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4. Thrombus formation during ECMO: Insights from a detailed histological analysis of thrombus composition

Author

Staessens, Senna, Moussa, Mouhamed D., Pierache, Adeline, Rauch, Antoine, Rousse, Natacha, Boulleaux, Eric, Ung, Alexandre, Desender, Linda, Pradines, Bénédicte, Vincentelli, André, Mercier, Olaf, Labreuche, Julien, Duhamel, Alain, Van Belle, Eric, Vincent, Flavien, Dupont, Annabelle, Vanhoorelbeke, Karen, Corseaux, Delphine, De Meyer, Simon F., and Susen, Sophie

Published
2022
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5. Quantitative 3D analysis of tissue damage in a rat model of microembolization

Author

Majoie, Charles, Marquering, Henk, van Bavel, Ed, Hoekstra, Alfons, Dippel, Diederik, Lingsma, Hester, van der Lugt, Aad, Samuels, Noor, Boodt, Nikki, Roos, Yvo, De Meyer, Simon F, Staessens, Senna, Vandelanotte, Sarah, Konduri, Praneeta, Terreros, Nerea Arrarte, Chopard, Bastien, Raynaud, Franck, Petkantchin, Remy, Panteleev, Mikhail, Shibeko, Alexey, Boudjeltia, Karim Zouaoui, Blanc-Guillemaud, Vanessa, Migliavacca, Francesco, Dubini, Gabriele, Luraghi, Giulia, Matas, Jose Felix Rodriguez, Bridio, Sara, Mc Garry, Patrick, Gilvarry, Michael, McCarthy, Ray, Moerman, Kevin, Fereidoonnezhad, Behrooz, Dwivedi, Anushree, Duffy, Sharon, Payne, Stephen, Jozsa, Tamas, Georgakopoulou, Sissy, Padmos, Raymond, Azizi, Victor, Miller, Claire, van der Kolk, Max, Georgakopoulou, Theodosia, van der Wijk, Anne-Eva, Bakker, Erik N.T.P., and vanBavel, Ed

Published
2021
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7. Endotheliopathy Is Induced by Plasma From Critically Ill Patients and Associated With Organ Failure in Severe COVID-19

Author

Rauch, Antoine, Dupont, Annabelle, Goutay, Julien, Caplan, Morgan, Staessens, Senna, Moussa, Mouhamed, Jeanpierre, Emmanuelle, Corseaux, Delphine, Lefevre, Guillaume, Lassalle, Fanny, Faure, Karine, Lambert, Marc, Duhamel, Alain, Labreuche, Julien, Garrigue, Delphine, De Meyer, Simon F., Staels, Bart, Van Belle, Eric, Vincent, Flavien, Kipnis, Eric, Lenting, Peter J., Poissy, Julien, and Susen, Sophie

Published
2020
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8. Identifying ex vivo acute ischemic stroke thrombus composition using electrochemical impedance spectroscopy

Author

Darcourt, Jean, primary, Brinjikji, Waleed, additional, François, Olivier, additional, Giraud, Alice, additional, Johnson, Collin R., additional, Patil, Smita, additional, Staessens, Senna, additional, Kadirvel, Ramanathan, additional, Mohammaden, Mahmoud H, additional, Pisani, Leonardo, additional, Rodrigues, Gabriel Martins, additional, Cancelliere, Nicole M, additional, Pereira, Vitor Mendes, additional, Bozsak, Franz, additional, Doyle, Karen, additional, De Meyer, Simon F, additional, Messina, Pierluca, additional, Kallmes, David, additional, Cognard, Christophe, additional, and Nogueira, Raul G, additional

Published
2023
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9. A simplified mesoscale 3D model for characterizing fibrinolysis under flow conditions

Author

Petkantchin, Rémy, Rousseau, Alexandre, Eker, Omer, Zouaoui Boudjeltia, Karim, Raynaud, Franck, Chopard, Bastien, Majoie, Charles, van Bavel, Ed, Marquering, Henk, Arrarte-Terreros, Nerea, Konduri, Praneeta, Georgakopoulou, Sissy, Roos, Yvo, Hoekstra, Alfons, Padmos, Raymond, Azizi, Victor, Miller, Claire, van der Kolk, Max, van der Lugt, Aad, Dippel, Diederik W.J., Lingsma, Hester L., Boodt, Nikki, Samuels, Noor, Payne, Stephen, Jozsa, Tamas, El-Bouri, Wahbi K., Gilvarry, Michael, McCarthy, Ray, Duffy, Sharon, Dwivedi, Anushree, Fereidoonnezhad, Behrooz, Moerman, Kevin, McGarry, Patrick, Staessens, Senna, de Meyer, Simon, Vandelanotte, Sarah, Migliavacca, Francesco, Dubini, Gabriele, Luraghi, Giulia, Rodriguez Matas, Jose Felix, Bridio, Sara, Blanc-Guillemaud, Vanessa, Panteleev, Mikhail, Shibeko, Alexey, Petkantchin, Rémy, Rousseau, Alexandre, Eker, Omer, Zouaoui Boudjeltia, Karim, Raynaud, Franck, Chopard, Bastien, Majoie, Charles, van Bavel, Ed, Marquering, Henk, Arrarte-Terreros, Nerea, Konduri, Praneeta, Georgakopoulou, Sissy, Roos, Yvo, Hoekstra, Alfons, Padmos, Raymond, Azizi, Victor, Miller, Claire, van der Kolk, Max, van der Lugt, Aad, Dippel, Diederik W.J., Lingsma, Hester L., Boodt, Nikki, Samuels, Noor, Payne, Stephen, Jozsa, Tamas, El-Bouri, Wahbi K., Gilvarry, Michael, McCarthy, Ray, Duffy, Sharon, Dwivedi, Anushree, Fereidoonnezhad, Behrooz, Moerman, Kevin, McGarry, Patrick, Staessens, Senna, de Meyer, Simon, Vandelanotte, Sarah, Migliavacca, Francesco, Dubini, Gabriele, Luraghi, Giulia, Rodriguez Matas, Jose Felix, Bridio, Sara, Blanc-Guillemaud, Vanessa, Panteleev, Mikhail, and Shibeko, Alexey

Abstract

One of the routine clinical treatments to eliminate ischemic stroke thrombi is injecting a biochemical product into the patient’s bloodstream, which breaks down the thrombi’s fibrin fibers: intravenous or intravascular thrombolysis. However, this procedure is not without risk for the patient; the worst circumstances can cause a brain hemorrhage or embolism that can be fatal. Improvement in patient management drastically reduced these risks, and patients who benefited from thrombolysis soon after the onset of the stroke have a significantly better 3-month prognosis, but treatment success is highly variable. The causes of this variability remain unclear, and it is likely that some fundamental aspects still require thorough investigations. For that reason, we conducted in vitro flow-driven fibrinolysis experiments to study pure fibrin thrombi breakdown in controlled conditions and observed that the lysis front evolved non-linearly in time. To understand these results, we developed an analytical 1D lysis model in which the thrombus is considered a porous medium. The lytic cascade is reduced to a second-order reaction involving fibrin and a surrogate pro-fibrinolytic agent. The model was able to reproduce the observed lysis evolution under the assumptions of constant fluid velocity and lysis occurring only at the front. For adding complexity, such as clot heterogeneity or complex flow conditions, we propose a 3-dimensional mesoscopic numerical model of blood flow and fibrinolysis, which validates the analytical model’s results. Such a numerical model could help us better understand the spatial evolution of the thrombi breakdown, extract the most relevant physiological parameters to lysis efficiency, and possibly explain the failure of the clinical treatment. These findings suggest that even though real-world fibrinolysis is a complex biological process, a simplified model can recover the main features of lysis evolution.

Published
2023

11. Prédiction de la concentration en globules rouges des caillots d'avc en combinant l'irm t2* et des données cliniques et biologiques simples

Author

Mateos, Marjorie, primary, Staessens, Senna, additional, Bretzner, Martin, additional, Corseaux, Delphine, additional, Cordonnier, Charlotte, additional, Casolla, Barbara, additional, Pruvo, Jean-Pierre, additional, Leclerc, Xavier, additional, Boulleaux, Eric, additional, Desender, Linda, additional, Vandenbulcke, Aline, additional, De Meyer, Simon, additional, Susen, Sophie, additional, and Kuchcinski, Grégory, additional

Published
2022
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12. Quantitative 3D analysis of tissue damage in a rat model of microembolization

Author

Georgakopoulou, Theodosia, primary, van der Wijk, Anne-Eva, additional, Bakker, Erik N.T.P., additional, vanBavel, Ed, additional, Majoie, Charles, additional, Marquering, Henk, additional, van Bavel, Ed, additional, Hoekstra, Alfons, additional, Dippel, Diederik, additional, Lingsma, Hester, additional, van der Lugt, Aad, additional, Samuels, Noor, additional, Boodt, Nikki, additional, Roos, Yvo, additional, De Meyer, Simon F, additional, Staessens, Senna, additional, Vandelanotte, Sarah, additional, Konduri, Praneeta, additional, Terreros, Nerea Arrarte, additional, Chopard, Bastien, additional, Raynaud, Franck, additional, Petkantchin, Remy, additional, Panteleev, Mikhail, additional, Shibeko, Alexey, additional, Boudjeltia, Karim Zouaoui, additional, Blanc-Guillemaud, Vanessa, additional, Migliavacca, Francesco, additional, Dubini, Gabriele, additional, Luraghi, Giulia, additional, Matas, Jose Felix Rodriguez, additional, Bridio, Sara, additional, Mc Garry, Patrick, additional, Gilvarry, Michael, additional, McCarthy, Ray, additional, Moerman, Kevin, additional, Fereidoonnezhad, Behrooz, additional, Dwivedi, Anushree, additional, Duffy, Sharon, additional, Payne, Stephen, additional, Jozsa, Tamas, additional, Georgakopoulou, Sissy, additional, Padmos, Raymond, additional, Azizi, Victor, additional, Miller, Claire, additional, and van der Kolk, Max, additional

Published
2021
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17. Thrombus heterogeneity in ischemic stroke.

Author

Staessens, Senna and De Meyer, Simon F.

Subjects
*ISCHEMIC stroke, *THROMBOSIS, *ENDOVASCULAR surgery, *HETEROGENEITY
Abstract

The structure of stroke thrombi has gained an increasing amount of interest in recent years. The advent of endovascular thrombectomy has offered the unique opportunity to provide and analyze thrombi removed from ischemic stroke patients. It has become clear that the composition of ischemic stroke thrombi is relatively heterogenous and various molecular and cellular patterns become apparent. Good understanding of the histopathologic characteristics of thrombi is important to lead future advancements in acute ischemic stroke treatment. In this review, we give a brief overview of the main stroke thrombus components that have been recently characterized in this rapidly evolving field. We also summarize how thrombus heterogeneity can affect stroke treatment. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Identifying ex vivo acute ischemic stroke thrombus composition using electrochemical impedance spectroscopy

Author

Darcourt, Jean, Brinjikji, Waleed, François, Olivier, Giraud, Alice, Johnson, Collin R., Patil, Smita, Staessens, Senna, Kadirvel, Ramanathan, Mohammaden, Mahmoud H, Pisani, Leonardo, Rodrigues, Gabriel Martins, Cancelliere, Nicole M, Pereira, Vitor Mendes, Bozsak, Franz, Doyle, Karen, De Meyer, Simon F, Messina, Pierluca, Kallmes, David, Cognard, Christophe, and Nogueira, Raul G

Abstract

Background Intra-procedural characterization of stroke thromboemboli might guide mechanical thrombectomy (MT) device choice to improve recanalization rates. Electrochemical impedance spectroscopy (EIS) has been used to characterize various biological tissues in real time but has not been used in thrombus.Objective To perform a feasibility study of EIS analysis of thrombi retrieved by MT to evaluate: (1) the ability of EIS and machine learning to predict red blood cell (RBC) percentage content of thrombi and (2) to classify the thrombi as “RBC-rich” or “RBC-poor” based on a range of cutoff values of RBC.Methods ClotbasePilot was a multicentric, international, prospective feasibility study. Retrieved thrombi underwent histological analysis to identify proportions of RBC and other components. EIS results were analyzed with machine learning. Linear regression was used to evaluate the correlation between the histology and EIS. Sensitivity and specificity of the model to classify the thrombus as RBC-rich or RBC-poor were also evaluated.Results Among 514 MT,179 thrombi were included for EIS and histological analysis. The mean composition in RBC of the thrombi was 36% ± 24. Good correlation between the impedance-based prediction and histology was achieved (slope of 0.9, R2=  0.53, Pearson coefficient  =  0.72). Depending on the chosen cutoff, ranging from 20 to 60% of RBC, the calculated sensitivity for classification of thrombi ranged from 77 to 85% and the specificity from 72 to 88%.Conclusion Combination of EIS and machine learning can reliably predict the RBC composition of retrieved ex vivo AIS thrombi and then classify them into groups according to their RBC composition with good sensitivity and specificity.

Published
2024
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19. Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance.

Author

Staessens S, Denorme F, Francois O, Desender L, Dewaele T, Vanacker P, Deckmyn H, Vanhoorelbeke K, Andersson T, and De Meyer SF

Subjects
Humans, Thrombectomy, Brain Ischemia therapy, Ischemic Stroke, Stroke therapy, Thrombosis etiology, Thrombosis therapy
Abstract

Ischemic stroke is caused by a thromboembolic occlusion of cerebral arteries. Treatment is focused on fast and efficient removal of the occluding thrombus, either via intravenous thrombolysis or via endovascular thrombectomy. Recanalization, however, is not always successful and factors contributing to failure are not completely understood. Although the occluding thrombus is the primary target of acute treatment, little is known about its internal organization and composition. The aim of this study, therefore, was to better understand the internal organization of ischemic stroke thrombi on a molecular and cellular level. A total of 188 thrombi were collected from endovascularly treated ischemic stroke patients and analyzed histologically for fibrin, red blood cells (RBC), von Willebrand factor (vWF), platelets, leukocytes and DNA, using bright field and fluorescence microscopy. Our results show that stroke thrombi are composed of two main types of areas: RBC-rich areas and platelet-rich areas. RBC-rich areas have limited complexity as they consist of RBC that are entangled in a meshwork of thin fibrin. In contrast, platelet-rich areas are characterized by dense fibrin structures aligned with vWF and abundant amounts of leukocytes and DNA that accumulate around and in these platelet-rich areas. These findings are important to better understand why platelet-rich thrombi are resistant to thrombolysis and difficult to retrieve via thrombectomy, and can guide further improvements of acute ischemic stroke therapy., (Copyright© 2020 Ferrata Storti Foundation.)

Published
2020
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