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486 results on '"Srivastava, Brijesh"'

6. Exploring the QGP phase above the deconfinement temperature in $pp$ and $A-A$ collisions at LHC energies

Author

Mishra, Aditya Nath, Paić, Guy, Pajares, Carlos, Scharenberg, Rolf P, and Srivastava, Brijesh K

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, Nuclear Experiment
Abstract

In the present work we have analyzed the transverse momentum spectra of charged particles in high multiplicity ${\it pp}$ collisions at LHC energies $\sqrt s = $ 5.02 and 13 TeV published by the ALICE Collaboration using the Color String Percolation Model (CSPM). For heavy ions Pb-Pb at $\sqrt {s_{NN}} =$ 2.76 and 5.02 TeV along with Xe-Xe at $\sqrt {s_{NN}} = $ 5.44 TeV have been analyzed. The initial temperature is extracted both in low and high multiplicity events in ${\it pp}$ collisions. For $A-A$ collisions the temperature is obtained as a function of centrality. A universal scaling in the temperature from $pp$ and $A-A$ collisions is obtained when multiplicity is scaled by the transverse interaction area.From the measured energy density $\bm \varepsilon$ and the temperature the dimensionless quantity $\bm \varepsilon/T^{4}$ is obtained. Our results for Pb-Pb and Xe-Xe collisions show a sharp increase in $\bm \varepsilon/T^{4}$ above T $\sim$ 210 MeV and reaching the ideal gas of quarks and gluons value of $\bm \varepsilon/T^{4} \sim$ 16 at temperature $\sim $ 230 MeV. In case of $pp$ collisions only $\bm \varepsilon/T^{4} \sim $ 10 corresponding to $\sim$ 30 degrees of freedom., Comment: 18 pages, 13 figures. arXiv admin note: text overlap with arXiv:2006.10169

Published
2022

9. Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls

Author

Sturgess, Richard, Healey, Christopher, Gunasekera, Anton, Kallis, Yiannis, Wright, Gavin, Mathialahan, Thiriloganathan, Evans, Richard, Gasem, Jaber, Ramanaden, David, Ward, Emma, Bhalme, Mahesh, Southern, Paul, Maggs, James, Yousif, Mohamed, Mells, George, Srivastava, Brijesh, Foxton, Matthew, Collins, Carole, Prasad, Yash, Porras-Perez, Francisco, Yapp, Tom, Patel, Minesh, Ede, Roland, Carte, Martyn, Koss, Konrad, Sattianayagam, Prayman, Grimley, Charles, Tidbury, Jude, Mansour, Dina, Beckley, Matilda, Hollywood, Coral, Ramag, John, Gordon, Harriet, Ridpath, Joanne, Grover, Bob, Abouda, George, Rees, Ian, Narain, Mark, Salam, Imroz, Banim, Paul, Das, Debasish, Matthews, Helen, Mohammed, Faiyaz, Jones, Rebecca, Sen, Sambit, Bird, George, Prince, Martin, Prasad, Geeta, Kitchen, Paul, Hutchinson, John, Gupta, Prakash, Jones, David, Shah, Amir, Saha, Subrata, Pollock, Katharine, Barclay, Stephen, McDonald, Natasha, Rushbrook, Simon, Przemioslo, Robert, Millar, Andrew, Mitchell, Steven, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom, Ryder, Stephen, Collier, Jane, Cramp, Matthew, Aspinal, Richard, Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Christie, John, Chaudhry, Tehreem, Thorburn, Douglas, Mann, Stephen, Ala, Aftab, Maltby, Julia, Corbett, Chris, Singhal, Saket, Hoeroldt, Barbara, Butterworth, Jeff, Douglas, Andrew, Sinha, Rohit, Panter, Simon, Shearman, Jeremy, Bray, Gary, Roberts, Michael, Forton, Daniel, Taylor, Nicola, Jafar, Wisam, Cowan, Matthew, Ch'ng, Chin Lye, Rahman, Mesbah, Wesley, Emma, Jain, Sanjiv, Mandal, Aditya, Wright, Mark, Trivedi, Palak, Gordon, Fiona, Unitt, Esther, Austin, Andrew, Palegwala, Altaf, Vemala, Vishwaraj, Higham, Andrew, Fraser, Jocelyn, Li, Andy, Ramakrishnan, Subramaniam, King, Alistair, Whalley, Simon, Gee, Ian, Keld, Richard, Fellows, Helen, Gotto, James, Millson, Charles, Murillo Perez, C. Fiorella, Fisher, Holly, Hiu, Shaun, Kareithi, Dorcas, Adekunle, Femi, Mayne, Tracy, Malecha, Elizabeth, Ness, Erik, van der Meer, Adriaan J., Lammers, Willem J., Trivedi, Palak J., Battezzati, Pier Maria, Nevens, Frederik, Kowdley, Kris V., Bruns, Tony, Cazzagon, Nora, Floreani, Annarosa, Mason, Andrew L., Parés, Albert, Londoño, Maria-Carlota, Invernizzi, Pietro, Carbone, Marco, Lleo, Ana, Mayo, Marlyn J., Dalekos, George N., Gatselis, Nikolaos K., Verhelst, Xavier, Gulamhusein, Aliya, Janssen, Harry L.A., Smith, Rachel, Flack, Steve, Mulcahy, Victoria, Trauner, Michael, Bowlus, Christopher L., Lindor, Keith D., Corpechot, Christophe, Hirschfield, Gideon M., Wason, James, and Hansen, Bettina E.

Published
2022
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10. Thermodynamic and transport properties in Au + Au collisions at RHIC energies from the clustering of color strings

Author

Sahoo, Pragati, Tiwari, Swatantra Kumar, De, Sudipan, Sahoo, Raghunath, Scharenberg, Rolf P., and Srivastava, Brijesh K.

Subjects
High Energy Physics - Phenomenology, High Energy Physics - Experiment, High Energy Physics - Lattice, Nuclear Experiment, Nuclear Theory
Abstract

In this work, we have extracted the initial tempearture from the transverse momentum spectra of charged particles in $Au+Au$ collisions using STAR data at RHIC energies from $\sqrt{s_{NN}}$ = 7.7 to 200 GeV. The initial energy density ($\varepsilon$), shear viscosity to entropy density ratio ($\eta/s$), trace anomaly ($\Delta$), the squared speed of sound ($C_s^2$), entropy density, and bulk viscosity to entropy density ratio ($\zeta/s$) are obtained and compared with the lattice QCD calculations for (2+1) flavor. The initial temperatures obtained are compared with various hadronization and chemical freeze-out temperatures. The analysis of the data shows that the deconfinement to confinement transition possibly takes place between $\sqrt{s_{NN}}$ = 11.5 and 19.6 GeV., Comment: Same as published version in MPLA

Published
2017
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11. US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

Author

Battaglieri, Marco, Belloni, Alberto, Chou, Aaron, Cushman, Priscilla, Echenard, Bertrand, Essig, Rouven, Estrada, Juan, Feng, Jonathan L., Flaugher, Brenna, Fox, Patrick J., Graham, Peter, Hall, Carter, Harnik, Roni, Hewett, JoAnne, Incandela, Joseph, Izaguirre, Eder, McKinsey, Daniel, Pyle, Matthew, Roe, Natalie, Rybka, Gray, Sikivie, Pierre, Tait, Tim M. P., Toro, Natalia, Van De Water, Richard, Weiner, Neal, Zurek, Kathryn, Adelberger, Eric, Afanasev, Andrei, Alexander, Derbin, Alexander, James, Antochi, Vasile Cristian, Asner, David Mark, Baer, Howard, Banerjee, Dipanwita, Baracchini, Elisabetta, Barbeau, Phillip, Barrow, Joshua, Bastidon, Noemie, Battat, James, Benson, Stephen, Berlin, Asher, Bird, Mark, Blinov, Nikita, Boddy, Kimberly K., Bondi, Mariangela, Bonivento, Walter M., Boulay, Mark, Boyce, James, Brodeur, Maxime, Broussard, Leah, Budnik, Ranny, Bunting, Philip, Caffee, Marc, Caiazza, Sabato Stefano, Campbell, Sheldon, Cao, Tongtong, Carosi, Gianpaolo, Carpinelli, Massimo, Cavoto, Gianluca, Celentano, Andrea, Chang, Jae Hyeok, Chattopadhyay, Swapan, Chavarria, Alvaro, Chen, Chien-Yi, Clark, Kenneth, Clarke, John, Colegrove, Owen, Coleman, Jonathon, Cooke, David, Cooper, Robert, Crisler, Michael, Crivelli, Paolo, D'Eramo, Francesco, D'Urso, Domenico, Dahl, Eric, Dawson, William, De Napoli, Marzio, De Vita, Raffaella, DeNiverville, Patrick, Derenzo, Stephen, Di Crescenzo, Antonia, Di Marco, Emanuele, Dienes, Keith R., Diwan, Milind, Dongwi, Dongwi Handiipondola, Drlica-Wagner, Alex, Ellis, Sebastian, Ezeribe, Anthony Chigbo, Farrar, Glennys, Ferrer, Francesc, Figueroa-Feliciano, Enectali, Filippi, Alessandra, Fiorillo, Giuliana, Fornal, Bartosz, Freyberger, Arne, Frugiuele, Claudia, Galbiati, Cristian, Galon, Iftah, Gardner, Susan, Geraci, Andrew, Gerbier, Gilles, Graham, Mathew, Gschwendtner, Edda, Hearty, Christopher, Heise, Jaret, Henning, Reyco, Hill, Richard J., Hitlin, David, Hochberg, Yonit, Hogan, Jason, Holtrop, Maurik, Hong, Ziqing, Hossbach, Todd, Humensky, T. B., Ilten, Philip, Irwin, Kent, Jaros, John, Johnson, Robert, Jones, Matthew, Kahn, Yonatan, Kalantarians, Narbe, Kaplinghat, Manoj, Khatiwada, Rakshya, Knapen, Simon, Kohl, Michael, Kouvaris, Chris, Kozaczuk, Jonathan, Krnjaic, Gordan, Kubarovsky, Valery, Kuflik, Eric, Kusenko, Alexander, Lang, Rafael, Leach, Kyle, Lin, Tongyan, Lisanti, Mariangela, Liu, Jing, Liu, Kun, Liu, Ming, Loomba, Dinesh, Lykken, Joseph, Mack, Katherine, Mans, Jeremiah, Maris, Humphrey, Markiewicz, Thomas, Marsicano, Luca, Martoff, C. J., Mazzitelli, Giovanni, McCabe, Christopher, McDermott, Samuel D., McDonald, Art, McKinnon, Bryan, Mei, Dongming, Melia, Tom, Miller, Gerald A., Miuchi, Kentaro, Nazeer, Sahara Mohammed Prem, Moreno, Omar, Morozov, Vasiliy, Mouton, Frederic, Mueller, Holger, Murphy, Alexander, Neilson, Russell, Nelson, Tim, Neu, Christopher, Nosochkov, Yuri, O'Hare, Ciaran, Oblath, Noah, Orrell, John, Ouellet, Jonathan, Pastore, Saori, Paul, Sebouh, Perelstein, Maxim, Peter, Annika, Phan, Nguyen, Phinney, Nan, Pivovaroff, Michael, Pocar, Andrea, Pospelov, Maxim, Pradler, Josef, Privitera, Paolo, Profumo, Stefano, Raggi, Mauro, Rajendran, Surjeet, Randazzo, Nunzio, Raubenheimer, Tor, Regenfus, Christian, Renshaw, Andrew, Ritz, Adam, Rizzo, Thomas, Rosenberg, Leslie, Rubbia, Andre, Rybolt, Ben, Saab, Tarek, Safdi, Benjamin R., Santopinto, Elena, Scarff, Andrew, Schneider, Michael, Schuster, Philip, Seidel, George, Sekiya, Hiroyuki, Seong, Ilsoo, Simi, Gabriele, Sipala, Valeria, Slatyer, Tracy, Slone, Oren, Smith, Peter F, Smolinsky, Jordan, Snowden-Ifft, Daniel, Solt, Matthew, Sonnenschein, Andrew, Sorensen, Peter, Spooner, Neil, Srivastava, Brijesh, Stancu, Ion, Strigari, Louis, Strube, Jan, Sushkov, Alexander O., Szydagis, Matthew, Tanedo, Philip, Tanner, David, Tayloe, Rex, Terrano, William, Thaler, Jesse, Thomas, Brooks, Thorpe, Brianna, Thorpe, Thomas, Tiffenberg, Javier, Tran, Nhan, Trovato, Marco, Tully, Christopher, Tyson, Tony, Vachaspati, Tanmay, Vahsen, Sven, van Bibber, Karl, Vandenbroucke, Justin, Villano, Anthony, Volansky, Tomer, Wang, Guojian, Ward, Thomas, Wester, William, Whitbeck, Andrew, Williams, David A., Wing, Matthew, Winslow, Lindley, Wojtsekhowski, Bogdan, Yu, Hai-Bo, Yu, Shin-Shan, Yu, Tien-Tien, Zhang, Xilin, Zhao, Yue, and Zhong, Yi-Ming

Subjects
High Energy Physics - Phenomenology, Astrophysics - Cosmology and Nongalactic Astrophysics, High Energy Physics - Experiment
Abstract

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017., Comment: 102 pages + references

Published
2017

12. Shelf life and storage stability of cold plasma treated kiwifruit juice: kinetic models.

Author

Kumar, Sitesh, Pipliya, Sunil, Srivastav, Prem Prakash, and Srivastava, Brijesh

Subjects
LOW temperature plasmas, THERMAL plasmas, OXIDANT status, VITAMIN C, PRINCIPAL components analysis
Abstract

This study examined the quality changes and shelf life of cold plasma (Cold plasma-optimized, S2: 30 kV/5 mm/6.7 min and Cold plasma-extreme, S3: 30 kV/2 mm/10 min) and thermally-treated (S4: 90°C/5 min) kiwifruit juice packed in glass and polyethylene terephthalate bottles stored at 5, 15, and 25°C. Cold plasma and thermally treated juice samples were analyzed for peroxidase activity, microbial enumeration, bioactive compounds degradation, and sensory quality for up to 120 days. The residual activity of peroxidase enzyme in S2 sample after cold plasma treatment was 23.85%, decreasing with increase in storage time and temperature. After cold plasma and thermal treatment, the aerobic mesophiles and yeasts and molds count were below detectable limits in kiwifruit juice. Aerobic mesophiles and yeasts & molds emerged in S2, S3, and S4 samples stored at 5°C after 70, 70, and 90 days, respectively. The total color change increased with increase in storage time and temperature, whereas ascorbic acid, total phenolic content, total antioxidant capacity, and overall acceptability decreased. The shelf life of S2 in glass bottles was 100, 80, and 60 days at 5, 15, and 25°C based on total color change ≥ 12, ascorbic acid loss ≥ 50%, microbial count ≥ 6 Log CFU/mL, or overall acceptability < 5. Quality indices, including total color change, overall sensory acceptability, and ascorbic acid, were modeled, and zero-order model performed better than first and second-order reaction models. Furthermore, Arrhenius, Eyring, and Ball models were employed to model temperature-dependent reaction rates, and the Ball model performed better. So, the zero-order reaction and Ball model were combined to predict kiwifruit juice's shelf life. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Cold plasma processing of kiwifruit juice: Effect on physicochemical, nutritional, microstructure, rheological properties and sensory attributes.

Author

Kumar, Sitesh, Pipliya, Sunil, Srivastav, Prem Prakash, Srivastava, Brijesh, Battula, Satyanarayana Reddy, and Sen, Ramkrishna

Subjects
LOW temperature plasmas, PARTICLE size distribution, RHEOLOGY, PLASMA materials processing, VITAMIN C, KIWIFRUIT
Abstract

This study aimed to compare the untreated, cold plasma (CP)‐optimized (30 kV/5 mm/6.7 min), CP‐extreme (30 kV/2 mm/10 min), and thermally treated (TT) (90 ℃/5 min) kiwifruit juices based on the physicochemical (pH, total soluble solids (TSS), titratable acidity (TA), total color change (ΔE)), physical (particle size and rheology), microstructure (optical microscope), bioactive compounds (polyphenol, ascorbic acid, and sugar compounds), and sensory characteristics of kiwifruit juice. The pH, TSS, and TA were not significantly affected in CP and TT juice, whereas the ΔE (6.52) of TT juice lies in the range of "greatly visible." The microstructure characteristics of juice significantly changed after CP and thermal treatment. The cell and tissue disruption in CP‐extreme and thermally treated juice was more than CP‐optimized. The particle size of juice decreased irrespective of treatment, but the span value of CP‐optimized juice was the lowest. Further, the CP treatment showed a lower consistency index, apparent viscosity, and pseudoplasticity of juice than the thermal treatment. The CP‐treated juice retained bioactive and nutritional attributes more than thermally treated juice. The CP‐optimized, CP‐extreme, and thermal treatment reduced the sucrose content by 54, 55, and 23%, while the fructose and glucose content were increased by 17, 12, & 93%, and 17, 11 & 99%, respectively. Among the CP‐treated juice, CP‐optimized (71.36 mg/100g) contained a higher amount of ascorbic acid than the CP‐extreme (64.36 mg/100g). Based on the similarity values in the fuzzy logic analysis, the sensory attributes of CP‐optimized treated juice were superior to CP‐extreme and thermal treated. Practical Application: In this era, non‐thermal processing techniques are trending for retaining the nutrition and stability of juice. The old plasma (CP)‐treated kiwifruit juice had better nutritional, bioactive compounds, and sensory attributes than the thermally treated juice. Further, the CP‐treated juice had higher flowability and lower viscosity, making it ideal for juice processing. The conclusions drawn suggest that CP processing is a better alternative for processing kiwifruit juice than thermal processing. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

Author

Alberts, Rudi, de Vries, Elisabeth MG, Goode, Elizabeth C, Jiang, Xiaojun, Sampaziotis, Fotis, Rombouts, Krista, Böttcher, Katrin, Folseraas, Trine, Weismüller, Tobias J, Mason, Andrew L, Wang, Weiwei, Alexander, Graeme, Alvaro, Domenico, Bergquist, Annika, Björkström, Niklas K, Beuers, Ulrich, Björnsson, Einar, Boberg, Kirsten Muri, Bowlus, Christopher L, Bragazzi, Maria C, Carbone, Marco, Chazouillères, Olivier, Cheung, Angela, Dalekos, Georgios, Eaton, John, Eksteen, Bertus, Ellinghaus, David, Färkkilä, Martti, Festen, Eleonora AM, Floreani, Annarosa, Franceschet, Irene, Gotthardt, Daniel Nils, Hirschfield, Gideon M, Hoek, B van, Holm, Kristian, Hohenester, Simon, Hov, Johannes Roksund, Imhann, Floris, Invernizzi, Pietro, Juran, Brian D, Lenzen, Henrike, Lieb, Wolfgang, Liu, Jimmy Z, Marschall, Hanns-Ulrich, Marzioni, Marco, Melum, Espen, Milkiewicz, Piotr, Müller, Tobias, Pares, Albert, Rupp, Christian, Rust, Christian, Sandford, Richard N, Schramm, Christoph, Schreiber, Stefan, Schrumpf, Erik, Silverberg, Mark S, Srivastava, Brijesh, Sterneck, Martina, Teufel, Andreas, Vallier, Ludovic, Verheij, Joanne, Vila, Arnau Vich, Vries, Boudewijn de, Zachou, Kalliopi, Chapman, Roger W, Manns, Michael P, Pinzani, Massimo, Rushbrook, Simon M, Lazaridis, Konstantinos N, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, Ponsioen, Cyriel Y, and Weersma, Rinse K

Subjects
Genetics, Transplantation, Chronic Liver Disease and Cirrhosis, Liver Disease, Clinical Research, Rare Diseases, Digestive Diseases - (Gallbladder), Digestive Diseases, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Adult, Cholangitis, Sclerosing, Cohort Studies, Disease Progression, Female, Humans, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Polymorphism, Single Nucleotide, Proportional Hazards Models, Thrombospondins, International PSC Study Group, The UK PSC Consortium, Primary sclerosing cholangitis, genetics, liver transplantation, Clinical Sciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology
Abstract

ObjectivePrimary sclerosing cholangitis (PSC) is a genetically complex, inflammatory bile duct disease of largely unknown aetiology often leading to liver transplantation or death. Little is known about the genetic contribution to the severity and progression of PSC. The aim of this study is to identify genetic variants associated with PSC disease progression and development of complications.DesignWe collected standardised PSC subphenotypes in a large cohort of 3402 patients with PSC. After quality control, we combined 130 422 single nucleotide polymorphisms of all patients-obtained using the Illumina immunochip-with their disease subphenotypes. Using logistic regression and Cox proportional hazards models, we identified genetic variants associated with binary and time-to-event PSC subphenotypes.ResultsWe identified genetic variant rs853974 to be associated with liver transplant-free survival (p=6.07×10-9). Kaplan-Meier survival analysis showed a 50.9% (95% CI 41.5% to 59.5%) transplant-free survival for homozygous AA allele carriers of rs853974 compared with 72.8% (95% CI 69.6% to 75.7%) for GG carriers at 10 years after PSC diagnosis. For the candidate gene in the region, RSPO3, we demonstrated expression in key liver-resident effector cells, such as human and murine cholangiocytes and human hepatic stellate cells.ConclusionWe present a large international PSC cohort, and report genetic loci associated with PSC disease progression. For liver transplant-free survival, we identified a genome-wide significant signal and demonstrated expression of the candidate gene RSPO3 in key liver-resident effector cells. This warrants further assessments of the role of this potential key PSC modifier gene.

Published
2018

15. An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs

Author

Siminovitch, Katherine A., Hirschfield, Gideon M., Mason, Andrew, Vincent, Catherine, Xie, Gang, Zhang, Jinyi, Tang, Ruqi, Ma, Xiong, Li, Zhiqiang, Shi, Yongyong, Affronti, Andrea, Almasio, Piero L., Alvaro, Domenico, Andreone, Pietro, Andriulli, Angelo, Azzaroli, Francesco, Battezzati, Pier Maria, Benedetti, Antonio, Bragazzi, MariaConsiglia, Brunetto, Maurizia, Bruno, Savino, Calvaruso, Vincenza, Cardinale, Vincenzo, Casella, Giovanni, Cazzagon, Nora, Ciaccio, Antonio, Coco, Barbara, Colli, Agostino, Colloredo, Guido, Colombo, Massimo, Colombo, Silvia, Cristoferi, Laura, Cursaro, Carmela, Crocè, Lory Saveria, Crosignani, Andrea, D’Amato, Daphne, Donato, Francesca, Elia, Gianfranco, Fabris, Luca, Fagiuoli, Stefano, Ferrari, Carlo, Floreani, Annarosa, Galli, Andrea, Giannini, Edoardo, Grattagliano, Ignazio, Lampertico, Pietro, Lleo, Ana, Malinverno, Federica, Mancuso, Clara, Marra, Fabio, Marzioni, Marco, Massironi, Sara, Mattalia, Alberto, Miele, Luca, Milani, Chiara, Morini, Lorenzo, Morisco, Filomena, Muratori, Luigi, Muratori, Paolo, Niro, Grazia A., O’Donnell, Sarah, Picciotto, Antonio, Portincasa, Piero, Rigamonti, Cristina, Ronca, Vincenzo, Rosina, Floriano, Spinzi, Giancarlo, Strazzabosco, Mario, Tarocchi, Mirko, Tiribelli, Claudio, Toniutto, Pierluigi, Valenti, Luca, Vinci, Maria, Zuin, Massimo, Nakamura, Hitomi, Abiru, Seigo, Nagaoka, Shinya, Komori, Atsumasa, Yatsuhashi, Hiroshi, Ishibashi, Hiromi, Ito, Masahiro, Migita, Kiyoshi, Ohira, Hiromasa, Katsushima, Shinji, Naganuma, Atsushi, Sugi, Kazuhiro, Komatsu, Tatsuji, Mannami, Tomohiko, Matsushita, Kouki, Yoshizawa, Kaname, Makita, Fujio, Nikami, Toshiki, Nishimura, Hideo, Kouno, Hiroshi, Kouno, Hirotaka, Ota, Hajime, Komura, Takuya, Nakamura, Yoko, Shimada, Masaaki, Hirashima, Noboru, Komeda, Toshiki, Ario, Keisuke, Nakamuta, Makoto, Yamashita, Tsutomu, Furuta, Kiyoshi, Kikuchi, Masahiro, Naeshiro, Noriaki, Takahashi, Hironao, Mano, Yutaka, Tsunematsu, Seiji, Yabuuchi, Iwao, Shimada, Yusuke, Yamauchi, Kazuhiko, Sugimoto, Rie, Sakai, Hironori, Mita, Eiji, Koda, Masaharu, Tsuruta, Satoru, Kamitsukasa, Hiroshi, Sato, Takeaki, Masaki, Naohiko, Kobata, Tatsuro, Fukushima, Nobuyoshi, Ohara, Yukio, Muro, Toyokichi, Takesaki, Eiichi, Takaki, Hitoshi, Yamamoto, Tetsuo, Kato, Michio, Nagaoki, Yuko, Hayashi, Shigeki, Ishida, Jinya, Watanabe, Yukio, Kobayashi, Masakazu, Koga, Michiaki, Saoshiro, Takeo, Yagura, Michiyasu, Hirata, Keisuke, Tanaka, Atsushu, Takikawa, Hajime, Zeniya, Mikio, Abe, Masanori, Onji, Morikazu, Kaneko, Shuichi, Honda, Masao, Arai, Kuniaki, Arinaga-Hino, Teruko, Hashimoto, Etsuko, Taniai, Makiko, Umemura, Takeji, Joshita, Satoru, Nakao, Kazuhiko, Ichikawa, Tatsuki, Shibata, Hidetaka, Yamagiwa, Satoshi, Seike, Masataka, Honda, Koichi, Sakisaka, Shotaro, Takeyama, Yasuaki, Harada, Masaru, Senju, Michio, Yokosuka, Osamu, Kanda, Tatsuo, Ueno, Yoshiyuki, Kikuchi, Kentaro, Ebinuma, Hirotoshi, Himoto, Takashi, Yasunami, Michio, Murata, Kazumoto, Mizokami, Masashi, Kawata, Kazuhito, Shimoda, Shinji, Miyake, Yasuhiro, Takaki, Akinobu, Yamamoto, Kazuhide, Hirano, Katsuji, Ichida, Takafumi, Ido, Akio, Tsubouchi, Hirohito, Chayama, Kazuaki, Harada, Kenichi, Nakanuma, Yasuni, Maehara, Yoshihiko, Taketomi, Akinobu, Shirabe, Ken, Soejima, Yuji, Mori, Akira, Yagi, Shintaro, Uemoto, Shinji, H, Egawa, Tanaka, Tomohiro, Yamashiki, Noriyo, Tamura, Sumito, Sugawara, Yasuhiro, Kokudo, Norihiro, Juran, Brian D., Atkinson, Elizabeth J., Cheung, Angela, de Andrade, Mariza, Lazaridis, Konstantinos N., Chalasani, Naga, Luketic, Vel, Odin, Joseph, Chopra, Kapil, Baras, Aris, Horowitz, Julie, Abecasis, Goncalo, Cantor, Michael, Coppola, Giovanni, Economides, Aris, Lotta, Luca A., Overton, John D., Reid, Jeffrey G., Shuldiner, Alan, Beechert, Christina, Forsythe, Caitlin, Fuller, Erin D., Gu, Zhenhua, Lattari, Michael, Lopez, Alexander, Schleicher, Thomas D., Padilla, Maria Sotiropoulos, Toledo, Karina, Widom, Louis, Wolf, Sarah E., Pradhan, Manasi, Manoochehri, Kia, Ulloa, Ricardo H., Bai, Xiaodong, Balasubramanian, Suganthi, Barnard, Leland, Blumenfeld, Andrew, Eom, Gisu, Habegger, Lukas, Hawes, Alicia, Khalid, Shareef, Maxwell, Evan K., Salerno, William, Staples, Jeffrey C., Jones, Marcus B., Mitnaul, Lyndon J., Sturgess, Richard, Healey, Christopher, Yeoman, Andrew, Gunasekera, Anton VJ., Kooner, Paul, Kapur, Kapil, Sathyanarayana, V., Kallis, Yiannis, Subhani, Javaid, Harvey, Rory, McCorry, Roger, Rooney, Paul, Ramanaden, David, Evans, Richard, Mathialahan, Thiriloganathan, Gasem, Jaber, Shorrock, Christopher, Bhalme, Mahesh, Southern, Paul, Tibble, Jeremy A., Gorard, David A., Jones, Susan, Mells, George, Mulcahy, Victoria, Srivastava, Brijesh, Foxton, Matthew R., Collins, Carole E., Elphick, David, Karmo, Mazn, Porras-Perez, Francisco, Mendall, Michael, Yapp, Tom, Patel, Minesh, Ede, Roland, Sayer, Joanne, Jupp, James, Fisher, Neil, Carter, Martyn J., Koss, Konrad, Shah, Jayshri, Piotrowicz, Andrzej, Scott, Glyn, Grimley, Charles, Gooding, Ian R., Williams, Simon, Tidbury, Judith, Lim, Guan, Cheent, Kuldeep, Levi, Sass, Mansour, Dina, Beckley, Matilda, Hollywood, Coral, Wong, Terry, Marley, Richard, Ramage, John, Gordon, Harriet M., Ridpath, Jo, Ngatchu, Theodore, Bob Grover, Vijay Paul, Shidrawi, Ray G., Abouda, George, Corless, L., Narain, Mark, Rees, Ian, Brown, Ashley, Taylor-Robinson, Simon, Wilkins, Joy, Grellier, Leonie, Banim, Paul, Das, Debasish, Heneghan, Michael A., Curtis, Howard, Matthews, Helen C., Mohammed, Faiyaz, Aldersley, Mark, Srirajaskanthan, Raj, Walker, Giles, McNair, Alistair, Sharif, Amar, Sen, Sambit, Bird, George, Prince, Martin I., Prasad, Geeta, Kitchen, Paul, Barnardo, Adrian, Oza, Chirag, Sivaramakrishnan, Nurani N., Gupta, Prakash, Shah, Amir, Evans, Chris DJ., Saha, Subrata, Pollock, Katharine, Bramley, Peter, Mukhopadhya, Ashis, Barclay, Stephen T., McDonald, Natasha, Bathgate, Andrew J., Palmer, Kelvin, Dillon, John F., Rushbrook, Simon M., Przemioslo, Robert, McDonald, Chris, Millar, Andrew, Tai, Cheh, Mitchell, Stephen, Metcalf, Jane, Shaukat, Syed, Ninkovic, Mary, Shmueli, Udi, Davis, Andrew, Naqvi, Asifabbas, Lee, Tom JW., Ryder, Stephen, Collier, Jane, Klass, Howard, Cramp, Matthew E., Sharer, Nichols, Aspinall, Richard, Ghosh, Deb, Douds, Andrew C., Booth, Jonathan, Williams, Earl, Hussaini, Hyder, Christie, John, Mann, Steven, Thorburn, Douglas, Marshall, Aileen, Patanwala, Imran, Ala, Aftab, Maltby, Julia, Matthew, Ray, Corbett, Chris, Vyas, Sam, Singhal, Saket, Gleeson, Dermot, Misra, Sharat, Butterworth, Jeff, George, Keith, Harding, Tim, Douglass, Andrew, Mitchison, Harriet, Panter, Simon, Shearman, Jeremy, Bray, Gary, Roberts, Michael, Butcher, Graham, Forton, Daniel, Mahmood, Zahid, Cowan, Matthew, Das, Debashis, Ch’ng, Chin Lye, Rahman, Mesbah, Whatley, Gregory C.A., Wesley, Emma, Mandal, Aditya, Jain, Sanjiv, Pereira, Stephen P., Wright, Mark, Trivedi, Palak, Gordon, Fiona H., Unitt, Esther, Palejwala, Altaf, Austin, Andrew, Vemala, Vishwaraj, Grant, Allister, Higham, Andrew D., Brind, Alison, Mathew, Ray, Cox, Mark, Ramakrishnan, Subramaniam, King, Alistair, Whalley, Simon, Fraser, Jocelyn, Thomson, S.J., Bell, Andrew, Wong, Voi Shim, Kia, Richard, Gee, Ian, Keld, Richard, Ransford, Rupert, Gotto, James, Millson, Charles, Cordell, Heather J., Fryett, James J., Ueno, Kazuko, Darlay, Rebecca, Aiba, Yoshihiro, Hitomi, Yuki, Kawashima, Minae, Nishida, Nao, Khor, Seik-Soon, Gervais, Olivier, Kawai, Yosuke, Nagasaki, Masao, Tokunaga, Katsushi, Gerussi, Alessio, Carbone, Marco, Asselta, Rosanna, Ferreira, Manuel A.R., Sun, Dylan, Jones, David E., Flack, Steven, Spicer, Ann, Mulcahy, Victoria L., Byan, Jinyoung, Han, Younghun, Sandford, Richard N., Amos, Christopher I., Seldin, Michael F., Invernizzi, Pietro, Nakamura, Minoru, and Mells, George F.

Published
2021
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17. Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

Author

Ji, Sun-Gou, Juran, Brian D, Mucha, Sören, Folseraas, Trine, Jostins, Luke, Melum, Espen, Kumasaka, Natsuhiko, Atkinson, Elizabeth J, Schlicht, Erik M, Liu, Jimmy Z, Shah, Tejas, Gutierrez-Achury, Javier, Boberg, Kirsten M, Bergquist, Annika, Vermeire, Severine, Eksteen, Bertus, Durie, Peter R, Farkkila, Martti, Müller, Tobias, Schramm, Christoph, Sterneck, Martina, Weismüller, Tobias J, Gotthardt, Daniel N, Ellinghaus, David, Braun, Felix, Teufel, Andreas, Laudes, Mattias, Lieb, Wolfgang, Jacobs, Gunnar, Beuers, Ulrich, Weersma, Rinse K, Wijmenga, Cisca, Marschall, Hanns-Ulrich, Milkiewicz, Piotr, Pares, Albert, Kontula, Kimmo, Chazouillères, Olivier, Invernizzi, Pietro, Goode, Elizabeth, Spiess, Kelly, Moore, Carmel, Sambrook, Jennifer, Ouwehand, Willem H, Roberts, David J, Danesh, John, Floreani, Annarosa, Gulamhusein, Aliya F, Eaton, John E, Schreiber, Stefan, Coltescu, Catalina, Bowlus, Christopher L, Luketic, Velimir A, Odin, Joseph A, Chopra, Kapil B, Kowdley, Kris V, Chalasani, Naga, Manns, Michael P, Srivastava, Brijesh, Mells, George, Sandford, Richard N, Alexander, Graeme, Gaffney, Daniel J, Chapman, Roger W, Hirschfield, Gideon M, de Andrade, Mariza, Rushbrook, Simon M, Franke, Andre, Karlsen, Tom H, Lazaridis, Konstantinos N, and Anderson, Carl A

Subjects
Human Genome, Digestive Diseases, Autoimmune Disease, Digestive Diseases - (Gallbladder), Genetics, Rare Diseases, Inflammatory Bowel Disease, 2.1 Biological and endogenous factors, Aetiology, Oral and gastrointestinal, Adaptor Proteins, Signal Transducing, Alleles, Cholangitis, Sclerosing, Colitis, Ulcerative, Genome-Wide Association Study, Humans, Inflammatory Bowel Diseases, Polymorphism, Single Nucleotide, RNA, Messenger, Risk Factors, UK-PSC Consortium, International IBD Genetics Consortium, International PSC Study Group, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Primary sclerosing cholangitis (PSC) is a rare progressive disorder leading to bile duct destruction; ∼75% of patients have comorbid inflammatory bowel disease (IBD). We undertook the largest genome-wide association study of PSC (4,796 cases and 19,955 population controls) and identified four new genome-wide significant loci. The most associated SNP at one locus affects splicing and expression of UBASH3A, with the protective allele (C) predicted to cause nonstop-mediated mRNA decay and lower expression of UBASH3A. Further analyses based on common variants suggested that the genome-wide genetic correlation (rG) between PSC and ulcerative colitis (UC) (rG = 0.29) was significantly greater than that between PSC and Crohn's disease (CD) (rG = 0.04) (P = 2.55 × 10-15). UC and CD were genetically more similar to each other (rG = 0.56) than either was to PSC (P < 1.0 × 10-15). Our study represents a substantial advance in understanding of the genetics of PSC.

Published
2017

21. Pulsed light technology for fresh‐cut produce: A review on mechanism and inactivation kinetics of microbes and enzymes.

Author

Jaiswal, Monica, Nungleppam, Monica, Kumar, Manibhushan, and Srivastava, Brijesh

Subjects
PHOTOTHERMAL effect, MICROBIAL inactivation, ENZYME inactivation, SURFACE potential, PROBLEM solving
Abstract

Consumers are becoming more aware of the benefits of eating healthy foods like fresh‐cut produce without compromising the quality of sensory and nutritional aspects. Emerging non‐thermal technology like pulsed light (PL) is one of the most potential surface decontamination methods for fresh‐cut produce. Unlike conventional methods, PL does not cause unwanted changes in finished products like nutritional losses, color, textural changes, production of off‐flavors, etc. Its application is confined to not only surface disinfection but also enzyme inactivation. The death of microbes is due to PL's photochemical and photothermal effects. The photochemical effect is also responsible for enzyme inactivation, and Weibull or log‐linear models can explain their inactivation kinetics. Despite several advantages, PL has limitations of less effectiveness in eliminating microorganisms due to low penetration into the tissue of fresh‐cut produce, which can be overcome by applying different absorption‐enhancing agents to improve absorption capacity. Moreover, in‐package treatment can avoid the problem of recontamination of the treated products. This review provides an overview of the mechanisms and kinetics involved in the inactivation of microbes and enzymes in PL treatment. Additionally, this paper reviews the advantages and limitations of utilizing PL technology for shelf‐life enhancement of fresh‐cut produce and compiles the recent works done to enhance the efficacy of PL treatment. Furthermore, future scope and remedies to solve the existing problems of PL and for commercialization of this technique in the field of fresh produce are discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Percolation Approach to Initial Stage Effects in High Energy Collisions

Author

Srivastava, Brijesh K

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

Possible phase transition of strongly interacting matter from hadron to a quark-gluon plasma state have in the past received considerable interest. The clustering of color sources provides a framework of the the partonic interactions in the initial stage of the collisions. The onset of de-confinement transition is identified by the spanning percolation cluster in 2D percolation. In this talk results are presented both for the multiplicity and the elliptic flow at RHIC and LHC energies. The thermodynamic quantities temperature, equation of state and transport coefficient are obtained in the framework of clustering of color sources. It is shown that the results are in excellent agreement with the recent lattice QCD calculations(LQCD)., Comment: 9 pages, 8 figures, Invited talk at IS2013, Illa da Toxa, Galicia - Spain, September 8-14 2013. arXiv admin note: text overlap with arXiv:1210.2626 by other authors

Published
2014
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26. Clustering of Color Sources and the Equation of State of the QGP

Author

Srivastava, Brijesh K.

Subjects
Nuclear Experiment, High Energy Physics - Phenomenology
Abstract

Possible phase transition of strongly interacting matter from hadron to a quark-gluon plasma state have in the past received c onsiderable interest. It has been suggested that this problem might be treated by percolation theory. The clustering of color sources with percolation (CSPM) is used to determine the equation of state (EOS) and the transport coefficient of the Quark-Gl uon Plasma (QGP) produced in central A-A collisions at RHIC and LHC energies., Comment: 8 pages, 5 figures Invited talk given at the International Conference on New Frontiers in Physics(ICFP) 2012}, Creta, Greece, June10-16, 2012

Published
2012

27. Percolation and Deconfinement

Author

Srivastava, Brijesh K

Subjects
Nuclear Experiment, High Energy Physics - Lattice, High Energy Physics - Phenomenology
Abstract

Possible phase transition of strongly interacting matter from hadron to a Quark-Gluon Plasma (QGP) state have in the p ast received considerable interest. It has been suggested that this problem might be treated by percolation theory. Th e Color String Percolation Model (CSPM) is used to determine the equation of state (EOS) of the QGP produced in central Au-Au collisions at RHIC energies. The bulk thermodynamic quantities- energy density, entropy density and t he sound velocity- are obtained in the framework of CSPM. It is shown that the results are in excellent agreement with the recent lattice QCD calculations(LQCD)., Comment: 8 pages, 5 figures Talk given at ICPAQGP-2010, Dec. 6-10, 2010, Goa, India

Published
2011
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28. Evaluating the impact of pulsed light treatment on microbial and enzyme inactivation and quality attributes in fresh‐cut watermelon.

Author

Jaiswal, Monica and Srivastava, Brijesh

Subjects
ENZYME inactivation, MICROBIAL enzymes, MICROBIAL inactivation, WATERMELONS, PECTINESTERASE, FOOD standards
Abstract

This study investigated the impact of pulsed light (PL) applied at a fluence of 4–12 J cm−2 (complying with U.S. Food and Drug Administration standards) on fresh‐cut watermelon, focusing on its efficacy in inactivating various food‐borne pathogenic gram‐positive (Escherichia coli and Staphylococcus aureus) and gram‐negative (Listeria monocytogenes and Salmonella) bacteria. The inactivation data were used to fit the log‐linear and Weibull kinetic models. Additionally, the impact of PL on physicochemical properties, lycopene content, total phenolic content, antioxidant activity, and pectin methylesterase (PME) residual activity (RA) was studied. The results demonstrated that the inactivation rate increases with the increase in fluence. Salmonella was most sensitive to PL, resulting in a reduction of 2.55 ± 0.08 log CFU g−1 and a higher kmax, whereas S. aureus was most resistant, with a reduction of 1.87 ± 0.24 log CFU g−1 and a lower kmax. The Weibull model was the best to predict the inactivation kinetics based on standard statistics and information theory criteria. For all assayed food‐borne pathogens, the inactivation curve showed non‐linearity with upward concavity except for L. monocytogenes, which followed a concave downward curve (β >1). Results showed that PL was effective in the retention of color, firmness, pH levels, total soluble solids, and titratable acidity, and also had a positive effect on enhancing the levels of essential components such as lycopene, total phenolic compounds, and antioxidant activity. Additionally, the PME RA significantly decreased with an increase in fluence due to structural modification. Therefore, PL can be explored to enhance fresh‐cut watermelon's safety and quality attributes. Practical Applications: The implementation of this research holds significant potential for practical benefits in the fresh‐cut fruit industry. The findings could revolutionize processing practices, ensuring enhanced microbial safety, enzyme inactivation, and an extended shelf‐life of fresh‐cut watermelon. The study strongly contributes to preserving the desirable texture, color, and overall quality of the product, enhancing the retention of lycopene and other valuable antioxidants by standardizing the pulsed light treatment parameters while adhering to U.S. Food and Drug Administration standards for food application. Moreover, this research will scientifically contribute to addressing the critical challenges of foodborne outbreaks in the fresh‐cut fruit sector while providing consumers with a healthy, convenient food choice. [ABSTRACT FROM AUTHOR]

Published
2024
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29. STAR's measurement of Long-range forward-backward multiplicity correlations as the signature of 'dense partonic matter' in the Heavy Ion collisions at $\sqrt{s_{NN}}=$200 GeV.}

Author

Srivastava, Brijesh K

Subjects
Nuclear Experiment
Abstract

Forward-backward multiplicity correlations have been measured with the STAR detector for Au+Au, Cu+Cu and {\it p+p} collisions at $\sqrt{s_{NN}}$ = 200 GeV. A strong, long-range correlation is observed for central heavy ion collisions that vanishes in semi-peripheral events and {\it pp} collisions. There is no apparent scaling of correlation strength with the number of participants involved in the collision. Both the Dual Parton Model and the Color Glass condensate indicate that the long range correlations are due to multiple parton interactions. This suggests that the dense partonic matter might have been created in mid-central and central Au+Au collisions at $\sqrt{s_{NN}}$ = 200 GeV., Comment: 4 pages, 3 figures,presented at the 19th International Conference on Ultra-Relativistic Nucleus-Nucleus Collisions, "Quark Matter 2008", Jaipur, India, February 4-10, 2008

Published
2008
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30. Energy and System Size Dependence Study of the Percolation Phase Transition

Author

Tarnowsky, Terence, Scharenberg, Rolf, and Srivastava, Brijesh

Subjects
Nuclear Experiment
Abstract

Multiparticle production at high energies is described in terms of color strings stretched between the projectile and target. As the string density increases, overlap in the transverse plane leads to cluster formation. At some critical density a macroscopic cluster appears, spanning the entire system. This marks the percolation phase transition. Data from $\sqrt{s_{NN}}$ = 200 GeV p+p, d+Au and Au+Au collisions at RHIC has been analyzed using the STAR detector to obtain the percolation density parameter, $\eta$. The particle p$_{T}$ spectrum from 200 GeV p+p data is parameterized using a power law. Values of the fit parameters are used in the d+Au and Au+Au analysis. For 200 GeV Au+Au collisions, the value of $\eta$ is found to lie above the critical percolation threshold, while for other collision systems and energies, it is below the critical value. This supports the idea of string percolation, which at high enough string density is a possible mechanism to explore the hadronic phase transition to a quark-gluon plasma., Comment: 6 pages, 3 figures, Poster Proceedings for Quark Matter 2006, Shanghai, China, November 14-20, 2006

Published
2007
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31. Forward-Backward Multiplicity Correlations in Au+Au Collisions at $\sqrt{s_{NN}}$ = 200 Gev

Author

Srivastava, Brijesh K.

Subjects
Nuclear Experiment
Abstract

The study of correlations among particles produced in different rapidity regions may provide understanding of the mechanisms of particle production. Correlations that extend over a longer range are observed in hadron-hadron interactions only at higher energies. Results for short and long-range multiplicity correlations (Forward-Backward) are presented for Au+Au collisions at $\sqrt{s_{NN}}$ = 200 GeV. The growth of long range correlations are observed as a function of the pseudorapidity gap in central Au+Au collisions. The Dual Parton model and Color Glass Condensate phenomenology have been explored to understand the origin of long range correlations., Comment: 8 pages, 4 figures, IWCF06, Hangzhou, China, Nov. 21-24, 2006

Published
2007
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32. Fluctuations and Correlations in STAR

Author

Srivastava, Brijesh K

Subjects
Nuclear Experiment
Abstract

The study of correlations and fluctuations can provide evidence for the production of the quark-gluon plasma (QGP) in relativistic heavy ion collisions. Various theories predict that the production of a QGP phase in relativistic heavy ion collisions could produce significant event-by-event correlations and fluctuations in, transverse momentum, multiplicity, etc. Some of the recent results using STAR at RHIC will be presented along with results from other experiments at RHIC. The focus is on forward-backward multiplicity correlations, balance function, charge and transverse momentum fluctuations, and correlations., Comment: 6 pages, 13 figures, Invited talk at QNP06, Madrid, Spain,June 2006

Published
2007
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33. Transverse Momentum Distributions and String Percolation Study in p+p, d+Au and Au+Au at $\sqrt{s_{NN}}$ = 200 GeV

Author

Tarnowsky, Terence J., Srivastava, Brijesh K., and Scharenberg, Rolf P.

Subjects
Nuclear Experiment
Abstract

Multiparticle production at high energies is described in terms of color strings stretched between the projectile and target. As string density increases, overlap among the strings leads to cluster formation. At some critical density a macroscopic cluster appears, spanning the entire system. This marks the percolation phase transition. Data from p+p, d+Au and Au+Au collisions at 200 GeV has been analyzed using the STAR detector to obtain the percolation density parameter, $\eta$. For 200 GeV Au+Au collisions, the value of $\eta$ is found to lie above the critical percolation threshold, while for 200 GeV d+Au collisions it is below the critical value. This supports the idea of string percolation, which at high enough string density is a possible mechanism to explore the hadronic phase transition to a quark-gluon plasma., Comment: 4 pages, 3 figures, Poster Proceedings for Quark Matter 2005, Budapest, Hungary, August 4-9, 2005

Published
2006

35. Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

Author

Liu, Jimmy Z, Hov, Johannes Roksund, Folseraas, Trine, Ellinghaus, Eva, Rushbrook, Simon M, Doncheva, Nadezhda T, Andreassen, Ole A, Weersma, Rinse K, Weismüller, Tobias J, Eksteen, Bertus, Invernizzi, Pietro, Hirschfield, Gideon M, Gotthardt, Daniel Nils, Pares, Albert, Ellinghaus, David, Shah, Tejas, Juran, Brian D, Milkiewicz, Piotr, Rust, Christian, Schramm, Christoph, Müller, Tobias, Srivastava, Brijesh, Dalekos, Georgios, Nöthen, Markus M, Herms, Stefan, Winkelmann, Juliane, Mitrovic, Mitja, Braun, Felix, Ponsioen, Cyriel Y, Croucher, Peter JP, Sterneck, Martina, Teufel, Andreas, Mason, Andrew L, Saarela, Janna, Leppa, Virpi, Dorfman, Ruslan, Alvaro, Domenico, Floreani, Annarosa, Onengut-Gumuscu, Suna, Rich, Stephen S, Thompson, Wesley K, Schork, Andrew J, Næss, Sigrid, Thomsen, Ingo, Mayr, Gabriele, König, Inke R, Hveem, Kristian, Cleynen, Isabelle, Gutierrez-Achury, Javier, Ricaño-Ponce, Isis, van Heel, David, Björnsson, Einar, Sandford, Richard N, Durie, Peter R, Melum, Espen, Vatn, Morten H, Silverberg, Mark S, Duerr, Richard H, Padyukov, Leonid, Brand, Stephan, Sans, Miquel, Annese, Vito, Achkar, Jean-Paul, Boberg, Kirsten Muri, Marschall, Hanns-Ulrich, Chazouillères, Olivier, Bowlus, Christopher L, Wijmenga, Cisca, Schrumpf, Erik, Vermeire, Severine, Albrecht, Mario, UK-PSCSC Consortium, Rioux, John D, Alexander, Graeme, Bergquist, Annika, Cho, Judy, Schreiber, Stefan, Manns, Michael P, Färkkilä, Martti, Dale, Anders M, Chapman, Roger W, Lazaridis, Konstantinos N, International PSC Study Group, Franke, Andre, Anderson, Carl A, Karlsen, Tom H, and International IBD Genetics Consortium

Subjects
UK-PSCSC Consortium, International PSC Study Group, International IBD Genetics Consortium, Humans, Cholangitis, Sclerosing, Oligonucleotide Array Sequence Analysis, Risk Factors, Case-Control Studies, Gene Frequency, Linkage Disequilibrium, Polymorphism, Single Nucleotide, Genome-Wide Association Study, Genetic Loci, Genetic Pleiotropy, Genotyping Techniques, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Primary sclerosing cholangitis (PSC) is a severe liver disease of unknown etiology leading to fibrotic destruction of the bile ducts and ultimately to the need for liver transplantation. We compared 3,789 PSC cases of European ancestry to 25,079 population controls across 130,422 SNPs genotyped using the Immunochip. We identified 12 genome-wide significant associations outside the human leukocyte antigen (HLA) complex, 9 of which were new, increasing the number of known PSC risk loci to 16. Despite comorbidity with inflammatory bowel disease (IBD) in 72% of the cases, 6 of the 12 loci showed significantly stronger association with PSC than with IBD, suggesting overlapping yet distinct genetic architectures for these two diseases. We incorporated association statistics from 7 diseases clinically occurring with PSC in the analysis and found suggestive evidence for 33 additional pleiotropic PSC risk loci. Together with network analyses, these findings add to the genetic risk map of PSC and expand on the relationship between PSC and other immune-mediated diseases.

Published
2013

37. Identification and preclinical characterization of a novel and potent poly (ADP-ribose) polymerase (PARP) inhibitor ZYTP1

Author

Jain, Mukul R., Mohapatra, Jogeswar, Bandhyopadhyay, Debdutta, Chatterjee, Abhijit, Ghoshdastidar, Krishnarup, Patel, Dinesh, Patel, Ankit, Bhayani, Hitesh, Srivastava, Brijesh Kumar, Shedage, Sandeep A., Kadam, Pravin, Sundar, Rajesh, Patel, Harilal, Giri, Poonam, Patel, Prakash, Gupta, Laxmikant, Srinivas, Nuggehally R., Patel, Pankaj R., and Desai, Ranjit C.

Published
2018
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40. Greater Transplant-Free Survival in Patients Receiving Obeticholic Acid for Primary Biliary Cholangitis in a Clinical Trial Setting Compared to Real-World External Controls

Author

Murillo Perez, C. Fiorella, primary, Fisher, Holly, additional, Hiu, Shaun, additional, Kareithi, Dorcas, additional, Adekunle, Femi, additional, Mayne, Tracy, additional, Malecha, Elizabeth, additional, Ness, Erik, additional, van der Meer, Adriaan J., additional, Lammers, Willem J., additional, Trivedi, Palak J., additional, Battezzati, Pier Maria, additional, Nevens, Frederik, additional, Kowdley, Kris V., additional, Bruns, Tony, additional, Cazzagon, Nora, additional, Floreani, Annarosa, additional, Mason, Andrew L., additional, Parés, Albert, additional, Londoño, Maria-Carlota, additional, Invernizzi, Pietro, additional, Carbone, Marco, additional, Lleo, Ana, additional, Mayo, Marlyn J., additional, Dalekos, George N., additional, Gatselis, Nikolaos K., additional, Thorburn, Douglas, additional, Verhelst, Xavier, additional, Gulamhusein, Aliya, additional, Janssen, Harry L.A., additional, Smith, Rachel, additional, Flack, Steve, additional, Mulcahy, Victoria, additional, Trauner, Michael, additional, Bowlus, Christopher L., additional, Lindor, Keith D., additional, Corpechot, Christophe, additional, Jones, David, additional, Mells, George, additional, Hirschfield, Gideon M., additional, Wason, James, additional, Hansen, Bettina E., additional, Sturgess, Richard, additional, Healey, Christopher, additional, Gunasekera, Anton, additional, Kallis, Yiannis, additional, Wright, Gavin, additional, Mathialahan, Thiriloganathan, additional, Evans, Richard, additional, Gasem, Jaber, additional, Ramanaden, David, additional, Ward, Emma, additional, Bhalme, Mahesh, additional, Southern, Paul, additional, Maggs, James, additional, Yousif, Mohamed, additional, Srivastava, Brijesh, additional, Foxton, Matthew, additional, Collins, Carole, additional, Prasad, Yash, additional, Porras-Perez, Francisco, additional, Yapp, Tom, additional, Patel, Minesh, additional, Ede, Roland, additional, Carte, Martyn, additional, Koss, Konrad, additional, Sattianayagam, Prayman, additional, Grimley, Charles, additional, Tidbury, Jude, additional, Mansour, Dina, additional, Beckley, Matilda, additional, Hollywood, Coral, additional, Ramag, John, additional, Gordon, Harriet, additional, Ridpath, Joanne, additional, Grover, Bob, additional, Abouda, George, additional, Rees, Ian, additional, Narain, Mark, additional, Salam, Imroz, additional, Banim, Paul, additional, Das, Debasish, additional, Matthews, Helen, additional, Mohammed, Faiyaz, additional, Jones, Rebecca, additional, Sen, Sambit, additional, Bird, George, additional, Prince, Martin, additional, Prasad, Geeta, additional, Kitchen, Paul, additional, Hutchinson, John, additional, Gupta, Prakash, additional, Shah, Amir, additional, Saha, Subrata, additional, Pollock, Katharine, additional, Barclay, Stephen, additional, McDonald, Natasha, additional, Rushbrook, Simon, additional, Przemioslo, Robert, additional, Millar, Andrew, additional, Mitchell, Steven, additional, Davis, Andrew, additional, Naqvi, Asifabbas, additional, Lee, Tom, additional, Ryder, Stephen, additional, Collier, Jane, additional, Cramp, Matthew, additional, Aspinal, Richard, additional, Booth, Jonathan, additional, Williams, Earl, additional, Hussaini, Hyder, additional, Christie, John, additional, Chaudhry, Tehreem, additional, Mann, Stephen, additional, Ala, Aftab, additional, Maltby, Julia, additional, Corbett, Chris, additional, Singhal, Saket, additional, Hoeroldt, Barbara, additional, Butterworth, Jeff, additional, Douglas, Andrew, additional, Sinha, Rohit, additional, Panter, Simon, additional, Shearman, Jeremy, additional, Bray, Gary, additional, Roberts, Michael, additional, Forton, Daniel, additional, Taylor, Nicola, additional, Jafar, Wisam, additional, Cowan, Matthew, additional, Ch'ng, Chin Lye, additional, Rahman, Mesbah, additional, Wesley, Emma, additional, Jain, Sanjiv, additional, Mandal, Aditya, additional, Wright, Mark, additional, Trivedi, Palak, additional, Gordon, Fiona, additional, Unitt, Esther, additional, Austin, Andrew, additional, Palegwala, Altaf, additional, Vemala, Vishwaraj, additional, Higham, Andrew, additional, Fraser, Jocelyn, additional, Li, Andy, additional, Ramakrishnan, Subramaniam, additional, King, Alistair, additional, Whalley, Simon, additional, Gee, Ian, additional, Keld, Richard, additional, Fellows, Helen, additional, Gotto, James, additional, and Millson, Charles, additional

Published
2022
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42. Light nuclei collectivity from √sNN = 3 GeV Au+Au collisions at RHIC

Author

Abdallah, Mohamed Samy, Aboona, Bassam, Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph R., Adkins, J. Kevin, Agakishiev, Geydar, Aggarwal, I., Aggarwal, Madan Mohan, Ahammed, Zubayer, Aitbaev, A., Alekseev, Igor G., Anderson, Derek M., Aparin, Alexey, Aschenauer, Elke Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Averichev, Georgy S., Bairathi, Vipul, Baker, W., Ball Cap, Jonathan Gonzalo, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhagat, P., Bhasin, Anju, Bielčík, Jaroslav, Bielčíková, Jana, Bordyuzhin, Igor G., Brandenburg, James D., Brandin, Andrei V., Cai, X.Z., Caines, Helen Louise, Calderón de la Barca Sánchez, Manuel, Cebra, Daniel A., Chakaberia, Irakli, Chaloupka, Petr, Chan, B.K., Chang, F.-H., Chang, Z., Chatterjee, A., Chattopadhyay, S., Chen, D., Chen, J., Chen, J.H., Chen, X., Chen, Z., Cheng, J., Choudhury, Subikash, Christie, William, Chu, X., Crawford, Henry J., Csanád, Máté, Daugherity, M., Dedovič, Tatiana G., Deppner, Ingo Martin, Derevschikov, Anatoly A., Dhamija, A., Di Carlo, L., Didenko, Lidia, Dixit, P., Dong, X., Drachenberg, James Lucus, Duckworth, E., Dunlop, James C., Engelage, Jon M., Eppley, Geary Wareham, Esumi, ShinIchi, Evdokimov, Olga Y., Ewigleben, A., Eyser, Kjeld Oleg, Fatemi, Renee H., Fawzi, F.M., Fazio, Salvatore, Feng, C.J., Feng, Y., Finch, Evan, Fisyak, Yuri V., Francisco, Audrey, Fu, C., Gagliardi, Carl A., Galatyuk, Tetyana, Geurts, Frank, Ghimire, N., Gibson, Adam, Gopal, Krishan, Gou, X., Grosnick, David P., Gupta, Anik, Guryn, Włodzimierz, Hamed, Ahmed M., Han, Y., Harabasz, Szymon, Harasty, M.D., Harris, John W., Harrison, H., He, S., He, W., He, X.H., He, Y., Heppelmann, Steven Francis, Herrmann, Norbert, Hoffman, E., Holub, Lukáš, Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H.Z., Huang, Shengli, Huang, T., Huang, X., Huang, Y., Humanic, Thomas J., Isenhower, D., Isshiki, M., Jacobs, William W., Jena, Chitrasen, Jentsch, Alexander, Ji, Y., Jia, J., Jiang, K., Ju, X., Judd, Eleanor G., Kabana, Sonia, Kabir, M.L., Kagamaster, Skipper, Kalinkin, Dmitry, Kang, K., Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia V., Kikoła, Daniel P., Kimelman, B., Kincses, D., Kisel, Ivan, Kiselev, A., Knospe, Anders Garritt, Ko, H.S., Kočenda, L. M., Korobitsin, A., Kosarzewski, Leszek Krzysztof, Kramárik, Lukáš, Kravtsov, Peter, Kumar, Lokesh, Kumar, Shyam, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph H., Lacey, Roy Alphanso, Lan, S., Landgraf, Jeffery M., Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, J.H., Leung, Y.H., Lewis, N., Li, C., Li, W., Li, Xiaomei, Li, Y., Liang, X., Liang, Y., Licenik, Robert, Lin, T., Lin, Y., Lisa, Michael A., Liu, F., Liu, H., Liu, P., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, Tonko A., Llope, William Joseph, Longacre, Ronald S., Loyd, E., Lu, T., Lukow, N.S., Luo, X.F., Ma, L., Ma, R., Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Mallick, Dukhishyam, Manukhov, S.L., Margetis, Spyridon, Markert, Christina, Matis, Howard S., Mazer, Joel Anthony, Minaev, Nikolai G., Mioduszewski, Saskia, Mohanty, Bedangadas, Mondal, Mriganka Mouli, Mooney, Isaac A., Morozov, Dmitry A., Mukherjee, Ayon, Nagy, M., Nam, J.D., Nasim, Md., Nayak, Kishora, Neff, D., Nelson, John M., Nemes, Daniel B., Nie, Maowu, Nigmatkulov, Grigory A., Niida, Takafumi, Nishitani, R., Nogach, Larisa V., Nonaka, Toshihiro, Nunes, A.S., Odyniec, Grazyna Janina, Ogawa, Akio, Oh, S., Okorokov, Vitaly A., Okubo, K., Page, Brian S., Pak, Robert, Pan, Jinjin, Pandav, A., Pandey, Ashutosh Kumar, Panebratsev, Yuri, Parfenov, P., Paul, A., Pawlik, Bogdan, Pawłowska, Diana, Perkins, Chris, Pinsky, Lawrence, Pluta, Jan Marian, Pokhrel, B.R., Porter, Jeffrey Brent, Posik, Matthew, Prozorova, V., Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Jörn H., Qiu, H., Quintero, Amilkar, Racz, C., Radhakrishnan, Sooraj Krishnan, Raha, N., Ray, Robert L., Reed, Rosi Jan, Ritter, Hans Georg, Robotkova, M., Rogačevskij, Oleg V., Romero, Juan L., Roy, D., Ruan, Lijuan, Sahoo, A.K., Sahoo, Nihar Ranjan, Sako, H., Salur, Sevil, Samigullin, Eduard, Sandweiss, Jack H., Sato, S., Schmidke, William B., Schmitz, Norbert, Schweid, Benjamin R., Seck, Florian, Seger, Janet Elizabeth, Seto, Richard, Seyboth, Peter, Shah, N., Shahaliev, Ehtiram, Shanmuganathan, Prashanth V., Shao, M., Shao, T., Sharma, R., Sheikh, Ashik Ikbal, Shen, D.Y., Shi, S.S., Shi, Y., Shou, Q.Y., Sichtermann, Ernst P., Sikora, Rafał, Singh, Jagbir, Singha, Subhash, Sinha, P., Skoby, M.J., Smirnov, Nikolai, Söhngen, Y., Solyst, William, Song, Y., Spinka, Harold. M., Srivastava, Brijesh Kumar, Stanislaus, T. D. Shirvel, Stefaniak, Maria, Stewart, David J., Strichanov, Michail Nikolaevič, Stringfellow, Blair, Suaide, Alexandre Alarcon do Passo, Šumbera, Michal, Summa, Branden, Sun, X.M., Sun, X., Sun, Y., Surrow, Bernd, Svirida, Dmitry N., Sweger, Z.W., Szymański, Paweł, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terence J., Thomas, James H., Timmins, Anthony Robert, Tlusty, David, Todoroki, Takahito, Tokarev, Mikhail V., Tomkiel, Catherine A., Trentalange, Stephen, Tribble, Robert E., Tribedy, Prithwish, Tripathy, Srikanta Kumar, Truhlar, T., Trzeciak, Barbara Antonina, Tsai, Oleg D., Tu, Z., Ullrich, Thomas, Underwood, David G., Upsal, Isaac, Van Buren, Gene, Vanek, Jan, Vasiliev, Alexander Nikolaevich, Vassiliev, Iouri, Verkest, V., Videbæk, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, F., Wang, G., Wang, J.S., Wang, P., Wang, X., Wang, Y., Wang, Z., Webb, Jason C., Weidenkaff, P.C., Westfall, Gary D., Wieman, Howard, Wissink, Scott W., Witt, Richard, Wu, J., Wu, Y., Xi, B., Xiao, Z.G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q.H., Xu, Y., Xu, Z., Yan, G., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, Hanna Paulina, Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, Y., Zhang, Z.J., Zhang, Zuman, Zhao, F., Zhao, J., Zhao, M., Zhou, C., Zhou, You, Zhu, X., Zurek, Marian, Zyzak, Maksym, Abdallah, Mohamed Samy, Aboona, Bassam, Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph R., Adkins, J. Kevin, Agakishiev, Geydar, Aggarwal, I., Aggarwal, Madan Mohan, Ahammed, Zubayer, Aitbaev, A., Alekseev, Igor G., Anderson, Derek M., Aparin, Alexey, Aschenauer, Elke Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Averichev, Georgy S., Bairathi, Vipul, Baker, W., Ball Cap, Jonathan Gonzalo, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhagat, P., Bhasin, Anju, Bielčík, Jaroslav, Bielčíková, Jana, Bordyuzhin, Igor G., Brandenburg, James D., Brandin, Andrei V., Cai, X.Z., Caines, Helen Louise, Calderón de la Barca Sánchez, Manuel, Cebra, Daniel A., Chakaberia, Irakli, Chaloupka, Petr, Chan, B.K., Chang, F.-H., Chang, Z., Chatterjee, A., Chattopadhyay, S., Chen, D., Chen, J., Chen, J.H., Chen, X., Chen, Z., Cheng, J., Choudhury, Subikash, Christie, William, Chu, X., Crawford, Henry J., Csanád, Máté, Daugherity, M., Dedovič, Tatiana G., Deppner, Ingo Martin, Derevschikov, Anatoly A., Dhamija, A., Di Carlo, L., Didenko, Lidia, Dixit, P., Dong, X., Drachenberg, James Lucus, Duckworth, E., Dunlop, James C., Engelage, Jon M., Eppley, Geary Wareham, Esumi, ShinIchi, Evdokimov, Olga Y., Ewigleben, A., Eyser, Kjeld Oleg, Fatemi, Renee H., Fawzi, F.M., Fazio, Salvatore, Feng, C.J., Feng, Y., Finch, Evan, Fisyak, Yuri V., Francisco, Audrey, Fu, C., Gagliardi, Carl A., Galatyuk, Tetyana, Geurts, Frank, Ghimire, N., Gibson, Adam, Gopal, Krishan, Gou, X., Grosnick, David P., Gupta, Anik, Guryn, Włodzimierz, Hamed, Ahmed M., Han, Y., Harabasz, Szymon, Harasty, M.D., Harris, John W., Harrison, H., He, S., He, W., He, X.H., He, Y., Heppelmann, Steven Francis, Herrmann, Norbert, Hoffman, E., Holub, Lukáš, Hu, C., Hu, Q., Hu, Y., Huang, H., Huang, H.Z., Huang, Shengli, Huang, T., Huang, X., Huang, Y., Humanic, Thomas J., Isenhower, D., Isshiki, M., Jacobs, William W., Jena, Chitrasen, Jentsch, Alexander, Ji, Y., Jia, J., Jiang, K., Ju, X., Judd, Eleanor G., Kabana, Sonia, Kabir, M.L., Kagamaster, Skipper, Kalinkin, Dmitry, Kang, K., Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia V., Kikoła, Daniel P., Kimelman, B., Kincses, D., Kisel, Ivan, Kiselev, A., Knospe, Anders Garritt, Ko, H.S., Kočenda, L. M., Korobitsin, A., Kosarzewski, Leszek Krzysztof, Kramárik, Lukáš, Kravtsov, Peter, Kumar, Lokesh, Kumar, Shyam, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph H., Lacey, Roy Alphanso, Lan, S., Landgraf, Jeffery M., Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, J.H., Leung, Y.H., Lewis, N., Li, C., Li, W., Li, Xiaomei, Li, Y., Liang, X., Liang, Y., Licenik, Robert, Lin, T., Lin, Y., Lisa, Michael A., Liu, F., Liu, H., Liu, P., Liu, T., Liu, X., Liu, Y., Liu, Z., Ljubicic, Tonko A., Llope, William Joseph, Longacre, Ronald S., Loyd, E., Lu, T., Lukow, N.S., Luo, X.F., Ma, L., Ma, R., Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Mallick, Dukhishyam, Manukhov, S.L., Margetis, Spyridon, Markert, Christina, Matis, Howard S., Mazer, Joel Anthony, Minaev, Nikolai G., Mioduszewski, Saskia, Mohanty, Bedangadas, Mondal, Mriganka Mouli, Mooney, Isaac A., Morozov, Dmitry A., Mukherjee, Ayon, Nagy, M., Nam, J.D., Nasim, Md., Nayak, Kishora, Neff, D., Nelson, John M., Nemes, Daniel B., Nie, Maowu, Nigmatkulov, Grigory A., Niida, Takafumi, Nishitani, R., Nogach, Larisa V., Nonaka, Toshihiro, Nunes, A.S., Odyniec, Grazyna Janina, Ogawa, Akio, Oh, S., Okorokov, Vitaly A., Okubo, K., Page, Brian S., Pak, Robert, Pan, Jinjin, Pandav, A., Pandey, Ashutosh Kumar, Panebratsev, Yuri, Parfenov, P., Paul, A., Pawlik, Bogdan, Pawłowska, Diana, Perkins, Chris, Pinsky, Lawrence, Pluta, Jan Marian, Pokhrel, B.R., Porter, Jeffrey Brent, Posik, Matthew, Prozorova, V., Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Jörn H., Qiu, H., Quintero, Amilkar, Racz, C., Radhakrishnan, Sooraj Krishnan, Raha, N., Ray, Robert L., Reed, Rosi Jan, Ritter, Hans Georg, Robotkova, M., Rogačevskij, Oleg V., Romero, Juan L., Roy, D., Ruan, Lijuan, Sahoo, A.K., Sahoo, Nihar Ranjan, Sako, H., Salur, Sevil, Samigullin, Eduard, Sandweiss, Jack H., Sato, S., Schmidke, William B., Schmitz, Norbert, Schweid, Benjamin R., Seck, Florian, Seger, Janet Elizabeth, Seto, Richard, Seyboth, Peter, Shah, N., Shahaliev, Ehtiram, Shanmuganathan, Prashanth V., Shao, M., Shao, T., Sharma, R., Sheikh, Ashik Ikbal, Shen, D.Y., Shi, S.S., Shi, Y., Shou, Q.Y., Sichtermann, Ernst P., Sikora, Rafał, Singh, Jagbir, Singha, Subhash, Sinha, P., Skoby, M.J., Smirnov, Nikolai, Söhngen, Y., Solyst, William, Song, Y., Spinka, Harold. M., Srivastava, Brijesh Kumar, Stanislaus, T. D. Shirvel, Stefaniak, Maria, Stewart, David J., Strichanov, Michail Nikolaevič, Stringfellow, Blair, Suaide, Alexandre Alarcon do Passo, Šumbera, Michal, Summa, Branden, Sun, X.M., Sun, X., Sun, Y., Surrow, Bernd, Svirida, Dmitry N., Sweger, Z.W., Szymański, Paweł, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terence J., Thomas, James H., Timmins, Anthony Robert, Tlusty, David, Todoroki, Takahito, Tokarev, Mikhail V., Tomkiel, Catherine A., Trentalange, Stephen, Tribble, Robert E., Tribedy, Prithwish, Tripathy, Srikanta Kumar, Truhlar, T., Trzeciak, Barbara Antonina, Tsai, Oleg D., Tu, Z., Ullrich, Thomas, Underwood, David G., Upsal, Isaac, Van Buren, Gene, Vanek, Jan, Vasiliev, Alexander Nikolaevich, Vassiliev, Iouri, Verkest, V., Videbæk, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, F., Wang, G., Wang, J.S., Wang, P., Wang, X., Wang, Y., Wang, Z., Webb, Jason C., Weidenkaff, P.C., Westfall, Gary D., Wieman, Howard, Wissink, Scott W., Witt, Richard, Wu, J., Wu, Y., Xi, B., Xiao, Z.G., Xie, G., Xie, W., Xu, H., Xu, N., Xu, Q.H., Xu, Y., Xu, Z., Yan, G., Yang, C., Yang, Q., Yang, S., Yang, Y., Ye, Z., Yi, L., Yip, K., Yu, Y., Zbroszczyk, Hanna Paulina, Zha, W., Zhang, C., Zhang, D., Zhang, J., Zhang, S., Zhang, Y., Zhang, Z.J., Zhang, Zuman, Zhao, F., Zhao, J., Zhao, M., Zhou, C., Zhou, You, Zhu, X., Zurek, Marian, and Zyzak, Maksym

Abstract

In high-energy heavy-ion collisions, partonic collectivity is evidenced by the constituent quark number scaling of elliptic flow anisotropy for identified hadrons. A breaking of this scaling and dominance of baryonic interactions is found for identified hadron collective flow measurements in √sNN = 3 GeV Au+Au collisions. In this paper, we report measurements of the first- and second-order azimuthal anisotropic parameters, v1 and v2, of light nuclei (d, t, 3He, 4He) produced in √sNN = 3 GeV Au+Au collisions at the STAR experiment. An atomic mass number scaling is found in the measured v1 slopes of light nuclei at mid-rapidity. For the measured v2 magnitude, a strong rapidity dependence is observed. Unlike v2 at higher collision energies, the v2 values at mid-rapidity for all light nuclei are negative and no scaling is observed with the atomic mass number. Calculations by the Jet AA Microscopic Transport Model (JAM), with baryonic mean-field plus nucleon coalescence, are in good agreement with our observations, implying baryonic interactions dominate the collective dynamics in 3 GeV Au+Au collisions at RHIC.

Published
2022

46. Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice

Author

Patel, Kartikkumar Navinchandra, Joharapurkar, Amit Arvind, Patel, Vishal, Kshirsagar, Samadhan Govind, Bahekar, Rajesh, Srivastava, Brijesh Kumar, and Jain, Mukul R.

Subjects
Obesity -- Drug therapy, Antagonists (Biochemistry) -- Dosage and administration, Peptides -- Usage -- Health aspects, Glucagon -- Health aspects, Biological sciences
Abstract

Cannabinoid 1 (CB1) receptor antagonists reduce body weight and improve insulin sensitivity. Preclinical data indicates that an acute dose of CB1 antagonist rimonabant causes an increase in blood glucose. A stable analog of glucagon-like peptide 1 (GLP-1), exendin-4 improves glucose-stimulated insulin secretion in pancreas, and reduces appetite through activation of GLP-1 receptors in the central nervous system and liver. We hypothesized that the insulin secretagogue effect of GLP-1 agonist exendin-4 may synergize with the insulin-sensitizing action of rimonabant. Intraperitoneal as well as intracerebroventricular administration of rimonabant increased serum glucose upon glucose challenge in overnight fasted, diet-induced obese C57 mice, with concomitant rise in serum glucagon levels. Exendin-4 reversed the acute hyperglycemia induced by rimonabant. The combination of exendin-4 and rimonabant showed an additive effect in the food intake, and sustained body weight reduction upon repeated dosing. The acute efficacy of both the compounds was additive for inducing nausea-like symptoms in conditioned aversion test in mice, whereas exendin-4 treatment antagonized the effect of rimonabant on forced swim test upon chronic dosing. Thus, the addition of exendin-4 to rimonabant produces greater reduction in food intake owing to increased aversion, but reduces the other central nervous system side effects of rimonabant. The hyperglucagonemia induced by rimonabant is partially responsible for enhancing the antiobesity effect of exendin-4. Key words: rimonabant, insulin, exendin-4, hyperglycemia. Les antagonistes du recepteur des cannabinoides 1 (' CB1') reduisent le poids corporel et ameliorent la sensibilite a l'insuline. Des donnees precliniques indiquent qu'une dose aigue de rimonabant, un antagoniste du CB1, provoque un accroissement de glucose sanguin. Un analogue stable du peptide GLP-1 (glucagon-like peptide 1), l'exendine-4, ameliore la secretion d'insuline stimulee par le glucose par le pancreas et reduit l'appetit, par l'intermediaire de l'activation des recepteurs de GLP-1 dans le systeme nerveux cerebro-spinal et le foie. Les auteurs ont pose l'hypothese que l'effet secretagogue d'insuline de l'agoniste du GLP-1, l'exendine-4, peut agir en synergie avec l'action sensibilisante a l'insuline du rimonabant. Une administration intra-peritoneale aussi bien qu'intra-cerebrovasculaire de rimonabant accroissait le glucose serique a la suite d'une charge en glucose chez des souris C57 obeses (obesite induite par la diete) apres un jeune d'une nuit, de maniere concomitante a une augmentation des niveaux seriques de glucagon. L'exendine-4 renversait l'hyperglycemie aigue induite par le rimonabant. La combinaison d'exendine-4 et de rimonabant produisait un effet additif sur la prise alimentaire, et soutenait une reduction du poids corporel en fonction d'une administration repetee. L'efficacite aigue des deux composes etait additive en ce qui concerne l'induction de symptomes nauseeux lors d'un test d'aversion conditionnee chez la souris, alors que le traitement a l'exendine-4 antagonisait l'effet du rimonabant lors d'un test de nage forcee, en fonction d'une administration chronique. Ainsi, l'addition d'exendine-4 au rimonabant reduit davantage la prise alimentaire a cause d'une aversion accrue, mais elle reduit les autres effets secondaires du rimonabant sur le systeme nerveux cerebro-spinal. L'hyperglucagonemie induite par le rimonabant est partiellement responsable de l'augmentation de l'effet anti-obesite de l'exendine-4. [Traduit par la Redaction] Mots-cles: rimonabant, insuline, exendine-4, hyperglycemie., Introduction Obesity is a severe health concern across the globe because of increase in sedentary lifestyle (James 2008). Enhanced acceptance of obesity as a disease has increased the need for [...]

Published
2014
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47. Discovery of novel, potent and orally efficacious inhibitor of neutral amino acid transporter B0AT1 (SLC6A19)

Author

Desai, Jigar, Patel, Bhaumin, Darji, Brijesh, Gite, Archana, Panchal, Nandini, Bhosale, Gokul, Shedage, Sandeep, Patel, Sandip, Kadam, Pravin, Patel, Gautam, Kumar Srivastava, Brijesh, Joharapurkar, Amit, Kshirsagar, Samadhan, Giri, Poonam, Bhayani, Hitesh, Patel, Ankit, Ghoshdastidar, Krishnarup, Bandyopadhyay, Debdutta, Kumar, Sanjay, Jain, Mukul, and Sharma, Rajiv

Published
2021
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48. Probing the Gluonic Structure of the Deuteron with J/ψ Photoproduction in d+Au Ultraperipheral Collisions

Author

Abdallah, Mohamed, Aboona, Bassam, Adam, Jaroslav, Adamczyk, Leszek, Adams, Joseph, Adkins, Kevin, Agakishiev, Geydar, Aggarwal, Ishu, Aggarwal, Madan, Ahammed, Zubayer, Aitbaev, A., Alekseev, Igor, Anderson, Derek, Aparin, Alexey, Aschenauer, Elke-Caroline, Ashraf, Muhammad Usman, Atetalla, Fareha, Attri, Anjali, Averichev, Georgy, Bairathi, Vipul, Baker, William, Ball Cap, Jonathan Gonzalo, Barish, Kenneth, Behera, Arabinda, Bellwied, Rene, Bhagat, Pratibha, Bhasin, Anju, Bielcik, Jaroslav, Bielcikova, Jana, Bordyuzhin, Igor, Brandenburg, James, Brandin, Andrei, Bunzarov, Ivan, Cai, Xiang-Zhou, Caines, Helen, Calderon de la Barca Sanchez, Manuel, Cebra, Daniel, Chakaberia, Irakli, Chaloupka, Petr, Chan, Brian, Chang, Feng-Han, Chang, Zilong, Chankova-Bunzarova, Nedialka, Chatterjee, Arghya, Chattopadhyay, Subhasis, Chen, Ding, Chen, Jia, Chen, Jinhui, Chen, Xiaolong, Chen, Zhenyu, Cheng, Jianping, Chevalier, Malia, Choudhury, Subikash, Christie, W., Christie, Bill, Chu, Xiaoxuan, Crawford, Hank, Csanad, Mate, Daugherity, Michael, Dedovich, Tatiana, Deppner, Ingo, Derevschikov, Anatoly, Dhamija, Arushi, Di Carlo, Launa, Didenko, Lidia, Dixit, Prabhupada, Dong, Xin, Drachenberg, James, Duckworth, Eddie, Dunlop, James, Elsey, Nicholas, Engelage, Jack, Eppley, Geary, Esumi, ShinIchi, Evdokimov, Olga, Ewigleben, Annika, Eyser, Oleg, Fatemi, Renee, Fawzi, Fares, Fazio, Salvatore, Federic, Pavol, Fedorisin, Jan, Feng, Chan-Jui, Feng, Yicheng, Filip, Peter, Finch, Evan, Fisyak, Yuri, Francisco, Audrey, Fu, Chuan, Fulek, Lukasz, Gagliardi, Carl, Galatyuk, Tatyana, Geurts, Frank, Ghimire, Navagyan, Gibson, Adam, Gopal, Krishan, Gou, Xingrui, Grosnick, David, Gupta, Anik, Guryn, Wlodek, Hamad, Ayman, Hamed, Ahmed, Han, Yiding, Harabasz, Szymon, Harasty, Matthew, Harris, John, Harrison, Hannah, He, Shu, He, Wanbing, He, Xionghong, He, Yang, Heppelmann, Samuel, Heppelmann, Steven, Herrmann, Norbert, Hoffman, Eric, Holub, Lukas, Hu, C., Hu, Q., Hu, Yu, Huang, Hao, Huang, Huan, Huang, Shengli, Huang, Te-Chuan, Huang, Xinjie, Huang, Yan, Humanic, T.J., Igo, George, Isenhower, Donald, Isshiki, M., Jacobs, William, Jena, Chitrasen, Jentsch, Alexander, Ji, Yuanjing, Jia, Jiangyong, Jiang, Kun, Ju, Xinyue, Judd, Eleanor, Kabana, Sonia, Kabir, Md Latiful, Kagamaster, Skipper, Kalinkin, Dmitry, Kang, Kejun, Kapukchyan, David, Kauder, Kolja, Ke, Hongwei, Keane, Declan, Kechechyan, Armen, Kelsey, Matthew, Khyzhniak, Yevheniia, Kikola, Daniel, Kim, Chong, Kimelman, Benjamin, Kincses, Daniel, Kisel, Ivan, Kiselev, Alexander, Knospe, Anders, Ko, Ho San, Kochenda, Leonid, Korobitsin, A., Kosarzewski, Leszek, Kramarik, Lukas, Kravtsov, Petr, Kumar, Lokesh, Kumar, Shyam, Kunnawalkam Elayavalli, Raghav, Kwasizur, Joseph, Lacey, Roy, Lan, Shaowei, Landgraf, Jeffery, Lauret, Jerome, Lebedev, Alexei, Lednicky, Richard, Lee, Jeong-Hun, Leung, Yue-Hang, Lewis, Nicole, Li, Changfeng, Li, Cheng, Li, Wei, Li, Xin, Li, Yuanjing, Liang, Xilin, Liang, Yue, Licenik, Robert, Lin, Ting, Lin, Yufu, Lisa, Mike, Liu, Feng, Liu, Huanzhao, Liu, Hui, Liu, Peifeng, Liu, Tong, Liu, Xiaoyu, Liu, Yanfang, Liu, Zhen, Ljubicic, Tonko, Llope, W.J., Longacre, R.S., Loyd, Erik, Lu, T., Lukow, Nicholas, Luo, Xiaofeng, Ma, Long, Ma, Rongrong, Ma, Yu-Gang, Magdy Abdelwahab Abdelrahman, Niseem, Mallick, Debasish, Manukhov, S.L., Margetis, Spiros, Markert, Christina, Matis, Howard, Mazer, Joel, Minaev, Nikolai, Mioduszewski, Saskia, Mohanty, Bedanga, Mondal, Mriganka, Mooney, Isaac, Morozov, Dmitry, Mukherjee, Ayon, Nagy, Marton, Nam, J.D., Nasim, Md., Nayak, Kishora, Neff, Dylan, Nelson, John, Nemes, Daniel, Nie, Maowu, Nigmatkulov, Grigory, Niida, Takafumi, Nishitani, Risa, Nogach, Larisa, Nonaka, Toshihiro, Nunes, Ana Sofia, Odyniec, Grazyna, Ogawa, Akio, Oh, Saehanseul, Okorokov, Vitalii, Okubo, K., Page, Brian, Pak, Robert, Pan, Jinjin, Pandav, Ashish, Pandey, Ashutosh, Panebratsev, Yuri, Parfenov, Petr, Pinsky, Lawrence, Paul, A., Pawlik, Bogdan, Pawlowska, Diana, Perkins, Chris, Pluta, Jan, Pokhrel, Babu, Ponimatkin, Georgij, Porter, Jeff, Posik, Matthew, Prozorova, Veronika, Pruthi, Navneet Kumar, Przybycien, Mariusz, Putschke, Joern, Qiu, Hao, Quintero, Amilkar, Racz, Cameron, Radhakrishnan, Sooraj, Raha, Nandita, Ray, Lanny, Reed, Rosi, Ritter, Hans Georg, Robotkova, Monika, Rogachevskiy, Oleg, Romero, Juan, Roy, Diptanil, Ruan, Lijuan, Rusnak, Jan, Sahoo, Aswini, Sahoo, Nihar, Sako, Hiroyuki, Salur, Sevil, Samigullin, E., Sandweiss, Jack, Sato, Susumu, Schmidke, Bill, Schmitz, Norbert, Schweid, Benjamin, Seck, Florian, Seger, Janet, Sergeeva, Maria, Seto, Richard, Seyboth, Peter, Shah, Neha, Shahaliev, Ehtiram, Shanmuganathan, Prashanth, Shao, Ming, Shao, Tianhao, Sharma, R., Sheikh, Ashik Ikbal, Shen, Diyu, Shi, Shusu, Shi, Yingying, Shou, Qi-Ye, Sichtermann, Ernst, Sikora, Rafal, Simko, Miroslav, Singh, Jagbir, Singha, Subhash, Sorensen, Paul, Sinha, P., Skoby, Michael, Smirnov, Nikolai, Soehngen, Yannick, Solyst, William, Song, Youqi, Spinka, H.M., Srivastava, Brijesh, Stanislaus, Shirvel, Stefaniak, Maria, Stewart, David, Strikhanov, Mikhail, Stringfellow, Blair, Suaide, Alexandre Alarcon, Sumbera, Michal, Summa, Branden, Sun, Xiangming, Sun, Xu, Sun, Yongjie, Sun, Yuliang, Surrow, Bernd, Svirida, Dmitry, Sweger, Zachary, Szymanski, Pawel, Tang, Aihong, Tang, Zebo, Taranenko, Arkadiy, Tarnowsky, Terry, Thomas, J.H., Timmins, Anthony, Tlusty, David, Todoroki, Takahito, Tokarev, Michael, Tomkiel, Catherine, Trentalange, Steven, Tribble, Robert, Tribedy, Prithwish, Tripathy, Srikanta Kumar, Truhlar, Tomas, Trzeciak, Barbara, Tsai, Oleg, Tu, Zhoudunming (Kong), Ullrich, Thomas, Underwood, Dave, Upsal, Isaac, Van Buren, Gene, Vanek, Jan, Vasiliev, Alexander, Vassiliev, Iouri, Verkest, Veronica, Videbaek, Flemming, Vokal, Stanislav, Voloshin, Sergei, Wang, Fuqiang, Wang, Gang, Wang, Jiansong, Wang, Pengfei, Wang, Xiaofeng, Wang, Yaping, Wang, Yi, Wang, Zhen, Webb, Jason, Weidenkaff, Philipp, Wen, Liwen, Westfall, Gary, Wieman, Howard, Wissink, Scott, Witt, Richard, Wu, Jin, Wu, Junlin, Wu, Yang, Xi, Baoshan, Xiao, Zhigang, Xie, Guannan, Xie, Wei, Xu, Haojie, Xu, Nu, Xu, Qinghua, Xu, Yike, Xu, Zhangbu, Xu, Zhiwan, Yan, Gaoguo, Yang, Chi, Yang, Qian, Yang, Shuai, Yang, Yi, Ye, Zaochen, Ye, Zhenyu, Yi, Li, Yip, Kin, Yu, Yi, Zbroszczyk, Hanna, Zha, Wangmei, Zhang, ChunJian, Zhang, Dingwei, Zhang, Jinlong, Zhang, Xiaoping, Zhao, F., Zhang, Shenghui, Zhang, Song, Zhang, Yapeng, Zhang, Yifei, Zhang, Yu, Zhang, Zhe-Jia, Zhang, Zhengqiao, Zhang, Ziyue, Zhao, Jie, Zhao, M., Zhou, Chensheng, Zhou, Yingjie, Zhu, Xianglei, Zurek, Maria, and Zyzak, Maksym

Subjects
Nuclear Theory, nucl-th, hep-ex, FOS: Physical sciences, nucl-ex, High Energy Physics - Experiment, Nuclear Theory (nucl-th), High Energy Physics - Experiment (hep-ex), Nuclear Physics - Theory, High Energy Physics::Experiment, Nuclear Physics - Experiment, Nuclear Experiment (nucl-ex), Nuclear Experiment, Particle Physics - Experiment
Abstract

Understanding gluon density distributions and how they are modified in nuclei are among the most important goals in nuclear physics. In recent years, diffractive vector meson production measured in ultra-peripheral collisions (UPCs) at heavy-ion colliders has provided a new tool for probing the gluon density. In this Letter, we report the first measurement of $J/\psi$ photoproduction off the deuteron in UPCs at the center-of-mass energy $\sqrt{s_{_{\rm NN}}}=200~\rm GeV$ in d$+$Au collisions. The differential cross section as a function of momentum transfer $-t$ is measured. In addition, data with a neutron tagged in the deuteron-going Zero-Degree Calorimeter is investigated for the first time, which is found to be consistent with the expectation of incoherent diffractive scattering at low momentum transfer. Theoretical predictions based on the Color Glass Condensate saturation model and the gluon shadowing model are compared with the data quantitatively. A better agreement with the saturation model has been observed. With the current measurement, the results are found to be directly sensitive to the gluon density distribution of the deuteron and the deuteron breakup, which provides insights into the nuclear gluonic structure., Comment: Final published version Phys. Rev. Lett. 128, 122303

Published
2021

49. Corrigendum to ‘An international genome-wide meta-analysis of primary biliary cholangitis: Novel risk loci and candidate drugs’ [J Hepatol 2021;75(3):572–581]

Author

Cordell, Heather J., primary, Fryett, James J., additional, Ueno, Kazuko, additional, Darlay, Rebecca, additional, Aiba, Yoshihiro, additional, Hitomi, Yuki, additional, Kawashima, Minae, additional, Nishida, Nao, additional, Khor, Seik-Soon, additional, Gervais, Olivier, additional, Kawai, Yosuke, additional, Nagasaki, Masao, additional, Tokunaga, Katsushi, additional, Tang, Ruqi, additional, Shi, Yongyong, additional, Li, Zhiqiang, additional, Juran, Brian D., additional, Atkinson, Elizabeth J., additional, Gerussi, Alessio, additional, Carbone, Marco, additional, Asselta, Rosanna, additional, Cheung, Angela, additional, de Andrade, Mariza, additional, Baras, Aris, additional, Horowitz, Julie, additional, Ferreira, Manuel A.R., additional, Sun, Dylan, additional, Jones, David E., additional, Flack, Steven, additional, Spicer, Ann, additional, Mulcahy, Victoria L., additional, Byun, Jinyoung, additional, Han, Younghun, additional, Sandford, Richard N., additional, Lazaridis, Konstantinos N., additional, Amos, Christopher I., additional, Hirschfield, Gideon M., additional, Seldin, Michael F., additional, Invernizzi, Pietro, additional, Siminovitch, Katherine A., additional, Ma, Xiong, additional, Nakamura, Minoru, additional, Mells, George F., additional, Mason, Andrew, additional, Vincent, Catherine, additional, Xie, Gang, additional, Zhang, Jinyi, additional, Affronti, Andrea, additional, Almasio, Piero L., additional, Alvaro, Domenico, additional, Andreone, Pietro, additional, Andriulli, Angelo, additional, Azzaroli, Francesco, additional, Battezzati, Pier Maria, additional, Benedetti, Antonio, additional, Bragazzi, MariaConsiglia, additional, Brunetto, Maurizia, additional, Bruno, Savino, additional, Calvaruso, Vincenza, additional, Cardinale, Vincenzo, additional, Casella, Giovanni, additional, Cazzagon, Nora, additional, Ciaccio, Antonio, additional, Coco, Barbara, additional, Colli, Agostino, additional, Colloredo, Guido, additional, Colombo, Massimo, additional, Colombo, Silvia, additional, Cristoferi, Laura, additional, Cursaro, Carmela, additional, Crocè, Lory Saveria, additional, Crosignani, Andrea, additional, D’Amato, Daphne, additional, Donato, Francesca, additional, Elia, Gianfranco, additional, Fabris, Luca, additional, Fagiuoli, Stefano, additional, Ferrari, Carlo, additional, Floreani, Annarosa, additional, Galli, Andrea, additional, Giannini, Edoardo, additional, Grattagliano, Ignazio, additional, Lampertico, Pietro, additional, Lleo, Ana, additional, Malinverno, Federica, additional, Mancuso, Clara, additional, Marra, Fabio, additional, Marzioni, Marco, additional, Massironi, Sara, additional, Mattalia, Alberto, additional, Miele, Luca, additional, Milani, Chiara, additional, Morini, Lorenzo, additional, Morisco, Filomena, additional, Muratori, Luigi, additional, Muratori, Paolo, additional, Niro, Grazia A., additional, O’Donnell, Sarah, additional, Picciotto, Antonio, additional, Portincasa, Piero, additional, Rigamonti, Cristina, additional, Ronca, Vincenzo, additional, Rosina, Floriano, additional, Spinzi, Giancarlo, additional, Strazzabosco, Mario, additional, Tarocchi, Mirko, additional, Tiribelli, Claudio, additional, Toniutto, Pierluigi, additional, Valenti, Luca, additional, Vinci, Maria, additional, Zuin, Massimo, additional, Nakamura, Hitomi, additional, Abiru, Seigo, additional, Nagaoka, Shinya, additional, Komori, Atsumasa, additional, Yatsuhashi, Hiroshi, additional, Ishibashi, Hiromi, additional, Ito, Masahiro, additional, Migita, Kiyoshi, additional, Ohira, Hiromasa, additional, Katsushima, Shinji, additional, Naganuma, Atsushi, additional, Sugi, Kazuhiro, additional, Komatsu, Tatsuji, additional, Mannami, Tomohiko, additional, Matsushita, Kouki, additional, Yoshizawa, Kaname, additional, Makita, Fujio, additional, Nikami, Toshiki, additional, Nishimura, Hideo, additional, Kouno, Hiroshi, additional, Kouno, Hirotaka, additional, Ota, Hajime, additional, Komura, Takuya, additional, Nakamura, Yoko, additional, Shimada, Masaaki, additional, Hirashima, Noboru, additional, Komeda, Toshiki, additional, Ario, Keisuke, additional, Nakamuta, Makoto, additional, Yamashita, Tsutomu, additional, Furuta, Kiyoshi, additional, Kikuchi, Masahiro, additional, Naeshiro, Noriaki, additional, Takahashi, Hironao, additional, Mano, Yutaka, additional, Tsunematsu, Seiji, additional, Yabuuchi, Iwao, additional, Shimada, Yusuke, additional, Yamauchi, Kazuhiko, additional, Sugimoto, Rie, additional, Sakai, Hironori, additional, Mita, Eiji, additional, Koda, Masaharu, additional, Tsuruta, Satoru, additional, Kamitsukasa, Hiroshi, additional, Sato, Takeaki, additional, Masaki, Naohiko, additional, Kobata, Tatsuro, additional, Fukushima, Nobuyoshi, additional, Ohara, Yukio, additional, Muro, Toyokichi, additional, Takesaki, Eiichi, additional, Takaki, Hitoshi, additional, Yamamoto, Tetsuo, additional, Kato, Michio, additional, Nagaoki, Yuko, additional, Hayashi, Shigeki, additional, Ishida, Jinya, additional, Watanabe, Yukio, additional, Kobayashi, Masakazu, additional, Koga, Michiaki, additional, Saoshiro, Takeo, additional, Yagura, Michiyasu, additional, Hirata, Keisuke, additional, Tanaka, Atsushu, additional, Takikawa, Hajime, additional, Zeniya, Mikio, additional, Abe, Masanori, additional, Onji, Morikazu, additional, Kaneko, Shuichi, additional, Honda, Masao, additional, Arai, Kuniaki, additional, Arinaga-Hino, Teruko, additional, Hashimoto, Etsuko, additional, Taniai, Makiko, additional, Umemura, Takeji, additional, Joshita, Satoru, additional, Nakao, Kazuhiko, additional, Ichikawa, Tatsuki, additional, Shibata, Hidetaka, additional, Yamagiwa, Satoshi, additional, Seike, Masataka, additional, Honda, Koichi, additional, Sakisaka, Shotaro, additional, Takeyama, Yasuaki, additional, Harada, Masaru, additional, Senju, Michio, additional, Yokosuka, Osamu, additional, Kanda, Tatsuo, additional, Ueno, Yoshiyuki, additional, Kikuchi, Kentaro, additional, Ebinuma, Hirotoshi, additional, Himoto, Takashi, additional, Yasunami, Michio, additional, Murata, Kazumoto, additional, Mizokami, Masashi, additional, Kawata, Kazuhito, additional, Shimoda, Shinji, additional, Miyake, Yasuhiro, additional, Takaki, Akinobu, additional, Yamamoto, Kazuhide, additional, Hirano, Katsuji, additional, Ichida, Takafumi, additional, Ido, Akio, additional, Tsubouchi, Hirohito, additional, Chayama, Kazuaki, additional, Harada, Kenichi, additional, Nakanuma, Yasuni, additional, Maehara, Yoshihiko, additional, Taketomi, Akinobu, additional, Shirabe, Ken, additional, Soejima, Yuji, additional, Mori, Akira, additional, Yagi, Shintaro, additional, Uemoto, Shinji, additional, H, Egawa, additional, Tanaka, Tomohiro, additional, Yamashiki, Noriyo, additional, Tamura, Sumito, additional, Sugawara, Yasuhiro, additional, Kokudo, Norihiro, additional, Chalasani, Naga, additional, Luketic, Vel, additional, Odin, Joseph, additional, Chopra, Kapil, additional, Abecasis, Goncalo, additional, Cantor, Michael, additional, Coppola, Giovanni, additional, Economides, Aris, additional, Lotta, Luca A., additional, Overton, John D., additional, Reid, Jeffrey G., additional, Shuldiner, Alan, additional, Beechert, Christina, additional, Forsythe, Caitlin, additional, Fuller, Erin D., additional, Gu, Zhenhua, additional, Lattari, Michael, additional, Lopez, Alexander, additional, Schleicher, Thomas D., additional, Padilla, Maria Sotiropoulos, additional, Toledo, Karina, additional, Widom, Louis, additional, Wolf, Sarah E., additional, Pradhan, Manasi, additional, Manoochehri, Kia, additional, Ulloa, Ricardo H., additional, Bai, Xiaodong, additional, Balasubramanian, Suganthi, additional, Barnard, Leland, additional, Blumenfeld, Andrew, additional, Eom, Gisu, additional, Habegger, Lukas, additional, Hawes, Alicia, additional, Khalid, Shareef, additional, Maxwell, Evan K., additional, Salerno, William, additional, Staples, Jeffrey C., additional, Jones, Marcus B., additional, Mitnaul, Lyndon J., additional, Sturgess, Richard, additional, Healey, Christopher, additional, Yeoman, Andrew, additional, Gunasekera, Anton VJ., additional, Kooner, Paul, additional, Kapur, Kapil, additional, Sathyanarayana, V., additional, Kallis, Yiannis, additional, Subhani, Javaid, additional, Harvey, Rory, additional, McCorry, Roger, additional, Rooney, Paul, additional, Ramanaden, David, additional, Evans, Richard, additional, Mathialahan, Thiriloganathan, additional, Gasem, Jaber, additional, Shorrock, Christopher, additional, Bhalme, Mahesh, additional, Southern, Paul, additional, Tibble, Jeremy A., additional, Gorard, David A., additional, Jones, Susan, additional, Mells, George, additional, Mulcahy, Victoria, additional, Srivastava, Brijesh, additional, Foxton, Matthew R., additional, Collins, Carole E., additional, Elphick, David, additional, Karmo, Mazn, additional, Porras-Perez, Francisco, additional, Mendall, Michael, additional, Yapp, Tom, additional, Patel, Minesh, additional, Ede, Roland, additional, Sayer, Joanne, additional, Jupp, James, additional, Fisher, Neil, additional, Carter, Martyn J., additional, Koss, Konrad, additional, Shah, Jayshri, additional, Piotrowicz, Andrzej, additional, Scott, Glyn, additional, Grimley, Charles, additional, Gooding, Ian R., additional, Williams, Simon, additional, Tidbury, Judith, additional, Lim, Guan, additional, Cheent, Kuldeep, additional, Levi, Sass, additional, Mansour, Dina, additional, Beckley, Matilda, additional, Hollywood, Coral, additional, Wong, Terry, additional, Marley, Richard, additional, Ramage, John, additional, Gordon, Harriet M., additional, Ridpath, Jo, additional, Ngatchu, Theodore, additional, Bob Grover, Vijay Paul, additional, Shidrawi, Ray G., additional, Abouda, George, additional, Corless, L., additional, Narain, Mark, additional, Rees, Ian, additional, Brown, Ashley, additional, Taylor-Robinson, Simon, additional, Wilkins, Joy, additional, Grellier, Leonie, additional, Banim, Paul, additional, Das, Debasish, additional, Heneghan, Michael A., additional, Curtis, Howard, additional, Matthews, Helen C., additional, Mohammed, Faiyaz, additional, Aldersley, Mark, additional, Srirajaskanthan, Raj, additional, Walker, Giles, additional, McNair, Alistair, additional, Sharif, Amar, additional, Sen, Sambit, additional, Bird, George, additional, Prince, Martin I., additional, Prasad, Geeta, additional, Kitchen, Paul, additional, Barnardo, Adrian, additional, Oza, Chirag, additional, Sivaramakrishnan, Nurani N., additional, Gupta, Prakash, additional, Shah, Amir, additional, Evans, Chris DJ., additional, Saha, Subrata, additional, Pollock, Katharine, additional, Bramley, Peter, additional, Mukhopadhya, Ashis, additional, Barclay, Stephen T., additional, McDonald, Natasha, additional, Bathgate, Andrew J., additional, Palmer, Kelvin, additional, Dillon, John F., additional, Rushbrook, Simon M., additional, Przemioslo, Robert, additional, McDonald, Chris, additional, Millar, Andrew, additional, Tai, Cheh, additional, Mitchell, Stephen, additional, Metcalf, Jane, additional, Shaukat, Syed, additional, Ninkovic, Mary, additional, Shmueli, Udi, additional, Davis, Andrew, additional, Naqvi, Asifabbas, additional, Lee, Tom JW., additional, Ryder, Stephen, additional, Collier, Jane, additional, Klass, Howard, additional, Cramp, Matthew E., additional, Sharer, Nichols, additional, Aspinall, Richard, additional, Ghosh, Deb, additional, Douds, Andrew C., additional, Booth, Jonathan, additional, Williams, Earl, additional, Hussaini, Hyder, additional, Christie, John, additional, Mann, Steven, additional, Thorburn, Douglas, additional, Marshall, Aileen, additional, Patanwala, Imran, additional, Ala, Aftab, additional, Maltby, Julia, additional, Matthew, Ray, additional, Corbett, Chris, additional, Vyas, Sam, additional, Singhal, Saket, additional, Gleeson, Dermot, additional, Misra, Sharat, additional, Butterworth, Jeff, additional, George, Keith, additional, Harding, Tim, additional, Douglass, Andrew, additional, Mitchison, Harriet, additional, Panter, Simon, additional, Shearman, Jeremy, additional, Bray, Gary, additional, Roberts, Michael, additional, Butcher, Graham, additional, Forton, Daniel, additional, Mahmood, Zahid, additional, Cowan, Matthew, additional, Das, Debashis, additional, Ch'ng, Chin Lye, additional, Rahman, Mesbah, additional, Whatley, Gregory C.A., additional, Wesley, Emma, additional, Mandal, Aditya, additional, Jain, Sanjiv, additional, Pereira, Stephen P., additional, Wright, Mark, additional, Trivedi, Palak, additional, Gordon, Fiona H., additional, Unitt, Esther, additional, Palejwala, Altaf, additional, Austin, Andrew, additional, Vemala, Vishwaraj, additional, Grant, Allister, additional, Higham, Andrew D., additional, Brind, Alison, additional, Mathew, Ray, additional, Cox, Mark, additional, Ramakrishnan, Subramaniam, additional, King, Alistair, additional, Whalley, Simon, additional, Fraser, Jocelyn, additional, Thomson, S.J., additional, Bell, Andrew, additional, Wong, Voi Shim, additional, Kia, Richard, additional, Gee, Ian, additional, Keld, Richard, additional, Ransford, Rupert, additional, Gotto, James, additional, and Millson, Charles, additional

Published
2021
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