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18 results on '"Stambuk, Jerko"'

1. Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)

Author

Arnott, Ian, Cahill, Aiden, Smith, Malcolm, Ahmad, Tariq, Subramanian, Sreedhar, Travis, Simon, Morris, John, Hamlin, John, Dhar, Anjan, Nwokolo, Chuka, Edwards, Cathryn, Creed, Tom, Bloom, Stuart, Yousif, Mohamed, Thomas, Linzi, Campbell, Simon, Lewis, Stephen J., Sebastian, Shaji, Sen, Sandip, Lal, Simon, Hawkey, Chris, Murray, Charles, Cummings, Fraser, Goh, Jason, Lindsay, James O., Arebi, Naila, Potts, Lindsay, McKinley, Aileen J., Thomson, John M., Todd, John A., Collie, Mhairi, Mowat, Ashley, Gaya, Daniel R., Winter, Jack, Naismith, Graham D., Ennis, Holly, Keerie, Catriona, Lewis, Steff, Prescott, Robin J., Lauc, Gordan, Campbell, Harry, McGovern, Dermot P.B., Annese, Vito, Zoldoš, Vlatka, Permberton, Iain K., Wuhrer, Manfred, Kolarich, Daniel, Fernandes, Daryl L., Theorodorou, Evropi, Daniel I. Spencer, Victoria Merrick, Gardner, Richard A., Doran, Ray, Shubhakar, Archana, Boyapati, Ray, Rudan, Igor, Lionetti, Paolo, Akmačić, Irena Trbojević, Krištić, Jasminka, Vuč ković, Frano, Štambuk, Jerko, Novokmet, Mislav, Pučić-Baković, Maja, Gornik, Olga, Andriulli, Angelo, Cantoro, Laura, Sturniolo, Giancarlo, Fiorino, Gionata, Manetti, Natalia, Latiano, Anna, Kohn, Anna, D’Inca`, Renata, Danese, Silvio, Arnott, Ian D., Noble, Colin L., Lees, Charlie W., Shand, Alan G., Ho, Gwo-Tzer, Murphy, Lee, Gibson, Jude, Evenden, Louise, Wrobel, Nicola, Gilchrist, Tamara, Fawkes, Angie, Kammeijer, Guinevere S.M., Clerc, Florent, de Haan, Noortje, Vojta, Aleksandar, Samaržija, Ivana, Markulin, Dora, Klasić, Marija, Dobrinić, Paula, Aulchenko, Yurii, van den Heuve, Tim, Jonkers, Daisy, Pierik, Marieke, Ventham, Nicholas T., Kennedy, Nicholas A., Kalla, Rahul, Adams, Alex T., Noble, Alexandra, Mowat, Craig, Dunlop, Malcolm G., and Satsangi, Jack

Published
2023
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4. Plasma N-Glycan Signatures Are Associated With Features of Inflammatory Bowel Diseases

Author

Satsangi, Jack, Nimmo, Elaine R., Ventham, Nicholas T., Drummond, Hazel, Kalla, Rahul, Adams, Alex T., O'Leary, Kate, Boyapati, Ray, Wilson, David C., Merrick, Victoria, Campbell, Harry, Theodoratou, Evropi, Rudan, Igor, Kennedy, Nicholas A., Fernandes, Daryl L., Spencer, Daniel I.R., Gardner, Richard A., Shubhakar, Archana, Urbanowicz, Paulina A., Trbojević-Akmačić, Irena, Krištić, Jasminka, Štambuk, Jerko, Pučić-Baković, Maja, Vilaj, Marija, Pezer, Marija, Razdorov, Genadij, Šimurina, Mirna, Gornik, Olga, Biscaglia, Giuseppe, Palmieri, Orazio, Bossa, Fabrizio, D'incà, Renata, Danese, Silvio, Kohn, Anna, Pemberton, Iain K., Kolarich, Daniel, Zoldos, Vlatka, Aulchenko, Yurii, Pierik, Marieke, Jonkers, Daisy, van den Heuvel, Tim, Clerc, Florent, Novokmet, Mislav, Dotz, Viktoria, Reiding, Karli R., de Haan, Noortje, Kammeijer, Guinevere S.M., Dalebout, Hans, Bladergroen, Marco R., Vukovic, Frano, Rapp, Erdmann, Targan, Stephan R., Barron, Gildardo, Manetti, Natalia, Latiano, Anna, McGovern, Dermot P.B., Annese, Vito, Lauc, Gordan, and Wuhrer, Manfred

Published
2018
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5. Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases

Author

Campbell, Harry, Zoldoš, Vlatka, Permberton, Iain K., Kolarich, Daniel, Fernandes, Daryl L., Theorodorou, Evropi, Merrick, Victoria, Spencer, Daniel I., Gardner, Richard A., Doran, Ray, Shubhakar, Archana, Boyapati, Ray, Rudan, Igor, Lionetti, Paolo, Krištić, Jasminka, Novokmet, Mislav, Pučić-Baković, Maja, Gornik, Olga, Andriulli, Angelo, Cantoro, Laura, Sturniolo, Giancarlo, Fiorino, Gionata, Manetti, Natalia, Arnott, Ian D., Noble, Colin L., Lees, Charlie W., Shand, Alan G., Ho, Gwo-Tzer, Dunlop, Malcolm G., Murphy, Lee, Gibson, Jude, Evenden, Louise, Wrobel, Nicola, Gilchrist, Tamara, Fawkes, Angie, Kammeijer, Guinevere S.M., Vojta, Aleksandar, Samaržija, Ivana, Markulin, Dora, Klasić, Marija, Dobrinić, Paula, Aulchenko, Yurii, van den Heuve, Tim, Jonkers, Daisy, Pierik, Marieke, Šimurina, Mirna, de Haan, Noortje, Vučković, Frano, Kennedy, Nicholas A., Štambuk, Jerko, Falck, David, Trbojević-Akmačić, Irena, Clerc, Florent, Razdorov, Genadij, Khon, Anna, Latiano, Anna, D'Incà, Renata, Danese, Silvio, Targan, Stephan, Landers, Carol, Dubinsky, Marla, McGovern, Dermot P.B., Annese, Vito, Wuhrer, Manfred, and Lauc, Gordan

Published
2018
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6. Mapping of the gene network that regulates glycan clock of ageing

Author

Frkatovic-Hodzic, Azra, primary, Miskec, Karlo, additional, Mijakovac, Anika, additional, Nostaeva, Arina, additional, Sharapov, Sodbo Z., additional, Landini, Arianna, additional, Haller, Toomas, additional, van den Akker, Erik, additional, Sharma, Sapna, additional, Cuadrat, Rafael R. C., additional, Mangino, Massimo, additional, Li, Yong, additional, Keser, Toma, additional, Rudman, Najda, additional, Stambuk, Tamara, additional, Pucic-Bakovic, Maja, additional, Trbojevic-Akmacic, Irena, additional, Gudelj, Ivan, additional, Stambuk, Jerko, additional, Pribic, Tea, additional, Radovani, Barbara, additional, Tominac, Petra, additional, Fischer, Krista, additional, Beekman, Marian, additional, Wuhrer, Manfred, additional, Gieger, Christian, additional, Schulze, Matthias B., additional, Wittenbecher, Clemens, additional, Polasek, Ozren, additional, Hayward, Caroline, additional, Wilson, James F., additional, Spector, Tim D., additional, Kottgen, Anna, additional, Vuckovic, Frano, additional, Aulchenko, Yurii S., additional, Vojta, Aleksandar, additional, Kristic, Jasminka, additional, Klaric, Lucija, additional, Zoldos, Vlatka, additional, and Lauc, Gordan, additional

Published
2023
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7. Global variability of the human IgG glycome

Author

Stambuk, Jerko, Nakic, Natali, Vuckovic, Frano, Pucic-Bakovic, Maja, Razdorov, Genadij, Trbojevic-Akmacic, Irena, Novokmet, Mislav, Keser, Toma, Vilaj, Marija, Stambuk, Tamara, Gudelj, Ivan, Simurina, Mirna, Song, Manshu, Wang, Hao, Salihovic, Marijana Pericic, Campbell, Harry, Rudan, Igor, Kolcic, Ivana, Eller, Leigh Anne, McKeigue, Paul, Robb, Merlin L., Halfvarson, Jonas, Kurtoglu, Metin, Annese, Vito, Skaric-Juric, Tatjana, Molokhia, Mariam, Polasek, Ozren, Hayward, Caroline, Kibuuka, Hannah, Thaqi, Kujtim, Primorac, Dragan, Geieger, Christian, Nitayaphan, Sorachai, Spector, Tim, Wang, Youxin, Tillin, Therese, Chaturvedi, Nish, Wilson, James F., Schanfield, Moses, Filipenko, Maxim, Wang, Wei, Lauc, Gordan, Stambuk, Jerko, Nakic, Natali, Vuckovic, Frano, Pucic-Bakovic, Maja, Razdorov, Genadij, Trbojevic-Akmacic, Irena, Novokmet, Mislav, Keser, Toma, Vilaj, Marija, Stambuk, Tamara, Gudelj, Ivan, Simurina, Mirna, Song, Manshu, Wang, Hao, Salihovic, Marijana Pericic, Campbell, Harry, Rudan, Igor, Kolcic, Ivana, Eller, Leigh Anne, McKeigue, Paul, Robb, Merlin L., Halfvarson, Jonas, Kurtoglu, Metin, Annese, Vito, Skaric-Juric, Tatjana, Molokhia, Mariam, Polasek, Ozren, Hayward, Caroline, Kibuuka, Hannah, Thaqi, Kujtim, Primorac, Dragan, Geieger, Christian, Nitayaphan, Sorachai, Spector, Tim, Wang, Youxin, Tillin, Therese, Chaturvedi, Nish, Wilson, James F., Schanfield, Moses, Filipenko, Maxim, Wang, Wei, and Lauc, Gordan

Abstract

Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics and effector functions are modulated through the attachment of various sugar moieties called glycans. Composition of the IgG N-glycome changes with age of an individual and in different diseases. Variability of IgG glycosylation within a population is well studied and is known to be affected by both genetic and environmental factors. However, global inter-population differences in IgG glycosylation have never been properly addressed. Here we present population-specific N-glycosylation patterns of IgG, analyzed in 5 different populations totaling 10,482 IgG glycomes, and of IgG’s fragment crystallizable region (Fc), analyzed in 2,579 samples from 27 populations sampled across the world. Country of residence associated with many N-glycan features and the strongest association was with monogalactosylation where it explained 38% of variability. IgG monogalactosylation strongly correlated with the development level of a country, defined by United Nations health and socioeconomic development indicators, and with the expected lifespan. Subjects from developing countries had low levels of IgG galactosylation, characteristic for inflammation and ageing. Our results suggest that citizens of developing countries may be exposed to environmental factors that can cause low-grade chronic inflammation and the apparent increase in biological age.

Published
2020

8. NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods

Author

De Leoz, Maria Lorna A., Duewer, David L, Fung, Adam, Liu, Lily, Kei Yau, Hoi, Potter, Oscar, Staples, Gregory O, Furuki, Kenichiro, Frenkel, Ruth, Hu, Yunli, Socic, Zoran, Zhang, Peiqing, Altmann, Friedrich, Grunwald-Grube, Clemens, Shao, Chun, Zaia, Joseph, Evers, Waltraud, Pengelley, Stuart, Detlev, Suckau, Wiechmann, Anja, Resemann, Anja, Jabs, Wolfgang, Beck, Alain, Froehlich, John W, Huang, Chuncui, Yan, Li, Yaming, Liu, Sun, Shiwei, Wang, Yaojun, Seo, Youngsuk, An, Hyun Joo, Reichardt, Niels-Christian, Ruiz, Juan Echevarria, Archer-Hartmann, Stephanie, Azadi, Parastoo, Bell, Len, Lakos, Zsuzsanna, An, Yanming, Cipollo, John F, Pucic-Bakovic, Maja, Stambuk, Jerko, Lauc, Gordan, Li, Xu, Wang, Peng George, Bock, Andreas, Hennig, Rene, Rapp, Erdmann, Creskey, Marybeth, Cyr, Terry D, Nakano, Miyako, Sugiyama, Taiki, Leung, Pui-King Amy, Link-Lenczowski, Pawel, Jaworek, Jolanta, Yoo, Jong Shin, Kim, Sa-Rang, Suh, Soo-Kyung, de Haan, Noortje, Falck, David, Lageveen-Kammeijer, Guinevere S. M., Wuhrer, Manfred, Emery, Robert J, Liew, Li Phing, Royle, Louise, Urbanowicz, Paulina A, Packer, Nicolle H, Song, Xiaomin, Everest-Dass, Arun, Lattova, Erika, Cajic, Samanta, Alagesan, Kathirvel, Kolarich, Daniel, Kasali, Toyin, Lindo, Viv, Chen, Yuetian, Goswami, Kudrat, Gau, Brian, Amunugama, Ravi, Jones, Richard, Stroop, Corné J M, Kato, Koichi, Yagi, Hirokazu, Kondo, Sachiko, Yuen, C T, Harazono, Akira, Shi, Xiafeng, Magnelli, Paula, Kasper, Brian T, Mahai, Lara, Harvey, David J, O'Flaherty, Roisin, Rudd, Pauline M., Saldova, Radka, Hecht, Elizabeth S, Muddiman, David C, Kang, Jichao, Bhoskar, Prachi, Menard, Daniele, Saati, Andrew, Merle, Christine, Mast, Steven, Tep, Sam, Truong, Jennie, Nishikaze, Takashi, Sekiya, Sadanori, Shafer, Aaron, Funaoka, Sohei, Toyoda, Masaaki, de Vreugd, Peter, Caron, Cassie, Pradhan, Pralima, Tan, Niclas Chiang, Mechref, Yehia, Patil, Sachin, Rohrer, Jeffrey S, Chakrabarti, Ranjan, Dadke, Disha, Lahori, Mohammedazam, Zou, Chunxia, Cairo, Christopher, Reiz, Béla, Whittal, Randy M, Lebrilla, Carlito B, Wu, Lauren, Guttman, Andras, Szigeti, Marton, Kremkow, Benjamin G, Lee, Kevin H, Sihlbom, Carina, Adamczyk, Barbara, Jin, Chunsheng, Karlsson, Niclas G, Omros, Jessica, Larson, Goran, Nilsson, Jonas, Meyer, Bernd, Alena, Wiegandt, Komatsu, Emy, Perreault, Helene, Bodnar, Edward D, Said, Nassur, Francois, Yannis-Nicolas, Leize-Wagner, Emmanuelle, Maier, Sandra, Zeck, Anne, Heck, Albert J R, Yang, Yang, Haselberg, Rob, Qing Yu, Ying, Alley, William, Leone, Joseph W, Yuan, Hua, Stein, Stephen E, De Leoz, Maria Lorna A., Duewer, David L, Fung, Adam, Liu, Lily, Kei Yau, Hoi, Potter, Oscar, Staples, Gregory O, Furuki, Kenichiro, Frenkel, Ruth, Hu, Yunli, Socic, Zoran, Zhang, Peiqing, Altmann, Friedrich, Grunwald-Grube, Clemens, Shao, Chun, Zaia, Joseph, Evers, Waltraud, Pengelley, Stuart, Detlev, Suckau, Wiechmann, Anja, Resemann, Anja, Jabs, Wolfgang, Beck, Alain, Froehlich, John W, Huang, Chuncui, Yan, Li, Yaming, Liu, Sun, Shiwei, Wang, Yaojun, Seo, Youngsuk, An, Hyun Joo, Reichardt, Niels-Christian, Ruiz, Juan Echevarria, Archer-Hartmann, Stephanie, Azadi, Parastoo, Bell, Len, Lakos, Zsuzsanna, An, Yanming, Cipollo, John F, Pucic-Bakovic, Maja, Stambuk, Jerko, Lauc, Gordan, Li, Xu, Wang, Peng George, Bock, Andreas, Hennig, Rene, Rapp, Erdmann, Creskey, Marybeth, Cyr, Terry D, Nakano, Miyako, Sugiyama, Taiki, Leung, Pui-King Amy, Link-Lenczowski, Pawel, Jaworek, Jolanta, Yoo, Jong Shin, Kim, Sa-Rang, Suh, Soo-Kyung, de Haan, Noortje, Falck, David, Lageveen-Kammeijer, Guinevere S. M., Wuhrer, Manfred, Emery, Robert J, Liew, Li Phing, Royle, Louise, Urbanowicz, Paulina A, Packer, Nicolle H, Song, Xiaomin, Everest-Dass, Arun, Lattova, Erika, Cajic, Samanta, Alagesan, Kathirvel, Kolarich, Daniel, Kasali, Toyin, Lindo, Viv, Chen, Yuetian, Goswami, Kudrat, Gau, Brian, Amunugama, Ravi, Jones, Richard, Stroop, Corné J M, Kato, Koichi, Yagi, Hirokazu, Kondo, Sachiko, Yuen, C T, Harazono, Akira, Shi, Xiafeng, Magnelli, Paula, Kasper, Brian T, Mahai, Lara, Harvey, David J, O'Flaherty, Roisin, Rudd, Pauline M., Saldova, Radka, Hecht, Elizabeth S, Muddiman, David C, Kang, Jichao, Bhoskar, Prachi, Menard, Daniele, Saati, Andrew, Merle, Christine, Mast, Steven, Tep, Sam, Truong, Jennie, Nishikaze, Takashi, Sekiya, Sadanori, Shafer, Aaron, Funaoka, Sohei, Toyoda, Masaaki, de Vreugd, Peter, Caron, Cassie, Pradhan, Pralima, Tan, Niclas Chiang, Mechref, Yehia, Patil, Sachin, Rohrer, Jeffrey S, Chakrabarti, Ranjan, Dadke, Disha, Lahori, Mohammedazam, Zou, Chunxia, Cairo, Christopher, Reiz, Béla, Whittal, Randy M, Lebrilla, Carlito B, Wu, Lauren, Guttman, Andras, Szigeti, Marton, Kremkow, Benjamin G, Lee, Kevin H, Sihlbom, Carina, Adamczyk, Barbara, Jin, Chunsheng, Karlsson, Niclas G, Omros, Jessica, Larson, Goran, Nilsson, Jonas, Meyer, Bernd, Alena, Wiegandt, Komatsu, Emy, Perreault, Helene, Bodnar, Edward D, Said, Nassur, Francois, Yannis-Nicolas, Leize-Wagner, Emmanuelle, Maier, Sandra, Zeck, Anne, Heck, Albert J R, Yang, Yang, Haselberg, Rob, Qing Yu, Ying, Alley, William, Leone, Joseph W, Yuan, Hua, and Stein, Stephen E

Abstract

Glycosylation is a topic of intense current interest in the development of biopharmaceuticals because it is related to drug safety and efficacy. This work describes results of an interlaboratory study on the glycosylation of the Primary Sample (PS) of NISTmAb, a monoclonal antibody reference material. Seventy-six laboratories from industry, university, research, government, and hospital sectors in Europe, North America, Asia, and Australia submitted a total of 103 reports on glycan distributions. The principal objective of this study was to report and compare results for the full range of analytical methods presently used in the glycosylation analysis of mAbs. Therefore, participation was unrestricted, with laboratories choosing their own measurement techniques. Protein glycosylation was determined in various ways, including at the level of intact mAb, protein fragments, glycopeptides, or released glycans, using a wide variety of methods for derivatization, separation, identification, and quantification. Consequently, the diversity of results was enormous, with the number of glycan compositions identified by each laboratory ranging from 4 to 48. In total, one hundred sixteen glycan compositions were reported, of which 57 compositions could be assigned consensus abundance values. These consensus medians provide community-derived values for NISTmAb PS. Agreement with the consensus medians did not depend on the specific method or laboratory type. The study provides a view of the current state-of-the-art for biologic glycosylation measurement and suggests a clear need for harmonization of glycosylation analysis methods.

Published
2020

9. Defining the genetic control of human blood plasma N-glycome using genome-wide association study

Author

Sharapov, Sodbo Zh, primary, Tsepilov, Yakov A, additional, Klaric, Lucija, additional, Mangino, Massimo, additional, Thareja, Gaurav, additional, Shadrina, Alexandra S, additional, Simurina, Mirna, additional, Dagostino, Concetta, additional, Dmitrieva, Julia, additional, Vilaj, Marija, additional, Vuckovic, Frano, additional, Pavic, Tamara, additional, Stambuk, Jerko, additional, Trbojevic-Akmacic, Irena, additional, Kristic, Jasminka, additional, Simunovic, Jelena, additional, Momcilovic, Ana, additional, Campbell, Harry, additional, Doherty, Margaret, additional, Dunlop, Malcolm G, additional, Farrington, Susan M, additional, Pucic-Bakovic, Maja, additional, Gieger, Christian, additional, Allegri, Massimo, additional, Louis, Edouard, additional, Georges, Michel, additional, Suhre, Karsten, additional, Spector, Tim, additional, Williams, Frances M K, additional, Lauc, Gordan, additional, and Aulchenko, Yurii S, additional

Published
2019
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10. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

Author

Benedetti, Elisa, Pucic-Bakovic, Maja, Keser, Toma, Wahl, Annika, Hassinen, Antti, Yang, Jeong-Yeh, Liu, Lin, Trbojevic-Akmacic, Irena, Razdorov, Genadij, Stambuk, Jerko, Klaric, Lucija, Ugrina, Ivo, Selman, Maurice H. J., Wuhrer, Manfred, Rudan, Igor, Polasek, Ozren, Hayward, Caroline, Grallert, Harald, Strauch, Konstantin, Peters, Annette, Meitinger, Thomas, Gieger, Christian, Vilaj, Marija, Boons, Geert-Jan, Moremen, Kelley W, Ovchinnikova, Tatiana, Bovin, Nicolai, Kellokumpu, Sakari, Theis, Fabian J., Lauc, Gordan, Krumsiek, Jan, Afd Chemical Biology and Drug Discovery, Sub Algemeen Scheikunde, Chemical Biology and Drug Discovery, Afd Chemical Biology and Drug Discovery, Sub Algemeen Scheikunde, and Chemical Biology and Drug Discovery

Subjects
Male, Proteomics, 0301 basic medicine, Glycosylation, Statistical methods, Glycobiology, Datasets as Topic, General Physics and Astronomy, Bioinformatics, Mass Spectrometry, Immunoglobulin G, Cohort Studies, chemistry.chemical_compound, lcsh:Science, Chromatography, High Pressure Liquid, Aged, 80 and over, Multidisciplinary, biology, Chemistry, Effector, Middle Aged, Publisher Correction, 3. Good health, Glycoproteomics, symbols, Female, lipids (amino acids, peptides, and proteins), Algorithms, Metabolic Networks and Pathways, Adult, Glycan, animal structures, Science, In silico, Computational biology, macromolecular substances, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Young Adult, 03 medical and health sciences, symbols.namesake, Journal Article, Humans, Aged, Enzyme Assays, Biochemical networks, Computational Biology, Glycosyltransferases, General Chemistry, Golgi apparatus, In vitro, glycosylation pathway, N-glycans, mass spectrometry, Gaussian graphical models, carbohydrates (lipids), 030104 developmental biology, biology.protein, lcsh:Q, Caco-2 Cells, Genome-Wide Association Study
Abstract

Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and aberrations in IgG glycosylation are linked to various diseases. However, the molecular mechanisms underlying protein glycosylation are still poorly understood. We present a data-driven approach to infer reactions in the IgG glycosylation pathway using large-scale mass-spectrometry measurements. Gaussian graphical models are used to construct association networks from four cohorts. We find that glycan pairs with high partial correlations represent enzymatic reactions in the known glycosylation pathway, and then predict new biochemical reactions using a rule-based approach. Validation is performed using data from a GWAS and results from three in vitro experiments. We show that one predicted reaction is enzymatically feasible and that one rejected reaction does not occur in vitro. Moreover, in contrast to previous knowledge, enzymes involved in our predictions colocalize in the Golgi of two cell lines, further confirming the in silico predictions.

Published
2017

11. Defining the genetic control of human blood plasma N-glycome using genome-wide association study

Author

Sharapov, Sodbo Zh., primary, Tsepilov, Yakov A., additional, Klaric, Lucija, additional, Mangino, Massimo, additional, Thareja, Gaurav, additional, Simurina, Mirna, additional, Dagostino, Concetta, additional, Dmitrieva, Julia, additional, Vilaj, Marija, additional, Vuckovic, Frano, additional, Pavic, Tamara, additional, Stambuk, Jerko, additional, Trbojevic-Akmacic, Irena, additional, Kristic, Jasminka, additional, Simunovic, Jelena, additional, Momcilovic, Ana, additional, Campbell, Harry, additional, Dunlop, Malcolm, additional, Farrington, Susan, additional, Pucic-Bakovic, Maja, additional, Gieger, Christian, additional, Allegri, Massimo, additional, Louis, Edouard, additional, Georges, Michel, additional, Suhre, Karsten, additional, Spector, Tim, additional, Williams, Frances MK, additional, Lauc, Gordan, additional, and Aulchenko, Yurii, additional

Published
2018
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12. Network inference from glycoproteomics data reveals new reactions in the IgG glycosylation pathway

Author

Afd Chemical Biology and Drug Discovery, Sub Algemeen Scheikunde, Chemical Biology and Drug Discovery, Benedetti, Elisa, Pucic-Bakovic, Maja, Keser, Toma, Wahl, Annika, Hassinen, Antti, Yang, Jeong-Yeh, Liu, Lin, Trbojevic-Akmacic, Irena, Razdorov, Genadij, Stambuk, Jerko, Klaric, Lucija, Ugrina, Ivo, Selman, Maurice H. J., Wuhrer, Manfred, Rudan, Igor, Polasek, Ozren, Hayward, Caroline, Grallert, Harald, Strauch, Konstantin, Peters, Annette, Meitinger, Thomas, Gieger, Christian, Vilaj, Marija, Boons, Geert-Jan, Moremen, Kelley W, Ovchinnikova, Tatiana, Bovin, Nicolai, Kellokumpu, Sakari, Theis, Fabian J., Lauc, Gordan, Krumsiek, Jan, Afd Chemical Biology and Drug Discovery, Sub Algemeen Scheikunde, Chemical Biology and Drug Discovery, Benedetti, Elisa, Pucic-Bakovic, Maja, Keser, Toma, Wahl, Annika, Hassinen, Antti, Yang, Jeong-Yeh, Liu, Lin, Trbojevic-Akmacic, Irena, Razdorov, Genadij, Stambuk, Jerko, Klaric, Lucija, Ugrina, Ivo, Selman, Maurice H. J., Wuhrer, Manfred, Rudan, Igor, Polasek, Ozren, Hayward, Caroline, Grallert, Harald, Strauch, Konstantin, Peters, Annette, Meitinger, Thomas, Gieger, Christian, Vilaj, Marija, Boons, Geert-Jan, Moremen, Kelley W, Ovchinnikova, Tatiana, Bovin, Nicolai, Kellokumpu, Sakari, Theis, Fabian J., Lauc, Gordan, and Krumsiek, Jan

Published
2017

13. Effects of allergic diseases and age on the composition of serum IgG glycome in children

Author

Pezer, Marija, primary, Stambuk, Jerko, additional, Perica, Marija, additional, Razdorov, Genadij, additional, Banic, Ivana, additional, Vuckovic, Frano, additional, Gospic, Adrijana Miletic, additional, Ugrina, Ivo, additional, Vecenaj, Ana, additional, Bakovic, Maja Pucic, additional, Lokas, Sandra Bulat, additional, Zivkovic, Jelena, additional, Plavec, Davor, additional, Devereux, Graham, additional, Turkalj, Mirjana, additional, and Lauc, Gordan, additional

Published
2016
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14. Changes in the immunoglobulin G glycome associated with inflammatory bowel disease

Author

Keser, Toma, Akmacic, Irena Trbojevic, Ventham, Nicholas T., Theodoratou, Evropi, Vuckovic, Frano, Kennedy, Nicholas A., Nimmo, Elaine R., Kalla, Rahul, Drummond, Hazel, Stambuk, Jerko, Campbell, Harry, Hedin, Charlotte, D'Amato, Mauro, Halfvarson, Jonas, Satsangi, Jack, Lauc, Gordan, Keser, Toma, Akmacic, Irena Trbojevic, Ventham, Nicholas T., Theodoratou, Evropi, Vuckovic, Frano, Kennedy, Nicholas A., Nimmo, Elaine R., Kalla, Rahul, Drummond, Hazel, Stambuk, Jerko, Campbell, Harry, Hedin, Charlotte, D'Amato, Mauro, Halfvarson, Jonas, Satsangi, Jack, and Lauc, Gordan

Published
2015

16. FADD Deficiency Causes Changes in Apoptosis and Necroptosis of Mouse Embryonic Fibroblasts

Author

Stambuk, Jerko, Antunovic, Maja, Caput Mihalic, Katarina, Nagy, Biserka, Marijanovic, Inga, and Alexander M.M. Eggermont

Subjects
UVB, necroptosis, apoptosis
Abstract

Introduction: Necrosis, like apoptosis, can be strictly regulated and that form of necrosisis called necroptosis. FADD (Fas-associateddeathdomain)protein is a key molecule of extrinsic apoptotic pathway that transduces signal from the membrane death receptors to caspase 8, but it also plays pivotal role in activation of necroptosis. UV irradiation triggers intrinsic apoptotic pathway via DNA damage and caspase 9 and extrinsic pathway via death receptor trimerization and caspase 8. Material and Methods: The effect of FADD deficiency on cell survival and activation of cell death was investigated using knock-out mouse embryonic fibroblasts (FADD-/-) irradiated with different doses of UVB radiation. Cell viability was estimated using MTT test, caspase activity using commercial assays and detection of necroptosis using MTT test with necrostatin-1. Results and Discussion: Results showed that FADD-/- fibroblasts have lower proliferation rate than wild-type cells as their viability was reduced in comparison to wild-type cells, following the exposure to UVB radiation at intensity range 100–600 J/m2. Increased activation of caspases 3/7 and caspase 9 was detected in the irradiated FADD-/- fibroblasts and these cells did not have an increased viability in the presence of necrostatin-1 in comparison to the wild type. Caspase 8 activation was not detected in either cell type after the exposure to 300J/m2 of UVB. Conclusion: From results we can conclude that UVB radiation in FADD-/- fibroblasts causes stronger induction of apoptosis due to intrinsic pathway activation. Necroptosis can be excluded as the cause of increased UV sensitivity of FADD-/- cells. However, cell death of wild type fibroblasts seems to be partly due to apoptosis and partly due to necroptosis. Lack of caspase 8 activation indicates that the extrinsic pathway of apoptosis is not involved in UVB-induced apoptosis of mouse embryonic fibroblasts.

Published
2012

17. Inflammatory bowel disease associates with pro-inflammatory potential of the IgG glycome

Author

Akmacic, Irena Trbojevic, Ventham, Nicholas T., Theodoratou, Evropi, Vuckovic, Frano, Kennedy, Nicholas A., Kristic, Jasminka, Nimmo, Elaine, Kalla, Rahul, Drummond, Hazel E., Stambuk, Jerko, Malcolm Dunlop, Novokmet, Mislav, Aulchenko, Yurii, Gornik, Olga, Campbell, Harry, Pucic-Bakovic, Maja, Satsangi, Jack, Lauc, Gordan, and Ibd Biom, Consortium

18. Global variability of the human IgG glycome

Author

<p>National Health and Medical Research Council of Australia</p>, Stambuk, Jerko, Nakic, Natali, Vuckovic, Frano, Pucic-Bakovic, Maja, Razdorov, Genadij, Trbojevic-Akmacic, Irena, Novokmet, Mislav, Keser, Toma, Vilaj, Marija, Stambuk, Tamara, Gudelj, Ivan, Simurina, Mirna, Song, Manshu, Wang, Hao, Salihovic, Marijana Pericic, Campbell, Harry, Rudan, Igor, Kolcic, Ivana, Eller, Leigh Anne, McKeigue, Paul, Robb, Merlin L., Halfvarson, Jonas, Kurtoglu, Metin, Annese, Vito, Skaric-Juric, Tatjana, Molokhia, Mariam, Polasek, Ozren, Hayward, Caroline, Kibuuka, Hannah, Thaqi, Kujtim, Primorac, Dragan, Geieger, Christian, Nitayaphan, Sorachai, Spector, Tim, Wang, Youxin, Tillin, Therese, Chaturvedi, Nish, Wilson, James F., Schanfield, Moses, Filipenko, Maxim, Wang, Wei, Lauc, Gordan, <p>National Health and Medical Research Council of Australia</p>, Stambuk, Jerko, Nakic, Natali, Vuckovic, Frano, Pucic-Bakovic, Maja, Razdorov, Genadij, Trbojevic-Akmacic, Irena, Novokmet, Mislav, Keser, Toma, Vilaj, Marija, Stambuk, Tamara, Gudelj, Ivan, Simurina, Mirna, Song, Manshu, Wang, Hao, Salihovic, Marijana Pericic, Campbell, Harry, Rudan, Igor, Kolcic, Ivana, Eller, Leigh Anne, McKeigue, Paul, Robb, Merlin L., Halfvarson, Jonas, Kurtoglu, Metin, Annese, Vito, Skaric-Juric, Tatjana, Molokhia, Mariam, Polasek, Ozren, Hayward, Caroline, Kibuuka, Hannah, Thaqi, Kujtim, Primorac, Dragan, Geieger, Christian, Nitayaphan, Sorachai, Spector, Tim, Wang, Youxin, Tillin, Therese, Chaturvedi, Nish, Wilson, James F., Schanfield, Moses, Filipenko, Maxim, Wang, Wei, and Lauc, Gordan

Abstract

Štambuk, J., Nakić, N., Vučković, F., Pučić-Baković, M., Razdorov, G., Trbojević-Akmačić, I., ... & Lauc, G. (2020). Global variability of the human IgG glycome. Aging, 12(15), 15222 - 15259. https://doi.org/10.18632/aging.103884

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