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1. Abstracts from the 10th C1-inhibitor deficiency workshop

Author

Alvin H. Schmaier, Marco Cicardi, Avner Reshef, Dumitru Moldovan, Attila Mócsai, Margarita López-Trascasa, Alberto López Lera, Nancy J. Brown, Anastasios E. Germenis, Rafael Filippelli-Silva, Diego A. Duarte, Renan P. Martin, Camila L. Veronez, Michel Bouvier, Michael Bader, Claudio M. Costa-Neto, João Bosco Pesquero, Xavier Charest-Morin, François Marceau, Georges-É. Rivard, Arnaud Bonnefoy, Éric Wagner, Márta L. Debreczeni, Zsuzsanna Németh, Erika Kajdácsi, Endre Schwaner, László Cervenak, Gábor Oroszlán, András Szilágyi, Ráhel Dani, Péter Závodszky, Péter Gál, József Dobó, Jacques Hébert, Matthieu Vincent, Jean-Nicolas Boursiquot, Hugo Chapdeleine, Marylin Desjardins, Benoit Laramée, Rémi Gagnon, Nancy Payette, Oleksandra Lepeshkina, Delphine Charignon, Arije Ghannam, Denise Ponard, Christian Drouet, Kusumam Joseph, Baby G. Tholanikunnel, Daniel J. Sexton, Allen P. Kaplan, Stefania Loffredo, Maria Bova, Anne Lise Ferrara, Angelica Petraroli, Chiara Suffritti, Nóra Veszeli, Andrea Zanichelli, Henriette Farkas, Gianni Marone, Samuel Luyasu, Bertrand Favier, Ludovic Martin, Kinga Viktória Kőhalmi, György Temesszentandrási, Katalin Várnai, Lilian Varga, Bruce L. Zuraw, Annette Feussner, Michael A. Tortorici, Dipti Pawaskar, Huamin Henry Li, John Anderson, Jonathan A. Bernstein, Ying Zhang, Ingo Pragst, on behalf of COMPACT investigators, Emel Aygören-Pürsün, Kraig Jacobson, Jim Christensen, Arthur Van Leerberghe, Yi Wang, Jennifer Schranz, Inmaculada Martinez-Saguer, Daniel Soteres, Urs Steiner, Vesna Grivcheva Panovska, William Rae, Werner Aberer, Aarnoud Huissoon, Anette Bygum, Markus Magerl, Jochen Graff, Hilary Longhurst, Ramón Lleonart, Lei Fang, Melanie Cornpropst, Desiree Clemons, Amanda Mathis, Phil Collis, Sylvia Dobo, William P. Sheridan, Marcus Maurer, Marc A. Riedl, Timothy Craig, Aleena Banerji, Mustafa Shennak, William Yang, Jovanna Baptista, Paula Busse, Ira Kalfus, Andrew McDonald, Shawn Qian, Anthony Roberts, Con Panousis, Tim Green, Andreas Gille, Maria Zamanakou, Gedeon Loules, Dorottya Csuka, Fotis Psarros, Faidra Parsopoulou, Matthaios Speletas, Davide Firinu, Tiziana Maria Angela De Pasquale, Alessandra Zoli, Anna Radice, Stefano Pizzimenti, Emmanouil Manoussakis, George N. Konstantinou, Valeria Bafunno, Vincenzo Montinaro, Mauro Cancian, Maurizio Margaglione, Konrad Bork, Karin Wulff, Guenther Witzke, Jochen Hardt, Laurence Bouillet, Teresa Caballero, Anete S. Grumach, Christelle Pommie, Irmgard Andresen, Carmen Escuriola Ettingshausen, Zeynep Gutowski, Karin Andritschke, Richard Linde, Noémi Andrási, Tamás Szilágyi, Iris Leibovich-Nassi, Christine Symons, John Dempster, Isabelle Boccon-Gibod, Anne Pagnier, Audrey Lehmann, Kristian B. Kreiberg, Sandra A. Nieto, Raquel Martins, Renata Martins, Alejandra Menendez, Solange O. R. Valle, Margarita Olivares, Maria E. Hernandez-Landeros, Elma Nievas, Natalia Fili, Olga M. Barrera, René Bailleau, Ana Maria Gallardo-Olivos, Masumi Grau, Julian Rodriguez-Galindo, Marlon J. O. Carabantes, Edison Zapata-Venegas, Mario Martinez Alfonso, Maria Rosario-Grauert, Manuel Ratti, Daniel Vaszquez, Dario Josviack, Luis Fernando Landivar-Salinas, Oscar M. E. Calderón-Llosa, Rolando Campilay-Sarmiento, Pablo Raby, Jose Fabiani, William R. Lumry, Henrike Feuersenger, Douglas J. Watson, Thomas Machnig, on behalf of the Investigators of the COMPACT study, Donatella Lamacchia, Adriana Hernanz, Ana Alvez, Mariana Lluncor, Maria Pedrosa, Rosario Cabañas, Nieves Prior, Patrik Nordenfelt, Mats Nilsson, Anders Lindfors, Carl-Fredrik Wahlgren, Janne Björkander, Roman Hakl, Pavel Kuklínek, Irena Krčmová, Jana Hanzlíková, Martina Vachová, Radana Zachová, Marta Sobotková, Jana Strenková, Jiří Litzman, Maria Palasopoulou, Gerasimina Tsinti, Panagiota Gianni, Maria Kompoti, Sofia Garrido, Wojciech Dyga, Anna Bogdali, Aleksander Obtułowicz, Mikolajczyk Tomasz, Ewa Czarnobilska, Krystyna Obtulowicz, Teofila Książek, Anna Koncz, Dominik Gulyás, Maria Staevska, Milos Jesenak, Katarina Hrubiskova, L. Bellizzi, A. Relan, Maddalena A. Wu, Antonio Castelli, Riccardo Colombo, Gianmarco Podda, Marta Del Medico, Emanuele Catena, Francesco Casella, Francesca Perego, Nada Afifi Afifi, Eleonora Tobaldini, Nicola Montano, for the IOS Study Group, Marta Sánchez-Jareño, Marcin Stobiecki, Krystyna Obtułowicz, Irina Guryanova, Ekaterina Polyakova, Viktar Lebedz, Andrej Salivonchik, Svetlana Aleshkevich, Mikhail Belevtsev, Melanie Nordmann-Kleiner, Susanne Trainotti, Janina Hahn, Jens Greve, Liudmyla Zabrodska, Maria L. Oliva Alonso, Rosangela P. Tórtora, Alfeu T. França, Marcia G. Ribeiro, Lisa Fu, Amin Kanani, Gina Lacuesta, Susan Waserman, Stephen Betschel, Melissa I. Espinosa, Francisco A. Contreras, Martin Hrubisko, Ludmila Vavrova, Peter Banovcin, Maryam Ayazi, Mohammad Reza Fazlollahi, Shiva Saghafi, Sajedeh Mohammadian, Susan Nabilou Deshiry, Kiana Bidad, Raheleh Shokouhi Shoormasti, Iraj Mohammadzadeh, Mohammad Hassan Bemanian, Seyed Alireza Mahdaviani, Zahra Pourpak, Anna Valerieva, Mariela Vasileva, Tsvetelina Velikova, Elena Petkova, Vasil Dimitrov, Ruggero Di Maulo, on behalf of participating centers, Raz Somech, Hava Golander, Erika J. Sifuentes, Catherine Mansard, Anne Gompel, Bernard Floccard, Claire Blanchard-Delaunay, David Launay, Olivier Fain, Alain Sobel, Stéphane Gayet, Stéphanie Amarger, Guillaume Armengol, Yann Ollivier, Ariane Zélinsky-Gurung, Pierre-Yves Jeandel, Gisèle Kanny, Brigitte Coppéré, Marie Dubrel, Fabien Pelletier, Aurélie Du Thanh, Sébastien Trouiller, Jérôme Laurent, Claire De Moreuil, Christine Audouin Pajot, Alexandre Belot, Ana Rodríguez, Dasha Roa, Alicia Prieto, Maria Luisa Baeza, Borislava Krusheva, Stephanie K. A. Almeida, Rosemeire N. Constantino-Silva, Nyla Melo, Joanna Araujo Simoes, Sandra Mitie U. Palma, Jane da Silva, Bruna F. de Azevedo, Eli Mansour, Teresa González-Quevedo, Carmen Marcos, Teófilo Lobera, Blanca Sáenz de San Pedro, Ernie Avilla, Jacquie Badiou, Karen Binkley, Rozita Borici-Mazi, Linda Howlett, Paul K. Keith, Anne Rowe, Peter Waite, Aurore Billebeau, Isabelle Boccon-Gibbod, Kristina Lis, Yael Laitman, Eitan Friedman, N. M. Gokmen, O. Gulbahar, H. Onay, Z. P. Koc, and A. Z. Sin

Subjects
Immunologic diseases. Allergy, RC581-607
Published
2017
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2. Abstracts from the 10th C1-inhibitor deficiency workshop

Author

Mikhail Belevtsev, Jens Greve, Pierre-Yves Jeandel, Ana Maria Gallardo-Olivos, William R. Lumry, Yael Laitman, Marc A. Riedl, Jean-Nicolas Boursiquot, Dasha Roa, Péter Závodszky, Kraig Jacobson, Susanne Trainotti, Maria Staevska, Márcia Gonçalves Ribeiro, Zeynep Gutowski, François Marceau, Alejandra Menendez, Eric Wagner, Y. Ollivier, Alvin H. Schmaier, Rolando Campilay-Sarmiento, Amin S. Kanani, Valeria Bafunno, Christine Symons, Svetlana Aleshkevich, Stephanie K. A. Almeida, Kusumam Joseph, Teresa Caballero, Hava Golander, Nancy J. Brown, Xavier Charest-Morin, Peter Banovcin, Arnaud Bonnefoy, Sajedeh Mohammadian, Mustafa Shennak, William P. Sheridan, Ira Kalfus, Claudio M. Costa-Neto, Rafael Filippelli-Silva, Anete Sevciovic Grumach, Solange Oliveira Rodrigues Valle, Oscar M. E. Calderón-Llosa, Panagiota Gianni, Emel Aygören-Pürsün, Rosemeire Navickas Constantino-Silva, Zsuzsanna Németh, Irmgard Andresen, Konrad Bork, Mauro Cancian, Claire de Moreuil, Janne Björkander, Melissa I. Espinosa, Tamás Szilágyi, Maria Rosario-Grauert, Jane da Silva, Michael Bader, Ying Zhang, Jana Hanzlíková, Sylvia Dobo, Carl-Fredrik Wahlgren, Jacquie Badiou, Diego A. Duarte, Marta Del Medico, Stefania Loffredo, Avner Reshef, Maria Palasopoulou, Ludmila Vavrova, Marie Dubrel, Raheleh Shokouhi Shoormasti, Bruce L. Zuraw, Susan Nabilou Deshiry, Shiva Saghafi, Ekaterina Polyakova, Matthieu Vincent, Douglas J. Watson, Mohammad Reza Fazlollahi, Anne Rowe, Shawn Qian, Blanca Sáenz de San Pedro, Christelle Pommie, Sofía Garrido, Sandra Mitie Ueda Palma, András Szilágyi, Luis Fernando Landivar-Salinas, Audrey Lehmann, Maria L. Baeza, Kiana Bidad, Hugo Chapdeleine, Stéphane Gayet, Davide Firinu, Nancy Payette, Christine Pajot, Nyla Melo, Pavel Kuklínek, Pablo Raby, Nóra Veszeli, Ingo Pragst, Desiree Clemons, Anne Pagnier, Attila Mócsai, Carmen Escuriola Ettingshausen, Henrike Feuersenger, Noémi Andrási, Paul K. Keith, Phil Collis, Ernie Avilla, Olivier Fain, Iris Leibovich-Nassi, Dario O. Josviack, Jiří Litzman, Con Panousis, Denise Ponard, Sébastien Trouiller, Ráhel Dani, Francesco Casella, Ana Rodríguez, Isabelle Boccon-Gibod, Nada Afifi Afifi, Olga M. Barrera, Gina Lacuesta, Gian Marco Podda, Anne Lise Ferrara, Samuel Luyasu, Ludovic Martin, Patrik Nordenfelt, Linda Howlett, William H. Yang, Sandra A. Nieto, Anders Lindfors, Zahra Pourpak, Stéphanie Amarger, Adriana Hernanz, Jochen Hardt, Julian Rodriguez-Galindo, Claire Blanchard-Delaunay, Antonio Castelli, Marta Sánchez-Jareño, Renata Martins, Bertrand Favier, Yi Wang, Rosario Cabañas, Anthony Roberts, Renan Paulo Martin, Alexandre Belot, Vincenzo Montinaro, Eitan Friedman, João Bosco Pesquero, Maria Kompoti, Bruna Franca Azevedo, Mikolajczyk Tomasz, Georges-É. Rivard, Katalin Várnai, Gábor Oroszlán, Arije Ghannam, David Launay, Fotis Psarros, Manuel Ratti, Maria Luiza Oliva Alonso, Bernard Floccard, Mariana Lluncor, Karen Binkley, Gianni Marone, Anne Gompel, Dominik Gulyás, John Dempster, Liudmyla Zabrodska, Emanuele Catena, Anna Bogdali, Irina Guryanova, Andrej Salivonchik, Camila Lopes Veronez, L. Fang, Eleonora Tobaldini, Lilian Varga, Chiara Suffritti, Daniel Vaszquez, Peter Waite, Maria Zamanakou, Ana Alvez, Laurence Bouillet, Péter Gál, Susan Waserman, Krystyna Obtułowicz, Marcin Stobiecki, Alain Sobel, Karin Wulff, A. Z. Sin, Margarita Olivares, Dipti Pawaskar, Mats Nilsson, Endre Schwaner, Brigitte Coppere, Anna Valerieva, Remi Gagnon, Marlon J. O. Carabantes, Stefano Pizzimenti, H. Onay, Paula J. Busse, Delphine Charignon, William Rae, Marco Cicardi, Kinga Viktória Kőhalmi, Inmaculada Martinez-Saguer, Daniel J. Sexton, Matthaios Speletas, Aarnoud Huissoon, René Bailleau, Fabien Pelletier, Elena Petkova, Joanna Araujo Simoes, Guillaume Armengol, Amanda Mathis, Rosangela P. Tortora, Raz Somech, Andreas Gille, Anastasios E. Germenis, Martin Hrubisko, Marylin Desjardins, Dorottya Csuka, María Pedrosa, Jose Fabiani, Stephen Betschel, Timothy J. Craig, Vasil Dimitrov, Andrew McDonald, Alberto López Lera, Márta L. Debreczeni, Eli Mansour, Teofila Książek, Teófilo Lobera, Rozita Borici-Mazi, O. Gulbahar, Aleena Banerji, Jochen Graff, Marta Sobotkova, Annette Feussner, Andrea Zanichelli, Ewa Czarnobilska, Anna Koncz, Milos Jesenak, Edison Zapata-Venegas, Aurore Billebeau, Gedeon Loules, Melanie Nordmann-Kleiner, Werner Aberer, Richard Linde, Guenther Witzke, Kristina Lis, Markus Magerl, Jana Strenková, Emmanouil Manoussakis, József Dobó, Viktar Lebedz, Masumi Grau, Raquel Martins, Melanie Cornpropst, Jovanna Baptista, Marcus Maurer, Dumitru Moldovan, György Temesszentandrási, Isabelle Boccon-Gibbod, Thomas Machnig, C Marcos, Erika Kajdácsi, Tim Green, John Anderson, Karin Andritschke, D. Soteres, Riccardo Colombo, Mario Martinez Alfonso, Anna Radice, Huamin Henry Li, Tsvetelina Velikova, Ruggero Di Maulo, Mariela Borisova Vasileva, Angelica Petraroli, Francesca Perego, Francisco A. Contreras, Roman Hakl, Urs C. Steiner, Anurag Relan, N. Prior, Irena Krčmová, Jennifer Schranz, Martina Vachová, Baby G. Tholanikunnel, R. Lleonart, Maria Bova, Allen P. Kaplan, N. M. Gokmen, Nicola Montano, Margarita López-Trascasa, Tiziana Maria Angela De Pasquale, Alicia Prieto, Kristian Buur Kreiberg, Mohammad Hassan Bemanian, Alessandra Zoli, Michael A. Tortorici, Erika J. Sifuentes, László Cervenak, Borislava Krusheva, Maria E. Hernandez-Landeros, Wojciech Dyga, Oleksandra Lepeshkina, Elma Nievas, L. Bellizzi, Christian Drouet, C. Mansard, Michel Bouvier, Aurélie Du Thanh, Donatella Lamacchia, Janina Hahn, Radana Zachova, Iraj Mohammadzadeh, T González-Quevedo, Z. P. Koc, Jacques Hébert, Hilary Longhurst, Maddalena Alessandra Wu, Ariane Zélinsky-Gurung, Jim Christensen, Maurizio Margaglione, Maryam Ayazi, Vesna Grivcheva Panovska, Faidra Parsopoulou, Jonathan A. Bernstein, Anette Bygum, Seyed Alireza Mahdaviani, Henriette Farkas, Aleksander Obtułowicz, Natalia Fili, Gisèle Kanny, Gerasimina Tsinti, Alfeu Tavares França, George N. Konstantinou, Benoit Laramée, Katarina Hrubiskova, Lisa Fu, J. Laurent, and Arthur Van Leerberghe

Subjects
lcsh:Immunologic diseases. Allergy, 0301 basic medicine, 03 medical and health sciences, 030102 biochemistry & molecular biology, C1 inhibitor deficiency, business.industry, Immunology, Medicine, General Medicine, lcsh:RC581-607, business, Meeting Abstracts
Published
2017
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3. Acquired C1-Inhibitor Deficiency: 7 Patients Treated with Rituximab

Author

Stéphanie Amarger, Arsène Mekinian, Bertrand Dunogué, Claire Blanchard-Delaunay, Eric Oksenhendler, Christian Drouet, Denise Ponard, Luc Mouthon, Isabelle Boccon-Gibod, Laurence Bouillet, Olivier Fain, Nicolas Javaud, Albanne Branellec, Michel Thomas, and Y. Ollivier

Subjects
Male, medicine.medical_specialty, C1 inhibitor deficiency, Immunology, Context (language use), Complement C1 Inactivator Proteins, Antibodies, Monoclonal, Murine-Derived, Medical microbiology, medicine, Humans, Immunologic Factors, Immunology and Allergy, Angioedema, Aged, Aged, 80 and over, Danazol, business.industry, Autoantibody, Middle Aged, Antigens, CD20, Female, Rituximab, medicine.symptom, business, Complement C1 Inhibitor Protein, Tranexamic acid, medicine.drug
Abstract

Acquired C1-inhibitor deficiency can occur secondary to excessive C1-inhibitor consumption (type I) and be associated with a lymphoid hemopathy, or linked to the presence of anti-C1-inhibitor autoantibodies (type II) in a context of an isolated monoclonal gammopathy, sometimes associated with lymphoproliferation. Efficacy of danazol, tranexamic acid and/or corticosteroids is inconstant. Rituximab efficacy against type II angioedema has been reported.Description of 7 rituximab-treated patients, 6 with type II acquired angioedema and 1 with type I.Clinical efficacy (only for type II) was complete for 3, partial for 2 and 2 were therapeutic failures. Only 2 patients had improved biological parameters, with normalization of their C1-inhibitor levels and diminished anti-C1-inhibitor autoantibodies, observed 1-9 months after the last infusion of the second rituximab cycle. An associated lymphoproliferation did not affect the response to treatment.Rituximab efficacy in the treatment of acquired angioedema is inconstant and might require repeated cycles.

Published
2012
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4. Contents Vol. 231, 2015

Author

Anne Janin, Luigi Naldi, David Swanson, Daniela Cattoni, Gunseli Ozturk, C. Lheure, Valerio De Vita, Maxime Battistella, Béatrice Flageul, Nora Kramkimel, Andrew T. Patterson, Angèle Soria, Koji Sayama, Olivier Sorg, Bengu Gerceker Turk, Frances T. Tian, Masamoto Murakami, Nathalie Franck, David C. Whiteman, Marie Masson Regnault, Yeliz Erdemoğlu, Pascal Girardin, Vincent Sibaud, François Goldwasser, Pasquale Ena, Michelle R. Iannacone, Martine Bagot, Aysin Kaya, Fumiko Oda, Fisard, Alex Llambrich, Chika Namba, H. Peter Soyer, Kana Masuda, Ryo Utsunomiya, Sylvie Fraitag, Nicolas Dupin, Marie-Françoise Avril, Rocco Micciolo, Werner Druck Medien Ag, Camille Francès, Marcia Davis, Diane Kottler, Banu Yaman, Annick Barbaud, Jean-Hilaire Saurat, Lydia Deschamps, Sebastiana Boi, Angel Pizarro, Steven C. Campbell, Sarah Guenounou, Christian Recher, Nicole M. Isbel, Gürkan Kaya, Patricia Caseiro Silverio, Satz Mengensatzproduktion, Mario Cristofolini, Miesha Merati, Naiara Fraga-Braghiroli, Henri Roche, Jonathan Fawcett, Dirk M. Elston, Astrid Queant, Nicolas Ortonne, Serge Boulinguez, Stéphane Barete, Benjamin H. Kaffenberger, Luis Javier del Pozo, Luca Ena, Nirmala Pandeya, Michel Rybojad, Lisa Ferguson, Florence Tétart, Laurence Gladieff, Agnès Carlotti, Laurence Lamant, Saskia Ingen-Housz-Oro, Harold S. Rabinovitz, Nikhil Yawalkar, Marco Ferrari, Martine Avenel-Audran, Haudrey Assier, Maria Cristina Sicher, Emilie Tournier, Pedro Zaballos, José Bañuls, Sara Laurent-Roussel, Christian Landi, Adèle C. Green, Karolina Gadaldi, Noémie Gadaud, Simone Cazzaniga, Fabienne Fontao, Gaëlle Quéreux, Nadia Raison-Peyron, Alon Scope, Béatrice Crickx, Mehdi Iskandarli, Stéphanie Amarger, Adriano Decarli, Gabriella Fabbrocini, Vittorio Mazzarello, and Angel Vera

Subjects
Dermatology
Published
2015

5. Bradykinin-mediated angioedema: factors associated with admission to an intensive care unit, a multicenter study

Author

Laurence Bouillet, Y. Ollivier, Frédéric Lapostolle, Isabelle Boccon-Gibod, Marouane Boubaya, Stéphanie Amarger, Brigitte Coppere, Nicolas Javaud, Abdalia Boumedienne, Ludovic Martin, Florian Gontier, Pierre Asfar, Frédéric Adnet, Olivier Fain, and Bernard Floccard

Subjects
Adult, Male, medicine.medical_specialty, medicine.drug_class, Bradykinin, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Patient Admission, law, Risk Factors, Medicine, Humans, 030212 general & internal medicine, Risk factor, Angioedema, Aged, Retrospective Studies, business.industry, Angioedemas, Hereditary, Middle Aged, medicine.disease, Intensive care unit, Intensive Care Units, 030228 respiratory system, chemistry, Emergency medicine, Hereditary angioedema, Emergency Medicine, Corticosteroid, Observational study, Female, medicine.symptom, business, Airway
Abstract

OBJECTIVE Bradykinin-mediated angioedema is characterized by transient attacks of localized edema of subcutaneous or submucosal tissues and can be life-threatening when involving the upper airways. The aim of this study was to determine the features of acute attacks that might be associated with admission to an ICU. PATIENTS AND METHODS We carried out a retrospective, multicenter, observational study in consecutive patients attending one of six reference centers in France for acute bradykinin-mediated angioedema attacks. Patients had been hospitalized for an acute episode at least once previously. Acute attacks requiring ICU admission were compared with acute attacks that had not required ICU admission. RESULTS Overall, 118 acute attacks in 31 patients were analyzed (10 patients with hereditary angioedema, 19 patients with angiotensin-converting enzyme inhibitor-induced angioedema, and two patients with acquired C1-inhibitor deficiency angioedema). In multivariate analysis, upper airway involvement, corticosteroid, and C1-inhibitor concentrate administration were associated with ICU admission. Seven episodes (18%) needed airway protection. The evolution was favorable in 38 of 39 attacks warranting ICU admission: patients were able to get out of the service (mean ICU stay 4±5 days). One death was observed by asphyxiation because of laryngeal swelling. CONCLUSION Upper airway involvement is an independent risk factor for ICU admission. Corticosteroid use, which is an ineffective treatment, and C1-inhibitor concentrate use are factors for ICU admission. The presence of upper airway involvement should be a warning signal that the attack may be severe.

Published
2015

6. Cutaneous Adverse Drug Reactions with Antimalarials and Allergological Skin Tests

Author

Haudrey Assier, Fisard, Martine Avenel-Audran, P. Girardin, Angèle Soria, Stéphanie Amarger, Annick Barbaud, Florence Tetart, Nadia Raison-Peyron, and Camille Francès

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Provocation test, Dermatology, Risk Assessment, Antimalarials, Young Adult, Chloroquine, medicine, Humans, Drug reaction, Young adult, Child, Aged, Retrospective Studies, Skin Tests, business.industry, Retrospective cohort study, Hydroxychloroquine, Middle Aged, Female, Oral provocation test, Drug Eruptions, business, medicine.drug
Abstract

Background: Currently used antimalarial drugs (AM) are hydroxychloroquine and chloroquine, which are prescribed for many autoimmune disorders. The value of skin tests on cutaneous adverse drug reactions (CADR) with AM remains unknown. Objective: The main objective of this retrospective study is to know whether skin tests for AM are useful and how to manage the recovery of AM therapy in these patients. Methods: All patients referred for suspected CADR secondary to AM between 2001 and 2014 in eight French dermatology centers were retrospectively reviewed. Results: We report herein a retrospective series of 20 patients with CADR and AM involvement. Skin tests, performed in 14/20 patients, were negative in all cases. Six patients had an oral provocation test with recurrence of CADR in 1 case. Conclusion: We encourage dermatologists to perform oral provocation tests in nonsevere CADR in order to allow AM rechallenge at progressive doses.

Published
2015

7. Acknowledgement to Referees for Dermatology 2015

Author

Béatrice Crickx, Jean-Hilaire Saurat, Banu Yaman, Maria Cristina Sicher, Rocco Micciolo, Camille Francès, Noémie Gadaud, Sarah Guenounou, Jonathan Fawcett, Marcia Davis, Andrew T. Patterson, Christian Recher, Aysin Kaya, Nirmala Pandeya, Florence Tétart, Gunseli Ozturk, Sara Laurent-Roussel, Christian Landi, Lisa Ferguson, Steven C. Campbell, C. Lheure, Lydia Deschamps, François Goldwasser, Agnès Carlotti, Angèle Soria, Koji Sayama, Gaëlle Quéreux, Gürkan Kaya, Simone Cazzaniga, Henri Roche, Fabienne Fontao, Werner Druck Medien Ag, Mehdi Iskandarli, Serge Boulinguez, Naiara Fraga-Braghiroli, Fisard, Luigi Naldi, Michelle R. Iannacone, Nadia Raison-Peyron, Stéphane Barete, Stéphanie Amarger, Nikhil Yawalkar, Martine Bagot, Valerio De Vita, Adriano Decarli, Nicole M. Isbel, Marie Masson Regnault, Saskia Ingen-Housz-Oro, Michel Rybojad, Gabriella Fabbrocini, David Swanson, Satz Mengensatzproduktion, Fumiko Oda, Masamoto Murakami, Karolina Gadaldi, Yeliz Erdemoğlu, David C. Whiteman, Annick Barbaud, Harold S. Rabinovitz, Daniela Cattoni, Vittorio Mazzarello, Bengu Gerceker Turk, Angel Vera, Marco Ferrari, Angel Pizarro, Luis Javier del Pozo, Nicolas Ortonne, Anne Janin, Benjamin H. Kaffenberger, Sylvie Fraitag, Kana Masuda, Alon Scope, Ryo Utsunomiya, H. Peter Soyer, Laurence Lamant, Luca Ena, Alex Llambrich, Nora Kramkimel, Vincent Sibaud, Adèle C. Green, Olivier Sorg, Miesha Merati, Mario Cristofolini, Marie-Françoise Avril, Maxime Battistella, Béatrice Flageul, Diane Kottler, Dirk M. Elston, Martine Avenel-Audran, Haudrey Assier, Emilie Tournier, Chika Namba, Sebastiana Boi, Pedro Zaballos, José Bañuls, Pasquale Ena, Astrid Queant, Patricia Caseiro Silverio, Laurence Gladieff, Frances T. Tian, Nathalie Franck, Pascal Girardin, and Nicolas Dupin

Subjects
Medical education, Acknowledgement, Dermatology, Psychology
Published
2015
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8. A three-year-analysis of fixed drug eruptions in hospital settings in France

Author

Caroline Pouget-Jasson, Jean-Marie Bonnetblanc, Bénédicte Lebrun-Vignes, Jean-Claude Roujeau, Marie-Sylvie Doutre, Emmanuelle Amsler, Stéphanie Amarger, Laurent Machet, Dominique Leroy, Emilie Routier, Antoine Claeys, Brigitte Milpied, Nadia Raison-Peyron, Vincent Descamps, Nesrine Brahimi, Alain Dupuy, Nadège Cordel, Marie-Thérèse Guinnepain, Anne-Fleur Tronquoy, Bruno Sassolas, Olivier Chosidow, Annick Barbaud, and Anne Grange

Subjects
Drug, Adult, Male, medicine.medical_specialty, Adolescent, Hospital setting, media_common.quotation_subject, Dermatology, medicine, Adverse Drug Reaction Reporting Systems, Humans, Fixed drug eruptions, Child, Pathological, media_common, Acetaminophen, Aged, Retrospective Studies, Aged, 80 and over, Analgesics, Analysis of Variance, business.industry, Anti-Inflammatory Agents, Non-Steroidal, Retrospective cohort study, Middle Aged, Patch Tests, medicine.disease, Skin symptoms, Drug eruption, Surgery, Anti-Bacterial Agents, Female, Drug Eruptions, France, Drug intoxication, business
Abstract

Fixed drug eruption (FDE) is one of the most typical cutaneous drug adverse reactions. This localized drug-induced reaction is characterized by its relapse at the same sites. Few large series of FDE are reported. The aim of this study was to retrospectively collect and analyse well informed cases observed in a hospital setting. This study involved 17 academic clinical centers. A French nation-wide retrospective multicentric study was carried out on a 3-year-period from 2005 to 2007 by collecting data in seventeen departments of dermatology in France. Diagnosis of FDE was based essentially on clinical findings, at times confirmed by pathological data and patch-testing. Records were reviewed for demographics, causative drugs, localization, severity, and patch-tests, when available. Fifty nine cases were analysed. Patients were 59-years-old on average, with a female predilection. The most common drug was paracetamol, followed by the non-steroidal anti inflammatory drugs. The time between drug intake and skin symptoms was, on average, two days. Beside these classical characteristics, some original findings were found including, a frequent non pigmentation course and a sex-dependent pattern of distribution. Women often had lesions on the hands and feet, and men on the genitalia. Given the fact that skin pigmentation is an inconstant feature of FDE, its French name (erytheme pigmente fixe) should be reconsidered. The sex-dependent distribution could help our understanding of the pathophysiology of fixed drug eruption.

Published
2010

9. Polymyositis and pemphigus vulgaris in a patient: successful treatment with rituximab

Author

Michel D'Incan, Jean-Michel Ristori, Martin Soubrier, Anne Tournadre, Pascal Joly, and Stéphanie Amarger

Subjects
medicine.medical_specialty, Cyclophosphamide, Population, Antisynthetase syndrome, Polymyositis, Ligases, Antibodies, Monoclonal, Murine-Derived, Fatal Outcome, Rheumatology, immune system diseases, hemic and lymphatic diseases, Medicine, Humans, education, education.field_of_study, business.industry, Amyloidosis, Pemphigus vulgaris, Antibodies, Monoclonal, Syndrome, Middle Aged, medicine.disease, Dermatology, Shock, Septic, Pemphigus, Antibodies, Antinuclear, Prednisone, Rituximab, Drug Therapy, Combination, Female, Kidney Diseases, business, Immunosuppressive Agents, medicine.drug
Abstract

Rituximab has been documented to be an effective treatment for autoimmune diseases with contribution of B cells. We report a case of antisynthetase syndrome with a history of EBV-induced lymphoma which developed a pemphigus vulgaris. Rituximab was effective both on polymyositis and on pemphigus. Fifteen months later, the patient died from a septic shock after the first cyclophosphamide infusion for amyloidosis while the B cell population remained depleted. Rituximab may be a good alternative to immunosuppressive drugs in polymyositis and pemphigus especially in lymphoma-risk patients. However, it did not prevent progression to secondary amyloidosis and the fatal infection developed in this patient raises the question of whether a prolonged B cell depletion with rituximab contributes to a greater risk of infection.

Published
2007

10. Acquired Angioedema Responding to Rituximab

Author

Michel D'Incan, Amr Hassan, Pierre Souteyrand, Denise Ponard, Stéphanie Amarger, and Arlette Tridon

Subjects
medicine.medical_specialty, business.industry, Acquired angioedema, medicine, Rituximab, Dermatology, General Medicine, business, medicine.drug
Published
2011
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11. Polymyosite et pemphigus vulgaire : efficacité du rituximab chez une patiente

Author

Anne Tournadre, Pascal Joly, Martin Soubrier, Michel D'Incan, Stéphanie Amarger, and Jean-Michel Ristori

Subjects
Gynecology, medicine.medical_specialty, Systemic disease, Anticorps monoclonal, business.industry, Pemphigus vulgaris, Antisynthetase syndrome, medicine.disease, Pemphigus, Rheumatology, Immunopathology, medicine, Rituximab, Anti cd20, business, medicine.drug
Abstract

Resume Le rituximab a fait la preuve de son efficacite dans les maladies auto-immunes qui mettent en jeu les lymphocytes B. Nous decrivons un cas de syndrome des antisynthetases chez une malade qui avait un antecedent de lymphome induit par le virus d’Epstein-Barr et qui a presente un pemphigus vulgaire. Le rituximab a permis d’ameliorer la polymyosite et le pemphigus. La malade est decedee, 15 mois plus tard, de choc septique apres une premiere perfusion de cyclophosphamide donnee pour traiter une amylose, alors que les lymphocytes B restaient effondres. Le rituximab pourrait constituer une bonne alternative aux medicaments immunosuppresseurs dans la polymyosite et le pemphigus, surtout lorsqu’il existe un risque de lymphome. Toutefois, le rituximab n’a pas permis d’eviter l’evolution vers l’amylose chez notre malade. De plus, l’infection mortelle suggere qu’une depletion prolongee des lymphocytes B pourrait augmenter le risque de complications infectieuses.

Published
2008
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12. Allergic contact dermatitis to guggul in a slimming cream

Author

Pierre Souteyrand, Stéphanie Amarger, Hugues Roger, Michel D'Incan, Magali Salavert, and Marie Christine Ferrier Le Bouedec

Subjects
Adult, medicine.medical_specialty, Allergy, media_common.quotation_subject, Commiphora mukul, Dermatology, Cosmetics, Diagnosis, Differential, Abdomen, medicine, Humans, Immunology and Allergy, Natural resin, Commiphora, Allergic contact dermatitis, media_common, Traditional medicine, business.industry, Allergens, Patch Tests, medicine.disease, Dermatitis, Allergic Contact, Buttocks, Female, business, Contact dermatitis
Published
2007
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