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8 results on '"Stagg, Ryan"'

1. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

Author

Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., and Koehler, Angela N.

Published
2021
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2. Abstract 2853: Co-delivery of antigen-encoding mRNA and signal 2/3 mRNAs to PBMCs by Cell Squeeze® technology generates SQZ™ eAPCs that prime CD8+T cells in a humanized mouse model

Author

Maloney, Michael F., primary, Ozay, Emrah Ilker, additional, Blagovic, Katarina, additional, Smith, Carolyne, additional, Silva, Andrea A., additional, Martin, Amber, additional, Manja, Sanjana, additional, Upadhyay, Madhav, additional, Moore, Lindsay J., additional, Stagg, Ryan, additional, Mack, Henry, additional, Trumpfheller, Christine, additional, Umana, Pablo, additional, Sharei, Armon, additional, Bernstein, Howard, additional, and Loughhead, Scott M., additional

Published
2022
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3. ADHD Subtypes and Co-Occurring Anxiety, Depression, and Oppositional-Defiant Disorder: Differences in Gordon Diagnostic System and Wechsler Working Memory and Processing Speed Index Scores

Author

Mayes, Susan Dickerson, Calhoun, Susan L., Chase, Gary A., Mink, Danielle M., and Stagg, Ryan E.

Abstract

Objective: Wechsler Intelligence Scale for Children Freedom-from-Distractibility/Working Memory Index (FDI/WMI), Processing Speed Index (PSI), and Gordon Diagnostic System (GDS) scores in ADHD children were examined as a function of subtype and coexisting anxiety, depression, and oppositional-defiant disorder. Method: Participants were 587 children with ADHD combined type (alone, with oppositional-defiant disorder, and with anxiety or depression) and ADHD inattentive type (alone and with anxiety or depression). Results: Attention scores (FDI/WMI and GDS Vigilance and Distractibility) were similar and low for all groups. ADHD combined groups had greater impulsivity (GDS Delay) than ADHD inattentive groups, and ADHD inattentive groups had slower processing speed (PSI) than ADHD combined groups. Comorbidity did not affect test performance. Scores differentiated ADHD subtypes with 72% accuracy. Conclusion: Findings support the validity of "DSM-IV" ADHD combined and inattentive subtypes and the validity of the GDS, FDI/WMI, and PSI in assessing attention, impulsivity, and processing speed in children with ADHD. (Contains 2 tables.)

Published
2009
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4. Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

Author

Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., Koehler, Angela N., Richters, André, Doyle, Shelby K., Freeman, David B., Lee, Christina, Leifer, Becky S., Jagannathan, Sajjeev, Kabinger, Florian, Koren, Jošt Vrabič, Struntz, Nicholas B., Urgiles, Julie, Stagg, Ryan A., Curtin, Brice H., Chatterjee, Deep, Mathea, Sebastian, Mikochik, Peter J., Hopkins, Tamara D., Gao, Hua, Branch, Jonathan R., Xin, Hong, Westover, Lori, Bignan, Gilles C., Rupnow, Brent A., Karlin, Kristen L., Olson, Calla M., Westbrook, Thomas F., Vacca, Joseph, Wilfong, Chris M., Trotter, B. Wesley, Saffran, Douglas C., Bischofberger, Norbert, Knapp, Stefan, Russo, Joshua W., Hickson, Ian, Bischoff, James R., Gottardis, Marco M., Balk, Steven P., Lin, Charles Y., Pop, Marius S., and Koehler, Angela N.

Abstract

© 2020 The Authors Castration-resistant prostate cancers (CRPCs) lose sensitivity to androgen-deprivation therapies but frequently remain dependent on oncogenic transcription driven by the androgen receptor (AR) and its splice variants. To discover modulators of AR-variant activity, we used a lysate-based small-molecule microarray assay and identified KI-ARv-03 as an AR-variant complex binder that reduces AR-driven transcription and proliferation in prostate cancer cells. We deduced KI-ARv-03 to be a potent, selective inhibitor of CDK9, an important cofactor for AR, MYC, and other oncogenic transcription factors. Further optimization resulted in KB-0742, an orally bioavailable, selective CDK9 inhibitor with potent anti-tumor activity in CRPC models. In 22Rv1 cells, KB-0742 rapidly downregulates nascent transcription, preferentially depleting short half-life transcripts and AR-driven oncogenic programs. In vivo, oral administration of KB-0742 significantly reduced tumor growth in CRPC, supporting CDK9 inhibition as a promising therapeutic strategy to target AR dependence in CRPC. In the pursuit of hormone receptor modulators in prostate cancer, a potent, ultraselective CDK9 inhibitor is discovered. This study describes the most selective inhibitors of CDK9 known to date and provides compelling preclinical in vitro and in vivo support for CDK9 as a therapeutic target.

Published
2022

5. The leaf-area shrinkage effect can bias paleoclimate and ecology research

Author

Blonder, Benjamin, Buzzard, Vanessa, Simova, Irena, Sloat, Lindsey, Boyle, Brad, Lipson, Rebecca, Aguilar-Beaucage, Brianna, Andrade, Angelina, Barber, Benjamin, Barnes, Chris, Bushey, Dharma, Cartagena, Paulina, Chaney, Max, Contreras, Karina, Cox, Mandarava, Cueto, Maya, Curtis, Cannon, Fisher, Mariah, Furst, Lindsey, Gallegos, Jessica, Hall, Ruby, Hauschild, Amelia, Jerez, Alex, Jones, Nadja, Klucas, Aaron, Kono, Anita, Lamb, Mary, Matthai, Jacob David Ruiz, McIntyre, Colten, McKenna, Joshua, Mosier, Nicholas, Navabi, Maya, Ochoa, Alex, Pace, Liam, Plassmann, Ryland, Richter, Rachel, Russakoff, Ben, St. Aubyn, Holden, Stagg, Ryan, Sterner, Marley, Stewart, Emily, Thompson, Ting Ting, Thornton, Jake, Trujillo, Parker J., Volpe, Trevor J., and Enquist, Brian J.

Published
2012
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