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1. Evolving treatment implementation among HIV- infected pregnant women and their partners: Results from a national surveillance study in Italy, 2001-2015

Author

Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia M., Frisina V., Ravizza M., Marconi A. M., Pinnetti C., Cetin I., Sansone M., Molinari A., Cervi F., Meloni A., Luzi K., Masuelli G., Tamburrini E., Ensoli B., Moroni M., Lazzarin A., Sagnelli E., Antinori A., Carosi G., Marcotullio S., Mazzotta F., Vella S., Ammassari A., Antonucci G., Andreoni M., Angarano G., Armignacco O., Babudieri S., Baldelli F., Bini T., Bonfanti P., Bonora S., Borderi M., Bruno R., Bucciardini R., Castagna A., Cattelan A. M., Cauda R., Cerioli A., Chirianni A., Cingolani A., Cinque P., d'Arminio Monforte A., De Carli G., De Luca A., Di Perri G., Di Pietro M., El Hamad I., Errico M., Ferrazzi E., Gabrielli E., Galli M., Giaquinto C., Girardi E., Gori A., Grossi P., Guaraldi G., Liuzzi G., Lo Caputo S., Maggiolo F., Malena M., Maserati R., Mastroianni C., Matteelli A., Morrone A., Murri R., Mussini C., Nasta P., Oldrini M., Oleari F., Orlando G., Palu G., Pempinello R., Perno C. -F., Prestileo T., Pompa M. G., Puoti M., Puro V., Rancilio L., Rasi G., Rizzardini G., Savasi V. M., Signorini L., Sighinolfi L., Stagnitta M., Starace F., Starnini G., Sterrantino G., Suter F., Tambussi G., Tavio M., Torti C., Tozzi V., Trotta M. P., Vaccher E., Vigano A., Visintini R., Vullo V., Zuccotti G. V., Dell'Isola S., Manfredini V., Parisi S., Pezzoli M. C., Zona S., Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia M., Frisina V., Ravizza M., Marconi A. M., Pinnetti C., Cetin I., Sansone M., Molinari A., Cervi F., Meloni A., Luzi K., Masuelli G., Tamburrini E., Ensoli B., Moroni M., Lazzarin A., Sagnelli E., Antinori A., Carosi G., Marcotullio S., Mazzotta F., Vella S., Ammassari A., Antonucci G., Andreoni M., Angarano G., Armignacco O., Babudieri S., Baldelli F., Bini T., Bonfanti P., Bonora S., Borderi M., Bruno R., Bucciardini R., Castagna A., Cattelan A. M., Cauda R., Cerioli A., Chirianni A., Cingolani A., Cinque P., d'Arminio Monforte A., De Carli G., De Luca A., Di Perri G., Di Pietro M., El Hamad I., Errico M., Ferrazzi E., Gabrielli E., Galli M., Giaquinto C., Girardi E., Gori A., Grossi P., Guaraldi G., Liuzzi G., Lo Caputo S., Maggiolo F., Malena M., Maserati R., Mastroianni C., Matteelli A., Morrone A., Murri R., Mussini C., Nasta P., Oldrini M., Oleari F., Orlando G., Palu G., Pempinello R., Perno C. -F., Prestileo T., Pompa M. G., Puoti M., Puro V., Rancilio L., Rasi G., Rizzardini G., Savasi V. M., Signorini L., Sighinolfi L., Stagnitta M., Starace F., Starnini G., Sterrantino G., Suter F., Tambussi G., Tavio M., Torti C., Tozzi V., Trotta M. P., Vaccher E., Vigano A., Visintini R., Vullo V., Zuccotti G. V., Dell'Isola S., Manfredini V., Parisi S., Pezzoli M. C., and Zona S.

Abstract

Background The current global and national indications for antiretroviral treatment (ART, usually triple combination therapy) in adolescent and adults, including pregnant women, recommend early ART before immunologic decline, pre-exposure chemoprophylaxis (PrEP), and treatment of HIV-negative partners in serodiscordant couples. There is limited information on the implementation of these recommendations among pregnant women with HIV and their partners. Methods The present analysis was performed in 2016, using data from clinical records of pregnant women with HIV, followed between 2001 and 2015 at hospital or university clinics within a large, nationally representative Italian cohort study. The study period was divided in three intervals of five years each (2001-2005, 2006-2010, 2011-2015), and the analysis evaluated temporal trends in rates of HIV diagnosis in pregnancy, maternal antiretroviral treatment at conception, prevalence of HIV infection among partners of pregnant women with HIV, and proportion of seronegative and seropositive male partners receiving antiretroviral treatment. Results The analysis included 2755 pregnancies in women with HIV. During the three time intervals considered the rate of HIV diagnosis in pregnancy (overall 23.3%), and the distribution of HIV status among male partners (overall 48.7% HIV- negative, 28.6% HIV-positive and 22.8% unknown) remained substantially unchanged. Significant increases were observed in the proportion of women with HIV diagnosed before pregnancy who were on antiretroviral treatment at conception (from 62.0% in 2001-2005 to 81.3% in 2011-2015, P < 0.001), and in the proportion of HIV-positive partners on antiretroviral treatment (from 73.3% in 2001-2005 to 95.8% in 2011-2015, P = 0.002). Antiretroviral treatment was administered in 99.1% of the pregnancies that did not end early because of miscarriage, termination, or intrauterine death, and in 75.3% of those not ending in a live birth. No implementation of antir

Published
2017

2. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2016

Author

Antinori, Andrea, Di Biagio, Antonio, Marcotullio, Simone, Andreoni, Massimo, Chirianni, Antonio, d'Arminio Monforte, Antonella, Galli, Massimo, Mazzotta, Francesco, Mussini, Cristina, Puoti, Massimo, Lazzarin, Adriano, Matteelli, Alberto, Andreoni, M, Chirianni, A, Antinori, A, Galli, M, Lazzarin, A, d'Arminio Monforte, A, Di Perri, G, Perno, Cf, Puoti, M, Vella, S, Di Biagio, A, Marcotullio, S, Ammassari, A, Angarano, G, Armignacco, O, Babudieri, S, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Breveglieri, M, Calza, L, Capobianchi, Mr, Cagarelli, R, Calcagno, A, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cingolani, A, Cinque, P, Corbelli, Gm, D'Ettorre, G, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Gaeta, Gb, Gargiulo, M, Gervasoni, C, Giacomet, V, Giannini, A, Gianotti, N, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Lichtner, M, Liuzzi, G, Lo Caputo, S, Maggi, P, Maggiolo, F, Marchetti, G, Maserati, R, Mastroianni, C, Matteelli, A, Mazzotta, F, Menichetti, F, Mussini, C, Nozza, S, Oldrini, M, Parruti, G, Pascucci, Mg, Parrella, R, Prestileo, T, Puro, V, Rancilio, L, Marina, R, Rezza, G, Rizzardini, G, Rusconi, S, Santoro, M, Sighinolfi, L, Stagnitta, M, Starnini, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Vaccher, E, Viscoli, C, Visintini, R, Vullo, V, Zaccarelli, M, Zuccotti, Gv., Antinori, Andrea, Di Biagio, Antonio, Marcotullio, Simone, Andreoni, Massimo, Chirianni, Antonio, Antonella, Galli, Massimo, Mazzotta, Francesco, Mussini, Cristina, Puoti, Massimo, Lazzarin, Adriano, Italian Hiv Guidelines Working, Group, and Castagna, Antonella

Subjects
Settore MED/17 - Malattie Infettive, Anti-HIV Agents, Health Policy, Antiretroviral agents, Guidelines, HIV, Italy, Anti-HIV Agent, HIV Infections, Guideline, antiretroviral agents, Drug Administration Schedule, Drug Therapy, Combination, HIV-1, Practice Guidelines as Topic, Drug Therapy, antiretroviral agent, Combination, HIV Infection
Abstract

The Italian Society of Infectious and Tropical Diseases (SIMIT) of the Technical Health Committee, Ministry of Health (Sections L and M) of Italy have supported recommendations for the Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. This publication summarizes the latest updates to the 2016 version of the Italian Guidelines for the management of HIV-1 infected patients and the use of antiretroviral drugs. In particular, new recommendations were released concerning the following topics: estimate of the HIV continuum of care in Italy, optimal timing and preferred drug combinations for starting antiretroviral therapy, treatment optimization, and pre-exposure prophilaxis (PrEP). For a complete review of clinical and therapeutic relevant topics we refer the reader to the extended version of the Guidelines.

Published
2017

3. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update 2011

Author

Antinori A, Marcotullio S, Ammassari A, Andreoni M, Angarano G, Armignacco O, Carosi G, Cinque P, d'Arminio Monforte A, Di Perri G, Ensoli B, Floridia M, Galli M, Mastroianni C, Matteelli A, Mazzotta F, Moroni M, Palù G, Puoti M, Puro V, Rizzardini G, Sagnelli E, Vella S, Vullo V, Lazzarin A Collaborators (88) Ensoli B, Lazzarin A, Babudieri S, Baldelli F, Bini T, Bonfanti P, Bonora S, Borderi M, Bruno R, Bucciardini R, Castagna A, Castelli F, Cattelan AM, Cauda R, Cerioli A, Chirianni A, Cingolani A, Monforte Ad, De Carli G, De Luca A, Di Pietro M, El Hamad I, Errico M, Filice G, Gabrielli E, Gaeta G. B., Gervasoni C, Giacomet V, Giaquinto C, Girardi E, Gori A, Grossi P, Guaraldi G, Liuzzi G, Caputo SL, Maggi P, Maggiolo F, Malena M, Maserati R, Morrone A, Murri R, Mussini C, Nasta P, Oldrini M, Oleari F, Orlando G, Pali G, Perno CF, Prestileo T, Pompa MG, Rancilio L, Ravizza M, Savasi VM, Signorini L, Sighinolfi L, Stagnitta M, Starace F, Starnini G, Sterrantino G, Tamburrini E, Tambussi G, Tavio M, Torti C, Tozzi V, Trotta MP, Vaccher E, Visintini R, Zuccotti V., Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Armignacco, O, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Floridia, M, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Palù, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Vella, S, Vullo, V, Lazzarin, A Collaborators (88) Ensoli B, Lazzarin, A, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Monforte, Ad, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Filice, G, Gabrielli, E, Gaeta, G. B., Gervasoni, C, Giacomet, V, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Caputo, Sl, Maggi, P, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pali, G, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Ravizza, M, Savasi, Vm, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, Mp, Vaccher, E, Visintini, R, and Zuccotti, V.

Published
2012

4. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons. Update December 2014

Author

Antinori, A, Marcotullio, S, Andreoni, M, Ammassari, A, d'Arminio Monforte, A, Galli, M, Girardi, Enrico, Mazzotta, F, Mussini, C, Puoti, M, Lazzarin, A, Angarano, G, Armignacco, O, Babudieri, S, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Breveglieri, M, Bruno, R, Capobianchi, Mr, Cagarelli, R, Calcagno, A, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cinque, P, Corbelli, Gm, D'Ettorre, G, De Carli, G, De Luca, A, Di Biagio, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Finarelli Alba, C, Gaeta, Gb, Gervasoni, C, Giacomet, V, Gianotti, N, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Ivanovic, J, Lichtner, M, Liuzzi, G, Lo Caputo, S, Maggi, P, Maggiolo, F, Malena, M, Marchetti, G, Maserati, R, Mastroianni, C, Matteelli, Alberto, Nicastri, E, Nozza, S, Oldrini, M, Pascucci, Mg, Perno, Cf, Prestileo, T, Puro, V, Rancilio, L, Ravizza, M, Rizzardini, G, Rusconi, S, Santoro, M, Sighinolfi, L, Stagnitta, M, Starnini, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, C, Viscoli, C, Visintini, R, Vullo, V, Zaccarelli, M, and Zuccotti, G. v.

Subjects
Italy, Anti-HIV Agents, HIV-1, Humans, HIV Infections
Published
2015

5. Italian HIV GuidelinesWorking Group. Italian guidelines for the use of antiretroviral agents and thediagnostic-clinical management of HIV-1 infected persons. Update 2011

Author

Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Armignacco, O, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Floridia, M, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Pal, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Vella, S, Vullo, V, Lazzarin, A, Collaborators: Ensoli B, Italian HIV Guidelines Working G. r. o. u. p., Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Castelli, F, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Monforte, Ad, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Filice, G, Gabrielli, E, Gaeta, Gb, Gervasoni, C, Giacomet, V, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Caputo, Sl, Maggi, P, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pali, G, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Ravizza, M, Savasi, Vm, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburrini, E, Tambussi, G, Tavio, M, Torti, Carlo, Tozzi, V, Trotta, Mp, Vaccher, E, Visintini, R, and Zuccotti, V.

Published
2012

6. Italian guidelines for the use of antiretroviral agents and the diagnostic-clinical management of HIV-1 infected persons

Author

Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Carosi, G, Cinque, P, D' Arminio Monforte, A, Di Perri, G, Ensoli, B, Ferrazzi, E, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Pal, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Suter, F, Vella, S, Collaborators: Ensoli B, Lazzarin A., Lazzarin, A, Antonucci, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, Am, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, De Carli, G, De Luca, A, Di Pietro, M, El Hamad, I, Errico, M, Floridia, M, Gabrielli, E, Giaquinto, C, Girardi, E, Gori, A, Grossi, PAOLO ANTONIO, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Pempinello, R, Perno, Cf, Prestileo, T, Pompa, Mg, Rancilio, L, Rasi, G, Savasi, Vm, Signorini, L, Sighinolfi, L, Sighinolfi, M, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Tamburini, E, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, Mp, Vaccher, E, Vigan, A, Visintini, R, Vullo, V, Zuccotti, Gv, Antinori, A, Marcotullio, S, Ammassari, A, Andreoni, M, Angarano, G, Carosi, G, Cinque, P, d'Arminio Monforte, A, Di Perri, G, Ensoli, B, Ferrazzi, E, Galli, M, Mastroianni, C, Matteelli, A, Mazzotta, F, Moroni, M, Palù, G, Puoti, M, Puro, V, Rizzardini, G, Sagnelli, E, Suter, F, Vella, S, Lazzarin, A, Gori, A, Antinori, Andrea, Marcotullio, Simone, Ammassari, Adriana, Andreoni, Massimo, Angarano, Gioacchino, Carosi, Giampiero, Cinque, Paola, Monforte Antonella, D'Arminio, Di Perri, Giovanni, Ensoli, Barbara, Ferrazzi, Enrico, Galli, Massimo, Mastroianni, Claudio, Matteelli, Alberto, Mazzotta, Francesco, Moroni, Mauro, Palu, Giorgio, Puoti, Massimo, Puro, Vincenzo, Rizzardini, Giuliano, Sagnelli, Evangelista, Suter, Fredy, Vella, Stefano, and for the Italian HIV Guidelines Working, Group

Subjects
ACTIVE ANTIRETROVIRAL THERAPY, HIV, Guidelines, Antiretroviral therapy, Anti-HIV Agents, Anti-HIV Agent, HIV Infections, HIV infection, Settore MED/07 - Microbiologia e Microbiologia Clinica, Italy, therapeutic use, HIV Infections, diagnosis/drug therapy/immunology, HIV-1, drug effects/immunology, Italy, diagnosis/drug therapy/immunology, therapeutic use, HIV-1, guidelines, drug effects/immunology
Published
2011

7. Evolving treatment implementation among HIV- infected pregnant women and their partners: Results from a national surveillance study in Italy, 2001-2015

Author

Floridia, M., Frisina, V. b., Ravizza, M., Marconi, A. M., Pinnetti, C., Cetin, I., Sansone, M., Molinari, A., Cervi, F., Meloni, A., Luzi, K., Masuelli, G., Tamburrini, E., Ensoli, B., Moroni, M., Lazzarin, A., Sagnelli, E., Antinori, A., Carosi, G., Marcotullio, S., Mazzotta, F., Vella, S., Ammassari, A., Antonucci, G., Andreoni, M., Angarano, G., Armignacco, O., Babudieri, S., Baldelli, F., Bini, T., Bonfanti, Bonora, P., Borderi, S., Bruno, M., Bucciardini, R., Castagna, R, Cattelan, A., Cauda, A. M., Cerioli, R., Chirianni, A., Cingolani, A., Cinque, A., D'Arminio, Monforte, Carli, De, Luca, De, Perri, Di, Pietro, Di, Hamad, El, Errico, I., Ferrazzi, M., Gabrielli, E., Galli, E., Giaquinto, M., Girardi, C., Gori, E., Grossi, A., Guaraldi, P., Liuzzi, G., Caputo, Lo, Maggiolo, S., Malena, F., Maserati, M., Mastroianni, R., Matteelli, C., Morrone, A., Murri, A., Mussini, R., Nasta, C., Oldrini, P., Oleari, M., Orlando, F., Palù, G., Pempinello, G., Perno, R., Prestileo, C., Pompa, T., Puoti, M. G., Puro, M., Rancilio, V., Rasi, L., Rizzardini, G., Savasi, G., Signorini, V. M., Sighinolfi, L., Stagnitta, L., Starace, M., Starnini, F., Sterrantino, G., Suter, G., Tambussi, F., Tavio, G., Torti, M., Tozzi, C., Trotta, V., Vaccher, M. P., Viganò, E., Visintini, A., Vullo, R., Zuccotti, V., Dell'Isola, G. V., Manfredini, S., Parisi, V., Pezzoli, S., M. C., Floridia, M, Frisina, V, Ravizza, M, Marconi, A, Pinnetti, C, Cetin, I, Sansone, M, Molinari, A, Cervi, F, Meloni, A, Luzi, K, Masuelli, G, Tamburrini, E, Ensoli, B, Moroni, M, Lazzarin, A, Sagnelli, E, Antinori, A, Carosi, G, Marcotullio, S, Mazzotta, F, Vella, S, Ammassari, A, Antonucci, G, Andreoni, M, Angarano, G, Armignacco, O, Babudieri, S, Baldelli, F, Bini, T, Bonfanti, P, Bonora, S, Borderi, M, Bruno, R, Bucciardini, R, Castagna, A, Cattelan, A, Cauda, R, Cerioli, A, Chirianni, A, Cingolani, A, Cinque, P, d'Arminio Monforte, A, De Carli, G, De Luca, A, Di Perri, G, Di Pietro, M, El Hamad, I, Errico, M, Ferrazzi, E, Gabrielli, E, Galli, M, Giaquinto, C, Girardi, E, Gori, A, Grossi, P, Guaraldi, G, Liuzzi, G, Lo Caputo, S, Maggiolo, F, Malena, M, Maserati, R, Mastroianni, C, Matteelli, A, Morrone, A, Murri, R, Mussini, C, Nasta, P, Oldrini, M, Oleari, F, Orlando, G, Palu, G, Pempinello, R, Perno, C, Prestileo, T, Pompa, M, Puoti, M, Puro, V, Rancilio, L, Rasi, G, Rizzardini, G, Savasi, V, Signorini, L, Sighinolfi, L, Stagnitta, M, Starace, F, Starnini, G, Sterrantino, G, Suter, F, Tambussi, G, Tavio, M, Torti, C, Tozzi, V, Trotta, M, Vaccher, E, Vigano, A, Visintini, R, Vullo, V, Zuccotti, G, Dell'Isola, S, Manfredini, V, Parisi, S, Pezzoli, M, Zona, S, Floridia, M., Frisina, V., Ravizza, M., Marconi, A. M., Pinnetti, C., Cetin, I., Sansone, M., Molinari, A., Cervi, F., Meloni, A., Luzi, K., Masuelli, G., Tamburrini, E., Ensoli, B., Moroni, M., Lazzarin, A., Sagnelli, E., Antinori, A., Carosi, G., Marcotullio, S., Mazzotta, F., Vella, S., Ammassari, A., Antonucci, G., Andreoni, M., Angarano, G., Armignacco, O., Babudieri, S., Baldelli, F., Bini, T., Bonfanti, P., Bonora, S., Borderi, M., Bruno, R., Bucciardini, R., Castagna, A., Cattelan, A. M., Cauda, R., Cerioli, A., Chirianni, A., Cingolani, A., Cinque, P., d'Arminio Monforte, A., De Carli, G., De Luca, A., Di Perri, G., Di Pietro, M., El Hamad, I., Errico, M., Ferrazzi, E., Gabrielli, E., Galli, M., Giaquinto, C., Girardi, E., Gori, A., Grossi, P., Guaraldi, G., Liuzzi, G., Lo Caputo, S., Maggiolo, F., Malena, M., Maserati, R., Mastroianni, C., Matteelli, A., Morrone, A., Murri, R., Mussini, C., Nasta, P., Oldrini, M., Oleari, F., Orlando, G., Palu, G., Pempinello, R., Perno, C. -F., Prestileo, T., Pompa, M. G., Puoti, M., Puro, V., Rancilio, L., Rasi, G., Rizzardini, G., Savasi, V. M., Signorini, L., Sighinolfi, L., Stagnitta, M., Starace, F., Starnini, G., Sterrantino, G., Suter, F., Tambussi, G., Tavio, M., Torti, C., Tozzi, V., Trotta, M. P., Vaccher, E., Vigano, A., Visintini, R., Vullo, V., Zuccotti, G. V., Dell'Isola, S., Manfredini, V., Parisi, S., Pezzoli, M. C., and Zona, S.

Subjects
0301 basic medicine, Male, Infectious Disease Transmission, HIV Infections, Pre-Exposure Prophylaxi, Miscarriage, Cohort Studies, Pre-exposure prophylaxis, 0302 clinical medicine, Pregnancy, Prevalence, Medicine, Vertical, HIV Infection, 030212 general & internal medicine, Pregnancy Complications, Infectious, Treatment implementation, Obstetrics, Health Policy, Medicine (all), Infectious, Pregnancy Outcome, Articles, 3. Good health, Sexual Partner, Sexual Partners, Italy, Serodiscordant, Chemoprophylaxis, Female, Live birth, Adolescent, Adult, Anti-HIV Agents, Fertilization, Humans, Infectious Disease Transmission, Vertical, Pre-Exposure Prophylaxis, Cohort study, Human, medicine.medical_specialty, 03 medical and health sciences, Environmental health, business.industry, Public Health, Environmental and Occupational Health, Anti-HIV Agent, medicine.disease, 030112 virology, Pregnancy Complications, Pregnancy Complications, Infectiou, Cohort Studie, business
Abstract

Background The current global and national indications for antiretroviral treatment (ART, usually triple combination therapy) in adolescent and adults, including pregnant women, recommend early ART before immunologic decline, pre-exposure chemoprophylaxis (PrEP), and treatment of HIV-negative partners in serodiscordant couples. There is limited information on the implementation of these recommendations among pregnant women with HIV and their partners. Methods The present analysis was performed in 2016, using data from clinical records of pregnant women with HIV, followed between 2001 and 2015 at hospital or university clinics within a large, nationally representative Italian cohort study. The study period was divided in three intervals of five years each (2001-2005, 2006-2010, 2011-2015), and the analysis evaluated temporal trends in rates of HIV diagnosis in pregnancy, maternal antiretroviral treatment at conception, prevalence of HIV infection among partners of pregnant women with HIV, and proportion of seronegative and seropositive male partners receiving antiretroviral treatment. Results The analysis included 2755 pregnancies in women with HIV. During the three time intervals considered the rate of HIV diagnosis in pregnancy (overall 23.3%), and the distribution of HIV status among male partners (overall 48.7% HIV- negative, 28.6% HIV-positive and 22.8% unknown) remained substantially unchanged. Significant increases were observed in the proportion of women with HIV diagnosed before pregnancy who were on antiretroviral treatment at conception (from 62.0% in 2001-2005 to 81.3% in 2011-2015, P < 0.001), and in the proportion of HIV-positive partners on antiretroviral treatment (from 73.3% in 2001-2005 to 95.8% in 2011-2015, P = 0.002). Antiretroviral treatment was administered in 99.1% of the pregnancies that did not end early because of miscarriage, termination, or intrauterine death, and in 75.3% of those not ending in a live birth. No implementation of antiretroviral treatment was introduced among male HIV-negative partners. Conclusions The results suggest good implementation of antiretroviral treatment among HIV-positive women and their HIV-positive partners, but no implementation, even in recent years, of Pre-Exposure Prophylaxis (PrEP) among uninfected male partners. Further studies should assess the determinants of this occurrence and clarify the attitudes and the potential barriers to PrEP use.

Published
2017

8. Facilitators and barriers in HIV testing and continuum of care among migrant transgender women who are sex workers residing in Florence, Italy.

Author

Lagi F, Gatteschi C, Tilli M, Zocco N, Avarello A, Bellini S, Contanessi S, Zigliani MR, Stagnitta M, Mariano L, Gazzarri E, Belloni L, Fisher AD, Bartoloni A, Sterrantino G, and Ierardi F

Abstract

Background: An increased risk of contracting HIV infection, suboptimal adherence, and a loss to follow-up have been observed in migrants, particularly if those individuals are transgender or sex workers. A clear picture of the HIV epidemic among migrants is complex due to the lack of specific national data., Aims: We developed a qualitative study that describes the barriers and facilitators (cultural, social, and personal) in HIV testing and the continuum of care for a group of migrant transgender women who are sex workers., Methods: A semi-structured interview was conducted with a group of migrant transgender women who are sex workers living with HIV or with unknown HIV serostatus residing in the Florentine metropolitan area., Results: We included 12 participants: 3 had unknown HIV serostatus and 9 were living with HIV in follow-up at the Clinic of Infectious and Tropical Diseases, Careggi University hospiral, Florence, Italy. Among barriers, the perceived stigma due to their identity as migrants and transgender people, the language lack of ability and the legal position in the host country played a significant role. Moreover, the interviewees claimed having no alternative to sex work: for those individuals, changing their lifestyle condition is perceived as difficult or impossible due to social prejudices. Conversely, the interviewees considered support services, such as cultural mediators/interpreters and street units, as facilitators to HIV testing, access to care, and continuum of care. Having regular and accessible ART and the availability of a more consistent health care system, represent reasons for HIV-positive migrants living with HIV to move to Italy., Conclusions: Knowledge of this population's personal experience regarding the barriers and factors that facilitate access to the HIV care system is essential for planning public health interventions capable of responding to the real needs of patients., Competing Interests: The authors declare that they have no conflict of interest., (© 2023 Taylor & Francis Group, LLC.)

Published
2023
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