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3 results on '"Stable isotope tracer kinetics"'

1. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Author

Tuvdendorj, Demidmaa, Munoz, Alejandro O, Ruiz-Barros, Viviana, Schwarz, Jean-Marc, Montalto, Giuseppe, Chandalia, Manisha, Sowers, Lawrence C, Rizzo, Manfredi, Murphy, Elizabeth J, and Abate, Nicola

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Cardiovascular, Atherosclerosis, Clinical Research, Diabetes, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Aged, Blood Glucose, Cholesterol, HDL, Female, Humans, Insulin Resistance, Lipids, Lipogenesis, Male, Middle Aged, Obesity, Subcutaneous Fat, Abdominal, Triglycerides, Adipocyte, HDL-C metabolism, Stable isotope tracer kinetics, Atheroprotective, Gender-related, Mass spectrometry, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Backgrounds and aimsLow concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans.MethodsThe fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after (2)H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured.ResultsLinear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p

Published
2016

2. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Author

Elizabeth Murphy, Jean-Marc Schwarz, Giuseppe Montalto, Nicola Abate, Demidmaa Tuvdendorj, Manfredi Rizzo, Viviana Ruiz-Barros, Manisha Chandalia, Alejandro Munoz, Lawrence C. Sowers, Tuvdendorj, D., Munoz, A., Ruiz-Barros, V., Schwarz, J., Montalto, G., Chandalia, M., Sowers, L., Rizzo, M., Murphy, E., and Abate, N.

Subjects
Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Adipocyte, Atheroprotective, Gender-related, HDL-C metabolism, Mass spectrometry, Stable isotope tracer kinetics, Triglycerides, Cardiology and Cardiovascular Medicine, Adipose tissue, White adipose tissue, Type 2 diabetes, 030204 cardiovascular system & hematology, Triglyceride, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Insulin resistance, In vivo, Internal medicine, medicine, Humans, Obesity, Aged, Stable isotope tracer kinetic, business.industry, Lipogenesis, Cholesterol, HDL, nutritional and metabolic diseases, Middle Aged, Atherosclerosis, medicine.disease, Lipids, Subcutaneous Fat, Abdominal, 030104 developmental biology, Endocrinology, chemistry, Female, lipids (amino acids, peptides, and proteins), Insulin Resistance, business
Abstract

Backgrounds and aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans. Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after 2H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured. Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men. Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions.

Published
2016

3. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters.

Author

Tuvdendorj D, Munoz AO, Ruiz-Barros V, Schwarz JM, Montalto G, Chandalia M, Sowers LC, Rizzo M, Murphy EJ, and Abate N

Subjects
Aged, Blood Glucose metabolism, Female, Humans, Insulin Resistance, Lipids blood, Lipogenesis, Male, Middle Aged, Obesity blood, Triglycerides blood, Atherosclerosis blood, Cholesterol, HDL blood, Subcutaneous Fat, Abdominal metabolism, Triglycerides metabolism
Abstract

Backgrounds and Aims: Low concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans., Methods: The fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after (2)H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured., Results: Linear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p < 0.001), I-HDL (r = -0.765,p < 0.001) and S-HDL (r = -0.629, p = 0.009). When analyses were performed by gender, the associations remained significant in women (HDL-C: r = 0.822,p = 0.023; L-HDL: r = 0.892,p = 0.007; I-HDL: r = -0.927,p = 0.003) but not men., Conclusions: Our study demonstrated an in vivo association between subcutaneous abdominal adipose tissue lipid dynamics and HDL parameters in humans, but this was true for women not men. Positive association with L-HDL and negative with I-HDL suggest that subcutaneous abdominal adipose tissue lipid dynamics may play an important role in production of mature functional HDL particles. Further studies evaluating the mechanism responsible for these associations and the observed gender differences are important and warranted to identify potential novel targets of intervention to increase the production of atheroprotective subclasses of HDL-Cs and thus decreasing the risks of development of atherosclerotic conditions., (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)

Published
2016
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