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13. Early appearance of 2, 3-butanediol in acute myocardial infarction. A new marker for ischaemia?

Author

HEER, K. R., STALDER, H., THOELEN, H., HEER, K. R., STALDER, H., and THOELEN, H.

Abstract

In 28 patients with acute myocardial infarction, the release pattern of 2, 3-butanediol (BD), a product of intermediary metabolism, and creatine kinase activity (CK) in blood were compared. Whereas CKat entry was low in all patients, the BD level was elevated in 18 (64%). However, BD returned to normal levels during the next 24 h whereas CK increased. The BD level at entry did not allow differentiation between patients with transmural or non-transmural infarction; it was independent of clinical findings and biochemical parameters. We suggest that, in patients with acute myocardial infarction, elevated levels of BD originates from myo-cardial metabolism. Whether it reflects ongoing ischaemia or reperfusion of the infarcted area remains unresolved

Published
2017

14. Ceftazidime in severe infections: a Swiss multicentre study

Author

Francioli, P., Clément, M., Geroulanos, S., von Graevenitz, A., Luthy, R., Regamey, C., Stalder, H., Vogt, M., Waldvogel, F. A., Francioli, P., Clément, M., Geroulanos, S., von Graevenitz, A., Luthy, R., Regamey, C., Stalder, H., Vogt, M., and Waldvogel, F. A.

Abstract

A total of 105 patients (mean age 57, range 15 to 90) with serious infections were treated with intravenous ceftazidime, usually 2 g 8-hourly. Most patients had complicating factors such as major surgery, cancer, chronic obstructive lung disease, catheters or anatomical abnormalities. Eighty-seven infectious episodes in 77 patients could be assessed for efficacy. Bacteraemia was diagnosed in 26% of these episodes. Seventy-five per cent of infections were due to Gram-negative bacteria, Pseudomonas aeruginosa being the most frequent. The major sites of infections were the lower respiratory tract (30), the urinary tract (28), the soft tissues (9), the biliary tract (4), bones (4) and the ears (4). Overall, 67% of the patients were cured, 20% improved, 7% relapsed and 6% failed to respond. Among the 27 infections due to Ps aeruginosa, only two failures (in the same patient) and four relapses were recorded. However, in the two failures and in three other cases with persistent Ps. aeruginosa colonisation, the organism had become resistant to ceftazidime. Three failures were recorded in the seven Staphylococcus aureus infections included in this study. Superinfection occurred in four patients. Adverse events included rash (6), Clostridium difficile toxin-induced diarrhoea (3), transaminase elevation (3), weakly positive Coombs test (10). Ceftazidime appears to be safe and effective for the treatment of severe Gram-negative infections, including those caused by Ps. aeruginosa

Published
2017

21. Rieter: ComforSpin Spinning Process

Author

Stalder, H.

Subjects
Textile industry -- Product information, Business, Fashion, accessories and textiles industries
Published
2000

23. 1. Podiumsgespräch

Author

Lüthy, R., primary, Knothe, H., additional, Lode, H., additional, Stalder, H., additional, and Stille, W., additional

Published
1984
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25. Persistent infections after natural transmission of bovine viral diarrhoea virus from cattle to goats and among goats

Author

Bachofen, C, Vogt, H R, Stalder, H, Mathys, T, Zanoni, R, Hilbe, M, Schweizer, M, Peterhans, E, Bachofen, C, Vogt, H R, Stalder, H, Mathys, T, Zanoni, R, Hilbe, M, Schweizer, M, and Peterhans, E

Abstract

Bovine viral diarrhoea virus (BVDV) is an economically important pathogen of cattle worldwide. Infection of a pregnant animal may lead to persistent infection of the foetus and birth of a persistently infected (PI) calf that sheds the virus throughout its life. However, BVD viruses are not strictly species specific. BVDV has been isolated from many domesticated and wild ruminants. This is of practical importance as virus reservoirs in non-bovine hosts may hamper BVDV control in cattle. A goat given as a social companion to a BVDV PI calf gave birth to a PI goat kid. In order to test if goat to goat infections were possible, seronegative pregnant goats were exposed to the PI goat. In parallel, seronegative pregnant goats were kept together with the PI calf. Only the goat to goat transmission resulted in the birth of a next generation of BVDV PI kids whereas all goats kept together with the PI calf aborted. To our knowledge, this is the first report which shows that a PI goat cannot only transmit BVD virus to other goats but that such transmission may indeed lead to the birth of a second generation of PI goats. Genetic analyses indicated that establishment in the new host species may be associated with step-wise adaptations in the viral genome. Thus, goats have the potential to be a reservoir for BVDV. However, the PI goats showed growth retardation and anaemia and their survival under natural conditions remains questionable.

Published
2013

26. Symptomes, signes cliniques et radiologiques prédictifs de l'origine bactérienne des rhino-sinusites aiguës

Author

Ricchetti, A., Lacroix, Jean-Sylvain, Kaiser, Laurent, Morabia, Alfredo, Stalder, H., Auckenthaler, Raymond, Terrier, François, Hirschel, Bernard, Khaw, N., and Lew, Daniel Pablo

Subjects
Adult, Aged, 80 and over, Male, Neisseriaceae Infections/complications/diagnosis, Adolescent, Moraxella (Branhamella) catarrhalis, Middle Aged, Bacterial Infections/ complications/ diagnosis/radiography, Pneumococcal Infections/complications/diagnosis, Haemophilus influenzae, Haemophilus Infections/complications/diagnosis, Humans, ddc:576.5, Female, Rhinitis/diagnosis/ microbiology, Sinusitis/diagnosis/ microbiology, Aged
Abstract

A minority of patients with common cold and upper respiratory tract infections have a bacterial infection and may benefit from antibiotic therapy. The present analysis set out to determine whether there were clinical symptoms or signs which could help the clinician to identify a subset of patients with moderate forms of acute rhinosinusitis who are infected with pathogenic bacteria. Detailed clinical history and medical examination were obtained from 265 patients (mean age 35 years, 138 females and 127 males) presenting symptoms of upper respiratory tract infections but no fever above 38 degrees C. The presence of three pathogenic bacteria (S. pneumoniae, H. influenzae or M. catarrhalis) was determined in all patients by culture of nasopharyngeal secretions. Aggravating factors for severity of rhinosinusitis, such as severe nasal obstruction, inferior and/or middle turbinate hypertrophy, oedema of the middle meatus mucosa and septal defects, were not associated with the presence of bacteria. Pathogenic bacteria were found in 77 patients (29%). The clinical signs and symptoms which were significantly associated in a multivariate model with the presence of bacteria included facial pain (p < 0.003), coloured nasal discharge (p < 0.003) and radiological maxillary sinusitis (complete opacity, air-fluid level or mucosal thickening greater than 10 mm) (p < 0.002). This, the best predictive model, had a sensitivity of 69% and a specificity of 64% and therefore could not be used either as a screening tool or as a diagnostic criterion for bacterial rhinosinusitis. We conclude that signs and symptoms of acute rhinosinusitis in patients with a mild to moderate clinical presentation are poor predictors of the presence of bacteria. In agreement with previous studies, culture of nasopharyngeal secretions may identify patients who would benefit from antibiotic treatment. Thus, antibiotic therapy should not be prescribed in the absence of bacteriological evidence.

Published
2000

27. Radiological maxillary sinusitis in patients with common cold

Author

Kaiser, Laurent, Lew, Daniel Pablo, Hirschel, Bernard, Auckenthaler, Raymond, Morabia, Alfredo, Benedict, P., Terrier, François, and Stalder, H.

Subjects
Adult, Male, Maxillary Sinusitis/ radiography, Common Cold, Maxillary Sinus, Maxillary Sinusitis, Common Cold/ radiography, Maxillary Sinus/radiography, Humans, ddc:576.5, Female, Prospective Studies, Tomography, X-Ray Computed
Published
1998

30. ChemInform Abstract: Synthesis and Structure-Activity Relationship of (Lactamylvinyl) cephalosporins Exhibiting Activity Against Staphylococci, Pneumococci, and Enterococci.

Author

HEINZE-KRAUSS, I., primary, ANGEHRN, P., additional, GUERRY, P., additional, HEBEISEN, P., additional, HUBSCHWERLEN, C., additional, KOMPIS, I., additional, PAGE, M. G. P., additional, RICHTER, H. G. F., additional, RUNTZ, V., additional, STALDER, H., additional, WEISS, U., additional, and WEI, C.-C., additional

Published
2010
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37. Effects of Antibiotic Treatment in the Subset of Common-Cold Patients Who Have Bacteria in Nasopharyngeal Secretions

Author

Trenholme, Gordon M., primary, Kaiser, L, additional, Lew, D, additional, Hirschel, B, additional, Auckenthaler, R, additional, Morabia, A, additional, Heald, A, additional, Benedict, P, additional, Terrier, F, additional, Wunderli, W, additional, Matter, L, additional, Germann, D, additional, Voegeli, J, additional, and Stalder, H., additional

Published
1996
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47. Safety and Immunogenicity of a Genetically Engineered Human Immunodeficiency Virus Vaccine

Author

Wintsch, J., primary, Chaignat, C.-L., additional, Braun, D. G., additional, Jeannet, M., additional, Stalder, H., additional, Abrignani, S., additional, Montagna, D., additional, Clavijo, F., additional, Moret, P., additional, Dayer, J.-M., additional, Staehelin, T., additional, Doe, B., additional, Steimer, K. S., additional, Dina, D., additional, and Cruchaud, A., additional

Published
1991
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