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392 results on '"Stadil, F."'

2. Excretion of progastrin products in human urine

Author

Hansen, C. Palnaes, Goetze, J.P., Stadil, F., and Rehfeld, J.F.

Subjects
Excretion -- Research, Gastrointestinal system -- Physiological aspects, Stomach -- Secretions, Urination -- Research, Urine -- Physiological aspects, Peptides -- Physiological aspects, Biological sciences
Abstract

The renal handling of carboxyamidated gastrins, glycine-extended gastrins and NH2-terminal progastrin fragments has been investigated. Healthy subjects were subjected to intravenous administration of carboxyamidated gastrin-17, glycine-extended gastrin-17 and progastrin fragment to determine their respective urinary clearances. Results show that renal excretion of progastrin products is not significant compared with renal metabolism and that renal handling of the peptides is dependent on their molecular structure.

Published
1999

4. Pharmacokinetics and organ metabolism of carboxyamidated and glycine-extended gastrins in pigs

Author

Hansen, C. Palnaes, Stadil, F., Yucun, L., and Rehfeld, J.F.

Subjects
Gastrin -- Physiological aspects, Pharmacokinetics -- Research, Swine -- Physiological aspects, Metabolism -- Research, Biological sciences
Abstract

Elimination of amidated gastrin-17 and glycine-extended gastrin-17 were investigated as a measure of the arteriovenous difference of gastrin-17 during constant-rate infusion of the peptide in anesthetized pigs. Elimination were recorded in the hindlimb, kidney, head and the gut. Measurements of half-life, metabolic clearance rate and apparent volume of distribution for amidated gastrin-17 were different from those for glycine-extended gastrin-17. This suggests that extraction of these gastrins varies in different organs.

Published
1996

5. Metabolism and influence of gastrin-52 on gastric acid secretion in humans

Author

Hansen, C. Palnaes, Stadil, F., and Rehfeld, J.F.

Subjects
Gastrin -- Research, Gastric acid -- Research, Metabolism -- Research, Biological sciences
Abstract

Gastrin-52, an alpha-carboxyamidated product of progastrin, increases gastric acid secretion in humans but is less effective than gastrin-17, a nonsulfated product. This is probably because gastrin-52 has a greater half-life and takes longer to establish an equilibrium between its concentration in the plasma and its receptors. The removal of gastrin-52 is biexponential while that of gastrin-17 is monoexponential. A small amount of gastrin-52 breaks down into smaller peptides in the plasma or blood capillaries.

Published
1995

11. Metabolism and acid secretory effect of sulfated and nonsulfated gastrin-6 in humans

Author

HANSEN, C. PALNAES, STADIL, F., and REHFELD, J. F.

Subjects
Gastrin -- Physiological aspects, Sulfidation -- Physiological aspects, Pharmacokinetics -- Analysis, Protein research -- Analysis, Biological sciences
Abstract

Palnaes Hansen, C., F. Stadil, and J. F. Rehfeld. Metabolism and acid secretory effect of sulfated and nonsulfated gastrin-6 in humans. Am J Physiol Gastrointest Liver Physiol 279: G903-G909, 2000.--The antral hormone gastrin is synthesized by processing progastrin into different peptides that stimulate gastric secretion. The effect on acid secretion depends mainly on the metabolic clearance rate of the peptides, but some of them may differ in potency and maximum acid output at similar concentrations in plasma. Sulfated and nonsulfated gastrin-6 are the smallest circulating bioactive gastrins in humans. Their effect and metabolism have now been investigated in nine normal subjects and compared with nonsulfated gastrin-17, a main product of progastrin. Maximum acid output after stimulation with gastrin-17, sulfated gastrin-6, and nonsulfated gastrin-6 were 28.3 [+ or -] 2.0, 24.5 [+ or -] 2.0 (P [is less than] 0.02), and 19.3 [+ or -] 2.3 (P [is less than] 0.05) mmol [H.sup.+]/50 min, respectively, and the corresponding [EC.sub.50] values were 43 [+ or -] 6, 24 [+ or -] 2 (P [is less than] 0.01), and 25 [+ or -] 2 (not significant) pmol/l. The half-life of gastrin-17 was 5.3 [+ or -] 0.3 min, the metabolic clearance rate (MCR) was 16.5 [+ or -] 1.3 ml [multiplied by] [kg.sup.-1] [multiplied by][min.sup.-1], and the apparent volume of distribution ([V.sub.d]) was 124.3 [+ or -] 9.6 ml/kg. The half-lives of sulfated and nonsulfated gastrin-6 were 2.1 [+ or -] 0.3 and 1.9 [+ or -] 0.3 min, the MCRs were 42.8 [+ or -] 3.7 and 139.4 [+ or -] 9.6 ml [kg.sup.-1] [min.sup.-1] (P [is less than] 0.01), and the [V.sub.d] were 139.0 [+ or -] 30.5 and 392.0 [+ or -] 81.6 (P [is less than] 0.01) ml [kg.sup.-1]. All pharmacokinetic parameters differed significantly from gastrin-17 (P [is less than] 0.01). We conclude that gastrin 6 has a higher potency but a lower efficacy than gastrin-17. The efficacy of gastrin-6 is increased by tyrosine O-sulfation, which also enhances the protection against elimination. gastric acid; pharmacodynamics; pharmacokinetics

Published
2000

12. The metabolism of gastrin-52 and gastrin-6 in pigs

Author

PALNAES HANSEN, C., GOETZE, J. P., STADIL, F., and REHFELD, J. F.

Subjects
Gastrointestinal hormones -- Research, Laboratory animals -- Research, Biological sciences
Abstract

The metabolism of gastrin-52 and gastrin-6 in pigs. Am J Physiol Gastrointest Liver Physiol 279: G552-G560, 2000.-- The kinetics and metabolism in various organs of three bioactive products of progastrin, the small sulfated and nonsulfated gastrin-6 and the large nonsulfated gastrin-52, were examined during intravenous administration in anesthetized pigs. The kidney, hindlimb, liver, head, and gut eliminated the hexapeptides efficiently, with a fractional extraction ranging from 0.50 to 0.28 (P [is less than] 0.001-0.05). No metabolism was recorded in the lungs, and sulfation was without influence on the extraction of gastrin-6. Gastrin-52 was eliminated only in the kidney and the head, with a fractional extraction between 0.23 and 0.11 (P [is less than] 0.01-0.05). The half-life of sulfated and nonsulfated gastrin-6 was 1.5 [+ or -] 0.4 and 1.4 [+ or -] 0.3 min, the metabolic clearance rate (MCR) was 80.8 [+ or -] 7.6 and 116.0 [+ or -] 13.5 ml [multiplied by][kg.sup.- 1][multiplied by][min.sup.1-] (P [is less than] 0.05), and the apparent volume of distribution ([V.sub.dss]) was 199.3 [+ or -] 70.1 and 231.4 [+ or -] 37.3 ml/kg, respectively. The decay of gastrin-52 in plasma was biexponential. The half-lives of this biexponential after a bolus injection were 3.9 [+ or -] 0.5 ([T.sub.1/2[Alpha]]) and 25.7 [+ or -] 1.4 ([T.sub.1/2[Beta]]) min, and the MCR and [V.sub.dss] were 4.2[+ or -] 0.4 ml[multiplied by][kg.sup.-1][multiplied by][min.sup.-1] and 116.2 [+ or -] 16.2 ml/[kg.sup.1]. We conclude that there is a differential elimination of progastrin products in splanchnic and nonsplanchnic tissue, which depends on the chain length of the peptides. Sulfation of gastrin-6 had no influence on the organ-specific extraction but reduced the MCR. Our results are in keeping with previous studies of nonsulfated gastrin-17, which is extracted in the kidney, head, limb, and gut but not in the liver. gastrointestinal hormones

Published
2000

18. Annual Meeting of the Scandinavian Society for the Study of Diabetes: Stockholm, April 20–22, 1972

Author

Täljedal, I. -B., Ashcroft, S. J. H., Randle, P. J., Lernmark, Å., Whistler, R. L., Hedeskov, C. J., Idahl, L. -Å., Asplund, K., Gylfe, E., Hellman, B., Sehlin, J., Berne, Christian, Lundquist, Ingmar, Horstmann, Paul, Nerup, J., Andersen, O. Ortved, Egeberg, J., Bendixen, G., Poulsen, J. E., Vilien, M., Westrup, M., Linde, J., Deckert, T., Wahren, J., Cerasi, E., Luft, R., Felig, P., Hendler, R., Rasmussen, S. Munkgaard, Vølund, Aa., Carlström, S., Persson, G., Lundquist, I., Nordén, Å., Scherstén, B., Nilsén, R., Ledet, Th., Christensen, N. J., Nikkilä, E. A., Bøhmer, T., Havel, R., Long, J., Östman, J., Backman, L., Cerasi, E., Hallberg, D., Luft, R., Sövik, O., Oseid, S., Arnqvist, H. J., Pelkonen, R., Aro, A., Andersson, A., Edwards, J., Hellerström, C., Petersson, B., Westman, J., Howell, S., Iversen, J., Rehfeld, J. F., Stadil, F., Hoist, J. J., Wildenhoff, K. E., Sørensen, N. Schwartz, Johansen, J. P., Hansen, A. P., Hanssen, K. F., Svendsen, P. A., Ørskov, H., Seyer-Hansen, K., Johansen, K., Pruett, E. D. R., Maæhlum, S., Koivisto, V., Kiviluoto, M. K., and Åkerblom, H. K.

Published
1972
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20. Seventh Annual Meeting of the European Association for the Study of Diabetes: Southampton, England, September 15–17, 1971

Author

Knussman, R., Toeller, M., Kopf, A., Tchobroutsky, G., Eschwege, E., Dauchy, F., Korec, R., Koschinsky, Th., Gries, F. A., Herberg, L., Krug, E., Mialhe, P., Marliss, E. B., Kanazawa, Y., Kikuchi, M., Burr, I. M., Stauffacher, W., Renold, A. E., Lambert, A. E., Orci, L., Blondel, B., Rouiller, C., Langslow, D. R., Freeman, B. M., Laube H., Kruger, C., Goberna, R., Fussganger, R., Teller, W., Pfeiffer, E. F., Raptis, S., Legros, F., Conard, V., Metzger, P., Rogister, C., Tinant, A., Lernmark, A., Hellman, B., Sehlin, J., Täljedal, I. -B., Lesobre, B., Hewitt, J., Canivet, J., Levett, R. E., Korp, W., Loubatières, A., Mariani, M. M., Jallet, F., Lundbak, K., Speich, E., Johansen, K., Ørskov, H., Luyckx, A. S., Massi-Benedetti, F., Lefèbvre, P. J., Malaisse, W. J., Brisson, G. R., Marco, J., Diaz-Fierros, M., Baroja, I. M., Villanueva, M. L., Valverde, I., Massara, F., Camanni, F., Molinatti, G. M., McCarroll, A. M., Murphy, R. F., Teale, J. D., Buchanan, K. D., Menzinger, G., Javicoli, M., Fallucca, F., Tamburrano, G., Andreani, D., Michaelis, D., Jutzi, E., Neumann, I., Schulz, B., Hildmann, W., Bibergeil, H., Mincu, I., Campeanu, S., Dumitrescu, C., Mihalache, N., Mincu, T., Parvulescu, M., Georgescu, S., Nuteanu, V., Mogensen, C. E., Hansen, Aa. Prange, Seyer-Hansen, K., Ruth, C. E., Østerby, C. E., Möller, E. B., Bergström, A. L., Wingstrand, H., Persson, S., Morell, B., Froesch, E. R., Mosora, N., Baciu, Tr., Vincze, J., Motocou, M., Simionesco, Ligia, Duma, V., Gligore, V., Muggio, M., Fedele, D., Bagnariol, G., Tiengo, A., Fellin, R., Enzi, G., Rasmussen, S. Munkgaard, Nielsen, Poul Ebbe, Nielsen, S. Levin, Niklas, L., Otto, H., Fuchs, R., Nye, L., Triggs, S., Landon, J., de Mowbray, R., Oelz, O., Oppermann, W., Iwatsuka, H., Ehrenreich, T., Gordon, A., Camerini-Davalos, R. A., Ammon, H. P. T., Steinke, J., Orsetti, A., Bali, J. P., Serre, Mme A., Mirouze, J., Östman, J., Cerasi, E., Efendić, S., Luft, R., Brinck, U., Sabin, J., Sparthe, R., Wübbens, D., Page, M. A., Williamson, D. H., Panten, U., Kriedstein, Ev., Poser, W., Schönborn, J., Hasselblatt, A., Parry, D. G., Taylor, K. W., Polosa, P., Motta, L., Lunetta, M., Pozza, G., Melogli, O., Viberti, G. C., Pappalettera, A. E., Palmieri, G. C., Tognetti, A., Ghidoni, A., Pyörälä, K., Nikkilä, E. A., Lehtovirta, E., Taskinen, M. -R., Pelkonen, R., Siltanen, P., Schröder, K. E., Rothenbuchner, G., Thum, Ch., Fussgänger, R., Sträub, K., Klör, U., Rastogi, G. K., Sinha, M. K., Dash, R. J., Rehfeld, J. F., Stadil, F., Riveline, B., Verry, M., Rosak, C., Bartelt, K. M., Haupt, E., Beyer, J., Schöffling, K., Rosselin, G., Valleron, A. J., Papoz, L., Birk, J., Loos, U., Rudas, B., Wick, G., Samsel, J., Karmann, H., Schatz, H., Rahman, Y. Abdel, Hinz, M., Katsilambros, N., Maier, V., Fehm, H. L., Schenk, K. E., Quabbe, H. J., Klemens, U., Schröder, R., Schennetten, Felix P. N., Schlichtkrull, J., Scandellari, C., Conte, N., Federspil, G., Frezzato, S., Trisotto, A., Scott, R. D. M., Prud'homme, M., Kipnis, D. M., Bricker, N. S., Klahr, S., Skrabalo, Z., Smith, M. J., Hall, M. R. P., Sodovez, J. C., Sodovez-Goffaux, F., Dunbar, J. C., Foà, P. P., Spaethe, R., Meyer, B., Srivastava, M. C., Sönksen, P. H., Tompkins, C. V., Nabarro, J. D. N., Balant, L., Amherdt, M., Cameron, D. P., Steingaszner, O., Kammerer, L., Bretán, M., Sterne, J., Guilcher, S. Le, Rousselet, M., Stimmler, L., Snodgrass, G. J. A. I., Sutherland, Hamish, Tohobroutsky, G., Assan, R., Tompkins, C. V., Track, N. S., Trap-Jensen, J., Turner, M. R., Heard, C. R. C., Reeds, P. J., Munday, K. A., Vague, P., Oliver, C., Jacquet, P., Vague, J., Warnet, J. M., Claude, J. R., Rathery, M., Lozano, I., van Assche, F. A., van't Laar, A., Vigas, M., Haist, R. E., Braun, W., Drucker, W. R., Vitelli, A., Giangrandi, E., Fusco, E., Scaroina, F., Waldhäusl, W. K., Weiss, L., Löffler, G., Schirmann, A., Wieland, O., Westermark, Per, and Woodroffe, F. J.

Published
1972
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23. Case report:Somatostatin producing teratoma, causing rapidly alternating extreme hyperglycemia and hypoglycemia, and ovarian somatostatinoma

Author

Gregersen, Gunnar, Holst, J. J., Trankjaer, A., Stadil, F., Mogensen, Anne M., Gregersen, Gunnar, Holst, J. J., Trankjaer, A., Stadil, F., and Mogensen, Anne M.

Abstract

A 54-year-old woman presented with extremely fluctuating and symptomatic blood glucose levels. Very high levels of somatostatin and low levels of insulin, C-peptide, gastric inhibitory (GIP), and glucagon-like peptide-1 (GLP-1) in peripheral blood were constantly present. A benign somatostatinoma was localized by meta-iodobenzyl guanidine iodine 123 (MIBG-I123) scintigraphy and successfully removed encapsulated in an ovarian teratoma. The patient made a complete recovery. The case described is unique with regard to clinical symptomatology and anatomic localization of the tumor.

Published
2002

50. Neurotensin induced inhibition of gastric acid secretion in duodenal ulcer patients before and after parietal cell vagotomy.

Author

Olsen, P S, Pedersen, J H, Kirkegaard, P, Been, H, Stadil, F, Fahrenkrug, J, and Christiansen, J

Abstract

The influence of the vagal nerve on the inhibitory effect of neurotensin on pentagastrin stimulated gastric acid secretion was investigated in seven duodenal ulcer patients before and after parietal cell vagotomy without drainage. Preoperatively, neurotensin inhibited gastric acid secretion, whereas no effect was found postoperatively. Plasma concentration of neurotensin was identical pre-and postoperatively. This study shows that the inhibitory effect of neurotensin on gastric acid secretion is dependent on an intact vagal innervation of the parietal cell area. [ABSTRACT FROM PUBLISHER]

Published
1984

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