, Pedersen, MM, Olesen, JB, Jensen, JA, Nielsen, MB, Trunina, I, Sharykin, AS, Karelina, EV, Telezhnikova, ND, Basar, C, Ozhan, H, Kayapinar, O, Albayrak, ES, Lie, OH, Saberniak, J, Dejgaard, L, Nestaas, E, Edvardsen, T, Haugaa, KH, Sade, LE, Bal, U, Eroglu, S, Pirat, B, Muderrisoglu, H, Gopal, A S, Muthukumar, L, Saha, SK, Toole, RS, Klug, G, Reinstadler, S, Feistritzer, HJ, Pernter, B, Mayr, A, Franz, WM, Mueller, S, Metzler, B, Rodriguez Gonzalez, E, Mingo Santos, S, Palomero Monivas, V, Gonzalez Mirelis, J, Goirigolzarri Artaza, J, Zorita Gil, B, Fernandez Diaz, JA, Goicolea Ruigomez, J, Restrepo Cordoba, MA, Alonso Pulpon, L, Ferrara, F, Gargani, L, D'alto, M, Ghio, S, Acri, E, Carannante, L, Argiento, P, D'andrea, A, Vriz, O, Bossone, E, Moustafa, S, Ho, TH, Shah, P, Murphy, K, Nelluri, BK, Lee, H, Wilansky, S, Mookadam, F, Naksuk, N, Peeraphatdit, T, Chaiteerakij, R, Klarich, KW, Cantinotti, M, Scalese, M, Melo, M, Assanta, N, Marotta, M, Crocetti, M, Spadoni, I, Giordano, R, Kutty, S, Iervasi, I, Michelsen, MM, Mygind, ND, Pena, A, Frestad, D, Hoest, N, Prescott, E, Fernandes, JMG, Romao, BO, Rivera, IR, Mendonca, MA, Carvalho, AC, Campos, O, Amato, A, Moises, VA, Demir, OM, Bashir, A, Marshall, K, Douglas, M, Wasan, B, Plein, S, Alfakih, K, Cano Carrizal, R, Casanova Rodriguez, C, Cadenas Chamorro, R, Iglesias Del Valle, D, Martin-Penato Molina, A, De Juan Baguda, J, Prieto Moriche, E, Garcia Garcia, A, De La Cruz Berlanga, E, Plaza Perez, I, Bouzas-Mosquera, A, Peteiro, J, Broullon, FJ, Alvarez-Garcia, N, Barbeito-Caamano, C, Larranaga-Moreira, JM, Maneiro-Melon, N, Martinez-Ruiz, D, Yanez, JC, Vazquez-Rodriguez, JM, Leao, S, Cordeiro, F, Magalhaes, P, Moz, M, Trigo, J, Mateus, P, Fontes, P, Moreira, I, Kuznetsov, VA, Krinochkin, DV, Plusnin, AV, Soldatova, AM, Nazir, S A, Shetye, A, Khan, JN, Singh, A, Kanagala, P, Swarbrick, DJ, Graham-Brown, M, Mccann, GP, Trifunovic, D, Krljanac, G, Savic, L, Asanin, M, Aleksandric, S, Lasica, R, Srdic, M, Zlatic, N, Petrovic, M, Mrdovic, I, Rodriguez Gonzalez, E, Mingo Santos, S, Monivas Palomero, V, Gonzalez Mirelis, J, Zorita Gil, B, Fernandez Diaz, JA, Restrepo Cordoba, MA, Goirigolzarri Artaza, J, Rivero Arribas, B, Goicolea Ruigomez, J, Spampinato, RA, Dobrovie, M, Da Rocha E Silva, JG, Bonamigo Thome, F, Kluttig, R, Schloma, V, Dmitrieva, Y, Strotdrees, E, Mohr, FW, Antonini-Canterin, F, Luzza, G, Caruso, R, Belfiore, R, Della Mattia, A, Poli, S, Vriz, O, Zito, C, La Carrubba, S, Carerj, S, Ribeiro, JM, Teixeira, R, Goncalves, L, Morgado, GJ, Carvalho, JF, Gomes, AC, Caldeira, D, Cruz, IR, Stuart, B, Maia, R, Fazendas, P, Pereira, H, Trifunovic, D, Rakocevic, I, Tutos, V, Petrovic, O, Petrovic, M, Boricic-Kostic, M, Stepanovic, J, Jovanovic, I, Banovic, M, Vujisic-Tesic, B, Reis, L, Teixeira, R, Leite, L, Fernandes, A, Cassandra, M, Madeira, M, Botelho, A, Santos, M, Nascimento, J, Goncalves, L, Naratrekoon, B, Yingchoncharoen, T, Vathesatogkit, P, Yamwong, S, Sritara, P, Soto-Ruiz, RM, Bonaque Gonzalez, J C, Abellan-Huerta, J, Rubio-Paton, R, Soria, F, Ramos, JL, Egea, S, Garcia-Gomez, J, Martinez Diaz, JJ, Castillo, JA, Penicka, M, Vecera, J, Mirica, C, Kotrc, M, Kockova, R, Zilberszac, R, Gabriel, H, Maurer, G, Rosenhek, R, De Chiara, B, Botta, L, Musca, F, Belli, O, Costetti, A, Trolese, I, Spano, F, Russo, C, Giannattasio, C, Moreo, A, Rifai, R, Berthelot, E, Le, MT, Hilpert, L, Montani, D, Sitbon, O, Jais, X, Humbert, M, Assayag, P, Gunduz, S, Yesin, M, Kalcik, M, Gursoy, MO, Cersit, S, Astarcioglu, MA, Karakoyun, S, Aykan, AC, Ozkan, M, Cersit, S, Gunduz, S, Tabakci, M, Kalcik, M, Yesin, M, Bayam, E, Ozkan, M, Devecchi, C, Degiovanni, A, Di Ruocco, MV, Marino, P, Ancona, F, Rosa, I, Stella, S, Barletta, M, Marini, C, Latib, A, Montorfano, M, Colombo, A, Margonato, A, Agricola, E, Smith, D, Ray, R, Gallagher, M, Nazir, M, Perreso, V, Sharma, R, Gargani, L, Pang, PS, Miglioranza, M, Landi, P, Dini, FL, Picano, E, Asmarats Serra, L, Pons Llinares, J, Macaya Ten, F, Pericas Ramis, P, Caldes Llull, O, Grau Sepulveda, A, Frontera, G, Bethencourt, A, Abreu, A, Santa Clara, H, Santos, V, Oliveira, M, Cunha, P, Portugal, G, Rio, P, Branco, L, Ferreira, R, Mota Carmo, M, Ikonomidis, I, Paraskevaidis, I, Papadopoulos, C, Stasinos, V, Parissis, J, Lekakis, J, Biernacka, B, Rubis, P, Gackowski, A, Wisniowska-Smialek, S, Lesniak-Sobelga, A, Kostkiewicz, M, Gomes, AC, Bento, D, Correia, E, Teles, L, Picarra, B, Lourenco, C, Faria, R, Magalhaes, P, Domingues, K, Azevedo, O, Caballero, L, Climent Paya, V, Martinez Moreno, M, Gimeno, JR, Oliva, MJ, Saura, D, Sanchez Quinones, J, Garcia Honrubia, A, Valdes, M, De La Morena, G, Mansencal, N, Richard, P, Guerard, S, Brion, R, Paul, P, Dubourg, O, Komajda, M, Isnard, R, Arslan, M, Charron, P, Venturini, C, Avegliano, G, Andres, S, Costabel, JP, Kuschnir, P, Sciancalepore, A, Mendoza, O, Perea, G, Ronderos, R, Zaroui, A, Ben Said, RYM, EL Chalbia, TEJ, Wali, SANA, Mourali, MS, Mechmeche, RACHID, Leren, I S, Saberniak, J, Haland, TF, Edvardsen, T, Haugaa, KH, Astrom Aneq, M, Svetlichnaya, J S, Shikha, SS, Scheinmann, MS, Klein, LK, Nucifora, G, Prati, G, Vitrella, G, Allocca, G, Cukon Buttignoni, S, Muser, D, Morocutti, G, Pinamonti, B, Sinagra, G, Proclemer, A, Rocon, CRLA, Melo, MDTM, Bocchi, EAB, Araujo, JABAF, Demarchi, LMMFD, Mady, CM, Biselli, BB, Kalil, RKF, Salemi, VMCS, Tuma, RT, Cho, J Y, Kim, K H, Yoon, H J, Lee, K J, Park, H, Kim, J H, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Cho, J Y, Kim, K H, Yoon, H J, Park, H J, Kim, J H, Ahn, Y, Jeong, M H, Cho, J G, Park, J C, Sade, LE, Kozan, H, Eroglu, S, Pirat, B, Sezgin, A, Aydinalp, A, Muderrisoglu, H, Stampfli, S F, Oezkartal, T, Bernhart, S, Flammer, AJ, Vecchiati, A, Froehlich, GM, Ruschitzka, F, Tanner, FC, Cho, EJ, Choi, KY, Kim, DB, Jang, SW, Cho, JS, Park, CS, Jung, HO, Jeon, HK, Youn, HJ, Stevanovic, A, Dekleva, M, Pena, J L, Fortes, PRL, Passos, BR, Rodrigues, AB, Sampaio, IH, Oliveira, MCN, Silva, MG, Cardoso, RAF, Tofani, FA, Moreira, MCV, Ognibeni, F, Cioffi, G, Viapiana, O, Dalbeni, A, Fracassi, E, Di Nora, C, Cherubini, A, Mazzone, C, Di Lenarda, A, Rossini, M, Colunga, S, Corros, C, Garcia-Campos, A, Martin, M, Rodriguez-Suarez, M, Leon, V, Fidalgo, A, Lopez-Iglesias, F, Moris, C, De La Hera, JM, Borowiec, A, Dabrowski, R, Wozniak, J, Jasek, S, Chwyczko, T, Kowalik, I, Musiej-Nowakowska, E, Szwed, H, Hristova, K, Marinov, R, Stamenov, G, Mihova, M, Chacheva, K, Persenska, S, Racheva, A, Kosmala, W, Przewlocka-Kosmala, M, Rojek, A, Karolko, B, Mysiak, A, Marwick, TH, Lesniak-Sobelga, A M, Kostkiewicz, M, Wisniowska-Smialek, S, Biernacka, B, Rubis, P, Kaldararova, M, Tittel, P, Kardos, M, Vrsanska, V, Ondriska, M, Hraska, V, Nosal, M, Masura, J, Simkova, I, Stanojevic, D, Apostolovic, S, Salinger-Martinovic, S, Jankovic-Tomasevic, R, Djordjevic-Radojkovic, D, Stanojlovic, T, Atanaskovic, V, Pavlovic, M, Tahirovic, E, Dungen, HD, Carbonell San Roman, A, Moya Mur, JL, Rodriguez-Munoz, D, Lozano Granero, C, Jimenez Nacher, JJ, Gonzalez Gomez, A, Fraile Sanz, C, Segura De La Cal, T, Fernandez-Golfin, C, Zamorano Gomez, JL, Hoetink, A, Jansen Klomp, WW, Van 'T Hof, AWJ, Brandon Bravo Bruinsma, GJ, Spanjersberg, AJ, Grandjean, J, Nierich, AP, Ferreira, R, Ferreira, J, Lazaro Mendes, S, Martins, R, Monteiro, S, Pego, M, Rohani, A, Khamene Bagheri, R, Wierzbowska-Drabik, K, Peruga, JZ, Sobczak, M, Plewka, M, Wcislo, T, Krecki, R, Kasprzak, JD, Carvalho, J F, Morgado, G, Cruz, I, Caldeira, D, Almeida, AR, Joao, I, Lopes, L, Fazendas, P, Cotrim, C, Pereira, H, Cherubini, A, Cioffi, G, Mazzone, C, Faganello, G, Pandullo, C, Russo, G, Stefenelli, C, Furlanello, F, Tarantini, L, Di Lenarda, A, Teramoto, K, Suzuki, K, Satoh, Y, Minami, K, Mizukoshi, K, Kamijima, R, Kou, S, Takai, M, Izumo, M, Akashi, YJ, May, CJH, Ayuk, J, Geh, I, Shah, T, Edwards, NC, Steeds, RP, Wejner-Mik, P, Sobczak, M, Miskowiec, D, Wdowiak-Okrojek, K, Kasprzak, JD, Lipiec, P, Gurzun, M M, Rosca, M, Calin, A, Beladan, C, Serban, M, Ginghina, C, Popescu, BA, Perea, GO, Lombardero, M, Henquin, R, Corneli, M, Tinetti, M, Laveau, F, Hekimian, G, Achkar, M, Isnard, R, Combes, A, Hammoudi, N, Mahmoud, HM, Al-Ghamdi, M, Ghabashi, A, Ezzat, M H, Al-Amin, A, Sanz, M, Giraldeau, G, Sarvari, SI, Marin, J, Brambila, C, Gabrielli, L, Bijnens, B, Sitges, M, Sanchez-Martinez, S, Duchateau, N, Erdei, T, Fraser, A, Bijnens, B H, Piella, G, Montserrat, S, Sanchis, L, Borras, R, Vidal, B, Prat, S, Azqueta, M, Pare, C, Grazioli, G, Sanz, M, Sitges, M, Kowalczyk, E, Kasprzak, JD, Wejner-Mik, P, Wdowiak-Okrojek, K, Lipiec, P, Park, CS, Jung, MH, Ahn, HS, Kim, JH, Cho, JS, Jeon, HK, Youn, HJ, Hinojar, R, Fernandez-Golfin, C, Megias, A, Alonso, GL, Gonzalez-Gomez, A, Rincon, LM, Esteban, A, Fernandez Mendez, MA, Barrios, V, Zamorano, JL, Van Berendoncks, A M, Van Gaal, L, De Block, C, Salgado, R, Vrints, C, Shivalkar, B, Guedes, H, Pereira, A, Santos, R, Marques, L, Moreno, N, Carvalho, R, Pires, M, Sousa, R, Andrade, A, Pinto, P, Nestaas, E, Stoylen, A, Fugelseth, D, Onut, R, Tautu, O, Onciul, S, Marinescu, C, Zamfir, D, Dorobantu, M, Moran, L, Sanchez Sanchez, V, Navas, P, Garcia-Cosio, D, Diaz, B, Carballo-Alzola, L, Lombera, F, Delgado, J, Kisko, A, Babcak, M, Kishko, N, Agmon, Y, Eitan, A, Mutlak, D, Kehat, I, Corneli, M, Meretta, AH, Perea, GO, Belcastro, F, Aguirre, E, Rosa, D, Zaefferer, P, Masoli, O, Peovska Mitevska, IPM, Srbinovska, ES, Bosevski, MB, Antova, EA, Pop Gorceva, DPG, Barreiro Perez, M, Martin Fernandez, M, Costilla Garcia, SM, Diaz Pelaez, E, and Moris De La Tassa, C

Abstract

Background: The attainment of the primary (low density lipoprotein cholesterol; LDL-C) and the secondary (non-high density lipoprotein cholesterol; non-HDL) lipid therapeutic targets may depend on several potential factors. Our aim was assess the associations between ultrasound fat indexes, lipid levels and the lipid goals attainment in high and very high cardiovascular (CV) risk patients. Methods: Four hundred twenty (n=420) patients (F/M=146/274; age=61 ± 7 y.o.) with high (43%) or very high (57%) cardiovascular risk and chronic statin treatment (³12 months) were enrolled into the study. Obesity measures (body-mass index, BMI; bioelectrical impedance body fat; BF, waist circumference, WC, body adiposity index; BAI), serum levels of lipids (total cholesterol–TC, LDL-C, HDL-C and triglycerides–TG) and goal lipid levels (LDL-C and non-HDL-C) according to the CV risk were determined in all patients. The following ultrasound fat parameters were used in the study: intraabdominal fat (IAT), preperitoneal fat thickness (PreFT), epicardial (EFT) and pericardial (PFT) fat thickness and were indexed to BMI. Results: Our study patients had 5.2 ± 1.7 CV risk factors (80% hypertension, 32% diabetes, 59% metabolic syndrome), 49% were obese, 63% had high BF% and 85% had increased waist circumference (F>80 or M>94cm). All the patients were on a long-term statin treatment (rosuvastatin, atorvastatin or simvastatin). The attainment of the target lipid levels in the study group was as follows: LDL-C–34%, non-HDL-C–39%, both LDL-C and non-HDL-C 31%. Mean fat parameters in the study group were as follows: IAT–76.4 ± 26mm, PreFT–23.3 ± 6.5mm, EFT–3.5 ± 1.5mm and PFT–8.6 ± 3.8mm. Patients with LDL-C goal attainment had significantly higher BAI (34.6 ± 33 vs 30.5 ± 7, p=0.04), but significantly lower IAT/BMI (2.35 ± 0.7 vs 2.51 ± 0.7, p<0.05) with no differences in other clinical (BMI, BF%, WC) and ultrasound (PreFT/BMI, EFT/BMI, PFT/BMI) indexes. The LDL-C goal achievement revealed inverse association with IAT/BMI (r=-0.15, p<0.05) and no associations with PreFT/BMI, EFT/BMI or PFT/BMI. Multivariable regression analysis revealed independent association between IAT/BMI and the LDL-C goal achievement. Conclusions: Intraabdominal fat thickness representing visceral adipose tissue is inversely associated with the LDL-C goal attainment independently from general obesity. It may help to identify individuals requiring more aggressive management of dylipidaemia.

Published
2015
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26. Poster session 1: Wednesday 3 December 2014, 09:00-16:00 * Location: Poster area

Author

Tong, L, Huang, C, Ramalli, A, Tortoli, P, Luo, J, D'hooge, J, Tzemos, N, Mordi, I, Bishay, T, Bishay, T, Negishi, T, Hristova, K, Kurosawa, K, Bansal, M, Thavendiranathan, P, Yuda, S, Popescu, BA, Vinereanu, D, Penicka, M, Marwick, TH, study, SUCCOUR, Hamed, W, Kamel, MKA, Yaseen, RIY, El-Barbary, HSE, Nemes, A, Kis, O, Gavaller, H, Kanyo, E, Forster, T, Angelis, A, Vlachopoulos, C, Ioakimidis, N, Felekos, I, Chrysohoou, C, Aznaouridis, K, Abdelrasoul, M, Terentes, D, Ageli, K, Stefanadis, C, Kurnicka, K, Domienik-Karlowicz, J, Lichodziejewska, B, Goliszek, S, Grudzka, K, Krupa, M, Dzikowska-Diduch, O, Ciurzynski, M, Pruszczyk, P, Gual Capllonch, F, Lopez Ayerbe, J, Teis, A, Ferrer, E, Vallejo, N, Junca, G, Pla, R, Bayes-Genis, A, Schwaiger, JP, Knight, DS, Gallimore, A, Schreiber, BE, Handler, C, Coghlan, JG, Bruno, R M, Giardini, G, Malacrida, S, Catuzzo, B, Armenia, S, Brustia, R, Ghiadoni, L, Cauchy, E, Pratali, L, Kim, KH, Lee, KJ, Cho, JY, Yoon, HJ, Ahn, Y, Jeong, MH, Cho, JG, Park, JC, Cho, SK, Nastase, O, Enache, R, Mateescu, AD, Botezatu, D, Popescu, BA, Ginghina, C, Gu, H, Sinha, MD, Simpson, JM, Chowienczyk, PJ, Fazlinezhad, A, Tashakori Behesthi, AHMAD, Homaei, FATEME, Mostafavi, H, Hosseini, G, Bakaeiyan, M, Boutsikou, M, Petrou, E, Dimopoulos, A, Dritsas, A, Leontiadis, E, Karatasakis, G, Sahin, S T, Yurdakul, S, Yilmaz, N, Cengiz, B, Cagatay, Y, Aytekin, S, Yavuz, S, Karlsen, S, Dahlslett, T, Grenne, B, Sjoli, B, Smiseth, OA, Edvardsen, T, Brunvand, H, Nasr, G, Nasr, A, Eleraki, A, Elrefai, S, Mordi, I, Sonecki, P, Tzemos, N, Gustafsson, U, Naar, J, Stahlberg, M, Cerne, A, Capotosto, L, Rosato, E, D'angeli, I, Azzano, A, Truscelli, G, De Maio, M, Salsano, F, Terzano, C, Mangieri, E, Vitarelli, A, Renard, S, Najih, H, Mancini, J, Jacquier, A, Haentjens, J, Gaubert, JY, Habib, G, Caminiti, G, D'antoni, V, D'antoni, V, Cardaci, V, Cardaci, V, Conti, V, Conti, V, Volterrani, M, Volterrani, M, Ahn, J, Kim, DH, Lee, HO, Iliuta, L, Kim, SY, Ryu, S, Ko, CW, Pyun, YS, Yoon, SJ, Lo Iudice, F, Esposito, R, Lembo, M, Santoro, C, Ballo, PC, Mondillo, S, De Simone, G, Galderisi, M, Hwang, YM, Kim, JH, Kim, JH, Moon, KW, Yoo, KD, Kim, CM, Tagliamonte, E, Rigo, F, Cirillo, T, Caruso, A, Astarita, C, Cice, G, Quaranta, G, Romano, C, Capuano, N, Calabro', R, Zagatina, A, Zhuravskaya, N, Guseva, O, Huttin, O, Benichou, M, Voilliot, D, Venner, C, Micard, E, Girerd, N, Sadoul, N, Moulin, F, Juilliere, Y, Selton-Suty, C, Baron, T, Christersson, C, Johansson, K, Flachskampf, FA, Lee, S, Lee, J, Hur, S, Park, J, Yun, JY, Song, SK, Kim, WH, Ko, JK, Nyktari, E, Bilal, S, Ali, SA, Izgi, C, Prasad, SK, Aly, MFA, Kleijn, SAK, Kandil, HIK, Kamp, OK, Beladan, CC, Calin, A, Rosca, M, Craciun, AM, Gurzun, MM, Calin, C, Enache, R, Mateescu, A, Ginghina, C, Popescu, BA, Mornos, C, Mornos, A, Ionac, A, Cozma, D, Crisan, S, Popescu, I, Ionescu, G, Petrescu, L, Camacho, S, Gamaza Chulian, S, Carmona, R, Diaz, E, Giraldez, A, Gutierrez, A, Toro, R, Benezet, J, Antonini-Canterin, F, Vriz, O, La Carrubba, S, Poli, S, Leiballi, E, Zito, C, Careri, S, Caruso, R, Pellegrinet, M, Nicolosi, GL, Kong, W, Kyu, K, Wong, R, Tay, E, Yip, J, Yeo, TC, Poh, KK, Correia, M, Delgado, A, Marmelo, B, Correia, E, Abreu, L, Cabral, C, Gama, P, Santos, O, Rahman, MT, Borges, I P, Peixoto, ECS, Peixoto, RTS, Peixoto, RTS, Marcolla, VF, Okura, H, Kanai, M, Murata, E, Kataoka, T, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Generati, G, Bandera, F, Pellegrino, M, Alfonzetti, E, Labate, V, Guazzi, M, Kuznetsov, VA, Yaroslavskaya, EI, Pushkarev, GS, Krinochkin, DV, Zyrianov, IP, Carigi, S, Baldazzi, F, Bologna, F, Amati, S, Venturi, P, Grosseto, D, Biagetti, C, Fabbri, E, Arlotti, M, Piovaccari, G, Rahbi, H, Bin Abdulhaq, A, Tleyjeh, I, Santoro, C, Galderisi, M, Costantino, MF, Tarsia, G, Innelli, P, Dores, E, Esposito, G, Matera, A, De Simone, G, Trimarco, B, Capotosto, L, Azzano, A, Mukred, K, Ashurov, R, Tanzilli, G, Mangieri, E, Vitarelli, A, Merlo, M, Gigli, M, Stolfo, D, Pinamonti, B, Antonini Canterin, F, Muca, M, D'angelo, GA, Scapol, S, Di Nucci, M, Sinagra, G, Behaghel, A, Feneon, D, Fournet, M, Thebault, C, Martins, RP, Mabo, P, Leclercq, C, Daubert, C, Donal, E, Davinder Pal, SINGH, Prakash Chand, NEGI, Sanjeev, ASOTRA, Rajeev, MERWAH, Ankur, DWIVED, Ram Gopal, SOOD, Mzoughi, K, Zairi, I, Jabeur, M, Ben Moussa, F, Ben Chaabene, A, Kamoun, S, Mrabet, K, Fennira, S, Zargouni, A, Kraiem, S, Demkina, AE, Hashieva, FM, Krylova, NS, Kovalevskaya, EA, Potehkina, NG, Zaroui, A, Ben Said, R, Smaali, S, Rekik, B, Ben Hlima, M, Mizouni, H, Mechmeche, R, Mourali, MS, Malhotra, A, Sheikh, N, Dhutia, H, Siva, A, Narain, R, Merghani, A, Millar, L, Walker, M, Sharma, S, Papadakis, M, Siam-Tsieu, V, Mansencal, N, Arslan, M, Deblaise, J, Dubourg, O, Zaroui, A, Rekik, B, Ben Said, R, Boudiche, S, Larbi, N, Tababi, N, Hannachi, S, Mechmeche, R, Mourali, MS, Mechmeche, R, Zaroui, A, Chalbia, T, Ben Halima, M, Rekik, B, Boussada, R, Mourali, MS, Chistyakova, M V, Govorin, AV, Radaeva, EV, Lipari, P, Bonapace, S, Valbusa, F, Rossi, A, Zenari, L, Lanzoni, L, Targher, G, Canali, G, Molon, G, Barbieri, E, Novo, G, Giambanco, S, Sutera, MR, Bonomo, V, Giambanco, F, Rotolo, A, Evola, S, Assennato, P, Novo, S, Budnik, M, Piatkowski, R, Kochanowski, J, Opolski, G, Chatzistamatiou, E, Mpampatseva Vagena, I, Manakos, K, Moustakas, G, Konstantinidis, D, Memo, G, Mitsakis, O, Kasakogias, A, Syros, P, Kallikazaros, I, Park, SM, Kim, SA, Kim, MN, Shim, WJ, Marketou, M, Parthenakis, F, Kalyva, N, Pontikoglou, CH, Maragkoudakis, S, Zacharis, E, Patrianakos, A, Maragoudakis, F, Papadaki, H, Vardas, P, Rodrigues, AC, Perandini, LA, Souza, TR, Sa-Pinto, AL, Borba, E, Arruda, AL, Furtado, M, Carvalho, F, Bonfa, E, Andrade, JL, Hlubocka, Z, Malinova, V, Palecek, T, Danzig, V, Kuchynka, P, Dostalova, G, Zeman, J, Linhart, A, Chatzistamatiou, E, Konstantinidis, D, Memo, G, Mpampatzeva Vagena, I, Moustakas, G, Manakos, K, Trachanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Corut, H, Sade, LE, Ozin, B, Atar, I, Turgay, O, Muderrisoglu, H, Ledakowicz-Polak, A, Polak, L, Krauza, G, Zielinska, M, Szulik, M, Streb, W, Wozniak, A, Lenarczyk, R, Sliwinska, A, Kalarus, Z, Kukulski, T, Nogueira, MA, Branco, LM, Agapito, A, Galrinho, A, Borba, A, Teixeira, PP, Monteiro, AV, Ramos, R, Cacela, D, Cruz Ferreira, R, Guala, A, Camporeale, C, Tosello, F, Canuto, C, Ridolfi, L, Chatzistamatiou, E, Moustakas, G, Memo, G, Konstantinidis, D, Mpampatzeva Vagena, I, Manakos, K, Traxanas, K, Vergi, N, Feretou, A, Kallikazaros, I, Hristova, K, Marinov, R, Stamenov, G, Mihova, M, Persenska, S, Racheva, A, Plaskota, KJ, Trojnarska, O, Bartczak, A, Grajek, S, Ramush Bejiqi, RA, Retkoceri, R, Bejiqi, H, Beha, A, Surdulli, SH, Seya, M, Sasaoka, T, Hirasawa, K, Yoshikawa, S, Maejima, Y, Ashikaga, T, Hirao, K, Isobe, M, none, Dreyfus, J, Durand-Viel, G, Cimadevilla, C, Brochet, E, Vahanian, A, Messika-Zeitoun, D, Jin, CN, Fang, F, Meng, FX, Kam, K, Sun, JP, Tsui, GK, Wong, KK, Wan, S, Yu, CM, Lee, AP, Cho, I J, Chung, HM, Heo, R, Ha, SJ, Hong, GR, Shim, CY, Chang, HJ, Ha, JW, Chung, N, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Moral, S, Gruosso, D, Galuppo, V, Teixido, G, Rodriguez-Palomares, JF, Gutierrez, L, Evangelista, A, Alexopoulos, Alexan, Dawson, David, Nihoyannopoulos, Petros, Zainal Abidin, H A, Ismail, JOHAN, Arshad, KAMAL, Ibrahim, ZUBIN, Lim, CW, Abd Rahman, E, Kasim, SAZZLI, Peteiro, J, Barrio, A, Escudero, A, Bouzas-Mosquera, A, Yanez, J, Martinez, D, Castro-Beiras, A, Scali, MC, Simioniuc, A, Mandoli, GE, Lombardo, A, Massaro, F, Di Bello, V, Marzilli, M, Dini, FL, Adachi, H, Tomono, J, Oshima, S, Merchan Ortega, G, Bravo Bustos, D, Lazaro Garcia, R, Sanchez Espino, AD, Macancela Quinones, JJ, Ikuta, I, Ruiz Lopez, MF, Valencia Serrano, FM, Bonaque Gonzalez, JC, Gomez Recio, M, Romano, G, D'ancona, G, Pilato, G, Di Gesaro, G, Clemenza, F, Raffa, G, Scardulla, C, Sciacca, S, Lancellotti, P, Pilato, M, Addetia, K, Takeuchi, M, Maffessanti, F, Weinert, L, Hamilton, J, Mor-Avi, V, Lang, RM, Sugano, A, Seo, Y, Watabe, H, Kakefuda, Y, Aihara, H, Nishina, H, Ishizu, T, Fumikura, Y, Noguchi, Y, Aonuma, K, Luo, XX, Fang, F, Lee, APW, Shang, Q, Yu, CM, Sammut, E C, Chabinok, R, Jackson, T, Siarkos, M, Lee, L, Carr-White, G, Rajani, R, Kapetanakis, S, Byrne, D, Walsh, JP, Ellis, L, Mckiernan, S, Norris, S, King, G, Murphy, RT, Hristova, K, Katova, TZ, Simova, I, Kostova, V, Shuie, I, Ferferieva, V, Bogdanova, V, Castelon, X, Nemes, A, Sasi, V, Domsik, P, Kalapos, A, Lengyel, C, Orosz, A, Forster, T, Grapsa, J, Demir, O, Dawson, D, Sharma, R, Senior, R, Nihoyannopoulos, P, Pilichowska, E, Zaborska, B, Baran, J, Stec, S, Kulakowski, P, Budaj, A, Herrera, J E, Palacios, I F, Mendoza, I, Marquez, J A, Herrera, J A, Octavio, J A, Dempaire, G, Rotolo, M, Kosmala, W, Kaye, G, Saito, M, Negishi, K, Marwick, TH, Maceira Gonzalez, A M, Ripoll, C, Cosin-Sales, J, Igual, B, Salazar, J, Belloch, V, Dulai, R S, Taylor, A, and Gupta, S

Abstract

Purpose: We have previously demonstrated that multi-line transmit (MLT) beam forming can provide high quality full field-of-view (90° sector) B-mode images at very high frame rates, i.e. up to 500 fps. The purpose of this study was to test the feasibility of this technique in imaging the mechanical intraventricular waves such as the one associated with activation of the left ventricle. Methods: A dedicated pulse sequence using MLT was implemented on the ULA-OP research scanner equipped with a 2.0 MHz phased array to obtain 90° sector images at a frame rate of 436 fps. The left ventricle of a healthy volunteer was imaged from the apical 4 chamber view and the RF data was acquired. Subsequently, the strain rate was extracted from the RF data using a normalized cross-correlation method. Results: As expected, during the early filling phase, myocardium lengthening (positive strain rate) was observed propagating from the base of the septum to the apex and back (Figure a). A similar wave was detected in the lateral wall, although a brief shortening (negative strain rate) was detected in the mid-wall which could be the result of reverberations (Figure b). During isovolumetric contraction, the septal wall shortened before the lateral wall (as expected) - moreover - there seemed to be an intra-wall base-apex shortening gradient (Figure c and d). Conclusions: Our preliminary results show that visualization of the cardiac mechanical activation could be feasible using MLT based high frame rate imaging. Further research is required to examine this in depth, which is the topic of on-going work. Figure Curved M-mode of strain rate

Published
2014
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27. Sperm selection by zona adhesion improves assisted reproductive treatment outcomes.

Author

Ganeva R, Parvanov D, Vidolova N, Handzhiyska M, Ruseva M, Vasileva M, Nikolova K, Ivanova I, Shaban M, Shabarkova J, Hristova R, Miladinova M, and Stamenov G

Subjects
Humans, Female, Male, Pregnancy, Adult, Spermatozoa physiology, Treatment Outcome, Embryo Implantation physiology, Abortion, Spontaneous, Zona Pellucida physiology, Sperm Injections, Intracytoplasmic methods, Pregnancy Rate
Abstract

Background: Zona pellucida is one of the main selective barriers for the spermatozoa before reaching the oocyte. Using native zona in the sperm selection prior to Intracytoplasmic Sperm Injection (ICSI) has been proven effective but inconvenient approach in In Vitro Fertilisation (IVF) laboratory. The application of autologous solubilised zonae pellucidae in the sperm selection prior to ICSI has not been studied yet., Objectives: To compare the assisted reproductive treatment (ART) outcomes (implantation, pregnancy, live birth, and miscarriage rates) after ICSI performed with spermatozoa selected on their ability to adhere to immobilised solubilised zonae pellucidae and conventionally selected spermatozoa., Materials and Methods: In total, 500 couples fulfilled the inclusion criteria and 368 of them were included in the study. After random allocation, 192 couples had spermatozoa selected by sperm-zona adhesion for ICSI (study group) and 176 patients underwent standard ICSI (control group). In the study group, patients' own zonae were acid solubilised and immobilised on petri dishes. The partner's motile spermatozoa were placed in the dishes and the adhered spermatozoa were used for ICSI. For the control group, the conventional sperm selection by morphological criteria was applied prior ICSI. All women underwent frozen ET with euploid embryos. Chi square test was used to compare the data., Results: The sperm selection by zona adhesion resulted in significantly higher implantation rate (50.4% vs. 37.0%, p = 0.003), clinical pregnancy rate (43.8% vs. 33.3%, p = 0.018) and live birth rate (38.0% vs. 25.9%, p = 0.004) and significantly lower incidence of miscarriage (11.3% vs. 22.2%, p = 0.044) in comparison to the conventional method of the sperm selection., Discussion and Conclusion: The application of solubilised zonae pellucidae in the sperm selection for ICSI benefits ART outcomes in couples with unexplained infertility. Moreover, sperm-zona selection significantly reduces the risk of miscarriages., (© 2024 American Society of Andrology and European Academy of Andrology.)

Published
2024
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28. NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions.

Author

Metodiev D, Parvanov D, Ruseva M, Ganeva R, Handzhiyska M, Vidolova N, Chavoushian A, Hadjidekova S, and Stamenov G

Abstract

Adenomyosis and endometriosis are distinct gynecological disorders characterized by ectopic growth of endometrial tissue. Their etiology remains unclear, but stem cells have been implicated in both. The aim of this study was to investigate and compare the quantity of NOTCH1+ and CD117+ stem cells in endometriosis and adenomyosis lesions. Immunohistochemical staining of ectopic endometrium biopsies using antibodies against NOTCH1 and CD117 was performed. The quantity and spatial distribution of endometrial stromal cells positive for these markers were determined and compared between endometriosis and adenomyosis lesions. Additionally, their quantities were compared between endometriosis lesion types. Mann-Whitney U test showed that the median percentages of both NOTCH1+ and CD117+ cells in the endometriosis lesions were significantly higher than those in the adenomyosis lesions (2.26% vs. 0.13%, p = 0.002 and 0.44% vs. 0.26%, p = 0.016, respectively). Spearman's test showed a positive correlation between NOTCH1+ and CD117+ cells in endometriosis lesions (R = 0.45, p = 0.027) but no significant correlation in adenomyosis lesions (R = -0.11, p = 0.69). The quantity of both stem cell types was highest in extragenital endometriotic lesions. Unlike adenomyosis, endometriosis lesions are associated with higher quantities of NOTCH1+ and CD117+ stem cells and a coordinated increase in their number. These findings support the distinct origin of the two conditions.

Published
2024
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29. Cumulus matrix selection leads to isolation of spermatozoa with better motility, morphology, and lower DNA fragmentation.

Author

Handzhiyska M, Ganeva R, Parvanov D, Ruseva M, Eftimov P, Georgieva V, Velikova D, and Stamenov G

Abstract

The objective of this study was to compare the motility, morphology, and levels of DNA fragmentation of spermatozoa subjected to conventional swim-up or cumulus matrix (CM) sperm selection. Semen samples were collected from 60 normozoospermic men at a private hospital between December 2021 and March 2022. After liquefaction, semen samples were separated into two portions - one part was subjected to conventional swim-up preparation and the remaining spermatozoa were subjected to CM selection. The CM was obtained by mechanical isolation from healthy donor oocytes. Semen analysis and evaluation of sperm were performed according to WHO 6th Edition Laboratory Manual and Kruger's strict criteria, respectively. Sperm DNA fragmentation (SDF, %) of the two preparations was evaluated using Halosperm G2 detection kit (Halotech, Madrid, Spain). Wilcoxon rank-sum test was used to compare the characteristics of spermatozoa obtained by the two preparations. Spermatozoa selected by CM showed significantly better rapidly progressive motility (43.5% vs. 30.6%, respectively, p<0.001), higher percentage of morphologically normal forms (14.0% vs. 9.0%, respectively, p<0.05), and lower levels of SDF (26.0% vs. 45.0%, p<0.05) in comparison to those prepared by conventional swim-up. Moreover, the incidence of multiple sperm defects was considerably lower in the samples that underwent CM selection compared to those that did not (30.0% vs. 49.0%, respectively, p<0.05).The selection by CM significantly increases sperm motility and reduces morphologically abnormal spermatozoa and DNA fragmentation rates in comparison to the conventional swim-up preparation. The application of this selection technique may increase chances of successful IVF outcomes.

Published
2024
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30. NOTCH1- and CD117-positive stem cells in human endometrium and their implications for successful implantation.

Author

Ruseva M, Parvanov D, Ganeva R, Handzhiyska M, Vidolova N, Metodiev D, and Stamenov G

Subjects
Humans, Female, Prospective Studies, Endometrium, Estradiol metabolism, Stem Cells, Receptor, Notch1 metabolism, Progesterone metabolism, Embryo Implantation physiology
Abstract

Objective: To investigate the quantity of 2 stem cell types in the endometrial stroma of women undergoing in vitro fertilization and their association with steroid hormone signaling and implantation success after embryo transfer., Design: Prospective cohort study., Setting: Private hospital., Patient(s): A total of 109 patients undergoing in vitro fertilization., Intervention(s): Not applicable., Main Outcome Measure(s): Immunohistochemistry staining of endometrial biopsies taken during the midluteal phase using antibodies against NOTCH1 and CD117 was performed. The percentage of endometrial stromal cells positive for these markers was determined. The link of these stem cell percentages with the serum progesterone and estradiol levels and the endometrial expression of their respective receptors were assessed. After embryo transfer, the quantity of stained cells for each marker was also compared according to implantation outcome., Result(s): The percentage of NOTCH1+ stromal cells ranged from 0.003%-2.112% (median, 0.062%) and was significantly higher than that of CD117+ cells, which ranged from 0.000%-0.210% (median, 0.020%) (Z = -7.035). The percentage of NOTCH1+ stem cells showed no difference between the studied serum hormone level groups and no relationship with the expression of their receptors in the endometrium. In contrast, the number of CD117+ cells significantly differed between patients with high and low levels of serum progesterone (cutoff, 14.9 ng/mL) and estradiol (cutoff, 135.6 pg/mL). Furthermore, the quantity of CD117+ stem cells was positively correlated with the progesterone receptor (R = 0.277) and estradiol receptor (R= 0.318) expression levels in the endometrium. Although the quantity of NOTCH1+ cells did not differ between the 2 implantation groups, the median percentage of CD117+ cells was significantly higher in patients with successful implantation than in those with unsuccessful implantation (0.03% vs. 0.01%, respectively). The cutoff value for the percentage of CD117+ cells predicting successful implantation was 0.018% (area under the curve, 0.66; 95% confidence interval, 0.56-0.77; sensitivity, 63.1%; specificity, 61.4%)., Conclusion(s): This study indicates that the quantity of certain stem cell types (CD117+), but not others (NOTCH1+), in the functional endometrium is associated with implantation success and sex hormone signaling during the midluteal phase. These findings highlight the role of CD117+ cells in preparing the endometrium for embryo implantation, and their quantity may be an indirect indicator of endometrial receptivity., (Copyright © 2023 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2023
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31. Endometrial immune cell ratios and implantation success in patients with recurrent implantation failure.

Author

Ganeva R, Parvanov D, Vidolova N, Ruseva M, Handzhiyska M, Arsov K, Decheva I, Metodiev D, Moskova-Doumanova V, and Stamenov G

Subjects
Humans, Female, Adult, Middle Aged, Embryo Transfer, Reproductive Techniques, Assisted, Killer Cells, Natural, Embryo Implantation, Endometrium
Abstract

The objective of this study was to compare the endometrial immune cells quantities and ratios during the mid-luteal phase between women with recurrent implantation failure (RIF) with successful and unsuccessful embryo implantation. For this purpose, endometrial biopsies from 116 women aged between 29 and 46 with history of RIF undergoing Assisted Reproductive Technology (ART) without endometrial pathologies were immunohistochemically stained for CD3 + T-cells, CD4 + T-helpers, CD8 + T-killers, CD14 + monocytes, CD68 + macrophages, CD56 + NK cells and CD79α+ B-cells. Endometrial immune cells quantities and ratios were compared based on the embryo implantation outcome in the subsequent embryo transfer cycle. Spearman correlation analysis and Mann-Whitney U test were used to analyse the obtained data. Patients who experienced successful implantation at the subsequent cycle had significantly lower percentage of CD3 + T cells, and higher ratios of CD4 + /CD8 + , CD4 + /CD3 + and CD68 + /CD3 + than the patients who experienced another failure in implantation. In addition, the ratios of CD3 + /CD14 + , CD79α+ /CD14 + and CD56 + /CD14 + were significantly lower in the successful implantation group than that in the unsuccessful one. A cut off value of CD68 + /CD3 + ratio higher than 0.85 (AUC 0.67, 95% CI 0.56-0.79), CD4 + /CD3 + ratio higher than 0.19 (AUC 0.67, 95% CI 0.56-0.79) and CD4 + /CD8 + ratio higher than 0.43 (AUC 0.62, 95% CI 0.50-0.73) could be predictive factors for successful implantation in RIF patients. Knowledge on the immune cell composition could assist in the evaluation of the endometrial receptivity in RIF patients., Competing Interests: Declaration of Competing Interest The autors agree that they have no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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32. Vertical Transmission of SARS-CoV-2 Infection and Miscarriage in the Second Trimester: Report of an Immunohistochemically Proven Case.

Author

Metodiev D, Ruseva M, Parvanov D, Ganeva R, Handzhiyska M, Vidolova N, and Stamenov G

Abstract

It is an acknowledged fact that SARS-CoV-2 exhibits tropism for the human placenta. A possible mechanism of SARS-CoV-2 entry into host cells is via angiotensin-converting enzyme 2 (ACE2) receptors, which are expressed in trophoblasts, endothelial cells, and macrophages. The present study describes a case of spontaneous miscarriage in the 20th gestational week after maternal SARS-CoV-2 infection. The placenta and various fetal organs were examined for structural alterations and expression of the viral nucleocapsid protein and several immune cell markers via immunohistochemistry (IHC). Histopathological examination of the placenta revealed acute chorioamnionitis, acute subamnionic placentitis, multiple intervillous thrombi, increased fibrinoid deposition, and necrotic changes of the chorionic villi. Immunohistochemistry confirmed the presence of SARS-CoV-2 nucleocapsid protein regions predominantly in the syncytiotrophoblast. Staining of the placental tissue for different markers helped elucidate the distribution of immune cells. Pathomorphological examination of the fetal organs demonstrated changes in microcirculation with the presence of sludge phenomenon and diapedesis haemorrhages, mostly in the lungs, brain, and myocardium. IHC staining of fetal organs revealed expression of SARS-CoV-2 nucleocapsid protein, which was detected to the highest extent in the brain, lungs, and liver. The findings of the present report support the hypothesis of possible vertical transmission of SARS-CoV-2 from mother to fetus.

Published
2022
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33. Sperm morphology and DNA fragmentation after zona pellucida selection.

Author

Ganeva R, Parvanov D, Velikova D, Vasileva M, Nikolova K, and Stamenov G

Subjects
DNA Fragmentation, Humans, Male, Sperm-Ovum Interactions, Spermatozoa, Semen, Zona Pellucida
Abstract

Sperm DNA fragmentation (SDF) and sperm morphological defects can negatively affect ART outcomes. Consequently, there is a need for additional semen processing technique that accounts for sperm DNA status and morphology prior to ICSI. The objective was to evaluate the efficacy of an additional zona pellucida adhesion-based sperm selection for obtaining sperm populations with a high percentage of normal morphology and DNA integrity as compared to native semen and routine swim-up preparation. Semen samples from 78 normozoospermic men were subjected to swim up and placed in petri dishes coated with 48 acid-solubilized zonae pellucidae. Sperm DNA fragmentation and morphology were assessed in the native semen, the swim-up samples, and the zona-adhered spermatozoa from each patient. The mean sperm DNA fragmentation of the zona-selected spermatozoa (3.5 ± 0.7%) was significantly lower than the swim-up samples (15.3 ± 5.2%) ( P   < 0.001) and native semen (24.9 ± 7.1%) ( P   < 0.001). All of the samples had lower levels of DNA damage after additional selection by zona pellucida adhesion. Significantly higher percentage of sperm with normal morphology was observed after zona-adhesion selection (11.4 ± 3.9%) when compared to the swim-up samples (8.9 ± 4.3%) ( P   < 0.001) or the native semen (5.3 ± 3.2%) ( P   < 0.001). In 94% of the samples, the percentage of spermatozoa with normal morphology increased after the additional zona selection. This study demonstrates that sperm selection by additional zona-adhesion technique yields a significantly higher percentage of spermatozoa with normal morphology as well as a significantly decreased level of DNA fragmentation when compared to the native semen and the swim-up-only prepared samples., Lay Summary: High level of DNA folding known as sperm DNA fragmentation (SDF) inside each sperm and defects in the shape, size, and structure of the sperm can negatively affect assisted reproduction treatment (ART) outcomes. Consequently, there is a need for additional semen processing techniques that account for sperm quality prior to ART. Our team designed a simple technique using proteins from the coat around the egg (zona pellucida) to enhance sperm selection procedures based on natural sperm-egg interactions. Using this technique in combination with the most common techniques used in ART yields a significantly higher percentage of sperm with normal shape, size, and structure and a decreased level of DNA fragmentation. This sperm zona-selection technique would be beneficial if introduced in the ART practice to yield sperm with higher fertilization potential., (© The authors.)

Published
2021
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34. Decreased number of p16-positive senescent cells in human endometrium as a marker of miscarriage.

Author

Parvanov D, Ganeva R, Vidolova N, and Stamenov G

Subjects
Abortion, Habitual epidemiology, Abortion, Habitual metabolism, Adult, Bulgaria epidemiology, Embryo Implantation, Endometrium metabolism, Female, Fertilization in Vitro methods, Humans, Middle Aged, Pregnancy, Prospective Studies, Young Adult, Abortion, Habitual diagnosis, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16 metabolism, Embryo Transfer methods, Endometrium pathology, Infertility, Female therapy, Live Birth epidemiology
Abstract

Purpose: The aim of this study was to evaluate whether the number of p16-positive cells in the functional layer of the endometrium could be a useful biomarker to identify women with recurrent implantation failure (RIF) undergoing in vitro fertilization (IVF) at risk of miscarriage., Methods: Immunohistochemical staining was performed in 311 endometrial biopsies taken during mid-luteal phase using antibody against p16 INK4A . The percentage of p16-positive cells was determined in luminal, glandular and stromal endometrial cells. After embryo transfer, women were divided into the following groups: unsuccessful embryo implantation (n = 151), miscarriage (n = 66) and live birth (n = 94). The percentage of p16-positive cells in all endometrial compartments was compared among these groups., Results: We found that the percentages of p16-positive glandular and luminal epithelial endometrial cells were significantly higher in patients with live births compared to women with miscarriage (9.3% vs. 2.9%, P < 0.001; and 35.2% vs. 11.7%, P = 0.001, respectively). This tendency was not confirmed in thе stroma. The cut-off values with p16-positive luminal cells lower than 12.5% and p16-positive glandular cells lower than 3.2% could be predictive factors for miscarriage (AUC 0.80 and 0.79; sensitivity 71.3% and 74.5%; specificity 74.2% and 71.2%, respectively)., Conclusion: A decreased number of senescent p16-positive cells could be involved in the implantation failures and aetiology of recurrent miscarriage. Women with history of RIF with reduced populations of p16-positive cells in the endometrial glandular and luminal epithelium may be at greater risk for unsuccessful implantation and miscarriage. The percentage of p16-positive luminal epithelial cells may be clinically useful as a biomarker of miscarriage., (© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2021
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35. Office hysteroscopic myomectomy without myoma extraction: A multicenter prospective study.

Author

Tanvir T, Garzon S, Alonso Pacheco L, Lopez Yarto M, Rios M, Stamenov G, Moratalla E, Shokeir T, Adel S, Mikulasek L, Laganà AS, and Haimovich S

Subjects
Female, Humans, Hysteroscopy adverse effects, Pregnancy, Prospective Studies, Leiomyoma diagnostic imaging, Leiomyoma surgery, Myoma diagnostic imaging, Myoma surgery, Uterine Myomectomy adverse effects, Uterine Neoplasms diagnostic imaging, Uterine Neoplasms surgery
Abstract

Objective: To evaluate the feasibility and safety of leaving the submucous myoma (SM) in the uterine cavity after office hysteroscopic enucleation., Study Design: Prospective multicenter study including patients who had a single SM diagnosed by transvaginal ultrasounds with surgical indication. Office hysteroscopic enucleation of the SM was performed using a 5 mm continuous flow office hysteroscope with a 2.9 mm rod lens optical system and a 5 Fr operative channel. After the SM was released preserving the pseudo capsule using cold instruments, it was left into the uterine cavity. The primary endpoint was the proportion of patients without evidence of the myoma at the transvaginal ultrasound performed after 90 days from surgery., Results: Between January 1st, 2018, and March 31st, 2020, a total of 204 patients were enrolled. Most patients were nulliparous and reported abnormal uterine bleeding as the leading symptom. 76.5 % of enucleated myomas had a diameter ranging between 1.5 and 2.5 cm, and 81.4 % of SMs were of G0 or G1. Hysteroscopic procedures had a mean duration of 23.2 ± 10.5 min. The operative time was associated with the SM grade and size. All hysteroscopic procedures were completed. A vasovagal reaction was observed in 3 women (1.5 %), and minimal post-operative bleeding was reported after 7 procedures (3.4 %). None reported pelvic pain or vaginal discharges/bleeding during follow-up. The average patient satisfaction from surgery was 4.59 (5-points Likert scale). The level of patient satisfaction was not associated with the grade and the size of the myoma. In 192 (94.12 %; 98 %CI: 89.03-96.93 %) out of 204 patients, the SM was absent at the transvaginal ultrasound performed at the follow-up end. A higher prevalence of G2 SMs and lower prevalence of G1 SMs were observed among patients with evidence of the myoma after 90 days from the surgery., Conclusion: Office hysteroscopic myomectomy with SM enucleation without mass extraction appears safe, well-tolerated, and effective in at least 89 % of patients. G2 SMs may be the factor associated with the procedure's failure., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)

Published
2021
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36. Impact of sperm characteristics on time-lapse embryo morphokinetic parameters and clinical outcome of conventional in vitro fertilization.

Author

Nikolova S, Parvanov D, Georgieva V, Ivanova I, Ganeva R, and Stamenov G

Subjects
Adult, DNA Fragmentation, Embryo Implantation, Embryo, Mammalian anatomy & histology, Female, Humans, Male, Pregnancy, Sperm Motility, Time-Lapse Imaging, Treatment Outcome, Embryonic Development, Fertilization in Vitro, Spermatozoa pathology
Abstract

Background: Sperm abnormalities may negatively affect embryo development., Objectives: To determine the influence of sperm abnormalities (morphology, motility, DNA fragmentation) on embryo morphokinetic variables and clinical outcome of conventional IVF., Materials and Methods: Participants were 86 couples undergoing in vitro fertilization (IVF). Sperm morphology was evaluated according to the strict criteria proposed by Kruger/Tygerberg. CASA system was applied for sperm motility assessment. Sperm DNA fragmentation was assessed by the chromatin structure assay (SCSA). Morphokinetic parameters were determined in 223 embryos obtained from conventional IVF only and cultured in a single-step medium using time-lapse imaging technology., Results: Time-lapse variables from the initial embryo development, such as time of pronuclei fading (tPNf) and time for two cells (t2), were those more strongly related with abnormalities of sperm motility, morphology, and DNA fragmentation. Sperm morphological abnormalities rather than sperm motility were more closely associated with embryo morphokinetics. Sperm head defects were mainly correlated with the last stages of embryonic development (t9 to tHB), sperm midpiece defects with intermediate cleaving embryos (t5-t9), and sperm tail defects with the initial stages of embryonic development (tPNa-t4). Excess residual cytoplasm was positively correlated with all embryo morphokinetic parameters except t2 and tM. Absence of acrosomes, pinheads, coiled tails, and multiple sperm morphological defects correlated negatively with time-lapse embryo morphokinetic variables., Discussion: A large number of sperm-related variables, including frequency of specific morphological defects, morphological indexes, DNA fragmentation and motility, and time-lapse embryo variables, such as time intervals based mainly of 15 time points were recorded., Conclusion: There were strong associations between specific sperm defects of the head, midpiece, and tail with certain stages of embryonic development from observation of pronuclei to the hatched blastocyst. Coiled tail, cumulative head defects, and multiple abnormalities index (MAI) were associated both with embryo morphokinetics and the implantation success., (© 2020 American Society of Andrology and European Academy of Andrology.)

Published
2020
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37. G-CSFin RPL: what's new?

Author

Sbracia M, Scarpellini F, and Stamenov G

Subjects
Female, Granulocytes, Humans, Pregnancy, Abortion, Habitual, Granulocyte Colony-Stimulating Factor
Published
2020
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38. Unbalanced human embryos secrete more hyperglycosylated human chorionic gonadotrophin (hCG-H) than balanced ones.

Author

Parvanov D, Nikolova D, Ganeva R, Nikolova K, Vasileva M, Rangelov I, Pancheva M, Serafimova M, Staneva R, Hadjidekova S, Scarpellini F, and Stamenov G

Subjects
Adult, Biomarkers metabolism, Chorionic Gonadotropin chemistry, Chorionic Gonadotropin, beta Subunit, Human chemistry, Embryo Implantation genetics, Embryo Transfer, Embryo, Mammalian, Female, Fertilization in Vitro, Glycosylation, High-Throughput Nucleotide Sequencing, Humans, Male, Sperm Injections, Intracytoplasmic, Chorionic Gonadotropin genetics, Chorionic Gonadotropin, beta Subunit, Human genetics, Culture Media chemistry, Embryo Culture Techniques
Abstract

Purpose: The aim of this study was to compare the levels of hyperglycosylated human chorionic gonadotropin (hCG-H) secreted from balanced and unbalanced human embryos., Methods: Single-step culture media samples from 155 good quality embryos, derived from 90 good prognosis patients undergoing intracytoplasmic sperm injection (ICSI), were collected on the fifth day of embryo cultivation. All embryos were tested by next-generation sequencing (NGS) technique. The hCG-H levels in the culture media were evaluated by ELISA kit (Cusabio Biotech, CBS-E15803h) according to the manufacturer's instructions. Statistical analysis was performed using SPSS v.21 (IBM Corp., Armonk, NY, USA)., Results: The NGS analysis revealed that 36% of the embryos (n = 56) were balanced, and 64% of the embryos were unbalanced (n = 99). The presence of hCG-H was confirmed in all embryo culture media samples but was absent in the negative control. In addition, hCG-H concentration was significantly higher in the culture media from unbalanced embryos compared with the balanced ones (0.72 ± 0.30 mIU/ml vs. 0.62 ± 0.12 mIU/ml, p = 0.02, respectively). Furthermore, the mean levels of hCG-H were significantly increased in the samples from embryos with multiple abnormalities. Finally, the highest levels of hCG-H were expressed from embryos with monosomy of chromosome 11 (1.28 ± 0.04 mIU/ml) and those with trisomies of chromosomes 21 (2.23 mIU/ml) and 4 (1.02 ± 0.35 mIU/ml)., Conclusion: Our results suggest that chromosomal aberrations in human embryos are associated with an increased secretion of hCG-H. However, hCG-H concentration in embryo culture media as a single biomarker is not sufficient for an accurate selection of balanced embryos.

Published
2020
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39. A Novel Approach to Transmural Access to the Uterine Cavity in Cases of an Inaccessible Uterine Cavity: A Case Series.

Author

Thurkow AL, Kwee J, and Stamenov G

Subjects
Adult, Female, Humans, Pregnancy, Retrospective Studies, Treatment Outcome, Vagina pathology, Vagina surgery, Hysteroscopy methods, Ultrasonography, Interventional methods, Uterine Diseases surgery, Uterus diagnostic imaging, Uterus pathology, Uterus surgery
Abstract

Access to the uterine cavity can sometimes be a challenge or even impossible because of various causes such as prior surgery. We report our experience with a novel approach to this problem in 8 cases using ultrasound-guided transmural injection of dye; afterward, the cavity was successfully found in all cases by ultrasound-guided hysteroscopy following the colored epithelium., (Copyright © 2017 American Association of Gynecologic Laparoscopists. Published by Elsevier Inc. All rights reserved.)

Published
2018
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40. Genome-wide methylation profiling of schizophrenia.

Author

Rukova B, Staneva R, Hadjidekova S, Stamenov G, Milanova 5th, and Toncheva D

Abstract

Schizophrenia is one of the major psychiatric disorders. It is a disorder of complex inheritance, involving both heritable and environmental factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. We reasoned that genetic modifications that are a result of environmental stimuli could also make a contribution. We have performed 26 high-resolution genome-wide methylation array analyses to determine the methylation status of 27,627 CpG islands and compared the data between patients and healthy controls. Methylation profiles of DNAs were analyzed in six pools: 220 schizophrenia patients; 220 age-matched healthy controls; 110 female schizophrenia patients; 110 age-matched healthy females; 110 male schizophrenia patients; 110 age-matched healthy males. We also investigated the methylation status of 20 individual patient DNA samples (eight females and 12 males. We found significant differences in the methylation profile between schizophrenia and control DNA pools. We found new candidate genes that principally participate in apoptosis, synaptic transmission and nervous system development (GABRA2, LIN7B, CASP3). Methylation profiles differed between the genders. In females, the most important genes participate in apoptosis and synaptic transmission (XIAP, GABRD, OXT, KRT7), whereas in the males, the implicated genes in the molecular pathology of the disease were DHX37, MAP2K2, FNDC4 and GIPC1. Data from the individual methylation analyses confirmed, the gender-specific pools results. Our data revealed major differences in methylation profiles between schizophrenia patients and controls and between male and female patients. The dysregulated activity of the candidate genes could play a role in schizophrenia pathogenesis.

Published
2015
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41. Whole genome methylation analyses of schizophrenia patients before and after treatment.

Author

Rukova B, Staneva R, Hadjidekova S, Stamenov G, Milanova V, and Toncheva D

Abstract

The aetiology of schizophrenia is still unknown but it involves both heritable and non-heritable factors. DNA methylation is an inheritable epigenetic modification that stably alters gene expression. It takes part in the regulation of neurodevelopment and may be a contributing factor to the pathogenesis of brain diseases. It was found that many of the antipsychotic drugs may lead to epigenetic modifications. We have performed 42 high-resolution genome-wide methylation array analyses to determine the methylation status of 27,627 CpG islands. Differentially methylated regions were studied with samples from 20 Bulgarian individuals divided in four groups according to their gender (12 males/8 females) and their treatment response (6 in complete/14 in incomplete remission). They were compared to two age and sex matched control pools (110 females in female pool/110 males in male pool) before and after treatment. We found significant differences in the methylation profiles between male schizophrenia patients with complete remission and control male pool before treatment ( C16orf70 , CST3 , DDRGK1 , FA2H , FLJ30058 , MFSD2B , RFX4 , UBE2J1 , ZNF311 ) and male schizophrenia patients with complete remission and control male pool after treatment ( AP1S3 , C16orf59 , KCNK15 , LOC146336 , MGC16384 , XRN2 ) that potentially could be used as target genes for new therapeutic strategies as well as markers for good treatment response. Our data revealed major differences in methylation profiles between male schizophrenia patients in complete remission before and after treatment and healthy controls which supports the hypothesis that antipsychotic drugs may play a role in epigenetic modifications.

Published
2014
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42. Whole genome methylation array analysis reveals new aspects in Balkan endemic nephropathy etiology.

Author

Staneva R, Rukova B, Hadjidekova S, Nesheva D, Antonova O, Dimitrov P, Simeonov V, Stamenov G, Cukuranovic R, Cukuranovic J, Stefanovic V, Polenakovic M, Dimova I, Hlushchuk R, Djonov V, Galabov A, and Toncheva D

Subjects
Aged, Balkan Peninsula epidemiology, Bulgaria epidemiology, CpG Islands genetics, Female, Humans, Male, Middle Aged, Prevalence, Risk Factors, Serbia epidemiology, Balkan Nephropathy epidemiology, Balkan Nephropathy genetics, DNA Methylation genetics, Endemic Diseases statistics & numerical data, Genetic Predisposition to Disease epidemiology, Genetic Predisposition to Disease genetics, Genome, Human genetics
Abstract

Background: Balkan endemic nephropathy (BEN) represents a chronic progressive interstitial nephritis in striking correlation with uroepithelial tumours of the upper urinary tract. The disease has endemic distribution in the Danube river regions in several Balkan countries.DNA methylation is a primary epigenetic modification that is involved in major processes such as cancer, genomic imprinting, gene silencing, etc. The significance of CpG island methylation status in normal development, cell differentiation and gene expression is widely recognized, although still stays poorly understood., Methods: We performed whole genome DNA methylation array analysis on DNA pool samples from peripheral blood from 159 affected individuals and 170 healthy individuals. This technique allowed us to determine the methylation status of 27 627 CpG islands throughout the whole genome in healthy controls and BEN patients. Thus we obtained the methylation profile of BEN patients from Bulgarian and Serbian endemic regions., Results: Using specifically developed software we compared the methylation profiles of BEN patients and corresponding controls and revealed the differently methylated regions. We then compared the DMRs between all patient-control pairs to determine common changes in the epigenetic profiles.SEC61G, IL17RA, HDAC11 proved to be differently methylated throughout all patient-control pairs. The CpG islands of all 3 genes were hypomethylated compared to controls. This suggests that dysregulation of these genes involved in immunological response could be a common mechanism in BEN pathogenesis in both endemic regions and in both genders., Conclusion: Our data propose a new hypothesis that immunologic dysregulation has a place in BEN etiopathogenesis.

Published
2013
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43. [Expression of activating and inhibitory receptors on peripheral blood natural killer cell subsets of women with reproductive failures].

Author

Baltadzheiva D, Penkova K, Stamenov G, Dimitrova D, and Michailova A

Subjects
Adult, CD56 Antigen immunology, Female, Flow Cytometry, Humans, NK Cell Lectin-Like Receptor Subfamily B immunology, Pregnancy, Receptors, IgG immunology, Receptors, KIR2DL1 immunology, Abortion, Habitual immunology, Embryo Implantation, Killer Cells, Natural immunology
Abstract

It is now apparent that immunologic implantation failure and recurrent abortions are more than likely mediated through activation of natural killer (NK) cells. The NK cell activity is mediated by a balance between activating and inhibitory receptors upon recognition of MHC class I molecules. In this study, we investigated by flow cytometry the expression of activating and inhibitory receptors on NK cells of women with reproductive failures- recurrent spontaneous abortion (RSA) and implantation failures (IF). In women with implantation failures CD56+CD16+ NK cell subset was significantly increased (p = 0.017) and CD158a expressing NK cells was significantly decreased (p = 0.027). CD161-activating receptor expressing CD56+ NK cells were significantly decreased in women with RSA (p = 0.033). These data further support an imbalance in NK cell subsets in women with reproductive failures.

Published
2010

44. [Laparoscopy with low abdominal pressure].

Author

Novachkov V, Stamenov G, and Kostov I

Subjects
Air Pressure, Female, Humans, Treatment Outcome, Gynecologic Surgical Procedures methods, Laparoscopy methods, Pneumoperitoneum, Artificial
Abstract

The authors present their experience from operative laparoscopies performed with lower than usually accepted intaabdominal pressure.

Published
2003

45. [Factors influencing successful rate of intrauterine insemination].

Author

Todorov P, Dimitrov I, Stamenov G, Todorov Ia, Kolarov G, and Novachkov V

Subjects
Bulgaria epidemiology, Female, Humans, Male, Ovulation Induction, Pregnancy, Pregnancy Rate, Retrospective Studies, Sperm Count, Sperm Motility drug effects, Infertility, Female epidemiology, Infertility, Male epidemiology, Insemination, Artificial, Homologous instrumentation, Insemination, Artificial, Homologous methods
Abstract

Intrauterine insemination (IUI) is a method for the treatment of marital infertility involving the intrauterine or fallopian deposition of washed spermatozoa, depending on the amount of inseminated semen. Numerous factors may be affect of pregnancy rates after IUI.

Published
2003

46. [Effect of different co-culture systems on human sperm motility and longevity].

Author

Todorov P, Ivanova E, Dimitrov I, Nachev A, and Stamenov G

Subjects
Animals, Cattle, Cell Survival, Epithelial Cells cytology, Epithelial Cells physiology, Fallopian Tubes cytology, Female, Granulosa Cells cytology, Granulosa Cells physiology, Humans, Kidney cytology, Male, Time Factors, Coculture Techniques methods, Sperm Motility physiology, Spermatozoa physiology
Abstract

The experiments were conducted to evaluate the ability of different somatic-cell monolayers (human oviductal cells, granulose cells, MDBK-cells) for supporting motility and survival rates of human spermatozoa in-vitro. Results indicate that co-culture with epithelial cells enhanced human sperm longevity.

Published
2001
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47. [Preimplantation genetic diagnosis: current status and perspective].

Author

Todorov P, Konakchieva R, Dimitrov Iu, and Stamenov G

Subjects
Female, Humans, Pregnancy, Pregnancy Trimester, Second, Reproductive Techniques, Assisted, Genetic Diseases, Inborn diagnosis, Preimplantation Diagnosis methods
Abstract

Scientific and clinical aspects of preimplantation genetic are represented.

Published
2001

48. [Postmenopausal and posthysterectomy osteoporosis. December 1,2000].

Author

Racheva E, Georgiev D, Karag'ozov I, and Stamenov G

Subjects
Female, Humans, Insurance, Health, Reimbursement standards, Middle Aged, Osteoporosis, Postmenopausal diagnosis, Osteoporosis, Postmenopausal etiology, Osteoporosis, Postmenopausal pathology, Practice Guidelines as Topic, Time Factors, Hormone Replacement Therapy adverse effects, Hysterectomy adverse effects, Osteoporosis, Postmenopausal prevention & control
Published
2001

49. [Tonocalcin--a powerful and promising drug in the prophylaxis of osteoporosis].

Author

Stamenov G

Subjects
Adult, Aged, Aged, 80 and over, Calcitonin administration & dosage, Calcium therapeutic use, Drug Therapy, Combination, Female, Fractures, Bone prevention & control, Humans, Injections, Intramuscular, Middle Aged, Osteoporosis, Postmenopausal epidemiology, Vitamin D therapeutic use, Calcitonin therapeutic use, Osteoporosis, Postmenopausal prevention & control
Published
2001

50. [The possibility for treating the premenstrual syndrome with Periodin].

Author

Rachev E, Nalbanski B, and Stamenov G

Subjects
Adult, Capsules, Drug Combinations, Female, Humans, Middle Aged, Premenstrual Syndrome diagnosis, Minerals therapeutic use, Plant Extracts therapeutic use, Premenstrual Syndrome drug therapy, Vitamins therapeutic use
Abstract

We examined the possibility of treatment of premenstrual syndrome (PMS) with Periodin (Walmark). Periodin is a combination of polyvitamins, oligoelements and phytoextracts which have a relation with prostaglandin's synthesis and regulation of prolactin secretion. A group of 24 women with PMS and regular cycles in premenopausal period (mean age of 44.7) was examined and took Periodin 1-2 caps daily for a period of 3 months as a food supplement. The assessment was made by modified J. Mortola score system. After treatment the PMS symptoms decreased with 52.3% compared with the beginning. The authors conclude that Periodin has a considerable influence on PMS symptoms, no contraindications and could be useful widely in gynecological practice.

Published
2000

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