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1. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Position Paper on the role of renal denervation in the management of the difficult-to-treat hypertension

Author

Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Laurenzano, E, Scapaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Muiesan, ML, Ribichini, FL, Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Laurenzano, E, Scapaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Muiesan, ML, and Ribichini, FL

Abstract

Renal denervation (RDN) is a safe and effective strategy for the treatment of difficult to treat hypertension. The blood pressure (BP)-lowering efficacy of RDN is comparable to those of many single antihypertensive medications and it allows to consider the RDN as a valuable option for the treatment of difficult to treat hypertension together with lifestyle modifications and medical therapy. A multidisciplinary team is of pivotal importance from the selection of the patient candidate for the procedure to the post-procedural management. Further studies are needed to investigate the effect of RDN on clinical outcomes and to better identify the predictors of BP response to RDN in order to recognize the patients who are more likely to benefit from the procedure.

Published
2024

2. POR QUE ESCREVO? NARRATIVAS DOCENTES EM SERRA, ESPÍRITO SANTO

Author

CUNHA, C. L., primary, FARIA, I. M., additional, LOBATO, GABRIEL DIAMANTINO, additional, SANTOS, TÂNIA MARIA DOS, additional, ASSEREUY, Janaina E. F., additional, SPERANDIO, R. S., additional, BRITO, A. L., additional, STABILE, E. Q., additional, RAMOS, H. S. G., additional, SILVA, J. M., additional, SILETE, FELIPE DIAS, additional, GUARNIER, IDARLETE ARAÚJO DE OLIVEIRA, additional, RODRIGUES, J. D., additional, MARTIN, MARCELO KEFLER DE, additional, PERUCHI, MAYARA NUNES, additional, BRANDÃO, ROSIANE CAMATTA, additional, ALESSA, REGINA FERNANDES, additional, ROCHA, JULIANA BOA MORTE, additional, BUZIM, P. P., additional, EVÊNCIO, WANILDA MENDES S., additional, SANTIAGO, ANDRESSA DE SÁ, additional, GIMENES, C. C., additional, SOUZA, DACIENE SILVA, additional, OLIVEIRA, PATRÍCIA CAMPOS DE, additional, SOARES, MICHELLE ALVES PEREIRA, additional, COSTA, L. S., additional, SILVA, INGRID MACIEL DA, additional, BOBBIO, FERNANDA ALVES DE AMORIM RUY, additional, SILVA, S. R. F., additional, MONTEIRO, NEUZA ALVES DE OLIVEIRA, additional, DOROTEA, VANDERLEIA DE SOUZA, additional, SOUSA, WALTER SALGADO DE, additional, SILVA, HORTÊNCIA C. GOMES DA, additional, ALVES, PRISCILA SILVA NASCIMENTO PIONTI, additional, JESUS, YSLANE OLIVEIRA DE, additional, and SILVA, EDMA ROSA DA, additional

Published
2019
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5. Italian Society of Interventional Cardiology (GISE) and Italian Society of Arterial Hypertension (SIIA) Consensus document on the role of renal denervation in the management of the difficult to treat hypertension [Documento di consenso della Società Italiana di Cardiologia Interventistica (GISE) e della Società Italiana dell’Ipertensione arteriosa (SIIA) sul ruolo della denervazione renale nella gestione dell’ipertensione arteriosa difficile da trattare]

Author

Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, Esposito, Giovanni, Stabile, E, Muiesan, M, Ribichini, F, Sangiorgi, G, Taddei, S, Versaci, F, Villari, B, Bacca, A, Benedetto, D, Fioretti, V, Liccardo, G, Laurenzano, E, Scappaticci, M, Saia, F, Tarantini, G, Grassi, G, Esposito, G, Stabile, Eugenio, Muiesan, Maria Lorenza, Ribichini, Flavio Luciano, Sangiorgi, Giuseppe, Taddei, Stefano, Versaci, Francesco, Villari, Bruno, Bacca, Alessandra, Benedetto, Daniela, Fioretti, Vincenzo, Liccardo, Gaetano, Laurenzano, Eugenio, Scappaticci, Massimiliano, Saia, Francesco, Tarantini, Giuseppe, Grassi, Guido, and Esposito, Giovanni

Abstract

Arterial hypertension is the most prevalent cardiovascular risk factor worldwide. Despite the availability of many and effective antihypertensive medications, the prevalence of uncontrolled blood pressure (BP) remains high. As sympathetic hyperactivity has long been recognized as a major contributor to resistant hypertension, catheter-based renal denervation (RDN) has emerged as a new strategy to reduce BP. RDN aims to interrupt the activity of renal sympathetic nerves by applying radiofrequency (RF) energy, ultrasound (US) energy, or injection of alcohol in the perivascular space. The Symplicity HTN-3 trial, the largest sham-controlled trial using the first-generation RF-based RDN device, failed to significantly reduce BP. Since then, new devices and techniques have been developed and consequently many sham-controlled trials using second-generation RF or US-based RDN devices have demonstrated the BP lowering efficacy and safety of the procedure. A multidisciplinary team involving hypertension experts, interventionalists with expertise in renal interventions and anesthesiologists, plays a pivotal role from the selection of the patient candidate for the procedure to the post-procedural care. The aim of this consensus document is to summarize the current evidence about the use of RDN in difficult to treat hypertension and to propose a management strategy from the selection of the patient candidate for the procedure to the post-procedural care.

Published
2023

10. Use of Dual-Layered Stents for Carotid Artery Angioplasty : 1-Year Results of a Patient-Based Meta-Analysis

Author

Stabile E., de Donato G., Musialek P., Deloose K., Nerla R., Sirignano P., Mazurek A., Mansour W., Fioretti V., Esposito F., Chianese S., Bosiers M., Setacci C., Speziale F., Micari A., Esposito G., Stabile, E., de Donato, G., Musialek, P., Deloose, K., Nerla, R., Sirignano, P., Mazurek, A., Mansour, W., Fioretti, V., Esposito, F., Chianese, S., Bosiers, M., Setacci, C., Speziale, F., Micari, A., and Esposito, G.

Subjects
Aged, 80 and over, Male, carotid artery stenting, Databases, Factual, Time Factor, Risk Factor, Angioplasty, Carotid Stenosi, carotid artery disease, Prosthesis Design, stroke, Risk Assessment, Treatment Outcome, Recurrence, Thrombosi, Female, Stents, Aged, Human
Abstract

Objectives: This study sought to evaluate 1-year safety and efficacy of dual-layered mesh-covered carotid stent systems (DLS) for carotid artery stenting (CAS). Background: Small clinical studies evaluating 1-year outcomes of CAS performed with 2 available DLS, Roadsaver (RS) (Terumo Corp., Tokyo, Japan) and CGuard (CG) (InspireMD, Boston, Massachusetts), have been published. Methods: The authors performed an individual patient–level meta-analysis including studies enrolling more than 100 CAS with DLS. The primary endpoint was the death and stroke rate; secondary endpoints were restenosis and in-stent thrombosis rates at 1 year. Results: Patients were divided into 2 groups according to DLS (RS n = 250; CG n = 306). At 1 year, 11 patients died (1.97%), 7 patients in the group RS (2.8%) and 4 patients in the CG one (1.31%); and 10 strokes occurred, 4 in the group RS (1.6%) and 6 in the CG one (1.96%). Overall death and stroke rate was 3.77% (n = 21), 11 events in the group RS group (4.4%) and 10 in the CG group (3.27%). Symptomatic status was the only predictor of death and or stroke. At 1 year, restenosis occurred in 12 patients (2.1%), 10 in the group RS (4%) and 2 in the CG one (0.65%) (p = 0.007). In-stent thrombosis occurred in 1 patient (0.18%) in the CG group (0.32%). RS use was the only independent predictor of restenosis. Conclusions: This study suggests that DLS use for CAS is associated with a low 1-year death and stroke rate, and the specific DLS stent used could affect the restenosis rate.

Published
2020

14. Antithrombotic therapy in lower extremity arterial disease

Author

Franzese M., Coscioni E., Scalise M., Gerardi D., Giugliano G., Esposito G., Stabile E., Franzese, M., Coscioni, E., Scalise, M., Gerardi, D., Giugliano, G., Esposito, G., and Stabile, E.

Subjects
Antithrombotic therapy, Anticoagulant, Antiplatelet, Lower extremity arterial disease, Vascular disease
Abstract

Lower extremity arterial disease (LEAD) affects over 200 million people worldwide but, as of today, is not adequately treated and represents an important cause of morbidity, mortality and disability. Although the use of antithrombotic therapy is recommended to prevent cardiovascular adverse events, patients with LEAD often receive inadequate prescription for antithrombotic agents (antiplatelets and anticoagulants). Historically, the inadequate use of antithrombotic drugs in this clinical setting has been ascribed to the lack of high quality scientific data obtained from clinical trials enrolling patients with LEAD. However, the results of more recent clinical trials support the use of antithrombotic drugs for these patients. The aim of this article is to summarize the available evidence supporting the prescription of antithrombotic agents in patients with LEAD.

Published
2019

15. A new Percutaneous technique for effective vascular Access Site closure in patients undergoing Transfemoral aortic valve implantation and thoraco-abdominal aortic aneurysm rEpair: the PASTE study

Author

Sorropago, G, Singh, G, Sorropago, A, Sole, A, Rossi, J, Tolva, V, Stabile, E, Scalise, F, Sorropago G., Singh G., Sorropago A., Sole A., Rossi J., Tolva V. S., Stabile E., Scalise F., Sorropago, G, Singh, G, Sorropago, A, Sole, A, Rossi, J, Tolva, V, Stabile, E, Scalise, F, Sorropago G., Singh G., Sorropago A., Sole A., Rossi J., Tolva V. S., Stabile E., and Scalise F.

Abstract

AIMS: The success of transfemoral transcatheter aortic valve implantation (TAVI) and thoraco-abdominal aneurysm repair (TAAR) depends on haemostatic control of the access site, which is usually obtained with suture-based closure devices (Prostar or two ProGlide). A single ProGlide/Glubran technique, involving a suture placement on the vessel wall followed by tissue glue injection around the vessel wall, has not been previously investigated in this clinical setting. Our aim was to study the feasibility and safety of a single ProGlide/Glubran technique for vascular access-site closure after transfemoral TAVI and TAAR. METHODS AND RESULTS: This technique was used in 250 patients from 2012 to 2017. The primary endpoint was the success of the technique, defined as access-site haemostasis without complications and not requiring any additional intervention within 30 days of the index procedure. Patients had a mean age of 82.4±1.93 years, with a logistic EuroSCORE of 20.2±2.32. A total of 218 TAVI and 32 TAAR procedures were performed with a mean sheath size of 18.09±1.55 Fr. The mean sheath to femoral artery ratio was 1.04±0.16, with mean femoral artery minimal lumen diameter 6.65±0.64 mm. The overall success rate of this technique was 98.4%. Four patients (1.6%) developed critical stenosis of the femoral artery requiring balloon dilatation. No major VARC-2 vascular complications were observed. Thirty-day mortality was 0.4% (non-cardiovascular). CONCLUSIONS: The results of this study suggest that the single ProGlide/Glubran technique is a safe and effective method of closing the arterial access site after transfemoral TAVI and TAAR. The results of our study need to be confirmed in a randomised controlled trial before being adopted in routine clinical practice.

Published
2018

16. Use of dual layered stents in endovascular treatment of extracranial stenosis of the internal carotid artery: one year results of a patient-based meta-analysis of 4 clinical studies

Author

Stabile, E, primary, De Donato, G, additional, Musialek, P, additional, Deloose, K, additional, Nerla, R, additional, Sirignano, P, additional, Mazurek, A, additional, Mansour, W, additional, Fioretti, V, additional, Esposito, F, additional, Chianese, S, additional, Bosiers, M, additional, Speziale, F, additional, Micari, A, additional, and Esposito, G, additional

Published
2020
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18. 2017 ESC update on dual antiplatelet therapy in coronary disease developed in collaboration with the EACTS

Author

Valgimigli A. D. G. D. T. M., Bueno H., Byrne R. A., Collet J. -P., Costa F., Jeppsson A., Juni P., Kastrati A., Kolh P., Mauri L., Montalescot G., Neumann F. -J., Petricevic M., Roffi M., Steg P. G., Windecker S., Zamorano J. L., Levine C. A. G. N., Badimon R. D. D. L., Vranckx P., Agewall S., Andreotti F., Antman E., Barbato E., Bassand J. -P., Bugiardini R., Cikirikcioglu M., Cuisset T., De Bonis M., Delgado V., Fitzsimons D., Gaemperli O., Galie N., Gilard M., Hamm C. W., Ibanez B., Iung B., James S., Knuuti J., Landmesser U., Leclercq C., Lettino M., Lip G., Piepoli M. F., Pierard L., Schwerzmann M., Sechtem U., Simpson I. A., Uva M. S., Stabile E., Storey R. F., Tendera M., Van de Werf F., Verheugt F., Aboyans V., Valgimigli, A. D. G. D. T. M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Juni, P., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Windecker, S., Zamorano, J. L., Levine, C. A. G. N., Badimon, R. D. D. L., Vranckx, P., Agewall, S., Andreotti, F., Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Gaemperli, O., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., Iung, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van de Werf, F., Verheugt, F., and Aboyans, V.

Published
2018

20. The role of ventricular–arterial coupling in cardiac disease and heart failure: assessment, clinical implications and therapeutic interventions. A consensus document of the European Society of Cardiology Working Group on Aorta & Peripheral Vascular Diseases, European Association of Cardiovascular Imaging, and Heart Failure Association

Author

Ikonomidis, I. Aboyans, V. Blacher, J. Brodmann, M. Brutsaert, D.L. Chirinos, J.A. De Carlo, M. Delgado, V. Lancellotti, P. Lekakis, J. Mohty, D. Nihoyannopoulos, P. Parissis, J. Rizzoni, D. Ruschitzka, F. Seferovic, P. Stabile, E. Tousoulis, D. Vinereanu, D. Vlachopoulos, C. Vlastos, D. Xaplanteris, P. Zimlichman, R. Metra, M.

Abstract

Ventricular–arterial coupling (VAC) plays a major role in the physiology of cardiac and aortic mechanics, as well as in the pathophysiology of cardiac disease. VAC assessment possesses independent diagnostic and prognostic value and may be used to refine riskstratification and monitor therapeutic interventions. Traditionally, VAC is assessed by the non-invasive measurement of the ratio of arterial (Ea) to ventricular end-systolic elastance (Ees). With disease progression, both Ea and Ees may become abnormal and the Ea/Ees ratio may approximate its normal values. Therefore, the measurement of each component of this ratio or of novel more sensitive markers of myocardial (e.g. global longitudinal strain) and arterial function (e.g. pulse wave velocity) may better characterize VAC. In valvular heart disease, systemic arterial compliance and valvulo–arterial impedance have an established diagnostic and prognostic value and may monitor the effects of valve replacement on vascular and cardiac function. Treatment guided to improve VAC through improvement of both or each one of its components may delay incidence of heart failure and possibly improve prognosis in heart failure. In this consensus document, we describe the pathophysiology, the methods of assessment as well as the clinical implications of VAC in cardiac diseases and heart failure. Finally, we focus on interventions that may improve VAC and thus modify prognosis. © 2019 The Authors. European Journal of Heart Failure © 2019 European Society of Cardiology

Published
2019

22. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, M, Bueno, H, Byrne, RA, Collet, JP, Costa, F, Jeppsson, A, Juni, P, Kastrati, A, Kolh, P, Mauri, L, Montalescot, G, Neumann, FJ, Petricevic, M, Roffi, M, Steg, PG, Windecker, S, Zamorano, JL, Levine, GN, Badimon, L, Vranckx, P, Agewall, S, Andreotti, F, Antman, E, Barbato, E, Bassand, JP, Bugiardini, R, Cikirikcioglu, M, Cuisset, T, De Bonis, M, Delgado, V, Fitzsimons, D, Oliver, G, Galie, N, Gilard, M, Hamm, CW, Ibanez, B, Iung, B, James, S, Knuuti, J, Landmesser, U, Leclercq, C, Lettino, M, Lip, G, Piepoli, MF, Pierard, L, Schwerzmann, M, Sechtem, U, Simpson, IA, Uva, MS, Stabile, E, Storey, RF, Tendera, M, Van De Werf, F, Verheugt, F, Aboyans, V, Task Force Dual Antiplatelet Ther, and European Asso Cardio-Thoracic Surg

Subjects
Ticagrelor, Stable angina, Aspirin, Stent thrombosis, Revascularization, Bleeding, Coronary artery bypass grafting, Guidelines, Acute coronary syndromes, Recommendation, Coronary artery disease, Clopidogrel, Percutaneous coronary intervention, Myocardial infarction, Non-cardiac surgery, Dual antiplatelet therapy, Stents, Stable coronary artery disease, Oral anticoagulant, DAPT score, Triple therapy, Prasugrel, Drug-eluting stents, Risk stratification, PRECISE-DAPT score
Published
2018

23. Long-term clinical outcomes after bioresorbable vascular scaffold implantation for the treatment of coronary in-stent restenosis

Author

Moscarella E., Ielasi A., Granata F., Coscarelli S., Stabile E., Latib A., Cortese B., Tespili M., Tanaka A., Capozzolo C., Caliendo L., Colombo A., Varricchio A., Moscarella, E., Ielasi, A., Granata, F., Coscarelli, S., Stabile, E., Latib, A., Cortese, B., Tespili, M., Tanaka, A., Capozzolo, C., Caliendo, L., Colombo, A., and Varricchio, A.

Subjects
Male, Registrie, Time Factor, Metal, Risk Factor, Myocardial Infarction, Coronary Artery Disease, Kaplan-Meier Estimate, Middle Aged, Prosthesis Design, Prospective Studie, Treatment Outcome, Percutaneous Coronary Intervention, Italy, Coronary Restenosi, Recurrence, Absorbable Implant, Proportional Hazards Model, Drug-Eluting Stent, stent, Female, Stents, Human, Aged
Abstract

Background - Treatment of in-stent restenosis (ISR) is still challenging. In this setting, the use of bioresorbable vascular scaffold (BVS) seems attractive because it allows drug delivery combined with transient vessel scaffolding. We aimed to investigate the long-term results after BVS use in ISR lesions. Methods and Results - A prospective analysis was performed on all patients who underwent percutaneous coronary intervention with BVS implantation for ISR at 7 Italian Centers. Primary end point was the device-oriented composite end point (cardiac death, target vessel myocardial infarction, and ischemia-driven target lesion revascularization) at the longest follow-up available. From April 2012 to June 2014, 116 patients (127 lesions) underwent percutaneous coronary intervention for ISR with BVS implantation. Among the ISR lesions, the majority were drug-eluting stent ISR (78, 61.6%), de novo ISR (92, 72.4%), and diffuse ISR (81, 63.8%). Procedural success was achieved for all (100%) patients. No in-hospital death, myocardial infarction, or revascularization occurred. At 15 months of follow-up, the incidence of the device-oriented composite end point estimated with the Kaplan-Meier method was 9.1%. No significant differences were reported between drug-eluting stent and bare-metal stent ISR groups in terms of device-oriented composite end point (10.9% versus 6.4%; hazard ratio, 1.7; 95% confidence interval, 0.5-6.5; P=0.425) and its singular components (cardiac death: 2.8% versus 2.0%, hazard ratio, 1.3; 95% confidence interval, 0.1-14.1, P=0.843; target vessel myocardial infarction: 1.5% versus 0%, P=0.421; ischemia-driven target lesion revascularization: 9.6% versus 4.4%, hazard ratio, 2.3; 95% confidence interval, 0.5-10.8, P=0.309). Conclusions - Our registry suggests that the use of BVS implantation for the treatment of complex drug-eluting stent and bare-metal stent ISR lesions might be associated with acceptable long-term clinical outcomes.

Published
2016

24. 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS

Author

Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., Andreotti F. (ORCID:0000-0002-1456-6430), Valgimigli, M., Bueno, H., Byrne, R. A., Collet, J. -P., Costa, F., Jeppsson, A., Kastrati, A., Kolh, P., Mauri, L., Montalescot, G., Neumann, F. -J., Petricevic, M., Roffi, M., Steg, P. G., Zamorano, J. L., Levine, G. N., Badimon, L., Vranckx, P., Agewall, S., Andreotti, Felicita, Antman, E., Barbato, E., Bassand, J. -P., Bugiardini, R., Cikirikcioglu, M., Cuisset, T., De Bonis, M., Delgado, V., Fitzsimons, D., Galie, N., Gilard, M., Hamm, C. W., Ibanez, B., James, S., Knuuti, J., Landmesser, U., Leclercq, C., Lettino, M., Lip, G., Piepoli, M. F., Pierard, L., Schwerzmann, M., Sechtem, U., Simpson, I. A., Uva, M. S., Stabile, E., Storey, R. F., Tendera, M., Van De Werf, F., Verheugt, F., Aboyans, V., Windecker, S., Coca, A., Coman, I. M., Dean, V., Gaemperli, O., Hindricks, G., Iung, B., Juni, P., Katus, H. A., Lancellotti, P., Mcdonagh, T., Ponikowski, P., Richter, D. J., Shlyakhto, E., Roithinger, F. X., Aliyev, F., Stelmashok, V., Desmet, W., Postadzhiyan, A., Georghiou, G. P., Motovska, Z., Grove, E. L., Marandi, T., Kiviniemi, T., Kedev, S., Massberg, S., Alexopoulos, D., Kiss, R. G., Gudmundsdottir, I. J., Mcfadden, E. P., Lev, E., De Luca, L., Sugraliyev, A., Haliti, E., Mirrakhimov, E., Latkovskis, G., Petrauskiene, B., Huijnen, S., Magri, C. J., Cherradi, R., Ten Berg, J. M., Eritsland, J., Budaj, A., Aguiar, C. T., Duplyakov, D., Zavatta, M., Antonijevic, N. M., Fras, Z., Montoliu, A. T., Varenhorst, C., Tsakiris, D., Addad, F., Aydogdu, S., Parkhomenko, A., Kinnaird, T., and Andreotti F. (ORCID:0000-0002-1456-6430)

Abstract

N/A

Published
2018

25. Impact of postoperative acute kidney injury on clinical outcomes after TAVI: A meta-analysis of 5,971 patients

Author

Gargiulo G, Sannino A, Capodanno D, Perrino C, Capranzano P, Barbanti M, Stabile E, Trimarco B, Tamburino C, Esposito G., Gargiulo, G, Sannino, A, Capodanno, D, Perrino, C, Capranzano, P, Barbanti, M, Stabile, E, Trimarco, B, Tamburino, C, and Esposito, G.

Subjects
acute kidney injury, prognosis, severe aortic stenosis, transcatheter aortic valve implantation
Abstract

Background There is conflicting evidence on the safety and efficacy of transcatheter aortic valve implantation (TAVI) in patients with postoperative acute kidney injury (AKI). Therefore, we conducted a meta-analysis on the impact of AKI on clinical outcomes after TAVI. Methods and Results Twenty-four studies including 5,971 patients were analyzed. The mean incidence of AKI in this population was 22.1% ± 11.2. Postoperative AKI significantly increased early (odds ratio [OR] 5.09; 95% confidence interval [CI], 4.03-6.43 and OR 6.14; 95% CI, 3.26-11.55) and 1-year (OR 3.27; 95% CI, 2.42-4.42 and OR 1.93; 95% CI, 1.38-2.71) all-cause and cardiovascular mortality respectively, but also early myocardial infarction (OR 3.30; 95% CI, 1.44-7.57), life-threatening bleeding (OR 2.90; 95% CI, 1.67-5.05), need for transfusion (OR 2.42; 95% CI, 1.96-2.99), and dialysis (OR 14.35; 95% CI, 6.21-33.20), with a non-significant increase of stroke (OR 1.66; 95% CI, 0.94-2.95), hospitalization (mean difference [MD] 1.73; 95% CI, -0.31 to 3.77) and contrast medium received (MD 4.74; 95% CI, -2.33 to 11.81). Conclusions Postoperative AKI seems to significantly worsen TAVI prognosis. The results of the present meta-analysis should be considered hypothesis-generating and future studies on risk stratification, prevention, and postoperative management are needed.

Published
2015

26. Bioresorbable vascular scaffold implantation for the treatment of coronary in-stent restenosis: Results from a multicenter Italian experience

Author

Moscarella E, Varricchio A, Stabile E, Latib A, Ielasi A, Tespili M, Cortese B, Granata F, Panoulas VF, Franzone A, Trimarco B, Bonzani G, Esposito G, Colombo A., CALABRO', Paolo, Moscarella, E, Varricchio, A, Stabile, E, Latib, A, Ielasi, A, Tespili, M, Cortese, B, Calabro', Paolo, Granata, F, Panoulas, Vf, Franzone, A, Trimarco, B, Bonzani, G, Esposito, G, and Colombo, A.

Published
2015

30. 4058Effects of selective and nonselective beta-blockers on platelet aggregation in patients with acute coronary syndrome: the PLATE-BLOCK study

Author

Ilardi, F, primary, Gargiulo, G, additional, Schiattarella, G G, additional, Giugliano, G, additional, Paolillo, R, additional, Menafra, G, additional, De Angelis, E, additional, Franzone, A, additional, Stabile, E, additional, Perrino, C, additional, Cirillo, P, additional, Morisco, C, additional, Izzo, R, additional, Trimarco, V, additional, and Esposito, G, additional

Published
2018
Full Text
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33. Clinical Cases: Ischaemic heart disease899Asymptomatic very late presentation of ALCAPA900Usefulness of 3-dimensional contrast echocardiography in the diagnosis of a left ventricular pseudoaneurysm after acute myocardial infarction901Peri-procedural jailing of septal perforator branch retrospectively identified using speckle tracking echocardiography902Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA)903Coronary artery compression by aneurysmal pulmonary artery904A rare complication of myocardial infarction: pseudoaneurysm leading to ischaemic VSD905Single coronary ostium from the right aortic sinus of valsalva906Incremental value of regional longitudinal strain upon visual assessment for detection of ischemia during dobutamine stress echocardiography907One serious complication after myocardial infarction, isn't that enough?

Author

Cambronero Cortinas, E., primary, Marini, C., primary, Sorrentino, R., primary, Hassan, Y., primary, Badea, RG., primary, Heseltine, TD., primary, Laymouna, R., primary, Santoro, C., primary, Sawicka, K., primary, Gonzalez Garcia, AE., additional, Bret Zurita, M., additional, Garcia Hamilton, D., additional, Corbi Pascual, MJ., additional, Ruiz Cantador, J., additional, Oliver Ruiz, JM., additional, Ancona, F., additional, Stella, S., additional, Rosa, I., additional, Spartera, M., additional, Melisurgo, G., additional, Pappalardo, F., additional, Margonato, A., additional, Agricola, E., additional, Lo Iudice, F., additional, Niglio, T., additional, Stabile, E., additional, Galderisi, M., additional, Trimarco, B., additional, Elsharkawy, E., additional, Laymouna, R., additional, Elgowelly, M., additional, Almaghraby, A., additional, Enache, R., additional, Serban, M., additional, Gherasim, D., additional, Platon, P., additional, Ginghina, C., additional, Lima, E., additional, Cino-Polla, JM., additional, Hassan, Y., additional, Ilardi, F., additional, Lembo, M., additional, Cirillo, P., additional, Esposito, G., additional, Prasal, M., additional, Tomaszewski, M., additional, Wojtkowska, A., additional, and Tomaszewski, A., additional

Published
2016
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34. Pre-existing and new-onset atrial fibrillation: a meta-analysis of mortality outcomes and cerebrovascular events in 13,795 patients undergoing transcatheter aortic valve implantation

Author

Sannino, A., Gargiulo, G., Gabriele Schiattarella, Perrino, C., Stabile, E., Losi, M. A., Galderisi, M. A., Simone, G. G., Trmarco, B., Esposito, G., Sannino, Anna, Gargiulo, Giuseppe, Schiattarella, GABRIELE GIACOMO, Perrino, Cinzia, Stabile, Eugenio, Losi, MARIA ANGELA, Galderisi, Maurizio, De Simone, G, Trimarco, Bruno, and Esposito, Giovanni

Published
2015

38. Membrane-bound protein Kinase A amplifies cAMP-PKA signals and inhibits in vitro and in vivo the proliferation of smooth muscle cells

Author

INDOLFI, C., STABILE, E., COPPOLA, C., GALLO, A., PERRINO, C., ALLEVATO, G., CAVUTO, L., DI LORENZO, E. , TRONCONE, G. , FELICIELLO, AND CHIARIELLO, AVVEDIMENTO, VITTORIO ENRICO, Indolfi, C., Stabile, E., Coppola, C., Gallo, A., Perrino, C., Allevato, G., Cavuto, L., Di, Lorenzo, E., Troncone, G., Feliciello, Avvedimento, VITTORIO ENRICO, and And, Chiariello

Abstract

Avvedimento* corresponding author

Published
2001

40. Low grade of systemic inflammation exaggerates neointimal hyperplasia after balloon injury through JAK-Stat/iNOS activation

Author

Torella D, Coppola C, Curcio A, Stingone AM, Leccia A, Di Lorenzo E, Stabile E, Belardo L, Nardiello P, Indolfi C., ARCUCCI, ORESTE, RAPACCIUOLO, ANTONIO, Torella, D, Coppola, C, Curcio, A, Arcucci, Oreste, Stingone, Am, Leccia, A, Rapacciuolo, Antonio, Di Lorenzo, E, Stabile, E, Belardo, L, Nardiello, P, and Indolfi, C.

Subjects
Neointimal hyperplasia after, balloon injury, JAK-Stat/iNOS activation
Published
2000

42. Effetti della modulazione degli isoenzimi della proteina kinasi a sulla proliferazione delle cellule muscolari lisce vascolari in vitro e sull’iperplasia neointmale dopo angioplastica in vivo

Author

PERRINO, CINZIA, Indolfi C, Di Lorenzo E, Stingone A.M. Cioppa A, Stabile E, Leccia A, Tortora GP, ARCUCCI, ORESTE, RAPACCIUOLO, ANTONIO, CIARDIELLO, FORTUNATO, CHIARIELLO, MASSIMO, Perrino, Cinzia, Indolfi, C, Di Lorenzo, E, Cioppa A, Stingone A. M., Stabile, E, Leccia, A, Arcucci, Oreste, Rapacciuolo, Antonio, Tortora, Gp, Ciardiello, Fortunato, and Chiariello, Massimo

Subjects
cellule muscolari lisce, iperplasia neointimale, Proteina kinasi A
Published
1999

43. L’alterazione del rapporto fra le subunità Ria ed RII b della proteina kinasi A inibisce la proliferazione delle cellule muscolari lisce vascolari in vitro e l’iperplasia neointmale dopo angioplastica in vivo

Author

Di Lorenzo E, Indolfi C, Stingone AM, PERRINO, CINZIA, Stabile E, Leccia A, Torella D, Pascotto M, ARCUCCI, ORESTE, RAPACCIUOLO, ANTONIO, CHIARIELLO, MASSIMO, Di Lorenzo, E, Indolfi, C, Stingone, Am, Perrino, Cinzia, Stabile, E, Leccia, A, Torella, D, Pascotto, M, Arcucci, Oreste, Rapacciuolo, Antonio, and Chiariello, Massimo

Subjects
subunità Ria ed RII b, proteina kinasi A, neointima
Published
1999

44. A kinase anchor protein 75 hyperexpression increases p27kip1 levels in vitro and reduce smooth muscle cell proliferation in vivo by preventing p27kip1 loss after balloon injury

Author

Stabile E, Gallo A, TRONCONE, GIANCARLO, Coppola C, Torella D, Pascotto M, Indolfi C., PERRINO, CINZIA, RAPACCIUOLO, ANTONIO, Stabile, E, Gallo, A, Troncone, Giancarlo, Coppola, C, Perrino, Cinzia, Torella, D, Pascotto, M, Rapacciuolo, Antonio, and Indolfi, C.

Subjects
A kinase anchor protein 75, smooth muscle cell proliferation, balloon injury
Published
1999

46. La rottura della lamina elastica interna è necessaria per la proliferazione delle cellule muscolari lisce ma non per il rimodellamento arterioso dopo angioplastica

Author

PISANI A, INDOLFI C, STABILE E, DI LORENZO E, COPPOLA C, CAVUTO L, PERRINO, CINZIA, TORELLA D, CIOPPA A, D'URSO G, CHIARIELLO M., ESPOSITO, GIOVANNI, Pisani, A, Indolfi, C, Stabile, E, Esposito, Giovanni, DI LORENZO, E, Coppola, C, Cavuto, L, Perrino, Cinzia, Torella, D, Cioppa, A, D'Urso, G, and Chiariello, M.

Published
1998

47. L’attivazione del signaling intracellulae cAMP dipendente mediante l’iperespressione della proteina AKAP 75 (kinase A anchor protein 75) riduce la formazione di neointima dopo danno vascolare

Author

Stabile E, Coppola C, Allevato G, D’Urso G, Ottaviano L, Pascotto M, Pisani A, Cavuto L, Di Lorenzo E, Avvedimento EV, Indolfi C., ARCUCCI, ORESTE, RAPACCIUOLO, ANTONIO, ESPOSITO, GIOVANNI, Stabile, E, Coppola, C, Allevato, G, D’Urso, G, Ottaviano, L, Arcucci, Oreste, Pascotto, M, Pisani, A, Cavuto, L, Di Lorenzo, E, Rapacciuolo, Antonio, Esposito, Giovanni, Avvedimento, Ev, and Indolfi, C.

Subjects
cAMP, danno vascolare, AKAP 75 (kinase A anchor protein 75)
Published
1998

48. Terapia genica locale nella prevenzione della ristenosi: effetto dell'iperespressione delle proteine AKAP sulla formazione di neointima in un modello sperimentale di stenting arterioso

Author

STABILE E, INDOLFI C, DI LORENZO E, LECCIA A, COPPOLA C, PERRINO, CINZIA, PISANI A, CAVUTO L, PASCOTTO M, CHIARIELLO M., ESPOSITO, GIOVANNI, Stabile, E, Indolfi, C, DI LORENZO, E, Leccia, A, Coppola, C, Perrino, Cinzia, Pisani, A, Cavuto, L, Pascotto, M, Esposito, Giovanni, and Chiariello, M.

Published
1998

50. Effetti della somministrazione sistemica di un analogo del cAMP sulla proliferazione delle fibrocellule muscolari lisce indotta dal danno vascolare in vivo

Author

Stingone AM, Indolfi C, Di Lorenzo E, Stabile e, Cioppa A, Ottaviano L, Pascotto M, Leccia A, RAPACCIUOLO, ANTONIO, PERRINO, CINZIA, CHIARIELLO, MASSIMO, Stingone, Am, Indolfi, C, Di Lorenzo, E, Rapacciuolo, Antonio, Stabile, E, Cioppa, A, Perrino, Cinzia, Ottaviano, L, Pascotto, M, Leccia, A, and Chiariello, Massimo

Subjects
fibrocellule muscolari lisce, cAMP, danno vascolare
Published
1998

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